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Norflex Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Renal Failure Acute, Blood Creatinine Increased (8366506-8)
on Sep 09, 2011 Male from UNITED STATES , 50 years of age, weighting 177.0 lb, was treated with Norflex (orphenadrine Citrate)(100 Milligram, Tablets. Directly after, patient experienced the unwanted or unexpected Norflex side effects: renal failure acute, blood creatinine increased. Norflex (orphenadrine Citrate)(100 Milligram, Tablets dosage: N/A.
Associated medications used:
  • Folic Acid (folic Acid)(1 Milligram, Tablets)
  • Lisinopril (lisinopril)(2.5 Milligram, Tablets)
Patient was hospitalized.

Ear Infection (8260130-3)
Patient was taking Norflex. Patient felt the following Norflex side effects: ear infection on Apr 02, 2012 from UNITED STATES Additional patient health information: Female , weighting 202.8 lb, was diagnosed with
  • inflammation
  • thyroidectomy
  • nerve injury
and. Norflex dosage: Unk.
Multiple prescriptions taken:
  • Levothyroxine (Unk)
  • Lyrica (Unk)
  • Cymbalta (Unk)
  • Lipitor (20 Mg, 1x/day)
  • Potassium (Unk)


Pulmonary Embolism (8249282-9)
Adverse event was reported on Mar 23, 2012 by a Female taking Norflex (Dosage: 60 Mg, Unk) . Location: UNITED STATES , 21 years of age, After Norflex was administered, patient encountered several Norflex side effects: pulmonary embolism.
Multiple concurrent drugs taken:
  • Toradol (60 Mg, Unk)
  • Multi-vitamin (1 Tablet Daily)
  • Yaz
  • Fastin (30 Mg, Unk)
  • Vicodin (Unk)
Patient was hospitalized.

Injection Site Pain, Urticaria, Nasopharyngitis, Paranasal Sinus Hypersecretion, Blood Pressure Increased, Pyrexia, Ovarian Cyst (8129713-5)
on Feb 02, 2012 Female from UNITED STATES , 45 years of age, was treated with Norflex. Directly after, patient experienced the unwanted or unexpected Norflex side effects: injection site pain, urticaria, nasopharyngitis, paranasal sinus hypersecretion, blood pressure increased, pyrexia, ovarian cyst. Norflex dosage: N/A.
Associated medications used:
  • Humira (Twice Weekly, Every Monday And Thursday)
  • Humira
  • Muscle Relaxants



Withdrawal Syndrome, Hypersensitivity, Urinary Retention, Tremor, Agitation, Restlessness, Lethargy, Injury (8102140-2)
on Jan 26, 2012 Female from UNITED STATES , 38 years of age, was treated with Norflex. Patient felt the following Norflex side effects: withdrawal syndrome, hypersensitivity, urinary retention, tremor, agitation, restlessness, lethargy, injury. Norflex dosage: N/A.
Multiple prescriptions taken:
  • Celebrex (In Mrng)
  • Lexapro
  • Zolpidem (At Nyt)
  • Abilify (2mg Daily For 2 Days Then 5mg)
  • Tramadol Hcl (Pill)
  • Topamax (A Supper Time 20mg)
  • Clonazepam (1df-0.5 Units Nt Specified At Nyt)
Patient was hospitalized.

Pulmonary Embolism, Injury, Pain (7832343-3)
Patient was taking Norflex. After Norflex was administered, patient encountered several Norflex side effects: pulmonary embolism, injury, pain on Oct 05, 2011 from UNITED STATES Additional patient health information: Female , 24 years of age, weighting 179.0 lb, . Norflex dosage: N/A.
Multiple concurrent drugs taken:
  • Flexeril
  • Yaz (Unk)
  • Toradol
  • Naproxen
  • Benadryl


Insomnia, Urinary Retention, Somnolence, Dry Mouth, Breath Odour (7603033-7)
Adverse event was reported on Jul 12, 2011 by a Female taking Norflex (Dosage: 100 Mgs) was diagnosed with
  • muscle strain
and. Location: UNITED STATES , 73 years of age, weighting 150.0 lb, Directly after, patient experienced the unwanted or unexpected Norflex side effects: insomnia, urinary retention, somnolence, dry mouth, breath odour.

Abdominal Pain Upper, Diarrhoea, Lung Disorder (7501912-2)
on May 23, 2011 Male from UNITED STATES , weighting 125.0 lb, was diagnosed with
  • pain
  • oropharyngeal pain
and was treated with Norflex. Patient felt the following Norflex side effects: abdominal pain upper, diarrhoea, lung disorder. Norflex dosage: 100mg 2 A Day.
Multiple prescriptions taken:
  • Amoxicillin And Clavulanate Potassium (875mg/ 125mg Twice Daily)
  • Amoxicillin And Clavulanate Potassium (875mg/ 125mg Twice Daily)
Patient was hospitalized.

