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Nyquil Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 57 

Ill-defined Disorder, Fall, Road Traffic Accident, Lower Respiratory Tract Infection, Dehydration, Vomiting, Weight Decreased, Rib Fracture (7360852-2)
on Mar 09, 2011 Male from UNITED STATES , weighting 254.5 lb, was diagnosed with
  • lower respiratory tract infection
  • anxiety
  • blood testosterone decreased
  • depression
  • gastrooesophageal reflux disease
and was treated with Nyquil. Directly after, patient experienced the unwanted or unexpected Nyquil side effects: ill-defined disorder, fall, road traffic accident, lower respiratory tract infection, dehydration, vomiting, weight decreased, rib fracture. Nyquil dosage: N/A.
Associated medications used:
  • Clonazpam (Daily Dose: 2 Milligram(s))
  • Androgel (Daily Dose: 7.5 Gram(s), 3 Pumps/arm)
  • Lexapro (Daily Dose: 40 Milligram(s))
  • Omeprazole (Daily Dose: 40 Milligram(s))
  • Buspar (Daily Dose: 60 Milligram(s))
Patient was hospitalized and became disabled.

Disorientation, Loss Of Consciousness, Fall, Head Injury, Nervous System Disorder, Contusion, Memory Impairment, Limb Injury, Hyperhidrosis (7351102-1)
Patient was taking Nyquil. Patient felt the following Nyquil side effects: disorientation, loss of consciousness, fall, head injury, nervous system disorder, contusion, memory impairment, limb injury, hyperhidrosis on Mar 08, 2011 from UNITED STATES Additional patient health information: Female , weighting 108.0 lb, . Nyquil dosage: N/A.
Multiple prescriptions taken:
  • Dextromethorphan And Dextromethorphan Hydrobromide And Guaifenesin (Unk)


Respiratory Tract Congestion (7349656-4)
Adverse event was reported on Feb 22, 2011 by a Male taking Nyquil (Dosage: N/A) . Location: UNITED STATES , 36 years of age, After Nyquil was administered, patient encountered several Nyquil side effects: respiratory tract congestion.
Multiple concurrent drugs taken:
  • Augmentin '125' (1000mg Twice Per Day)


Ageusia, Anosmia (7282995-4)
on Jan 13, 2011 Male from UNITED STATES , weighting 145.0 lb, was treated with Nyquil. Directly after, patient experienced the unwanted or unexpected Nyquil side effects: ageusia, anosmia. Nyquil dosage: N/A.
Associated medications used:
  • Amoxicillin
  • Zicam Cold Remedy Gel Swabs (Qd X 10 Days)



Convulsion, Heart Rate Irregular, Loss Of Consciousness, Ventricular Tachycardia (6759980-1)
on May 20, 2010 Male from UNITED STATES , 42 years of age, was treated with Nyquil Cold/flu Alcohol 10% Pseudoephedrine Free, Original Flavor (par. Patient felt the following Nyquil side effects: convulsion, heart rate irregular, loss of consciousness, ventricular tachycardia. Nyquil Cold/flu Alcohol 10% Pseudoephedrine Free, Original Flavor (par dosage: Unk Dose, 1 /day For 1 Day Oral.

Dyspnoea, Pharyngeal Oedema, Urticaria (6573670-X)
Patient was taking Nyquil At Bedtime Previous Evening. After Nyquil was administered, patient encountered several Nyquil side effects: dyspnoea, pharyngeal oedema, urticaria on Feb 04, 2010 from UNITED STATES Additional patient health information: Male , 21 years of age, was diagnosed with
  • attention deficit/hyperactivity disorder
and. Nyquil At Bedtime Previous Evening dosage: Once Bid (40 Mg) Ongoing Daily.
Multiple concurrent drugs taken:
  • Amphetamine And Dextroamphetamine Salts


Chest Pain, Chills, Disorientation, Hypoaesthesia, Pyrexia, Rash, Skin Discolouration (6477898-9)
Adverse event was reported on Dec 03, 2009 by a Male taking Nyquil Normal (Dosage: Recommended, Two Pills 4-6 Hours) was diagnosed with
  • nasopharyngitis
and. Location: UNITED STATES , 31 years of age, weighting 175.0 lb, Directly after, patient experienced the unwanted or unexpected Nyquil side effects: chest pain, chills, disorientation, hypoaesthesia, pyrexia, rash, skin discolouration.

