Oxaliplatin Side Effects
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Oxaliplatin Safety Reports reported to FDA
Total Oxaliplatin reports: 178.Oxaliplatin FDA safety alerts: No.
Reported deaths: 50 Reported hospitalizations: 127.
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Reported Oxaliplatin Side Effects: diarrhoea, dehydration, nausea, vomiting, disease progression, pyrexia, fatigue, dyspnoea exertional, asthenia, haemoglobin decreased, hypotension.
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Oxaliplatin Side Effects Report #5391411-9Physician from UNITED STATES reported OXALIPLATIN problem on July 13, 2007. Female patient, weighting 179.7 lb, was diagnosed with non-small cell lung cancer, pain, anxiety, hypertension and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: pancytopenia. OXALIPLATIN dosage: unknown. During the same period patient was treated with DURAGESIC, VALIUM, LORTAB, MOBIC, VERAPAMIL, GEMCITABINE. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5392051-8
OXALIPLATIN problem was reported by a Physician from UNITED STATES on July 18, 2007. Male patient, weighting 185.0 lb, was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: blood pressure increased, dehydration, diarrhoea, fatigue, nausea, oral intake reduced, rectal haemorrhage, vomiting, weight decreased. OXALIPLATIN dosage: 40MG/M2 IV WEEKLY. During the same period patient was treated with LEUCOVORIN CALCIUM, LEUCOVORIN CALCIUM, FLUOROURACIL, BEVACIZUMAB. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5393094-0
Consumer or non-health professional from KOREA, REPUBLIC OF reported OXALIPLATIN problem on July 02, 2007. Male patient, 64 years of age, was diagnosed with gastric cancer recurrent, metastases to liver and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: cryptogenic organising pneumonia, pulmonary fibrosis. OXALIPLATIN dosage: unknown. During the same period patient was treated with FLUOROURACIL. Patient recovered.
Oxaliplatin Side Effects Report #5393095-2
OXALIPLATIN problem was reported by a Consumer or non-health professional from KOREA, REPUBLIC OF on July 02, 2007. Male patient, 75 years of age, was diagnosed with gastric cancer, metastases to lymph nodes and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: chest x-ray abnormal, diffuse alveolar damage, lung disorder. OXALIPLATIN dosage: unknown. During the same period patient was treated with FLUOROURACIL, FOLINIC ACID, FOLINIC ACID. Patient recovered.
Oxaliplatin Side Effects Report #5397633-5
Health Professional from UNITED STATES reported OXALIPLATIN problem on July 23, 2007. Female patient, 51 years of age, weighting 146.0 lb, was diagnosed with colon cancer and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: dizziness, dyspnoea, flushing, infusion related reaction, nausea, vomiting. OXALIPLATIN dosage: unknown. Patient recovered.
Oxaliplatin Side Effects Report #5399041-X
OXALIPLATIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 25, 2007. Male patient, weighting 120.2 lb, was diagnosed with neoplasm malignant and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: dehydration, disease progression, hypokalaemia, hyponatraemia, hypovolaemia, pneumonia. OXALIPLATIN dosage: 130 MG/M2 Q 21 DAYS IV. During the same period patient was treated with CETUXIMAB, ACIPHEX, HYDROCHLOROTHIAZIDE, IRON SULPHATETHIAMIN COMPOUND, CELEBREX, TRIAMCINOLONE. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5405165-0
Health Professional from JAPAN reported OXALIPLATIN problem on July 25, 2007. Male patient, weighting 116.8 lb, was diagnosed with rectal cancer and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: loss of consciousness, nausea, vomiting. OXALIPLATIN dosage: unknown. During the same period patient was treated with FLUOROURACIL, ISOVORIN. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5409240-6
OXALIPLATIN problem was reported by a Health Professional from UNITED STATES on Aug 08, 2007. Male patient, weighting 175.5 lb, was diagnosed with hepatic neoplasm malignant and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: bacteria stool identified, clostridium difficile colitis, diverticulum, haematocrit decreased, haemoglobin decreased. OXALIPLATIN dosage: 50MG/M2 D1 AND 8 Q21DAYS IV. During the same period patient was treated with XELODA. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5415369-9
