Common Oxycontin Side Effects


The most commonly reported Oxycontin side effects (click to view or check a box to report):

Anxiety (606)
Pain (554)
Depression (486)
Nausea (432)
Overdose (409)
Constipation (367)
Back Pain (360)
Death (321)
Arthralgia (314)
Vomiting (309)
Substance Abuse (306)
Headache (292)
Asthenia (278)
Diarrhoea (272)
Inadequate Analgesia (270)
Abdominal Pain Upper (251)
Abdominal Pain (238)
Polysubstance Abuse (233)
Coma (231)
Somnolence (227)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Oxycontin Side Effects Reported to FDA



Oxycontin Side Effect Report#9999296
Foreign Body Aspiration
This is a report of a 31-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Oxycontin (nda 22-272) (dosage: 80 Mg, Unk, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Foreign Body Aspiration after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Oxycontin (nda 22-272) treatment in female patients, resulting in Foreign Body Aspiration side effect.
Oxycontin Side Effect Report#9993362
Haemoptysis, Muscular Weakness, Somnolence, Stupor
This report suggests a potential Oxycontin Tablets Haemoptysis side effect(s) that can have serious consequences. A 82-year-old female patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: pain and used Oxycontin Tablets (dosage: 30 Mg, Q12h) starting
Jan 10, 2014. After starting Oxycontin Tablets the patient began experiencing various side effects, including: Haemoptysis, Muscular Weakness, Somnolence, StuporAdditional drugs used concurrently: NA. Although Oxycontin Tablets demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Haemoptysis, may still occur.
Oxycontin Side Effect Report#9993180
Intentional Overdose, Serotonin Syndrome, Somnolence, Dyspnoea, Rash
This Intentional Overdose problem was reported by a physician from FR. A 17-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Dec 26, 2013 this consumer started treatment with Oxycontin (dosage: 260 Mg In Total). The following drugs were being taken at the same time:
  • Tramadol Hcl (1400 To 1800mg Once)
  • Atarax (750 Mg, Single)
  • Donormyl (150 Mg, Single)
When using Oxycontin, the patient experienced the following unwanted symptoms/side effects: Intentional Overdose, Serotonin Syndrome, Somnolence, Dyspnoea, RashThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Intentional Overdose, may become evident only after a product is in use by the general population.
Oxycontin Side Effect Report#9990842
Spinal Fracture, Arthritis, Pain
This Spinal Fracture side effect was reported by a consumer or non-health professional from US. A 60-year-old male patient (weight:NA) experienced the following symptoms/conditions: pain.The patient was prescribed Oxycontin (nda 22-272) (drug dosage: 20 Mg, Q12h), which was initiated on
Feb 07, 2014. Concurrently used drugs: NA..After starting to take Oxycontin (nda 22-272) the consumer reported adverse symptoms, such as: Spinal Fracture, Arthritis, PainThese side effects may potentially be related to Oxycontin (nda 22-272).
Oxycontin Side Effect Report#9934669
Akathisia, Sneezing, Lacrimation Increased, Malaise, Anxiety, Restlessness, Muscle Spasms, Diarrhoea
This is a report of a 52-year-old male patient (weight: NA) from DK, suffering from the following health symptoms/conditions: pain, who was treated with Oxycontin Depottabletter (dosage: 20 Mg, Bid, start time: NS), combined with:
  • Nalmefene Hydrochloride (18 Mg, Unk)
and developed a serious reaction and side effect(s): Akathisia, Sneezing, Lacrimation Increased, Malaise, Anxiety, Restlessness, Muscle Spasms, Diarrhoea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Oxycontin Depottabletter treatment in male patients, resulting in Akathisia side effect. The patient was hospitalized.
Oxycontin Side Effect Report#9917570
Completed Suicide, Urosepsis, Delirium, Urinary Tract Infection, Delusion, Paranoia
This report suggests a potential Oxycontin (nda 22-272) Completed Suicide side effect(s) that can have serious consequences. A 31-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Oxycontin (nda 22-272) (dosage: NA) starting NS. After starting Oxycontin (nda 22-272) the patient began experiencing various side effects, including: Completed Suicide, Urosepsis, Delirium, Urinary Tract Infection, Delusion, ParanoiaAdditional drugs used concurrently: NA. Although Oxycontin (nda 22-272) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Completed Suicide, may still occur.
Oxycontin Side Effect Report#9916944
Homicide, Needle Track Marks, Laceration, Abnormal Behaviour, Speech Disorder, Anger, Anxiety, Agitation
This Homicide problem was reported by a consumer or non-health professional from AU. A 24-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Oxycontin (nda 22-272) (dosage: NA). The following drugs were being taken at the same time: NA. When using Oxycontin (nda 22-272), the patient experienced the following unwanted symptoms/side effects: Homicide, Needle Track Marks, Laceration, Abnormal Behaviour, Speech Disorder, Anger, Anxiety, AgitationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Homicide, may become evident only after a product is in use by the general population.
Oxycontin Side Effect Report#9913208
Stab Wound, Haemorrhage, Facial Bones Fracture, Blood Alcohol Increased, Vascular Injury
This Stab Wound side effect was reported by a consumer or non-health professional from AU. A 57-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Oxycontin (nda 22-272) (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Alcohol