Anaphylactic Shock (6361181-6)
on Sep 15, 2009 Female from UNITED STATES , 31 years of age, weighting 214.0 lb, was diagnosed with
  • nasopharyngitis
and was treated with Nyquil Cold + Flu Vicks. Patient felt the following Nyquil side effects: anaphylactic shock. Nyquil Cold + Flu Vicks dosage: 2 Gel Caps.

Hot Flush, Swelling Face (6329056-6)
on Aug 24, 2009 Female from UNITED STATES , 43 years of age, weighting 247.0 lb, was diagnosed with
  • cough
  • sinus disorder
  • sneezing
and was treated with Nyquill. After Nyquil was administered, patient encountered several Nyquil side effects: hot flush, swelling face. Nyquill dosage: 30ml.

Hepatomegaly, Pain (6311797-8)
Patient was taking Nyquil. Directly after, patient experienced the unwanted or unexpected Nyquil side effects: hepatomegaly, pain on Aug 13, 2009 from UNITED STATES Additional patient health information: Female , 33 years of age, was diagnosed with
  • nasopharyngitis
and. Nyquil dosage: 2 Dose Week.

Blood Pressure Increased, Chills, Dysphagia, Erythema, Eye Swelling, Feeling Abnormal, Hypersensitivity, Oropharyngeal Pain (6159076-6)
Adverse event was reported on Apr 05, 2009 by a Female taking Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Ch (Dosage: 30 Ml, 1 Day For 1 Day, Oral) was diagnosed with
  • oropharyngeal pain
  • sinus congestion
and. Location: UNITED STATES , 78 years of age, weighting 162.9 lb, Patient felt the following Nyquil side effects: blood pressure increased, chills, dysphagia, erythema, eye swelling, feeling abnormal, hypersensitivity, oropharyngeal pain.

Blood Pressure Decreased, Loss Of Consciousness, Somnolence (6158911-5)
on Apr 05, 2009 Male from UNITED STATES , 68 years of age, weighting 157.0 lb, was diagnosed with
  • nasal congestion
  • sleep disorder
and was treated with Nyquil Cold/flu, Pseudoephedrine Free (paracetamol 325 Mg, Dextrometho. After Nyquil was administered, patient encountered several Nyquil side effects: blood pressure decreased, loss of consciousness, somnolence. Nyquil Cold/flu, Pseudoephedrine Free (paracetamol 325 Mg, Dextrometho dosage: 1 Liqcap,1 Only For 1 Day, Oral. Patient was hospitalized.

Blood Pressure Increased, Chills, Dysphagia, Erythema, Eye Swelling, Feeling Abnormal, Hypersensitivity, Oropharyngeal Pain (6063904-2)
on Jan 22, 2009 Female from UNITED STATES , 78 years of age, weighting 162.9 lb, was diagnosed with
  • oropharyngeal pain
  • sinus congestion
and was treated with Nyquil Cold/flu, Alcohol 10%, Psudoephedrine Free, Cherry Flvr(paracet. Directly after, patient experienced the unwanted or unexpected Nyquil side effects: blood pressure increased, chills, dysphagia, erythema, eye swelling, feeling abnormal, hypersensitivity, oropharyngeal pain. Nyquil Cold/flu, Alcohol 10%, Psudoephedrine Free, Cherry Flvr(paracet dosage: 30 Ml, 1 Day For 1 Day, Oral.

Blood Pressure Decreased, Loss Of Consciousness, Somnolence (6059675-6)
Patient was taking Nyquil Cold/flu, Pseudophedrine Free (paracetamol 325 Mg, Dextromethor. Patient felt the following Nyquil side effects: blood pressure decreased, loss of consciousness, somnolence on Jan 15, 2009 from UNITED STATES Additional patient health information: Male , 68 years of age, weighting 157.0 lb, was diagnosed with
  • attention deficit/hyperactivity disorder
  • nasal congestion
  • sleep disorder
and. Nyquil Cold/flu, Pseudophedrine Free (paracetamol 325 Mg, Dextromethor dosage: 1 Liqcap, 1 Only For 1 Day, Oral. Patient was hospitalized.

