Pemetrexed Side Effects
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Pemetrexed Safety Reports reported to FDA
Total Pemetrexed reports: 132.Pemetrexed FDA safety alerts: No.
Reported deaths: 41 Reported hospitalizations: 89.
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Reported Pemetrexed Side Effects: haemoglobin decreased, thrombocytopenia, atrial fibrillation, nausea, interstitial lung disease, hepatic function abnormal, white blood cell count decreased, pyrexia, pneumonia, anaemia, dyspnoea.
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Pemetrexed Side Effects Report #5413765-7Physician from CANADA reported PEMETREXED problem on Aug 01, 2007. Female patient, 47 years of age, weighting 110.2 lb, was diagnosed with non-small cell lung cancer, cough, odynophagia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: myelodysplastic syndrome. PEMETREXED dosage: 500 MG, OTHER. During the same period patient was treated with CODEINE SUL, FENTANYL. Patient recovered.
Pemetrexed Side Effects Report #5417078-9
PEMETREXED problem was reported by a Physician from JAPAN on Aug 01, 2007. Male patient, 64 years of age, weighting 142.2 lb, was diagnosed with pleural mesothelioma malignant, gastritis, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: hyperkalaemia. PEMETREXED dosage: 840 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, PROTECADIN, SEROTONE, RINDERON, ROHYPNOL, NAUZELIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5417079-0
Physician from JAPAN reported PEMETREXED problem on Aug 02, 2007. Male patient, 72 years of age, weighting 124.8 lb, was diagnosed with pleural mesothelioma malignant, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, hepatic function abnormal, lymphocyte count decreased. PEMETREXED dosage: 830 MG, OTHER. During the same period patient was treated with CISPLATIN, ZOLPIDEM, LOXONIN, MEDICON, CYTOTEC, URSO, CALONAL. Patient recovered.
Pemetrexed Side Effects Report #5417081-9
PEMETREXED problem was reported by a Physician from JAPAN on Aug 09, 2007. Male patient, 70 years of age, weighting 140.0 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: melaena. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, DECADRON. Patient recovered.
Pemetrexed Side Effects Report #5419028-8
Physician from FRANCE reported PEMETREXED problem on June 26, 2007. Male patient, 85 years of age, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: toxic epidermal necrolysis. PEMETREXED dosage: unknown. Patient recovered.
Pemetrexed Side Effects Report #5419675-3
PEMETREXED problem was reported by a Physician from JAPAN on Aug 07, 2007. Male patient, 74 years of age, weighting 123.5 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, pyrexia. PEMETREXED dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5419677-7
Physician from HUNGARY reported PEMETREXED problem on Aug 07, 2007. Male patient, 49 years of age, weighting 121.3 lb, was diagnosed with neoplasm malignant, parenteral nutrition, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, trismus. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with DEXTROSE, INFUSAMIN S, INTRALIPID, POTASSIUM CHLORIDE, FOLIC ACID, VITAMIN B, MEDROL, CISPLATIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5419678-9
PEMETREXED problem was reported by a Physician from UNITED STATES on Aug 07, 2007. Female patient, 73 years of age, weighting 131.2 lb, was diagnosed with non-small cell lung cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pain. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5419680-7
Physician from INDIA reported PEMETREXED problem on Aug 10, 2007. Male patient, 50 years of age, weighting 145.5 lb, was diagnosed with small cell lung cancer metastatic, gastritis prophylaxis, vomiting, bronchospasm, hyperuricaemia, coagulopathy and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: acute left ventricular failure. PEMETREXED dosage: 800 MG. During the same period patient was treated with RICONIA, PANTOPRAZOLE, REGLAN, THEOPHYLLINE, UDILIV, ALLOPURINOL, ATIVAN, TRANEXAMIC ACID. Patient died on 08/09/2007.
Pemetrexed Side Effects Report #5422341-1
PEMETREXED problem was reported by a Physician from JAPAN on Aug 15, 2007. Male patient, 68 years of age, weighting 160.9 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anaemia, anorexia, lymphocyte count decreased, nausea, neutrophil count decreased, platelet count decreased, white blood cell count decreased. PEMETREXED dosage: 880 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, CYANOCOBALAMIN, DEPAS, ZOLPIDEM, ALOSENN. Patient recovered.
Pemetrexed Side Effects Report #5422343-5
Physician from JAPAN reported PEMETREXED problem on Aug 08, 2007. Female patient, 59 years of age, weighting 125.2 lb, was diagnosed with pleural mesothelioma malignant recurrent, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: peritonitis, white blood cell count decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, METHYCOBAL, PANVITAN, PRIMPERAN, DECADRON, ZOFRAN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5427628-4
PEMETREXED problem was reported by a Physician from UNITED STATES on Aug 14, 2007. Female patient, 73 years of age, weighting 131.2 lb, was diagnosed with non-small cell lung cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: bacteraemia, neuropathy, pain in extremity. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5427629-6
Physician from JAPAN reported PEMETREXED problem on Aug 20, 2007. Male patient, 54 years of age, weighting 126.3 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pneumonia, pulmonary necrosis. PEMETREXED dosage: 785 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, DECADRON, KYTRIL, ADONA, TRANSAMIN. Patient was hospitalized. Patient died on 08/01/2007.