.After starting to take Oxycontin (nda 22-272) the consumer reported adverse symptoms, such as: Stab Wound, Haemorrhage, Facial Bones Fracture, Blood Alcohol Increased, Vascular InjuryThese side effects may potentially be related to Oxycontin (nda 22-272).
Oxycontin Side Effect Report#9910339
Non-alcoholic Steatohepatitis, Pre-eclampsia, Premature Delivery, Maternal Exposure During Pregnancy, Hypertension, Hepatic Enzyme Increased
This is a report of a 36-year-old female patient (weight: NA) from CA, suffering from the following health symptoms/conditions: NA, who was treated with Oxycontin Tablets (dosage: 800 Mg, Unk, start time: NS), combined with:
  • Suboxone
  • Suboxone (Unk)
  • Subutex (16 Mg, Unk)
  • Nicotine
  • Paxil Cr
  • Diclectin
  • Folic Acid
  • Prenatal Vitamins /01549301/ (Unk)
and developed a serious reaction and side effect(s): Non-alcoholic Steatohepatitis, Pre-eclampsia, Premature Delivery, Maternal Exposure During Pregnancy, Hypertension, Hepatic Enzyme Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Oxycontin Tablets treatment in female patients, resulting in Non-alcoholic Steatohepatitis side effect.
Oxycontin Side Effect Report#9898484
Substance Abuse, Bedridden, Vomiting, Flushing, Pruritus, Euphoric Mood
This report suggests a potential Oxycontin Tablets Substance Abuse side effect(s) that can have serious consequences. A 35-year-old male patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: NA and used Oxycontin Tablets (dosage: 800 Mg, Daily) starting NS. After starting Oxycontin Tablets the patient began experiencing various side effects, including: Substance Abuse, Bedridden, Vomiting, Flushing, Pruritus, Euphoric MoodAdditional drugs used concurrently: NA. Although Oxycontin Tablets demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Substance Abuse, may still occur.
Oxycontin Side Effect Report#9892313
This Death problem was reported by a consumer or non-health professional from US. A 22-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Oxycontin (nda 22-272) (dosage: NA). The following drugs were being taken at the same time: NA. When using Oxycontin (nda 22-272), the patient experienced the following unwanted symptoms/side effects:Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Oxycontin Side Effect Report#9889257
Suicidal Ideation, Intervertebral Disc Protrusion, Ligament Rupture, Fall, Ankle Fracture, Carpal Tunnel Syndrome, Pain
This Suicidal Ideation side effect was reported by a consumer or non-health professional from US. A 47-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Oxycontin (nda 22-272) (drug dosage: 20 Mg, Tid), which was initiated on 1990. Concurrently used drugs: NA..After starting to take Oxycontin (nda 22-272) the consumer reported adverse symptoms, such as: Suicidal Ideation, Intervertebral Disc Protrusion, Ligament Rupture, Fall, Ankle Fracture, Carpal Tunnel Syndrome, PainThese side effects may potentially be related to Oxycontin (nda 22-272).
Oxycontin Side Effect Report#9881589
Polysubstance Dependence, Substance Abuse
This is a report of a male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Oxycontin (nda 22-272) (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Polysubstance Dependence, Substance Abuse after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Oxycontin (nda 22-272) treatment in male patients, resulting in Polysubstance Dependence side effect.
Oxycontin Side Effect Report#9871377
Loss Of Consciousness, Paraesthesia
This report suggests a potential Oxycontin Depottabletit Loss Of Consciousness side effect(s) that can have serious consequences. A 47-year-old female patient (weight: NA) from SE was diagnosed with the following symptoms/conditions: cervicobrachial syndrome and used Oxycontin Depottabletit (dosage: NA) starting NS. After starting Oxycontin Depottabletit the patient began experiencing various side effects, including: Loss Of Consciousness, ParaesthesiaAdditional drugs used concurrently: NA. Although Oxycontin Depottabletit demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Loss Of Consciousness, may still occur.
Oxycontin Side Effect Report#9858881
Product Substitution Issue
This Product Substitution Issue problem was reported by a physician from US. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: leg amputation,amputation stump pain. On 2012 this consumer started treatment with Oxycontin (dosage: NA). The following drugs were being taken at the same time: NA. When using Oxycontin, the patient experienced the following unwanted symptoms/side effects: Product Substitution IssueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Product Substitution Issue, may become evident only after a product is in use by the general population.
Oxycontin Side Effect Report#9850837
Gallbladder Operation, Hallucination
This Gallbladder Operation side effect was reported by a consumer or non-health professional from US. A 74-year-old male patient (weight:NA) experienced the following symptoms/conditions: gallbladder pain.The patient was prescribed Oxycontin (nda 22-272) (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Oxycontin (nda 22-272) the consumer reported adverse symptoms, such as: Gallbladder Operation, HallucinationThese side effects may potentially be related to Oxycontin (nda 22-272). The patient was hospitalized.
Oxycontin Side Effect Report#9842427
Ileus, Metabolic Syndrome, Renal Disorder, Urethral Stenosis, Dyspnoea, Syncope
This is a report of a 41-year-old female patient (weight: NA) from KR, suffering from the following health symptoms/conditions: procedural pain, who was treated with Oxycontin Tablet 20 Mg (dosage: 20 Mg, Daily, start time:
