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Nitrofur Side Effects

Common Nitrofur Side Effects


The most commonly reported Nitrofur side effects (click to view or check a box to report):

Dyspnoea (95)
Nausea (90)
Chills (87)
Headache (80)
Pyrexia (75)
Vomiting (61)
Asthenia (60)
Malaise (50)
Pain (50)
Cough (50)
Chest Pain (48)
Dizziness (48)
Fatigue (48)
Diarrhoea (41)
Rash (40)
Arthralgia (38)
Pruritus (33)
Myalgia (31)
Oedema Peripheral (31)
Pulmonary Fibrosis (30)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Nitrofur Side Effects Reported to FDA

The following Nitrofur reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Nitrofur on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Diarrhoea, Vomiting, Pyrexia, Chills, Lung Disorder, Lupus-like Syndrome, Interstitial Lung Disease, Antibody Test Positive, Dyspnoea
This is a report of a 50-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: prophylaxis urinary tract infection,bladder operation, who was treated with Nitrofurantoin Macrocrystals (dosage: 100 Mg/1 Pill Once Daily Taken By Mouth, start time: NS), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Diarrhoea
  • Vomiting
  • Pyrexia
  • Chills
  • Lung Disorder
  • Lupus-like Syndrome
  • Interstitial Lung Disease
  • Antibody Test Positive
  • Dyspnoea
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nitrofurantoin Macrocrystals treatment in female patients, resulting in diarrhoea side effect. The patient was hospitalized and became disabled.

Nausea, Pruritus, Urticaria, Eye Pruritus, Hypopnoea, Dizziness
This report suggests a potential Nitrofurantoin Nausea, Pruritus, Urticaria, Eye Pruritus, Hypopnoea, Dizziness side effect(s) that can have serious consequences. A 48-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: urinary tract infection and used Nitrofurantoin (dosage: NA) starting Mar 03, 2014. Soon after starting Nitrofurantoin the patient began experiencing various side effects, including:
  • Nausea
  • Pruritus
  • Urticaria
  • Eye Pruritus
  • Hypopnoea
  • Dizziness
Drugs used concurrently: NA. Although Nitrofurantoin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as nausea, may still occur.

Interstitial Lung Disease, Leukocytosis, Lymphopenia, Blood Lactate Dehydrogenase
This Interstitial Lung Disease, Leukocytosis, Lymphopenia, Blood Lactate Dehydrogenase problem was reported by a physician from DE. A 40-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: cystitis noninfective. On Feb 09, 2014 this consumer started treatment with Nitrofurantoinum (dosage: 2 Dosage Forms Daily;). The following drugs were being taken at the same time: NA. When commencing Nitrofurantoinum, the patient experienced the following unwanted symptoms/side effects:
  • Interstitial Lung Disease
  • Leukocytosis
  • Lymphopenia
  • Blood Lactate Dehydrogenase
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as interstitial lung disease, may become evident only after a product is in use by the general population.

Acute Respiratory Distress Syndrome, Maternal Exposure During Pregnancy
This is a report of a 23-year-old female patient (weight: NA) from EG. The patient developed the following symptoms/conditions: urinary tract infection and was treated with Nitrofurantoin (dosage: NA) starting NS. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Acute Respiratory Distress Syndrome
  • Maternal Exposure During Pregnancy
The patient was hospitalized. This opens a possibility that Nitrofurantoin treatment could cause the above reactions, including acute respiratory distress syndrome, and some female subjects may be more susceptible.


Local Swelling, Pain In Extremity, Arthralgia, Joint Swelling
A 73-year-old female patient (weight: NA) from US with the following symptoms/conditions: urinary tract infection started Nitrofurantoin Monohydrate treatment (dosage: NA) on Jan 28, 2014. Soon after starting Nitrofurantoin Monohydrate treatment, the subject experienced various side effects, including:
  • Local Swelling
  • Pain In Extremity
  • Arthralgia
  • Joint Swelling
Concurrently used drugs:
  • Simvastatin
  • Prednisone
  • Atenolol
  • Levothroxin
  • Aspirin
  • Vit E
  • Co Q10
  • Potassium
This finding indicates that some female patients could be more vulnerable to Nitrofurantoin Monohydrate.