Health Professional from UNITED STATES reported OXALIPLATIN problem on Aug 14, 2007. Female patient, 70 years of age, weighting 112.0 lb, was diagnosed with carcinoid tumour of the appendix and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: bilirubin conjugated increased, culture positive, enterococcal infection, escherichia infection, granulocytes abnormal, haematoma infection, haemoglobin decreased, jaundice. OXALIPLATIN dosage: 365MG INTRAPERITONEAL. During the same period patient was treated with LISINOPRIL, FOSAMAX, CENTRUM, ASPIRIN, FOLIC ACID. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5417293-4
OXALIPLATIN problem was reported by a Physician from UNITED STATES on Aug 06, 2007. Female patient, 48 years of age, was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: cholecystitis. OXALIPLATIN dosage: unknown. During the same period patient was treated with BENTYL, BEVACIZUMAB, ATROVENT, XANAX, LOVENOX, CALTRATE, PROTONIX. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5419292-5
Health Professional from JAPAN reported OXALIPLATIN problem on Aug 14, 2007. Male patient was diagnosed with gastric cancer and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: biliary tract infection. OXALIPLATIN dosage: 163 MG. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5423565-X
OXALIPLATIN problem was reported by a Physician from UNITED STATES on Aug 21, 2007. Female patient, 49 years of age, weighting 127.0 lb, was diagnosed with rectal cancer and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: anastomotic leak, rectal abscess. OXALIPLATIN dosage: 40MG/M2. During the same period patient was treated with BEVACIZUMAB, LEUCOVORIN CALCIUM, FLUOROURACIL. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5431691-4
Physician from UNITED STATES reported OXALIPLATIN problem on Aug 23, 2007. Female patient, 70 years of age, weighting 112.0 lb, was diagnosed with carcinoid tumour of the appendix and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: abdominal adhesions, bilirubin conjugated increased, central line infection, haemoglobin decreased, intestinal obstruction, leukocytosis, neutropenia, pelvic haematoma, pelvic infection. OXALIPLATIN dosage: unknown. During the same period patient was treated with FOLIC ACID, ASPIRIN, CENTRUM, FOSAMAX, LISINOPRIL. Patient was hospitalized. Patient died on 08/13/2007.
Oxaliplatin Side Effects Report #5441757-0
OXALIPLATIN problem was reported by a Health Professional from UNITED STATES on Aug 29, 2007. Male patient, weighting 145.5 lb, was diagnosed with prostate cancer and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: asthenia, chills, febrile neutropenia, white blood cell count decreased. OXALIPLATIN dosage: 70 MG/M^2 Q 21 DAYS IV. During the same period patient was treated with PEMETREXED. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5441824-1
Pharmacist from UNITED STATES reported OXALIPLATIN problem on Aug 30, 2007. Female patient, 35 years of age, was diagnosed with gastric cancer and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: aphonia, coordination abnormal, dyspnoea, ill-defined disorder, infusion related reaction, lethargy, oxygen saturation decreased, paraesthesia, sensation of foreign body. OXALIPLATIN dosage: 211MG EVERY 3 WEEKS IV BOLUS. During the same period patient was treated with CAPCETABINE. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5463863-7
OXALIPLATIN problem was reported by a Physician from UNITED STATES on Aug 11, 2006. Male patient, 67 years of age, weighting 197.0 lb, was diagnosed with colon cancer stage iii and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: diarrhoea. OXALIPLATIN dosage: 170 MG FORTNIGHTLY IV. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN, DECADRON. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5443649-X
Consumer or non-health professional from UNITED STATES reported OXALIPLATIN problem on Aug 29, 2007. Male patient, weighting 159.4 lb, was diagnosed with colorectal cancer metastatic and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: gastrointestinal haemorrhage, oesophagitis. OXALIPLATIN dosage: 85 MG/M2, 330MG IN 500 ML 5% DEXTROSE IN WATER OVER 120 MINUTES ON DAYS 1 AND 15 EVERY 28 DAYS. During the same period patient was treated with IRINOTECAN, BEVACIZUMAB. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5446476-2
OXALIPLATIN problem was reported by a Health Professional from BRAZIL on Sept 04, 2007. Female patient, weighting 91.49 lb, was diagnosed with neurological symptom and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: abdominal pain. OXALIPLATIN dosage: unknown. During the same period patient was treated with DEXAMETHASONE, ONDANSETRON, ACETAMINOPHEN W, HYDROCHLOROTHIAZIDE, LEUCOVORIN CALCIUM, FLUOROURACIL. Patient was hospitalized. Patient died on 08/21/2007.
