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Nexavar Side Effects

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Common Nexavar Side Effects


The most commonly reported Nexavar side effects (click to view or check a box to report):

Palmar-plantar Erythrodysaesthesia Syndrome (1909)
Diarrhoea (1683)
Hepatic Function Abnormal (1181)
Hypertension (1025)
Rash (927)
Alopecia (699)
Fatigue (696)
Decreased Appetite (690)
Pyrexia (650)
Nausea (552)
Hepatic Neoplasm Malignant (542)
Hepatic Encephalopathy (461)
Pain In Extremity (440)
Platelet Count Decreased (426)
Malaise (409)
Death (408)
Blister (406)
Asthenia (404)
Ascites (395)
Abdominal Pain (384)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Nexavar Side Effects Reported to FDA



Nexavar Side Effect Report#9996510
Multi-organ Failure, Palmar-plantar Erythrodysaesthesia Syndrome, Decreased Appetite, Diarrhoea
This is a report of a 72-year-old male patient (weight: NA) from CN, suffering from the following health symptoms/conditions: renal cell carcinoma,hepatic cancer, who was treated with Nexavar (dosage: 400 Mg, Bid, start time:
Jul 01, 2011), combined with: NA. and developed a serious reaction and side effect(s): Multi-organ Failure, Palmar-plantar Erythrodysaesthesia Syndrome, Decreased Appetite, Diarrhoea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexavar treatment in male patients, resulting in Multi-organ Failure side effect.
Nexavar Side Effect Report#9996349
Cerebrovascular Accident
This report suggests a potential Nexavar Cerebrovascular Accident side effect(s) that can have serious consequences. A 91-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: hepatic cancer and used Nexavar (dosage: NA) starting
Feb 10, 2014. After starting Nexavar the patient began experiencing various side effects, including: Cerebrovascular AccidentAdditional drugs used concurrently: NA.The patient was hospitalized. Although Nexavar demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Cerebrovascular Accident, may still occur.
Nexavar Side Effect Report#9994740
Tremor, Diarrhoea, Pruritus, Pruritus, Quality Of Life Decreased
This Tremor problem was reported by a pharmacist from US. A 80-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hepatic cancer. On
Feb 04, 2014 this consumer started treatment with Nexavar 200mg Bayer (dosage: NA). The following drugs were being taken at the same time: NA. When using Nexavar 200mg Bayer, the patient experienced the following unwanted symptoms/side effects: Tremor, Diarrhoea, Pruritus, Pruritus, Quality Of Life DecreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Tremor, may become evident only after a product is in use by the general population.
Nexavar Side Effect Report#9984560
Blood Pressure Abnormal, Arthralgia
This Blood Pressure Abnormal side effect was reported by a health professional from US. A 53-year-old male patient (weight:NA) experienced the following symptoms/conditions: hepatic cancer.The patient was prescribed Nexavar (drug dosage: 4 X 200 Mg), which was initiated on
Nov 04, 2013. Concurrently used drugs: NA..After starting to take Nexavar the consumer reported adverse symptoms, such as: Blood Pressure Abnormal, ArthralgiaThese side effects may potentially be related to Nexavar. The patient was hospitalized.
Nexavar Side Effect Report#9984549
Chest Pain, Abdominal Pain, Chromaturia
This is a report of a 54-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: hepatic cancer, who was treated with Nexavar (dosage: 400 Mg, Bid, start time:
Feb 19, 2014), combined with: NA. and developed a serious reaction and side effect(s): Chest Pain, Abdominal Pain, Chromaturia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexavar treatment in male patients, resulting in Chest Pain side effect.
Nexavar Side Effect Report#9984134
Inguinal Hernia, Abnormal Behaviour, Incoherent, Hallucination, Visual, Confusional State, Abnormal Behaviour, Decreased Appetite, Abdominal Pain
This report suggests a potential Nexavar Inguinal Hernia side effect(s) that can have serious consequences. A 50-year-old male patient (weight: NA) from BR was diagnosed with the following symptoms/conditions: hepatic cancer and used Nexavar (dosage: 2 Df, Bid) starting
Jan 09, 2014. After starting Nexavar the patient began experiencing various side effects, including: Inguinal Hernia, Abnormal Behaviour, Incoherent, Hallucination, Visual, Confusional State, Abnormal Behaviour, Decreased Appetite, Abdominal PainAdditional drugs used concurrently: NA.The patient was hospitalized. Although Nexavar demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Inguinal Hernia, may still occur.
Nexavar Side Effect Report#9981239
Hepatocellular Carcinoma, Palmar-plantar Erythrodysaesthesia Syndrome, Hypertension
This Hepatocellular Carcinoma problem was reported by a physician from JP. A 78-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hepatocellular carcinoma. On
Nov 27, 2013 this consumer started treatment with Nexavar (dosage: 400 Mg, Bid). The following drugs were being taken at the same time: NA. When using Nexavar, the patient experienced the following unwanted symptoms/side effects: Hepatocellular Carcinoma, Palmar-plantar Erythrodysaesthesia Syndrome, HypertensionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hepatocellular Carcinoma, may become evident only after a product is in use by the general population.
Nexavar Side Effect Report#9961795
Diarrhoea, Blood Magnesium Decreased, Blood Potassium Decreased
This Diarrhoea side effect was reported by a pharmacist from US. A 66-year-old female patient (weight:NA) experienced the following symptoms/conditions: liver disorder.The patient was prescribed Nexavar 200mg Bayer (drug dosage: NA), which was initiated on