Blood Pressure Increased, Chills, Dysphagia, Erythema, Feeling Abnormal, Hypersensitivity, Malaise, Oropharyngeal Pain, Pharyngeal Oedema (6034453-2)
Adverse event was reported on Dec 12, 2008 by a Female taking Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Cherry Flvr(paracet (Dosage: 30 Ml, 1 Only For 1 Day, Oral) was diagnosed with
  • oropharyngeal pain
  • sinus congestion
and. Location: UNITED STATES , 78 years of age, After Nyquil was administered, patient encountered several Nyquil side effects: blood pressure increased, chills, dysphagia, erythema, feeling abnormal, hypersensitivity, malaise, oropharyngeal pain, pharyngeal oedema.

Hypersensitivity (6018675-2)
on Dec 12, 2008 Female from UNITED STATES , 78 years of age, was treated with Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Cherry Flv (parace. Directly after, patient experienced the unwanted or unexpected Nyquil side effects: hypersensitivity. Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Cherry Flv (parace dosage: 30 Ml, 1 Only For 1 Day, Oral.

Choking, Dyspnoea, Foreign Body Trauma, Throat Irritation (6012753-X)
on Dec 09, 2008 Female from UNITED STATES , 82 years of age, was treated with Nyquil Cold/flu, Pseudoephedrine Free (paracetamol 325 Mg, Dextrometho. Patient felt the following Nyquil side effects: choking, dyspnoea, foreign body trauma, throat irritation. Nyquil Cold/flu, Pseudoephedrine Free (paracetamol 325 Mg, Dextrometho dosage: 1 Liqcap, 1 Only For 1 Day, Oral.

Chest Pain, Dizziness, Dyspnoea, Electrocardiogram Abnormal, Emphysema, Eye Disorder, Hypoventilation, Thrombosis, Unresponsive To Stimuli (5988362-5)
Patient was taking Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Cherry Flvr(paracet. After Nyquil was administered, patient encountered several Nyquil side effects: chest pain, dizziness, dyspnoea, electrocardiogram abnormal, emphysema, eye disorder, hypoventilation, thrombosis, unresponsive to stimuli on Nov 20, 2008 from UNITED STATES Additional patient health information: Patient , 76 years of age, was diagnosed with
  • oropharyngeal pain
and. Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Cherry Flvr(paracet dosage: 30ml, 1/day For 1/day, Oral; 15ml, 1/day For 1 Day, Oral. Patient was hospitalized.

Condition Aggravated, Malaise, Pyrexia, Vomiting (5875084-4)
Adverse event was reported on Aug 26, 2008 by a Male taking Nyquil Cough Relief, Cherry Flavor (ethanol 10%, Dextromethorphan Hydr (Dosage: Oral) . Location: UNITED STATES , 17 years of age, weighting 145.1 lb, Directly after, patient experienced the unwanted or unexpected Nyquil side effects: condition aggravated, malaise, pyrexia, vomiting. Patient was hospitalized.

Aggression, Contraindication To Medical Treatment, Dyskinesia, Loss Of Consciousness, Tremor (5736878-9)
on May 02, 2008 Female from UNITED STATES , 20 years of age, weighting 209.9 lb, was diagnosed with
  • nasopharyngitis
and was treated with Nyquil Cold/flu, Pseudoephedrine Free(paracetamol 325 Mg, Dextromethor. Patient felt the following Nyquil side effects: aggression, contraindication to medical treatment, dyskinesia, loss of consciousness, tremor. Nyquil Cold/flu, Pseudoephedrine Free(paracetamol 325 Mg, Dextromethor dosage: 2 Liqcap, 1 Only, Oral.
Multiple prescriptions taken:
  • Advil (2 Tablet, 1 Only For 1 Day, Oral)
  • Alka-seltzer Plus/01082701/(phenylpropanolamine Bitartrate, Chlorphena (2 Tablet, 1 Only For 1 Day, Oral)


Convulsion, Eye Rolling, Hyperhidrosis, Incorrect Dose Administered, Musculoskeletal Stiffness, Snoring, Tongue Haemorrhage, Tongue Injury (5712279-4)
on Apr 04, 2008 Male from UNITED STATES , 40 years of age, weighting 175.0 lb, was diagnosed with
  • nasopharyngitis
and was treated with Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Original Flavor(par. After Nyquil was administered, patient encountered several Nyquil side effects: convulsion, eye rolling, hyperhidrosis, incorrect dose administered, musculoskeletal stiffness, snoring, tongue haemorrhage, tongue injury. Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Original Flavor(par dosage: 60 Ml, 1/day, Oral. Patient was hospitalized.