Jun 05, 2012), combined with: NA. and developed a serious reaction and side effect(s): Ileus, Metabolic Syndrome, Renal Disorder, Urethral Stenosis, Dyspnoea, Syncope after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Oxycontin Tablet 20 Mg treatment in female patients, resulting in Ileus side effect.
Oxycontin Side Effect Report#9840893
Judgement Impaired, Aggression, Substance Abuse, Alcohol Poisoning, Euphoric Mood
This report suggests a potential Oxycontin Tablets Judgement Impaired side effect(s) that can have serious consequences. A 31-year-old male patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: NA and used Oxycontin Tablets (dosage: NA) starting NS. After starting Oxycontin Tablets the patient began experiencing various side effects, including: Judgement Impaired, Aggression, Substance Abuse, Alcohol Poisoning, Euphoric MoodAdditional drugs used concurrently:
  • Alcohol (Unk, Unk)
  • Cocaine (Unk, Unk)
  • Marijuana (Unk, Unk)
Although Oxycontin Tablets demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Judgement Impaired, may still occur.
Oxycontin Side Effect Report#9840412
Product Substitution Issue
This Product Substitution Issue problem was reported by a physician from US. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: leg amputation,amputation stump pain. On 2012 this consumer started treatment with Oxycontin (dosage: NA). The following drugs were being taken at the same time: NA. When using Oxycontin, the patient experienced the following unwanted symptoms/side effects: Product Substitution IssueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Product Substitution Issue, may become evident only after a product is in use by the general population.
Oxycontin Side Effect Report#9839061
Judgement Impaired, Aggression, Substance Abuse, Alcohol Poisoning
This Judgement Impaired side effect was reported by a consumer or non-health professional from CA. A 53-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Oxycontin Tablets (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Alcohol
.After starting to take Oxycontin Tablets the consumer reported adverse symptoms, such as: Judgement Impaired, Aggression, Substance Abuse, Alcohol PoisoningThese side effects may potentially be related to Oxycontin Tablets.
Oxycontin Side Effect Report#9839041
Judgement Impaired, Substance Abuse, Alcohol Poisoning, Euphoric Mood
This is a report of a 39-year-old male patient (weight: NA) from CA, suffering from the following health symptoms/conditions: NA, who was treated with Oxycontin Tablets (dosage: Unk, Unk, start time: NS), combined with:
  • Alcohol (Unk, Unk)
  • Cocaine
  • Marijuana
and developed a serious reaction and side effect(s): Judgement Impaired, Substance Abuse, Alcohol Poisoning, Euphoric Mood after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Oxycontin Tablets treatment in male patients, resulting in Judgement Impaired side effect.
Oxycontin Side Effect Report#9835670
Substance Abuse, Cardiac Arrest, Loss Of Consciousness, Rectal Haemorrhage, Respiratory Arrest, Tachycardia
This report suggests a potential Oxycontin (nda 22-272) Substance Abuse side effect(s) that can have serious consequences. A 47-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Oxycontin (nda 22-272) (dosage: NA) starting NS. After starting Oxycontin (nda 22-272) the patient began experiencing various side effects, including: Substance Abuse, Cardiac Arrest, Loss Of Consciousness, Rectal Haemorrhage, Respiratory Arrest, TachycardiaAdditional drugs used concurrently:
  • Amphetamine
  • Cannabis
  • Cocaine
  • Tricyclic Antidepressants
Although Oxycontin (nda 22-272) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Substance Abuse, may still occur.
Oxycontin Side Effect Report#9834700
Overdose, Polysubstance Dependence, Cardiac Aneurysm
This Overdose problem was reported by a consumer or non-health professional from US. A 27-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Oxycontin (nda 22-272) (dosage: NA). The following drugs were being taken at the same time:
  • Heroin
When using Oxycontin (nda 22-272), the patient experienced the following unwanted symptoms/side effects: Overdose, Polysubstance Dependence, Cardiac AneurysmAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Overdose, may become evident only after a product is in use by the general population.
Oxycontin Side Effect Report#9834393
Spinal Fracture, Paralysis, Road Traffic Accident, Fall, Sinusitis, Pain
This Spinal Fracture side effect was reported by a consumer or non-health professional from US. A male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Oxycontin (nda 22-272) (drug dosage: 160 Mg, Q12h), which was initiated on NS. Concurrently used drugs:
  • Oxycodone Hydrochloride (similar To Nda 22-272) (30 Mg, Prn)
.After starting to take Oxycontin (nda 22-272) the consumer reported adverse symptoms, such as: Spinal Fracture, Paralysis, Road Traffic Accident, Fall, Sinusitis, PainThese side effects may potentially be related to Oxycontin (nda 22-272).
Oxycontin Side Effect Report#9830759
Breast Cancer, Lung Neoplasm Malignant, Renal Cancer, Pain
This is a report of a 49-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: pain, who was treated with Oxycontin (nda 22-272) (dosage: 80 Mg, Tid, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Breast Cancer, Lung Neoplasm Malignant, Renal Cancer, Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Oxycontin (nda 22-272) treatment in female patients, resulting in Breast Cancer side effect.