Oral Herpes, Pain
A 50-year-old female patient from US (weight: NA) experienced symptoms, such as: cystitis and was treated with Nitrofurantoin(dosage: NA). The treatment was initiated on Jan 06, 2014. After that a consumer reported the following side effect(s):
  • Oral Herpes
  • Pain
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Nitrofurantoin efficacy: NA.

Respiratory Failure, Acute Respiratory Distress Syndrome, Dyspnoea, Tachypnoea, Cough, End-tidal Co2 Decreased, Oxygen Saturation Decreased, Breath Sounds Abnormal, Hypocapnia
In this report, Nitrofurantoin was administered for the following condition: urinary tract infection,prophylaxis.A 23-year-old female consumer from EG (weight: NA) started Nitrofurantoin treatment (dosage: 1 Df, Bid) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Respiratory Failure
  • Acute Respiratory Distress Syndrome
  • Dyspnoea
  • Tachypnoea
  • Cough
  • End-tidal Co2 Decreased
  • Oxygen Saturation Decreased
  • Breath Sounds Abnormal
  • Hypocapnia
A possible interaction with other drugs could have contributed to this reaction:
  • Enoxaparin Sodium (40 Mg, Unk)
  • Remifentanil (0.1 Ug/kg/min)
  • Propofol (50 Mg/hour)
  • Methylprednisolone (1 Mg/kg/day)
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Nitrofurantoin treatment could be related to the listed above side effect(s).

Pneumonia
This is a report of the following Nitrofurantoin Macro side effect(s):
  • Pneumonia
A 81-year-old female patient from US (weight: NA) presented with the following condition: cystitis and received a treatment with Nitrofurantoin Macro (dosage: NA) starting: Sep 08, 2011.The following concurrently used drugs could have generated interactions: NA.The patient was hospitalized.This report suggests that a Nitrofurantoin Macro treatment could be associated with the listed above side effect(s).

Rash, Back Pain, Oliguria, Prurigo, Macule, Erythema, Hypotension, Pyrexia
This Nitrofurantoin report was submitted by a 77-year-old female consumer from PT (weight: NA). The patient was diagnosed with: urinary tract infection and Nitrofurantoin was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Rash
  • Back Pain
  • Oliguria
  • Prurigo
  • Macule
  • Erythema
  • Hypotension
  • Pyrexia
Other drugs used simultaneously: NA.The patient was hospitalized.Those unexpected symptoms could be linked to a Nitrofurantoin treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Neuropathy Peripheral, Burning Sensation, Paraesthesia, Pain, Local Swelling, Rash Erythematous, Hypoaesthesia, Toxicity To Various Agents
This is a report of a possible correlation between Nitrofurantoin use and the following symptoms/side effect(s):
  • Neuropathy Peripheral
  • Burning Sensation
  • Paraesthesia
  • Pain
  • Local Swelling
  • Rash Erythematous
  • Hypoaesthesia
  • Toxicity To Various Agents
which could contribute to an assessment of Nitrofurantoin risk profile.A 76-year-old female consumer from GB (weight: NA) was suffering from prophylaxis urinary tract infection and was treated with Nitrofurantoin (dosage: 50 Milligram Daily;) starting Feb 05, 2013.Other concurrent medications:
  • Loperamide
  • Lansoprazole
  • Aspirin
  • Digoxin
  • Codeine Phosphate


Liver Function Test Abnormal, Immunoglobulins Increased
A 70-year-old female patient from GB (weight: NA) presented with the following symptoms: prophylaxis and after a treatment with Nitrofurantoin (dosage: 50 Milligram Daily; Inidcation: Prophylaxis For Recurrent Utis) experienced the following side effect(s):
  • Liver Function Test Abnormal
  • Immunoglobulins Increased
The treatment was started on 201210. Nitrofurantoin was used in combination with the following drugs:
  • Amitriptyline
  • Aspirin
  • Atorvastatin
  • Bisoprolol
  • Enalapril
  • Tolterodine
  • Amlodipine
The patient was hospitalized.This report could alert potential Nitrofurantoin consumers.