Apr 02, 2011. Concurrently used drugs: NA..After starting to take Nexavar 200mg Bayer the consumer reported adverse symptoms, such as: Diarrhoea, Blood Magnesium Decreased, Blood Potassium DecreasedThese side effects may potentially be related to Nexavar 200mg Bayer.
Nexavar Side Effect Report#9961523
Tongue Ulceration, Skin Ulcer
This is a report of a 58-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: hepatic cancer, who was treated with Nexavar 200mg Bayer (dosage: NA, start time: 2014), combined with: NA. and developed a serious reaction and side effect(s): Tongue Ulceration, Skin Ulcer after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexavar 200mg Bayer treatment in male patients, resulting in Tongue Ulceration side effect.
Nexavar Side Effect Report#9953630
Toxicity To Various Agents, Skin Toxicity, Blister, Oral Discomfort, Dysphagia, Oropharyngeal Pain, Aptyalism, Mucous Membrane Disorder, Pain In Extremity
This report suggests a potential Nexavar Toxicity To Various Agents side effect(s) that can have serious consequences. A 59-year-old male patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: metastatic renal cell carcinoma and used Nexavar (dosage: 400 Mg, Bid) starting 200311. After starting Nexavar the patient began experiencing various side effects, including: Toxicity To Various Agents, Skin Toxicity, Blister, Oral Discomfort, Dysphagia, Oropharyngeal Pain, Aptyalism, Mucous Membrane Disorder, Pain In ExtremityAdditional drugs used concurrently:
  • Interferon (Unk)
  • Interferon (Unk)
  • Sutent (Unk)
  • Afinitor (Unk)
Although Nexavar demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Toxicity To Various Agents, may still occur.
Nexavar Side Effect Report#9938154
Coronary Artery Disease, Left Ventricular Dysfunction, Palmar-plantar Erythrodysaesthesia Syndrome
This Coronary Artery Disease problem was reported by a physician from DE. A 57-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hepatocellular carcinoma. On 201311 this consumer started treatment with Nexavar (dosage: 200 Mg, Bid). The following drugs were being taken at the same time: NA. When using Nexavar, the patient experienced the following unwanted symptoms/side effects: Coronary Artery Disease, Left Ventricular Dysfunction, Palmar-plantar Erythrodysaesthesia SyndromeAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Coronary Artery Disease, may become evident only after a product is in use by the general population.
Nexavar Side Effect Report#9934848
Fatigue, Skin Lesion, Swelling Face, Ear Swelling
This Fatigue side effect was reported by a pharmacist from US. A 54-year-old female patient (weight:NA) experienced the following symptoms/conditions: hepatic cancer.The patient was prescribed Nexavar (drug dosage: Daily Dose 800 Mg), which was initiated on NS. Concurrently used drugs: NA..After starting to take Nexavar the consumer reported adverse symptoms, such as: Fatigue, Skin Lesion, Swelling Face, Ear SwellingThese side effects may potentially be related to Nexavar. The patient was hospitalized.
Nexavar Side Effect Report#9931848
Loose Tooth, Tooth Loss, Dry Skin, Aphthous Stomatitis, Oral Pain, Weight Decreased
This is a report of a 73-year-old male patient (weight: NA) from GT, suffering from the following health symptoms/conditions: hepatic cancer, who was treated with Nexavar (dosage: Total Daily Dose 800 Mg, start time:
Dec 24, 2013), combined with: NA. and developed a serious reaction and side effect(s): Loose Tooth, Tooth Loss, Dry Skin, Aphthous Stomatitis, Oral Pain, Weight Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexavar treatment in male patients, resulting in Loose Tooth side effect.
Nexavar Side Effect Report#9929520
Hypertension, Palmar-plantar Erythrodysaesthesia Syndrome, Proteinuria, Hypoalbuminaemia, Acute Myocardial Infarction, Dysgeusia, Palmar-plantar Erythrodysaesthesia Syndrome, Myalgia
This report suggests a potential Nexavar Hypertension side effect(s) that can have serious consequences. A 55-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: spindle cell sarcoma and used Nexavar (dosage: 200 Mg, Bid) starting NS. After starting Nexavar the patient began experiencing various side effects, including: Hypertension, Palmar-plantar Erythrodysaesthesia Syndrome, Proteinuria, Hypoalbuminaemia, Acute Myocardial Infarction, Dysgeusia, Palmar-plantar Erythrodysaesthesia Syndrome, MyalgiaAdditional drugs used concurrently: NA. Although Nexavar demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypertension, may still occur.
Nexavar Side Effect Report#9925443
Skin Exfoliation, Pain In Extremity
This Skin Exfoliation problem was reported by a pharmacist from US. A 80-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hepatic cancer. On
Oct 28, 2013 this consumer started treatment with Nexavar (dosage: NA). The following drugs were being taken at the same time: NA. When using Nexavar, the patient experienced the following unwanted symptoms/side effects: Skin Exfoliation, Pain In ExtremityAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Skin Exfoliation, may become evident only after a product is in use by the general population.
Nexavar Side Effect Report#9922669
Stomatitis, Dehydration, Cough
This Stomatitis side effect was reported by a consumer or non-health professional from US. A 67-year-old male patient (weight:NA) experienced the following symptoms/conditions: hepatocellular carcinoma.The patient was prescribed Nexavar (drug dosage: 400 Mg, Bid), which was initiated on
Jan 27, 2014. Concurrently used drugs: NA..After starting to take Nexavar the consumer reported adverse symptoms, such as: Stomatitis, Dehydration, CoughThese side effects may potentially be related to Nexavar. The patient was hospitalized.