Limb Discomfort, Fall, Arthralgia (7490441-0)
on May 09, 2011 Female from UNITED STATES , weighting 110.2 lb, was diagnosed with
  • back pain
and was treated with Norflex. After Norflex was administered, patient encountered several Norflex side effects: limb discomfort, fall, arthralgia. Norflex dosage: Unk.
Multiple concurrent drugs taken:
  • Vistaril (Unk)
  • Vistaril


Pain In Extremity, Mental Disorder, Headache, Deep Vein Thrombosis, Dyspnoea, Oedema Peripheral, Pulmonary Embolism (7436889-1)
Patient was taking Norflex. Directly after, patient experienced the unwanted or unexpected Norflex side effects: pain in extremity, mental disorder, headache, deep vein thrombosis, dyspnoea, oedema peripheral, pulmonary embolism on Aug 30, 2010 from UNITED STATES Additional patient health information: Female , 32 years of age, weighting 176.4 lb, . Norflex dosage: N/A.
Associated medications used:
  • Nonsteroidals
  • Jasmine
  • Yasmin (Unk Unk, Qd)
  • Anaprox (It Will Need To Stop When Her Inr Is Therapeutic)
  • Flexeril
Patient was hospitalized.

Swelling Face, Hypersensitivity, Dyspnoea, Obstructive Airways Disorder (7209677-9)
Adverse event was reported on Jan 03, 2011 by a Female taking Norflex (Dosage: 100 Mg, 2x/day) was diagnosed with
  • fibromyalgia
  • diabetes mellitus
and. Location: UNITED STATES , weighting 213.0 lb, Patient felt the following Norflex side effects: swelling face, hypersensitivity, dyspnoea, obstructive airways disorder.
Multiple prescriptions taken:
  • Sitagliptin (100 Mg, 1x/day)
  • Effexor (100 Mg, 1x/day)
  • Sectral (Unk)
  • Albuterol Sulfate (90 Ug, As Needed)
  • Levothyroxine (150 Ug, 1x/day)
  • Benicar Hct (40/25 Mg)
  • Zyrtec (Unk)
  • Benadryl (Unk)


Clavicle Fracture, Confusional State, Delirium, Fall, Hallucination, Lumbar Vertebral Fracture, Spinal Compression Fracture, Thoracic Vertebral Fracture (6211047-7)
on May 27, 2009 Male from UNITED STATES , 86 years of age, was diagnosed with
  • muscle strain
and was treated with Norflex. After Norflex was administered, patient encountered several Norflex side effects: clavicle fracture, confusional state, delirium, fall, hallucination, lumbar vertebral fracture, spinal compression fracture, thoracic vertebral fracture. Norflex dosage: N/A. Patient was hospitalized.

Hypoaesthesia, Musculoskeletal Discomfort, Neoplasm, Pain (5230441-4)
on Jan 15, 2007 Male from FINLAND , 40 years of age, was diagnosed with
  • back pain
and was treated with Norflex. Directly after, patient experienced the unwanted or unexpected Norflex side effects: hypoaesthesia, musculoskeletal discomfort, neoplasm, pain. Norflex dosage: (60 Mg, Single Dose).
Associated medications used:
  • Voltaren ((75 Mg, Single Dose))
  • Burana
Patient was hospitalized and became disabled.

Alcohol Use, Cardiac Failure Congestive (4842469-4)
Patient was taking Norflex. Patient felt the following Norflex side effects: alcohol use, cardiac failure congestive on Nov 17, 2005 from UNITED STATES Additional patient health information: Female , 48 years of age, was diagnosed with
  • back pain
and. Norflex dosage: (100 Mg, 2 In 1 Day(s)), Oral.
Multiple prescriptions taken:
  • Xanax
  • Restoril


Angina Pectoris, Anxiety (4777938-9)
Adverse event was reported on Nov 19, 2004 by a Female taking Norflex (Dosage: 100 Mg 1 In 1 Day(s), Oral) was diagnosed with
  • back disorder
  • neck injury
  • surgery
and. Location: UNITED STATES , 65 years of age, After Norflex was administered, patient encountered several Norflex side effects: angina pectoris, anxiety. Patient was hospitalized.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Norflex Information

Alternative NORFLEX Names:ORPHENADR

Active Ingredient: ORPHENADR

Norflex Dosage, Warnings, Usage.

Side Effects reported to FDA: 15. View Norflex Adverse Reports

Norflex safety alerts: No

Reported deaths: 1

Reported hospitalizations: 7

Managing Your Medicines

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Before Taking Norflex

Find Out How to Take Norflex

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