Lung Disorder, Nocturia, Urinary Incontinence, Thinking Abnormal, Skin Irritation, Constipation, Speech Disorder
In this report, a 85-year-old female patient from US (weight: NA) was affected by a possible Nitrofurantoin side effect.The patient was diagnosed with NA. After a treatment with Nitrofurantoin (dosage: Unk, 2x/day, start date: NS), the patient experienced the following side effect(s):
  • Lung Disorder
  • Nocturia
  • Urinary Incontinence
  • Thinking Abnormal
  • Skin Irritation
  • Constipation
  • Speech Disorder
The following simultaneously used drugs could have led to this reaction:
  • Detrol La (Unk)
  • Magnesium (Unk)
  • Calcium (Unk)
The findings here stress that side effects should be taken into consideration when evaluating a Nitrofurantoin treatment.

Musculoskeletal Chest Pain, Hyperhidrosis, Hypoxia, Lung Infiltration
This is a report of a 82-year-old female patient from US (weight: NA), who used Nitrofurantoin (dosage: 1 Capsule) for a treatment of urinary tract infection. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Musculoskeletal Chest Pain
  • Hyperhidrosis
  • Hypoxia
  • Lung Infiltration
The following drugs could possibly have interacted with the Nitrofurantoin treatment
  • Acetaminophen (tylenol)
  • Amb Home Oxygen
  • Apidra Solostar
  • B Complex
  • Calcium Carboante (caltrate)
  • Carvedilol (coreg)
  • Cholecalciferol (vitamin D)
  • Cyanocobalamin, Vitamin B-12
The patient was hospitalized.Taken together, these observations suggest that a Nitrofurantoin treatment could be related to side effect(s), such as Musculoskeletal Chest Pain, Hyperhidrosis, Hypoxia, Lung Infiltration.

Circulatory Collapse, Angina Pectoris, Dizziness, Tremor, Feeling Abnormal, Gait Disturbance
This circulatory collapse side effect was reported by a consumer or non-health professional from DE. A 65-year-old female patient (weight:NA) experienced the following symptoms/conditions: cystitis noninfective,parkinson^s disease. The patient was prescribed Nitrofurantoin-ratiopharm 100 Mg Retardkapseln (dosage: 100 Milligram Daily;), which was started on 201311. Concurrently used drugs:
  • Stalevo
  • Sifrol Ret
  • Azilect
When starting to take Nitrofurantoin-ratiopharm 100 Mg Retardkapseln the consumer reported the following symptoms:
  • Circulatory Collapse
  • Angina Pectoris
  • Dizziness
  • Tremor
  • Feeling Abnormal
  • Gait Disturbance
These side effects may potentially be related to Nitrofurantoin-ratiopharm 100 Mg Retardkapseln.

Pulmonary Fibrosis
This is a Nitrofurantoin side effect report of a 75-year-old male patient (weight:NA) from US, suffering from the following symptoms/conditions: pulmonary fibrosis, who was treated with Nitrofurantoin (dosage:NA, start time: Aug 20, 2013), combined with: NA., and developed a serious reaction and a pulmonary fibrosis side effect. The patient presented with:
  • Pulmonary Fibrosis
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Nitrofurantoin treatment in male patients suffering from pulmonary fibrosis, resulting in pulmonary fibrosis.

Cheilitis, Skin Exfoliation, Nikolsky^s Sign
This report suggests a potential Nitrofurantoin cheilitis side effect(s) that can have serious consequences. A 71-year-old female patient from FR (weight:NA) was diagnosed with the following health condition(s): NA and used Nitrofurantoin (dosage: NA) starting NS. Soon after starting Nitrofurantoin the patient began experiencing various side effects, including:
  • Cheilitis
  • Skin Exfoliation
  • Nikolsky^s Sign
Drugs used concurrently:
  • Pristinamycin
The patient was hospitalized. Although Nitrofurantoin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as cheilitis, may still occur.