Aggression, Dyskinesia, Loss Of Consciousness, Tremor (5706570-5)
Patient was taking Nyquil Cold/flu, Pseudoephedrine Free(paracetamol 325 Mg, Dextromethor. Directly after, patient experienced the unwanted or unexpected Nyquil side effects: aggression, dyskinesia, loss of consciousness, tremor on Apr 03, 2008 from UNITED STATES Additional patient health information: Female , 20 years of age, weighting 209.9 lb, was diagnosed with
  • nasopharyngitis
and. Nyquil Cold/flu, Pseudoephedrine Free(paracetamol 325 Mg, Dextromethor dosage: 2 Liqcap, 1 Only, Oral.
Associated medications used:
  • Advil (2 Tablet, 1 Only For 1 Day, Oral)
  • Alka-seltzer Plus /01082701/ (phenylpropanolamine Bitartrate, Chlorphe (2 Tablet, 1 Only For 1 Day, Oral)


Dyskinesia, Hypersensitivity, Loss Of Consciousness, Tremor (5638114-0)
Adverse event was reported on Feb 10, 2008 by a Female taking Nyquil Cold/flu Doxylamine(dextromethorphan Hydrobromide 10 Or 15 Mg, (Dosage: 2 Liqcap, 1 Only, Oral) . Location: UNITED STATES , 20 years of age, weighting 209.9 lb, Patient felt the following Nyquil side effects: dyskinesia, hypersensitivity, loss of consciousness, tremor.
Multiple prescriptions taken:
  • Advil (2 Tablet, 1 Only For 1 Day, Oral)
  • Alka-seltzer Plus /01082701/(phenylpropanolamine Bitartrate, Chlorphe (2 Tablet, 1 Only For 1 Day, Oral)


Abnormal Behaviour, Agitation, Anxiety, Disorientation, Dyspnoea, Feeling Abnormal, Restlessness, Stress, Tremor (5599172-5)
on Jan 04, 2008 Male from UNITED STATES , 22 years of age, was treated with Nyquil Cold/flu, Pseudoephedrine Free (paracetamol 325 Mg, Dextrometho. After Nyquil was administered, patient encountered several Nyquil side effects: abnormal behaviour, agitation, anxiety, disorientation, dyspnoea, feeling abnormal, restlessness, stress, tremor. Nyquil Cold/flu, Pseudoephedrine Free (paracetamol 325 Mg, Dextrometho dosage: 2 Liqcap, 1 Only, Oral.

Confusional State, Dizziness, Dyspnoea, Heart Rate Increased, Hepatic Failure, Overdose (5482022-5)
on Aug 20, 2007 Male from UNITED STATES , 36 years of age, weighting 203.0 lb, was diagnosed with
  • influenza
and was treated with Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Original Flavor(par. Directly after, patient experienced the unwanted or unexpected Nyquil side effects: confusional state, dizziness, dyspnoea, heart rate increased, hepatic failure, overdose. Nyquil Cold/flu, Alcohol 10% Pseudoephedrine Free, Original Flavor(par dosage: 30 Ml, 7 /day, Oral.
Associated medications used:
  • Altace
  • Levothyroxine Sodium
  • Hydrochlorothiazide
Patient was hospitalized.

Showing 1-25 of 57 

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Nyquil Information

ACETAMINO DEXTROMET

Active Ingredient: ACETAMINO DEXTROMET

More About Nyquil

Side Effects reported to FDA: 57. View Nyquil Adverse Reports

Nyquil safety alerts: No

Reported deaths: 3

Reported hospitalizations: 12

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