Oxaliplatin Side Effects Report #5447349-1
Health Professional from UNITED STATES reported OXALIPLATIN problem on Sept 05, 2007. Female patient, 80 years of age, weighting 152.1 lb, was diagnosed with pancreatic carcinoma and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: ascites, asthenia, failure to thrive, infection, malignant neoplasm progression, metastases to liver, urinary tract infection. OXALIPLATIN dosage: unknown. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient died on 09/02/2007.
Oxaliplatin Side Effects Report #5447582-9
OXALIPLATIN problem was reported by a Health Professional from UNITED STATES on Sept 05, 2007. Female patient, 80 years of age, weighting 152.1 lb, was diagnosed with pancreatic carcinoma and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: ascites, asthenia, disease progression, failure to thrive, infection, metastases to liver, pyrexia, urinary tract infection. OXALIPLATIN dosage: unknown. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient died on 09/02/2007.
Oxaliplatin Side Effects Report #5448311-5
Health Professional from UNITED STATES reported OXALIPLATIN problem on Sept 06, 2007. Female patient, 79 years of age, weighting 153.0 lb, was diagnosed with colon cancer and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: chest discomfort, throat tightness. OXALIPLATIN dosage: unknown. Patient recovered.
Oxaliplatin Side Effects Report #5461088-2
OXALIPLATIN problem was reported by a Pharmacist from UNITED STATES on Sept 18, 2007. Male patient, 64 years of age, was diagnosed with colon cancer and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: neuropathy peripheral. OXALIPLATIN dosage: 90 MG ONCE IV. Patient recovered.
Oxaliplatin Side Effects Report #5465293-0
Health Professional from UNITED STATES reported OXALIPLATIN problem on Sept 19, 2007. Female patient was diagnosed with non-hodgkin's lymphoma and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: subdural haemorrhage. OXALIPLATIN dosage: 130 MG/M2 IV Q21DAYS. During the same period patient was treated with CYTOSINE ARABINOSIDE. Patient died on 04/06/2007.
Oxaliplatin Side Effects Report #5465440-0
OXALIPLATIN problem was reported by a Health Professional from UNITED STATES on Sept 20, 2007. Male patient, 26 years of age, weighting 129.0 lb, was diagnosed with gastric cancer and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: feeding tube complication, infusion site reaction, nausea, vomiting. OXALIPLATIN dosage: unknown. During the same period patient was treated with LEUCOVORIN, FLUOROURACIL. Patient was hospitalized. Patient recovered.
Oxaliplatin Side Effects Report #5468680-X
Health Professional from JAPAN reported OXALIPLATIN problem on Sept 14, 2007. Male patient, weighting 123.5 lb, was diagnosed with colon cancer, nausea, diabetes mellitus and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, upper gastrointestinal haemorrhage. OXALIPLATIN dosage: 62.5 MG/M2. During the same period patient was treated with DECADRON, PRIMPERAN, FLUOROURACIL, ISOVORIN, HUMULIN, NASEA. Patient died on 05/08/2007.
Oxaliplatin Side Effects Report #5468690-2
OXALIPLATIN problem was reported by a Physician from UNITED STATES on Sept 21, 2007. Male patient, 51 years of age, was diagnosed with colon cancer stage iv and was treated with OXALIPLATIN. OXALIPLATIN dosage: unknown. During the same period patient was treated with AVASTIN, LEUCOVORIN, FLUOROURACIL. Patient died on 09/19/2007.
Oxaliplatin Side Effects Report #5468699-9
Physician from UNITED STATES reported OXALIPLATIN problem on Sept 21, 2007. Male patient, 53 years of age, was diagnosed with colorectal cancer stage iii and was treated with OXALIPLATIN. OXALIPLATIN dosage: unknown. During the same period patient was treated with LEUCOVORIN, FLUOROURACIL. Patient died on 08/01/2007.
Oxaliplatin Side Effects Report #5469343-7
OXALIPLATIN problem was reported by a Physician from UNITED STATES on Sept 26, 2007. Male patient, 68 years of age, weighting 243.0 lb, was diagnosed with neoplasm malignant and was treated with OXALIPLATIN. After drug was administered, patient experienced the following problems/side effects: tracheostomy. OXALIPLATIN dosage: 130MG/M2 - 260MG EVERY 3 WEEKS IV. During the same period patient was treated with CARBOPLATIN. Patient was hospitalized. Patient recovered.