Pemetrexed Side Effects Report #5431225-4
PEMETREXED problem was reported by a Physician from on Aug 10, 2007. Male patient, 70 years of age, weighting 91.49 lb, was diagnosed with non-small cell lung cancer, prophylaxis, analgesia and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anorexia, loss of consciousness. PEMETREXED dosage: unknown. During the same period patient was treated with FOLIC ACID, VITAMIN B, DEXAMETHASONE, ITOPRIDE, OXYCODONE, DUROGESIC, ALMAGATE. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5431229-1
Physician from GERMANY reported PEMETREXED problem on Aug 17, 2007. Male patient, 67 years of age, weighting 140.7 lb, was diagnosed with hypopharyngeal cancer, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: autonomic nervous system imbalance, nausea, vomiting. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5431520-9
PEMETREXED problem was reported by a Physician from JAPAN on Aug 22, 2007. Male patient, 74 years of age, weighting 154.3 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: dyspnoea, shock. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient recovered.
Pemetrexed Side Effects Report #5443302-2
Health Professional from UNITED STATES reported PEMETREXED problem on Aug 31, 2007. Male patient, weighting 134.5 lb, was diagnosed with non-small cell lung cancer and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pyrexia. PEMETREXED dosage: 500MG/M2 IV. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5441912-X
PEMETREXED problem was reported by a Physician from JAPAN on Aug 24, 2007. Male patient, 74 years of age, weighting 123.5 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, pyrexia. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with PANVITAN, METHYCOBAL, MAGNESIUM OXIDE, CISPLATIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5441913-1
Physician from JAPAN reported PEMETREXED problem on Aug 23, 2007. Male patient, 54 years of age, weighting 126.3 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: pneumonia, post procedural complication, pulmonary necrosis. PEMETREXED dosage: 785 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, DECADRON, KYTRIL, ADONA, TRANSAMIN. Patient was hospitalized. Patient died on 08/01/2007.
Pemetrexed Side Effects Report #5441917-9
PEMETREXED problem was reported by a Physician from JAPAN on Aug 23, 2007. Male patient, 58 years of age, weighting 141.1 lb, was diagnosed with pleural mesothelioma malignant, gastritis, cancer pain, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: anaemia, haemoglobin decreased, lymphocyte count decreased, white blood cell count decreased. PEMETREXED dosage: 880 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, FAMOTIDINE, OXYCONTIN, KYTRIL. Patient recovered.
Pemetrexed Side Effects Report #5442016-2
Physician from JAPAN reported PEMETREXED problem on Aug 27, 2007. Male patient, 75 years of age, weighting 145.5 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, hepatic function abnormal, neutrophil count decreased, renal impairment. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, SEROTONE, DECADRON, ROHYPNOL, NAUZELIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5444409-6
PEMETREXED problem was reported by a Physician from JAPAN on Aug 30, 2007. Male patient, 70 years of age, weighting 140.0 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: ulcer haemorrhage. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, DECADRON. Patient recovered.
Pemetrexed Side Effects Report #5444410-2
Physician from JAPAN reported PEMETREXED problem on Aug 30, 2007. Male patient, 64 years of age, weighting 142.2 lb, was diagnosed with pleural mesothelioma malignant, gastritis, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, hyperkalaemia. PEMETREXED dosage: 840 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, PROTECADIN, SEROTONE, RINDERON, ROHYPNOL. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5450185-3
PEMETREXED problem was reported by a Physician from JAPAN on Sept 03, 2007. Male patient, 54 years of age, weighting 126.3 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: disease progression, malignant pleural effusion, post procedural haemorrhage, pulmonary necrosis. PEMETREXED dosage: 785 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, DECADRON, KYTRIL, ADONA, TRANSAMIN. Patient was hospitalized. Patient died on 08/01/2007.
Pemetrexed Side Effects Report #5450192-0
Physician from JAPAN reported PEMETREXED problem on Sept 03, 2007. Female patient was diagnosed with pleural mesothelioma and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: gastric perforation. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN. Patient died on 08/31/2007.
Pemetrexed Side Effects Report #5452420-4
PEMETREXED problem was reported by a Physician from JAPAN on Aug 30, 2007. Male patient, 59 years of age, weighting 121.7 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, cardiac failure, febrile neutropenia, hypotension, oxygen saturation decreased, platelet count decreased, white blood cell count decreased. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, METHYCOBAL, GASTER D, AMOBAN, TERNELIN, PREDONINE. Patient recovered.