Neuropathy Peripheral, Dizziness, Clumsiness, Hypogeusia, Anosmia, Sensory Loss, Hypoaesthesia, Paraesthesia, Bradyphrenia
This neuropathy peripheral problem was reported by a consumer or non-health professional from GB. A 34-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): cystitis.On Sep 13, 2013 a consumer started treatment with Nitrofurantoin (dosage: NA). The following drugs/medications were being taken at the same time:
  • Sodium Citrate
  • Uva Ursi
  • Anadin Extra
  • Nurofen Express
  • Trimethoprim
When commencing Nitrofurantoin, the patient experienced the following unwanted symptoms /side effects:
  • Neuropathy Peripheral
  • Dizziness
  • Clumsiness
  • Hypogeusia
  • Anosmia
  • Sensory Loss
  • Hypoaesthesia
  • Paraesthesia
  • Bradyphrenia
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as neuropathy peripheral, may become evident only after a product is in use by the general population.

Paresis, Muscular Weakness
This is a Nitrofurantoin-ratiopharm 100 Mg Retardkapseln side effect report of a 66-year-old female patient (weight: NA) from DE. The patient developed the following symptoms/conditions: urinary tract infection and was treated with Nitrofurantoin-ratiopharm 100 Mg Retardkapseln (dosage: 200 Milligram Daily;) starting Feb 11, 2013. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Paresis
  • Muscular Weakness
This opens a possibility that Nitrofurantoin-ratiopharm 100 Mg Retardkapseln could cause paresis and that some female patients may be more susceptible.

Palpitations, Blood Pressure Systolic Increased, Renal Pain, Diarrhoea, Disorientation, Fatigue, Tremor, Balance Disorder, Dry Mouth
A 89-year-old female patient (weight: NA) from US with the following symptoms: urinary tract infection started Nitrofurantoin treatment (dosage: Two Capsules Twice Daily Taken By Mouth) on Dec 17, 2013. Soon after starting Nitrofurantoin treatment, the consumer experienced several side effects, including:
  • Palpitations
  • Blood Pressure Systolic Increased
  • Renal Pain
  • Diarrhoea
  • Disorientation
  • Fatigue
  • Tremor
  • Balance Disorder
  • Dry Mouth
. Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Nitrofurantoin side effects, such as palpitations.

Myalgia, Fatigue, Chills, Tremor, Pyrexia, Dizziness, Rash
This myalgia side effect was reported by a consumer or non-health professional from US. A 52-year-old female patient (weight:NA) experienced the following symptoms/conditions: cystitis.The patient was prescribed Nitrofurantoin (dosage: 1 Pill), which was started on Dec 09, 2013. Concurrently used drugs: NA..When starting to take Nitrofurantoin the consumer reported symptoms, such as:
  • Myalgia
  • Fatigue
  • Chills
  • Tremor
  • Pyrexia
  • Dizziness
  • Rash
These side effects may potentially be related to Nitrofurantoin.

Acute Hepatic Failure, Respiratory Failure, Cerebral Haemorrhage, Gastrointestinal Haemorrhage, Septic Shock, Clostridium Difficile Colitis, Coagulopathy, Pneumonia, Malnutrition
This is a report of a 50-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: urinary tract infection,pain, who was treated with Nitrofurantoin (dosage: NA, start time: NS), combined with:
  • Vicodin
  • Paracetamol
  • Hydromorphone Hydrochloride
  • Oral Contraceptive Nos (Estrogen Based)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Acute Hepatic Failure
  • Respiratory Failure
  • Cerebral Haemorrhage
  • Gastrointestinal Haemorrhage
  • Septic Shock
  • Clostridium Difficile Colitis
  • Coagulopathy
  • Pneumonia
  • Malnutrition
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nitrofurantoin treatment in female patients, resulting in acute hepatic failure side effect. The patient was hospitalized.

