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Review Pemetrexed Safety Reports submitted to FDA

Total Pemetrexed reports: 286.
Pemetrexed FDA safety alerts: No.
Reported deaths: 80    Reported hospitalizations: 188.
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FDA Reported Pemetrexed Side Effects: haemoglobin decreased, thrombocytopenia, atrial fibrillation, nausea, interstitial lung disease, hepatic function abnormal, white blood cell count decreased, pyrexia, pneumonia, anaemia, dyspnoea.
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Pemetrexed Side Effects Report #5518073-1
Physician from JAPAN reported PEMETREXED problem on Nov 06, 2007. Male patient, weighting 132.6 lb, was diagnosed with pleural mesothelioma malignant, nausea and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: blood sodium decreased. PEMETREXED dosage: 800 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, METOCLOPRAMIDE, LIORESAL, POLARAMINE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5518076-7
PEMETREXED problem was reported by a Physician from HUNGARY on Oct 31, 2007. Male patient, weighting 143.3 lb, was diagnosed with neoplasm malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: gastrointestinal necrosis. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, METHYLPREDNISOLONE. Patient died on 10/31/2007.

Pemetrexed Side Effects Report #5518077-9
Physician from UNITED STATES reported PEMETREXED problem on Nov 07, 2007. Female patient, weighting 112.0 lb, was diagnosed with small cell lung cancer extensive stage, vitamin supplementation, back pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dehydration, encephalopathy, febrile neutropenia, leukopenia, pancytopenia, thrombocytopenia, unresponsive to stimuli. PEMETREXED dosage: 715 MG, OTHER. During the same period patient was treated with CARBOPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE, LORTAB, NICOTINE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5518080-9
PEMETREXED problem was reported by a Consumer or non-health professional from CANADA on Nov 01, 2007. Female patient, weighting 147.7 lb, was diagnosed with metastatic neoplasm and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: diarrhoea, lipase increased, vomiting. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with FOLIC ACID, OMEPRAZOLE, NYSTATIN, HYDROCORTISONE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5522143-1
Consumer or non-health professional from UNITED STATES reported PEMETREXED problem on Nov 13, 2007. Male patient, weighting 150.0 lb, was diagnosed with non-small cell lung cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: infection, urosepsis. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient died on 11/06/2007.

Pemetrexed Side Effects Report #5522147-9
PEMETREXED problem was reported by a Physician from FRANCE on Nov 08, 2007. Male patient, 73 years of age, weighting 218.3 lb, was diagnosed with bronchial carcinoma, vitamin supplementation, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: diarrhoea, neutropenia, septic shock. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient died on 09/06/2007.

Pemetrexed Side Effects Report #5522149-2
Physician from JAPAN reported PEMETREXED problem on Nov 08, 2007. Male patient, weighting 102.5 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anaemia, lymphocyte count decreased, myelodysplastic syndrome, neutrophil count decreased, platelet count decreased, renal impairment, white blood cell count decreased. PEMETREXED dosage: 750 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, GEMCITABINE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5522156-X
PEMETREXED problem was reported by a Physician from JAPAN on Nov 14, 2007. Male patient, weighting 152.8 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: herpes zoster. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with PANVITAN, CYANOCOBALAMIN, GLYSENNID, MAGMITT, TAKEPRON, LOXONIN, MYSLEE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5522340-5
Physician from PORTUGAL reported PEMETREXED problem on Nov 12, 2007. Male patient, 68 years of age, weighting 154.3 lb, was diagnosed with non-small cell lung cancer, cancer pain, anaemia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anxiety, dyspnoea, malaise, mucosal inflammation, nausea, presyncope, vomiting. PEMETREXED dosage: 910 MG,EVERY 3 WEEKS. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE, TRANSTEC, ACETAMINOPHEN AND TRAMADOL, METRONIDAZOLE, NEORECORMON. Patient died on 09/14/2007.

Pemetrexed Side Effects Report #5523418-2
PEMETREXED problem was reported by a Physician from JAPAN on Nov 15, 2007. Male patient, weighting 157.4 lb, was diagnosed with pleural mesothelioma malignant recurrent, atrial fibrillation, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: cardiac failure, infection, neutropenia, platelet count decreased. PEMETREXED dosage: 850 MG, OTHER. During the same period patient was treated with CISPLATIN, CIBENOL, WARFARIN, GASTER D, DUROTEP. Patient died on 03/26/2007.