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The appearance of Oxycontin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Oxycontin Side Effects for Women?

Women Side Effects Reports
Pain 270
Anxiety 257
Nausea 224
Depression 178
Back Pain 160
Vomiting 157
Constipation 156
Overdose 155
Death 134
Headache 131

What are common Oxycontin Side Effects for Men?

Men Side Effects Reports
Anxiety 348
Depression 308
Pain 283
Overdose 248
Substance Abuse 213
Constipation 210
Nausea 205
Back Pain 197
Arthralgia 195
Death 175

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Oxycontin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Oxycontin Side Effects

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    Oxycontin Safety Alerts, Active Ingredients, Usage Information

    NDC 16590-616
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name OXYCONTIN
    Name OXYCODONE HYDROCHLORIDE
    Dosage Form TABLET, FILM COATED, EXTENDED RELEASE
    Route ORAL
    On market since 20100808
    Labeler STAT Rx USA LLC
    Active Ingredient(s) OXYCODONE HYDROCHLORIDE
    Strength(s) 20
    Unit(s) mg/1
    Pharma Class Full Opioid Agonists [MoA],Opioid Agonist [EPC]

    Oxycontin Dosage, Warnings, Usage.

    Side Effects reported to FDA: 5984

    Oxycontin safety alerts: 2007 2001

    Reported deaths: 1763

    Reported hospitalizations: 1885

    OxyContin, Illegal Promotion by Manufacturer

    Audience: Pain management specialists, healthcare professionals, consumers

    [Posted 05/10/2007] FDA informed healthcare professionals of criminal charges and civil liabilities brought against Purdue Frederick in connection with several illegal schemes to promote, market and sell OxyContin, a powerful prescription pain reliever that the company produces. The manufacturer's sales force was trained to make false claims about the product to healthcare professionals, thereby, misbranding OxyContin by illegally promoting the drug as being less addictive, less subject to abuse, and less likely to cause tolerance and withdrawal than other pain medications. These practices falsely promote the product and may cause health risks for consumers.

    [May 10, 2007 - News Release - FDA]

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