Nexavar Side Effect Report#9922449
Delirium, Depressed Level Of Consciousness
This is a report of a 60-year-old male patient (weight: NA) from CN, suffering from the following health symptoms/conditions: hepatocellular carcinoma, who was treated with Nexavar (dosage: 400 Mg, Bid (800mg Daily), start time:
Feb 13, 2014), combined with:
  • Pantoprazole (60 Mg, Unk)
  • Ornithine Aspartate (2.5 G, Unk)
  • Ademetionine (1000 Mg, Unk)
  • Ulinastatin (200000 U, Unk)
  • Ondansetron Hydrochloride (8 Mg, Unk)
  • Potassium Chloride (Unk)
  • Insulin (Unk)
  • Vitamin C (Unk)
and developed a serious reaction and side effect(s): Delirium, Depressed Level Of Consciousness after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexavar treatment in male patients, resulting in Delirium side effect.
Nexavar Side Effect Report#9922343
Disease Progression
This report suggests a potential Nexavar Disease Progression side effect(s) that can have serious consequences. A 71-year-old male patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: metastatic renal cell carcinoma and used Nexavar (dosage: Unk) starting
Apr 12, 2011. After starting Nexavar the patient began experiencing various side effects, including: Disease ProgressionAdditional drugs used concurrently: NA. Although Nexavar demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Disease Progression, may still occur.
Nexavar Side Effect Report#9922341
Convulsion, Loss Of Consciousness, Hypertonia, Tongue Biting
This Convulsion problem was reported by a health professional from IT. A 76-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: renal cancer. On NS this consumer started treatment with Nexavar (dosage: Daily Dose 800 Mg). The following drugs were being taken at the same time: NA. When using Nexavar, the patient experienced the following unwanted symptoms/side effects: Convulsion, Loss Of Consciousness, Hypertonia, Tongue BitingAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Convulsion, may become evident only after a product is in use by the general population.
Nexavar Side Effect Report#9919453
Confusional State
This Confusional State side effect was reported by a health professional from CN. A 82-year-old male patient (weight:NA) experienced the following symptoms/conditions: hepatocellular carcinoma.The patient was prescribed Nexavar (drug dosage: Unk), which was initiated on NS. Concurrently used drugs: NA..After starting to take Nexavar the consumer reported adverse symptoms, such as: Confusional StateThese side effects may potentially be related to Nexavar. The patient was hospitalized.
Nexavar Side Effect Report#9916477
Skin Toxicity, Gastrointestinal Toxicity, Headache, Gingival Pain
This is a report of a 55-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: hepatocellular carcinoma, who was treated with Nexavar (dosage: 200 Mg, Bid, start time: 201301), combined with: NA. and developed a serious reaction and side effect(s): Skin Toxicity, Gastrointestinal Toxicity, Headache, Gingival Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexavar treatment in male patients, resulting in Skin Toxicity side effect.
Nexavar Side Effect Report#9916470
Pulmonary Embolism
This report suggests a potential Nexavar Tablet 200 Mg Pulmonary Embolism side effect(s) that can have serious consequences. A 70-year-old male patient (weight: NA) from SG was diagnosed with the following symptoms/conditions: hepatocellular carcinoma and used Nexavar Tablet 200 Mg (dosage: Daily Dose 800 Mg) starting NS. After starting Nexavar Tablet 200 Mg the patient began experiencing various side effects, including: Pulmonary EmbolismAdditional drugs used concurrently: NA. Although Nexavar Tablet 200 Mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pulmonary Embolism, may still occur.
Nexavar Side Effect Report#9916043
Renal Cancer, Pain
This Renal Cancer problem was reported by a pharmacist from US. A 82-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: renal cancer. On
Jul 18, 2013 this consumer started treatment with Nexavar (dosage: NA). The following drugs were being taken at the same time: NA. When using Nexavar, the patient experienced the following unwanted symptoms/side effects: Renal Cancer, PainAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Renal Cancer, may become evident only after a product is in use by the general population.
Nexavar Side Effect Report#9914540
Bone Contusion, Sinusitis, Neck Pain, Pain In Extremity, Off Label Use, Hypersensitivity, Sinusitis, Dehydration, Diarrhoea
This Bone Contusion side effect was reported by a health professional from US. A 65-year-old female patient (weight:NA) experienced the following symptoms/conditions: colon cancer.The patient was prescribed Nexavar (drug dosage: 2 X 200 Mg), which was initiated on 2013. Concurrently used drugs: NA..After starting to take Nexavar the consumer reported adverse symptoms, such as: Bone Contusion, Sinusitis, Neck Pain, Pain In Extremity, Off Label Use, Hypersensitivity, Sinusitis, Dehydration, DiarrhoeaThese side effects may potentially be related to Nexavar.
Nexavar Side Effect Report#9914325
Pancytopenia, Rash
This is a report of a 39-year-old male patient (weight: NA) from JP, suffering from the following health symptoms/conditions: hepatocellular carcinoma, who was treated with Nexavar (dosage: Daily Dose 400 Mg, start time:
Feb 11, 2014), combined with: NA. and developed a serious reaction and side effect(s): Pancytopenia, Rash after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexavar treatment in male patients, resulting in Pancytopenia side effect.