Pemetrexed Side Effects Report #5523419-4
Physician from JAPAN reported PEMETREXED problem on Nov 15, 2007. Male patient, weighting 159.8 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anaemia, hypercapnia, neutrophil count decreased, polyneuropathy. PEMETREXED dosage: 925 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, FOLIAMIN, VITAMIN B, DECADRON. Patient recovered.

Pemetrexed Side Effects Report #5526514-9
PEMETREXED problem was reported by a Physician from PORTUGAL on Nov 12, 2007. Male patient, 78 years of age, was diagnosed with non-small cell lung cancer, chronic obstructive pulmonary disease and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anxiety, asthenia, bronchospasm, chest discomfort, dyspnoea, fatigue, fear. PEMETREXED dosage: 1000 MG, EVERY 3 WEEKS. During the same period patient was treated with SYMBICORT, SPIRIVA, FOLIC ACID, VITAMIN B, DEXAMETHASONE, DOCETAXEL. Patient recovered.

Pemetrexed Side Effects Report #5529444-1
Physician from JAPAN reported PEMETREXED problem on Nov 15, 2007. Male patient, weighting 114.0 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis, neurosis, hypertension, cerebrovascular disorder, gastric ulcer, benign prostatic hyperplasia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: hepatic function abnormal, pyrexia, white blood cell count decreased. PEMETREXED dosage: unknown. During the same period patient was treated with PANVITAN, CYANOCOBALAMIN, DEPAS, DIOVAN, ASPIRIN, ADALAT CR, GASTER D, AVISHOT. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5529446-5
PEMETREXED problem was reported by a Physician from JAPAN on Nov 16, 2007. Male patient, weighting 101.9 lb, was diagnosed with pleural mesothelioma malignant, hypertension and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: hyponatraemia. PEMETREXED dosage: 700 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, NORVASC, DIART, BLOPRESS. Patient recovered.

Pemetrexed Side Effects Report #5529451-9
Consumer or non-health professional from UNITED STATES reported PEMETREXED problem on Nov 20, 2007. Male patient, weighting 150.0 lb, was diagnosed with non-small cell lung cancer, prophylaxis, metastases to bone, headache and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: urosepsis. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE, ZOMETA, DOCUSATE, TYLENOL. Patient was hospitalized. Patient died on 11/06/2007.

Pemetrexed Side Effects Report #5475958-2
PEMETREXED problem was reported by a Physician from JAPAN on Sept 27, 2007. Male patient, weighting 103.6 lb, was diagnosed with pleural mesothelioma, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: gastrointestinal perforation, stress cardiomyopathy. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN, GOODMIN, POSTERISANTE, OXYCONTIN, MAGNESIUM OXIDE. Patient died on 08/30/2007.

Pemetrexed Side Effects Report #5475975-2
Physician from JAPAN reported PEMETREXED problem on Sept 26, 2007. Male patient, 78 years of age, weighting 150.6 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: sepsis. PEMETREXED dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B12 NOS. Patient was hospitalized. Patient died on 01/01/2007.

Pemetrexed Side Effects Report #5477604-0
PEMETREXED problem was reported by a Physician from JAPAN on Sept 28, 2007. Male patient, weighting 154.3 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dyspnoea, pyrexia, shock. PEMETREXED dosage: 850 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, PROMAC, DEPAS, NAUZELIN, OMEPRAL. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5477608-8
Physician from KOREA, REPUBLIC OF reported PEMETREXED problem on Sept 28, 2007. Male patient, weighting 91.49 lb, was diagnosed with non-small cell lung cancer, prophylaxis, flatulence, analgesia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anorexia, loss of consciousness, pneumonia aspiration. PEMETREXED dosage: 500 MG/M2, DAY 1 EVERY 3 WEEKS. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE, ITOPRIDE, OXYCODONE, DURAGESIC, ALMAGATE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5477609-X
PEMETREXED problem was reported by a Physician from JAPAN on Sept 25, 2007. Male patient, 61 years of age, weighting 141.5 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: constipation, hiccups, nausea. PEMETREXED dosage: 870 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, HYDROXOCOBALAMIN ACETATE. Patient recovered.