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Drug Information: Oxaliplatin Injection
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a607035.html
ox al" i pla' tinIMPORTANT WARNING:
| Oxaliplatin may cause severe allergic reactions. These allergic reactions may happen within a few minutes after you receive oxaliplatin and may cause death. Tell your doctor if you are allergic to oxaliplatin, carboplatin (Paraplatin), cisplatin (Platinol) or any other medications. If you experience any of the following symptoms, tell your doctor or other healthcare provider immediately: rash, hives, itching, reddening of the skin, difficulty breathing or swallowing, hoarseness, feeling as if your throat is closing, swelling of the lips and tongue, dizziness, lightheadness, or fainting. |
Why is this medication prescribed?
Oxaliplatin is used with other medications to treat advanced colon or rectal cancer (cancer that begins in the large intestine). Oxaliplatin is also used with other medications to prevent colon cancer from spreading in people who have had surgery to remove the tumor. Oxaliplatin is in a class of medications called platinum-containing antineoplastic agents. It works by killing cancer cells.
How should this medicine be used?
Oxaliplatin comes as a solution (liquid) to be injected into a vein. Oxaliplatin is administered by a doctor or nurse. It is usually given once every fourteen days.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before using oxaliplatin,
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention oral anticoagulants ('blood thinners') such as warfarin (Coumadin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had kidney disease.
- tell your doctor if you are pregnant or plan to become pregnant. Oxaliplatin may harm the fetus. You should use birth control to prevent pregnancy during your treatment with oxaliplatin. Talk to your doctor about types of birth control that will work for you.If you become pregnant while taking oxaliplatin, call your doctor. Do not breast-feed during your treatment with oxaliplatin.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are using oxaliplatin.
- you should know that oxaliplatin may decrease your ability to fight infection. Stay away from people who are sick during your treatment with oxaliplatin.
- you should know that exposure to cold air or objects may make some of the side effects of oxaliplatin worse. You should not eat or drink anything colder than room temperature, touch any cold objects, go near air conditioners or freezers, wash your hands in cold water, or go outside in cold weather unless absolutely necessary for five days after you receive each dose of oxaliplatin. If you must go outside in cold weather, wear a hat, gloves, and a scarf, and cover your mouth and nose.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
Do not eat or drink anything that is colder than room temperature for five days after you receive each dose of oxaliplatin.
What should I do if I forget a dose?
Call your doctor as soon as possible if you are unable to keep an appointment to receive oxaliplatin. It is very important that you receive your treatment on schedule.
What side effects can this medication cause?
Oxaliplatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- numbness, burning, or tingling in the fingers, toes, hands, feet, mouth, or throat
- pain in the hands or feet
- increased sensitivity, especially to cold
- decreased sense of touch
- nausea
- vomiting
- diarrhea
- constipation
- gas
- stomach pain
- heartburn
- sores in the mouth
- loss of appetite
- change in the ability to taste food
- weight gain or loss
- hiccups
- dry mouth
- muscle, back, or joint pain
- tiredness
- anxiety
- depression
- difficulty falling asleep or staying asleep
- hair loss
- dry skin
- redness or peeling of the skin on the hands and feet
- sweating
- flushing
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
- stumbling or loss of balance when walking
- difficulty with everyday activities such as writing or fastening buttons
- difficulty speaking
- strange feeling in the tongue
- tightening of the jaw
- chest pain or pressure
- cough
- shortness of breath
- sore throat, fever, chills, and other signs of infection
- pain, redness, or swelling in the place where oxaliplatin was injected
- pain when urinating
- decreased urination
- unusual bruising or bleeding
- nosebleed
- blood in urine
- vomit that is bloody or looks like coffee grounds
- bright red blood in stool
- black and tarry stools
- pale skin
- weakness
- problems with vision
- swelling of the arms, hands, feet, ankles, or lower legs
Oxaliplatin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- shortness of breath
- wheezing
- numbness or tingling in the fingers or toes
- vomiting
- chest pain
- slowed breathing
- slowed heartbeat
- tightening of the throat
- diarrhea
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to oxaliplatin.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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