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The appearance of Nexavar on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Nexavar Side Effects for Women?

Women Side EffectsReports
Palmar-plantar Erythrodysaesthesia Syndrome 465
Diarrhoea 423
Rash 322
Alopecia 265
Hypertension 236
Hepatic Function Abnormal 222
Fatigue 205
Nausea 175
Decreased Appetite 172
Blister 169

What are common Nexavar Side Effects for Men?

Men Side EffectsReports
Palmar-plantar Erythrodysaesthesia Syndrome 1438
Diarrhoea 1259
Hepatic Function Abnormal 959
Hypertension 789
Rash 602
Decreased Appetite 516
Pyrexia 497
Fatigue 491
Hepatic Neoplasm Malignant 445
Alopecia 434

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Nexavar reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Nexavar Side Effects

    Did You Have a Nexavar Side Effect?

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    How Effective is Nexavar for You?

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    Nexavar Safety Alerts, Active Ingredients, Usage Information

    NDC50419-488
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameNexavar
    Namesorafenib
    Dosage FormTABLET, FILM COATED
    RouteORAL
    On market since20051220
    LabelerBayer HealthCare Pharmaceuticals Inc.
    Active Ingredient(s)SORAFENIB
    Strength(s)200
    Unit(s)mg/1
    Pharma ClassKinase Inhibitor [EPC],Protein Kinase Inhibitors [MoA]

    Nexavar Dosage, Warnings, Usage.

    Side Effects reported to FDA: 9645

    Nexavar safety alerts: No

    Reported deaths: 2723

    Reported hospitalizations: 4562

    Latest Nexavar clinical trials