Pemetrexed Side Effects Report #5477611-8
Physician from JAPAN reported PEMETREXED problem on Sept 20, 2007. Male patient, 63 years of age, weighting 140.0 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: hypoacusis, parkinsonism. PEMETREXED dosage: 880 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, HYDROXOCOBALAMIN ACETATE, HYDROXOCOBALAMIN ACETATE, PREDNISOLONE, BAKTAR, LANSOPRAZOLE, SELBEX. Patient recovered.

Pemetrexed Side Effects Report #5477613-1
PEMETREXED problem was reported by a Physician from JAPAN on Sept 26, 2007. Male patient, 45 years of age, weighting 159.8 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: asthenia. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5478555-8
Physician from PORTUGAL reported PEMETREXED problem on Sept 27, 2007. Male patient, weighting 154.3 lb, was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anxiety, malaise, mucosal inflammation, nausea, presyncope, vomiting. PEMETREXED dosage: unknown. During the same period patient was treated with PARACETAMOL, TRAMADOL. Patient recovered.

Pemetrexed Side Effects Report #5478560-1
PEMETREXED problem was reported by a Physician from PORTUGAL on Sept 26, 2007. Male patient, weighting 163.4 lb, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anorexia, asthenia, dizziness, malaise, nausea, vomiting. PEMETREXED dosage: unknown. Patient recovered.

Pemetrexed Side Effects Report #5480186-0
Physician from JAPAN reported PEMETREXED problem on Sept 26, 2007. Male patient, weighting 83.78 lb, was diagnosed with pleural mesothelioma malignant, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anaemia, blood urea increased, neutrophil count decreased, platelet count decreased, white blood cell count decreased. PEMETREXED dosage: 640 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, LOXONIN, OXYCONTIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5482253-4
PEMETREXED problem was reported by a Physician from JAPAN on Sept 27, 2007. Female patient, weighting 132.5 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: cholecystitis, diarrhoea, gastritis, pseudomonal sepsis, vomiting. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, HYDROXOCOBALAMIN ACETATE, FAMOTIDINE, OMEPRAL, URSO, NORVASC, LIPITOR. Patient was hospitalized and became disabled. Patient recovered.

Pemetrexed Side Effects Report #5489360-0
Physician from PORTUGAL reported PEMETREXED problem on Oct 09, 2007. Male patient, weighting 154.3 lb, was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anxiety, malaise, mucosal inflammation, nausea, presyncope, vomiting. PEMETREXED dosage: unknown. During the same period patient was treated with PARACETAMOL, TRAMADOL. Patient recovered.

Pemetrexed Side Effects Report #5489410-1
PEMETREXED problem was reported by a Physician from PORTUGAL on Oct 09, 2007. Male patient, 68 years of age, weighting 154.3 lb, was diagnosed with non-small cell lung cancer, cancer pain, anaemia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anxiety, dyspnoea, malaise, mucosal inflammation, nausea, presyncope, vomiting. PEMETREXED dosage: 910 MG,EVERY 3 WEEKS. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE, TRANSTEC, ZALDIAR, METRONIDAZOLE, NEORECORMON. Patient recovered.

Pemetrexed Side Effects Report #5489411-3
Physician from PORTUGAL reported PEMETREXED problem on Oct 09, 2007. Male patient, weighting 163.4 lb, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anorexia, asthenia, dizziness, malaise, nausea, vomiting. PEMETREXED dosage: unknown. Patient recovered.

Pemetrexed Side Effects Report #5489413-7
PEMETREXED problem was reported by a Physician from PORTUGAL on Oct 09, 2007. Male patient, weighting 163.4 lb, was diagnosed with non-small cell lung cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anorexia, asthenia, dizziness, malaise, nausea, vomiting. PEMETREXED dosage: 935 MG, UNK. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient recovered.

Pemetrexed Side Effects Report #5490757-3
Physician from PORTUGAL reported PEMETREXED problem on Oct 09, 2007. Male patient, 78 years of age, was diagnosed with non-small cell lung cancer, chronic obstructive pulmonary disease and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anxiety, asthenia, bronchospasm, chest discomfort, dyspnoea, fatigue, fear, feeling abnormal. PEMETREXED dosage: 1000 MG, EVERY 3 WEEKS. During the same period patient was treated with SYMBICORT, SPIRIVA, FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient recovered.