Hepatic Cirrhosis, Autoimmune Hepatitis, Jaundice, Chromaturia, Ascites, Oedema Peripheral
This report suggests a potential Nitrofurantoin Hepatic Cirrhosis, Autoimmune Hepatitis, Jaundice, Chromaturia, Ascites, Oedema Peripheral side effect(s) that can have serious consequences. A 54-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: urinary tract infection and used Nitrofurantoin (dosage: NA) starting NS. Soon after starting Nitrofurantoin the patient began experiencing various side effects, including:
  • Hepatic Cirrhosis
  • Autoimmune Hepatitis
  • Jaundice
  • Chromaturia
  • Ascites
  • Oedema Peripheral
Drugs used concurrently: NA. Although Nitrofurantoin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hepatic cirrhosis, may still occur.

Headache, Nausea, Vomiting, Myalgia, Pyrexia, Night Sweats
This Headache, Nausea, Vomiting, Myalgia, Pyrexia, Night Sweats problem was reported by a consumer or non-health professional from US. A 54-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: urinary tract infection. On Nov 26, 2013 this consumer started treatment with Nitrofurantoin (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Nitrofurantoin, the patient experienced the following unwanted symptoms/side effects:
  • Headache
  • Nausea
  • Vomiting
  • Myalgia
  • Pyrexia
  • Night Sweats
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as headache, may become evident only after a product is in use by the general population.

Miosis, Pharyngeal Oedema, Chest Discomfort
This is a report of a 78-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: urinary tract infection and was treated with Nitrofurantoin (dosage: One Capsule, Twice Daily, Taken By Mouth) starting Nov 30, 2013. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Miosis
  • Pharyngeal Oedema
  • Chest Discomfort
This opens a possibility that Nitrofurantoin treatment could cause the above reactions, including miosis, and some female subjects may be more susceptible.

Atrial Fibrillation, Chest Discomfort, Heart Rate Irregular, Syncope, Dyspnoea
A 55-year-old male patient (weight: NA) from DE with the following symptoms/conditions: urogenital infection bacterial,prostatic specific antigen increased started Nitrofurantoin-ratiopharm 100 Mg Retardkapseln treatment (dosage: 200 Milligram Daily; 1-0-1) on Oct 08, 2013. Soon after starting Nitrofurantoin-ratiopharm 100 Mg Retardkapseln treatment, the subject experienced various side effects, including:
  • Atrial Fibrillation
  • Chest Discomfort
  • Heart Rate Irregular
  • Syncope
  • Dyspnoea
Concurrently used drugs: NA. This finding indicates that some male patients could be more vulnerable to Nitrofurantoin-ratiopharm 100 Mg Retardkapseln.

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Top 10 Nitrofur Side Effects for Women

Women Side EffectsReports
Nausea 82
Chills 80
Dyspnoea 79
Headache 77
Pyrexia 67
Vomiting 55
Asthenia 51
Pain 48
Dizziness 47
Malaise 47

Top 10 Nitrofur Side Effects for Men

Men Side EffectsReports
Dyspnoea 16
Asthenia 9
Pulmonary Fibrosis 9
Rash 9
Cough 8
Nausea 7
Pyrexia 7
Chills 6
Chromaturia 6
Abdominal Pain 5

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It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    Nitrofur Safety Alerts, Active Ingredients, Usage Information

    NDC0093-2130
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameNitrofurantoin Macrocrystals
    NameNitrofurantoin Macrocrystals
    Dosage FormCAPSULE
    RouteORAL
    On market since20070308
    LabelerTeva Pharmaceuticals USA Inc
    Active Ingredient(s)NITROFURANTOIN
    Strength(s)50
    Unit(s)mg/1
    Pharma ClassNitrofuran Antibacterial [EPC],Nitrofurans [Chemical/Ingredient]

    More About Nitrofur

    Side Effects reported to FDA: 726

    Nitrofur safety alerts: No

    Reported deaths: 31

    Reported hospitalizations: 230

    Latest Nitrofur clinical trials