Pemetrexed Side Effects Report #5492802-8
PEMETREXED problem was reported by a Physician from KOREA, REPUBLIC OF on Oct 18, 2007. Male patient, weighting 125.0 lb, was diagnosed with non-small cell lung cancer, nausea and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: malignant neoplasm progression, nephrotic syndrome. PEMETREXED dosage: unknown. During the same period patient was treated with CARBOPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE, GRANISETRON. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5493463-4
Physician from GERMANY reported PEMETREXED problem on Oct 10, 2007. Male patient, 65 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: skin necrosis, skin reaction. PEMETREXED dosage: unknown. Patient recovered.

Pemetrexed Side Effects Report #5496158-6
PEMETREXED problem was reported by a Health Professional from UNITED STATES on Oct 23, 2007. Female patient, 82 years of age, weighting 171.0 lb, was diagnosed with investigation, neoplasm malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: cellulitis, neutropenia, oedema peripheral, venous stasis. PEMETREXED dosage: unknown. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5502991-4
Physician from GERMANY reported PEMETREXED problem on Oct 16, 2007. Female patient, weighting 106.9 lb, was diagnosed with prophylaxis, c-reactive protein increased, insomnia, pain, nausea, respiratory disorder and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: gastric ulcer perforation, hyponatraemia, laryngeal oedema, lung infiltration. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, AVELOX, XIMOVAN, NOVALGIN, KEVATRIL. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5441912-X
PEMETREXED problem was reported by a Physician from JAPAN on Aug 24, 2007. Male patient, 74 years of age, weighting 123.5 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, pyrexia. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with PANVITAN, METHYCOBAL, MAGNESIUM OXIDE, CISPLATIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5441913-1
Physician from JAPAN reported PEMETREXED problem on Aug 23, 2007. Male patient, 54 years of age, weighting 126.3 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pneumonia, post procedural complication, pulmonary necrosis. PEMETREXED dosage: 785 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, DECADRON, KYTRIL, ADONA, TRANSAMIN. Patient was hospitalized. Patient died on 08/01/2007.

Pemetrexed Side Effects Report #5441917-9
PEMETREXED problem was reported by a Physician from JAPAN on Aug 23, 2007. Male patient, 58 years of age, weighting 141.1 lb, was diagnosed with pleural mesothelioma malignant, gastritis, cancer pain, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anaemia, haemoglobin decreased, lymphocyte count decreased, white blood cell count decreased. PEMETREXED dosage: 880 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, FAMOTIDINE, OXYCONTIN, KYTRIL. Patient recovered.

Pemetrexed Side Effects Report #5442016-2
Physician from JAPAN reported PEMETREXED problem on Aug 27, 2007. Male patient, 75 years of age, weighting 145.5 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, hepatic function abnormal, neutrophil count decreased, renal impairment. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, SEROTONE, DECADRON, ROHYPNOL, NAUZELIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5444409-6
PEMETREXED problem was reported by a Physician from JAPAN on Aug 30, 2007. Male patient, 70 years of age, weighting 140.0 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: ulcer haemorrhage. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, DECADRON. Patient recovered.

Pemetrexed Side Effects Report #5444410-2
Physician from JAPAN reported PEMETREXED problem on Aug 30, 2007. Male patient, 64 years of age, weighting 142.2 lb, was diagnosed with pleural mesothelioma malignant, gastritis, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, hyperkalaemia. PEMETREXED dosage: 840 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, PROTECADIN, SEROTONE, RINDERON, ROHYPNOL. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5450185-3
PEMETREXED problem was reported by a Physician from JAPAN on Sept 03, 2007. Male patient, 54 years of age, weighting 126.3 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: disease progression, malignant pleural effusion, post procedural haemorrhage, pulmonary necrosis. PEMETREXED dosage: 785 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, DECADRON, KYTRIL, ADONA, TRANSAMIN. Patient was hospitalized. Patient died on 08/01/2007.

Pemetrexed Side Effects Report #5450192-0
Physician from JAPAN reported PEMETREXED problem on Sept 03, 2007. Female patient was diagnosed with pleural mesothelioma and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: gastric perforation. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient died on 08/31/2007.

Pemetrexed Side Effects Report #5452420-4
PEMETREXED problem was reported by a Physician from JAPAN on Aug 30, 2007. Male patient, 59 years of age, weighting 121.7 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, cardiac failure, febrile neutropenia, hypotension, oxygen saturation decreased, platelet count decreased, white blood cell count decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, GASTER D, AMOBAN, TERNELIN, PREDONINE. Patient recovered.

Pemetrexed Side Effects Report #5453741-1
Physician from GERMANY reported PEMETREXED problem on Sept 03, 2007. Male patient, 67 years of age, weighting 140.7 lb, was diagnosed with hypopharyngeal cancer, prophylaxis, medical diet and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: infection, nausea, orthostatic hypotension, vomiting. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE, FRESUBIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5453743-5
PEMETREXED problem was reported by a Physician from JAPAN on Sept 05, 2007. Male patient, 61 years of age, weighting 141.5 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: constipation, hiccups, nausea. PEMETREXED dosage: 870 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, HYDROXOCOBALAMIN ACETATE. Patient recovered.

Pemetrexed Side Effects Report #5453745-9
Physician from JAPAN reported PEMETREXED problem on Sept 06, 2007. Male patient, 70 years of age, weighting 140.0 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: gastric ulcer. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, DECADRON. Patient recovered.

Pemetrexed Side Effects Report #5469864-7
PEMETREXED problem was reported by a Physician from JAPAN on Sept 13, 2007. Male patient, 71 years of age, weighting 121.3 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: atrial flutter. PEMETREXED dosage: 500 MG, OTHER. During the same period patient was treated with CISPLATIN, FOLIAMIN, METHYCOBAL, OMEPRAZOLE, OXYCONTIN, MAGNESIUM OXIDE, DECADRON, DIHYDROCODEINE PHOSPHATE. Patient recovered.

Pemetrexed Side Effects Report #5469875-1
Physician from HUNGARY reported PEMETREXED problem on Sept 13, 2007. Male patient, 49 years of age, weighting 121.3 lb, was diagnosed with neoplasm malignant, parenteral nutrition, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, trismus. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with DEXTROSE, INFUSAMIN S, INTRALIPID, POTASSIUM IN CHLORIDE, FOLIC ACID, VITAMIN B, MEDROL, CISPLATIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5469876-3
PEMETREXED problem was reported by a Physician from JAPAN on Sept 13, 2007. Female patient, 72 years of age, weighting 85.98 lb, was diagnosed with pleural mesothelioma malignant, iron deficiency anaemia, cholelithiasis, osteoporosis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: amyloidosis, blood albumin decreased, decreased appetite, diarrhoea, febrile neutropenia, gastric ulcer, haematocrit decreased, haemoglobin decreased, oedema. PEMETREXED dosage: unknown. During the same period patient was treated with PANVITAN, METHYCOBAL, FERROMIA, URSO, COSPANON, ALFAROL. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5403041-0
Physician from JAPAN reported PEMETREXED problem on July 18, 2007. Male patient, 59 years of age, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient recovered.

Pemetrexed Side Effects Report #5406469-8
PEMETREXED problem was reported by a Physician from RUSSIAN FEDERATION on July 26, 2007. Male patient, 55 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: malignant neoplasm progression. PEMETREXED dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B, VERAPAMIL, DEXAMETHASONE, CIPROFLOXACIN, EUPHYLLIN. Patient was hospitalized. Patient died on 06/22/2006.

Pemetrexed Side Effects Report #5406473-X
Physician from JAPAN reported PEMETREXED problem on July 26, 2007. Male patient, 62 years of age, weighting 101.9 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: blood sodium decreased. PEMETREXED dosage: 700 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, NORVASC, DIART, CANDESARTAN CILEXETIL. Patient recovered.

Pemetrexed Side Effects Report #5406480-7
PEMETREXED problem was reported by a Physician from JAPAN on July 26, 2007. Male patient, 37 years of age, weighting 169.5 lb, was diagnosed with pleural mesothelioma malignant recurrent, rhinitis allergic, epilepsy, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: deafness neurosensory. PEMETREXED dosage: 960 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, TEGRETOL, KYTRIL. Patient recovered.

Pemetrexed Side Effects Report #5411378-4
Physician from JAPAN reported PEMETREXED problem on Aug 01, 2007. Female patient, 67 years of age, weighting 121.3 lb, was diagnosed with pleural mesothelioma malignant, cryptogenic organising pneumonia, iron deficiency anaemia, gastritis, insomnia, osteoporosis prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: lymphocyte count decreased, pneumonia, pneumonia staphylococcal, urine output decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with PREDONINE, MUCODYNE, BISOLVON, LANSOPRAZOLE, LENDORMIN, ASPARA, ROCALTROL. Patient died on 03/11/2007.

Pemetrexed Side Effects Report #5411379-6
PEMETREXED problem was reported by a Physician from JAPAN on Aug 02, 2007. Male patient, 54 years of age, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pneumonia, pulmonary necrosis. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5413763-3
Physician from JAPAN reported PEMETREXED problem on Aug 06, 2007. Male patient, 61 years of age, weighting 120.9 lb, was diagnosed with pleural mesothelioma malignant, tumour associated fever, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: gastrointestinal haemorrhage, interstitial lung disease. PEMETREXED dosage: 740 MG, OTHER. During the same period patient was treated with PANVITAN, CYANOCOBALAMIN, PREDONINE, ZANTAC, LORAZEPAM. Patient died on 08/04/2007.

Pemetrexed Side Effects Report #5413764-5
PEMETREXED problem was reported by a Physician from JAPAN on July 30, 2007. Female patient, 71 years of age, weighting 122.8 lb, was diagnosed with pleural mesothelioma malignant, hypertension, neurogenic bladder, major depression and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with PANVITAN, METHYCOBAL, DIOVAN, NORVASC, UBRETID, PAXIL. Patient recovered.

Pemetrexed Side Effects Report #5413765-7
Physician from CANADA reported PEMETREXED problem on Aug 01, 2007. Female patient, 47 years of age, weighting 110.2 lb, was diagnosed with non-small cell lung cancer, cough, odynophagia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: myelodysplastic syndrome. PEMETREXED dosage: 500 MG, OTHER. During the same period patient was treated with CODEINE SUL, FENTANYL. Patient recovered.

Pemetrexed Side Effects Report #5417078-9
PEMETREXED problem was reported by a Physician from JAPAN on Aug 01, 2007. Male patient, 64 years of age, weighting 142.2 lb, was diagnosed with pleural mesothelioma malignant, gastritis, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: hyperkalaemia. PEMETREXED dosage: 840 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, PROTECADIN, SEROTONE, RINDERON, ROHYPNOL, NAUZELIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5417079-0
Physician from JAPAN reported PEMETREXED problem on Aug 02, 2007. Male patient, 72 years of age, weighting 124.8 lb, was diagnosed with pleural mesothelioma malignant, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, hepatic function abnormal, lymphocyte count decreased. PEMETREXED dosage: 830 MG, OTHER. During the same period patient was treated with CISPLATIN, ZOLPIDEM, LOXONIN, MEDICON, CYTOTEC, URSO, CALONAL. Patient recovered.

Pemetrexed Side Effects Report #5417081-9
PEMETREXED problem was reported by a Physician from JAPAN on Aug 09, 2007. Male patient, 70 years of age, weighting 140.0 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: melaena. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, DECADRON. Patient recovered.

Pemetrexed Side Effects Report #5419028-8
Physician from FRANCE reported PEMETREXED problem on June 26, 2007. Male patient, 85 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: toxic epidermal necrolysis. PEMETREXED dosage: unknown. Patient recovered.

Pemetrexed Side Effects Report #5419675-3
PEMETREXED problem was reported by a Physician from JAPAN on Aug 07, 2007. Male patient, 74 years of age, weighting 123.5 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, pyrexia. PEMETREXED dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5419677-7
Physician from HUNGARY reported PEMETREXED problem on Aug 07, 2007. Male patient, 49 years of age, weighting 121.3 lb, was diagnosed with neoplasm malignant, parenteral nutrition, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, trismus. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with DEXTROSE, INFUSAMIN S, INTRALIPID, POTASSIUM CHLORIDE, FOLIC ACID, VITAMIN B, MEDROL, CISPLATIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5419678-9
PEMETREXED problem was reported by a Physician from UNITED STATES on Aug 07, 2007. Female patient, 73 years of age, weighting 131.2 lb, was diagnosed with non-small cell lung cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pain. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5419680-7
Physician from INDIA reported PEMETREXED problem on Aug 10, 2007. Male patient, 50 years of age, weighting 145.5 lb, was diagnosed with small cell lung cancer metastatic, gastritis prophylaxis, vomiting, bronchospasm, hyperuricaemia, coagulopathy and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: acute left ventricular failure. PEMETREXED dosage: 800 MG. During the same period patient was treated with RICONIA, PANTOPRAZOLE, REGLAN, THEOPHYLLINE, UDILIV, ALLOPURINOL, ATIVAN, TRANEXAMIC ACID. Patient died on 08/09/2007.

Pemetrexed Side Effects Report #5422341-1
PEMETREXED problem was reported by a Physician from JAPAN on Aug 15, 2007. Male patient, 68 years of age, weighting 160.9 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anaemia, anorexia, lymphocyte count decreased, nausea, neutrophil count decreased, platelet count decreased, white blood cell count decreased. PEMETREXED dosage: 880 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, DEPAS, ZOLPIDEM, ALOSENN. Patient recovered.

Pemetrexed Side Effects Report #5422343-5
Physician from JAPAN reported PEMETREXED problem on Aug 08, 2007. Female patient, 59 years of age, weighting 125.2 lb, was diagnosed with pleural mesothelioma malignant recurrent, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: peritonitis, white blood cell count decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, METHYCOBAL, PANVITAN, PRIMPERAN, DECADRON, ZOFRAN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5427628-4
PEMETREXED problem was reported by a Physician from UNITED STATES on Aug 14, 2007. Female patient, 73 years of age, weighting 131.2 lb, was diagnosed with non-small cell lung cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: bacteraemia, neuropathy, pain in extremity. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5427629-6
Physician from JAPAN reported PEMETREXED problem on Aug 20, 2007. Male patient, 54 years of age, weighting 126.3 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pneumonia, pulmonary necrosis. PEMETREXED dosage: 785 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, DECADRON, KYTRIL, ADONA, TRANSAMIN. Patient was hospitalized. Patient died on 08/01/2007.

Pemetrexed Side Effects Report #5431225-4
PEMETREXED problem was reported by a Physician from on Aug 10, 2007. Male patient, 70 years of age, weighting 91.49 lb, was diagnosed with non-small cell lung cancer, prophylaxis, analgesia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anorexia, loss of consciousness. PEMETREXED dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE, ITOPRIDE, OXYCODONE, DUROGESIC, ALMAGATE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5431229-1
Physician from GERMANY reported PEMETREXED problem on Aug 17, 2007. Male patient, 67 years of age, weighting 140.7 lb, was diagnosed with hypopharyngeal cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: autonomic nervous system imbalance, nausea, vomiting. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5431520-9
PEMETREXED problem was reported by a Physician from JAPAN on Aug 22, 2007. Male patient, 74 years of age, weighting 154.3 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dyspnoea, shock. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient recovered.

Pemetrexed Side Effects Report #5443302-2
Health Professional from UNITED STATES reported PEMETREXED problem on Aug 31, 2007. Male patient, weighting 134.5 lb, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pyrexia. PEMETREXED dosage: 500MG/M2 IV. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5377503-9
PEMETREXED problem was reported by a Physician from JAPAN on June 21, 2007. Male patient, 75 years of age, weighting 145.5 lb, was diagnosed with prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, hepatic function abnormal, neutrophil count decreased, platelet count decreased, white blood cell count decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, SEROTONE, DECADRON, ROHYPNOL, NAUZELIN, SEPAMIT. Patient recovered.

Pemetrexed Side Effects Report #5383223-7
Physician from FRANCE reported PEMETREXED problem on June 26, 2007. Male patient, 85 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: toxic epidermal necrolysis. PEMETREXED dosage: unknown. Patient recovered.

Pemetrexed Side Effects Report #5389684-1
PEMETREXED problem was reported by a Physician from POLAND on July 09, 2007. Male patient, 58 years of age, weighting 174.2 lb, was diagnosed with small cell lung cancer extensive stage and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: cerebral haemorrhage, thrombocytopenia. PEMETREXED dosage: 500 MG/M2, DAY 1 OF 21 DAY CYCLE. During the same period patient was treated with CARBOPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient died on 07/09/2007.

Pemetrexed Side Effects Report #5389686-5
Physician from reported PEMETREXED problem on July 04, 2007. Female patient, 59 years of age, weighting 123.0 lb, was diagnosed with lung neoplasm malignant, dyspepsia, metastases to central nervous system, candidiasis, pain, sleep disorder and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dyspnoea, febrile neutropenia. PEMETREXED dosage: 762.5 MG, EVERY 21 DAYS. During the same period patient was treated with VITAMINS WITH MINERALS, OMEPRAZOLE, BETAMETHASONE, FLUKONAZOL, CODEINE W, FENTANYL, PREGABALIN, PROPIOMAZINE. Patient was hospitalized. Patient died.

Pemetrexed Side Effects Report #5389687-7
PEMETREXED problem was reported by a Physician from SPAIN on July 04, 2007. Male patient, 52 years of age, weighting 110.2 lb, was diagnosed with neoplasm malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: laryngeal dyspnoea. PEMETREXED dosage: 500 MG/M2, UNK. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5389688-9
Physician from RUSSIAN FEDERATION reported PEMETREXED problem on June 09, 2007. Male patient, 55 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pulmonary haemorrhage, tumour necrosis. PEMETREXED dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B, VERAPAMIL, DEXAMETHASONE, CIPROFLOXACIN, EUPHYLLIN. Patient was hospitalized. Patient died on 06/22/2006.

Pemetrexed Side Effects Report #5389692-0
PEMETREXED problem was reported by a Physician from INDIA on July 12, 2007. Male patient, 51 years of age, weighting 92.59 lb, was diagnosed with non-small cell lung cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dysphagia, fatigue, micturition disorder, paraplegia. PEMETREXED dosage: 725 MG, ONCE IN 3 WEEKS. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5389696-8
Physician from JAPAN reported PEMETREXED problem on July 10, 2007. Male patient, 61 years of age, weighting 120.9 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: interstitial lung disease. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient recovered.

Pemetrexed Side Effects Report #5391531-9
PEMETREXED problem was reported by a Physician from SPAIN on July 13, 2007. Male patient, 64 years of age, was diagnosed with mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: diarrhoea, neutropenia, pneumonia, renal failure. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient died on 03/01/2006.

Pemetrexed Side Effects Report #5394624-5
Physician from JAPAN reported PEMETREXED problem on July 09, 2007. Female patient, 67 years of age, weighting 121.3 lb, was diagnosed with pleural mesothelioma malignant, cryptogenic organising pneumonia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: hepatic function abnormal, oedema peripheral, pneumonia staphylococcal, pyrexia, respiratory failure, sepsis, urine output decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with PREDONINE, MUCODYNE, BISOLVON, LANSOPRAZOLE, LENDORM, ASPARA, ROCALTROL. Patient died on 03/11/2007.

Pemetrexed Side Effects Report #5394629-4
PEMETREXED problem was reported by a Physician from JAPAN on July 17, 2007. Male patient, 61 years of age, weighting 120.9 lb, was diagnosed with pleural mesothelioma malignant, tumour associated fever, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: interstitial lung disease. PEMETREXED dosage: 740 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, PREDONINE, ZANTAC, WYPAX. Patient recovered.

Pemetrexed Side Effects Report #5394630-0
Physician from JAPAN reported PEMETREXED problem on July 13, 2007. Female patient, 77 years of age, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: aneurysm, atrial fibrillation, cardiac failure, hypoproteinaemia, oedema, renal impairment. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5394631-2
PEMETREXED problem was reported by a Physician from JAPAN on July 17, 2007. Male patient, 75 years of age, weighting 145.5 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, hepatic function abnormal, neutrophil count decreased, renal impairment. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, SEROTONE, DECADRON, ROHYPNOL, NAUZELIN. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5398022-X
Physician from JAPAN reported PEMETREXED problem on July 13, 2007. Female patient, 71 years of age, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: cholelithiasis, gastritis, pseudomonal sepsis. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, FAMOTIDINE, OMEPRAZOLE. Patient was hospitalized. Patient recovered.

Pemetrexed Side Effects Report #5400686-9
PEMETREXED problem was reported by a Physician from FRANCE on July 18, 2007. Male patient, 85 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: toxic epidermal necrolysis. PEMETREXED dosage: unknown. Patient recovered.

Pemetrexed Side Effects Report #5377503-9
Physician from JAPAN reported PEMETREXED problem on June 21, 2007. Male patient, 75 years of age, weighting 145.5 lb, was diagnosed with prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, hepatic function abnormal, neutrophil count decreased, platelet count decreased,