Pemetrexed Side Effects Report #5453741-1
Physician from GERMANY reported PEMETREXED problem on Sept 03, 2007. Male patient, 67 years of age, weighting 140.7 lb, was diagnosed with hypopharyngeal cancer, prophylaxis, medical diet and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: infection, nausea, orthostatic hypotension, vomiting. PEMETREXED dosage: unknown. During the same period patient was treated with CISPLATIN, FOLIC ACID, VITAMIN B, DEXAMETHASONE, FRESUBIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5453743-5
PEMETREXED problem was reported by a Physician from JAPAN on Sept 05, 2007. Male patient, 61 years of age, weighting 141.5 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: constipation, hiccups, nausea. PEMETREXED dosage: 870 MG, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, HYDROXOCOBALAMIN ACETATE. Patient recovered.
Pemetrexed Side Effects Report #5453745-9
Physician from JAPAN reported PEMETREXED problem on Sept 06, 2007. Male patient, 70 years of age, weighting 140.0 lb, was diagnosed with pleural mesothelioma malignant and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: gastric ulcer. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with CISPLATIN, PANVITAN, DECADRON. Patient recovered.
Pemetrexed Side Effects Report #5469864-7
PEMETREXED problem was reported by a Physician from JAPAN on Sept 13, 2007. Male patient, 71 years of age, weighting 121.3 lb, was diagnosed with pleural mesothelioma malignant, prophylaxis, cancer pain and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: atrial flutter. PEMETREXED dosage: 500 MG, OTHER. During the same period patient was treated with CISPLATIN, FOLIAMIN, METHYCOBAL, OMEPRAZOLE, OXYCONTIN, MAGNESIUM OXIDE, DECADRON, DIHYDROCODEINE PHOSPHATE. Patient recovered.
Pemetrexed Side Effects Report #5469875-1
Physician from HUNGARY reported PEMETREXED problem on Sept 13, 2007. Male patient, 49 years of age, weighting 121.3 lb, was diagnosed with neoplasm malignant, parenteral nutrition, prophylaxis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, trismus. PEMETREXED dosage: 500 MG/M2, OTHER. During the same period patient was treated with DEXTROSE, INFUSAMIN S, INTRALIPID, POTASSIUM IN CHLORIDE, FOLIC ACID, VITAMIN B, MEDROL, CISPLATIN. Patient was hospitalized. Patient recovered.
Pemetrexed Side Effects Report #5469876-3
PEMETREXED problem was reported by a Physician from JAPAN on Sept 13, 2007. Female patient, 72 years of age, weighting 85.98 lb, was diagnosed with pleural mesothelioma malignant, iron deficiency anaemia, cholelithiasis, osteoporosis and was treated with PEMETREXED. After drug was administered, patient experienced the following problems/side effects: amyloidosis, blood albumin decreased, decreased appetite, diarrhoea, febrile neutropenia, gastric ulcer, haematocrit decreased, haemoglobin decreased, oedema. PEMETREXED dosage: unknown. During the same period patient was treated with PANVITAN, METHYCOBAL, FERROMIA, URSO, COSPANON, ALFAROL. Patient was hospitalized. Patient recovered.
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Drug Information: Pemetrexed Injection
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a607043.html
(pem'' e trex' ed)Why is this medication prescribed?
Pemetrexed is used with another chemotherapy (anti-cancer) medication to treat malignant pleural mesothelioma (a type of cancer that affects the inside lining of the chest cavity). Pemetrexed is also used to treat non-small cell lung cancer. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by blocking the action of a certain substance in the body that may help cancer cells multiply.
How should this medicine be used?
Pemetrexed comes as a solution (liquid) to be injected into a vein. Pemetrexed is administered by a doctor or nurse in a medical office or infusion center. It is usually given once every 21 days.
Your doctor will probably tell you to take other medications, such as folic acid (a vitamin), vitamin B12, and a corticosteroid such as dexamethasone (Decadron) to decrease some of the side effects of this medication. Your doctor will give you directions for taking these medications. Follow your doctor's directions carefully. Ask your doctor or pharmacist to explain any part you do not understand. If you miss a dose of one of these medications, call your doctor.
Your doctor will ask you to have regular blood tests before and during treatment with pemetrexed. Your doctor may change your dose of pemetrexed or delay treatment based on the results of the blood tests.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking pemetrexed,
- tell your doctor and pharmacist if you are allergic to pemetrexed, mannitol,or any other medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), or probenecid. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have a pleural effusion (excess fluid between the linings around the lung), ascites (excess fluid in the abdomen); or have or have ever had kidney or liver disease.
- tell your doctor if you are pregnant or plan to become pregnant. You should use birth control to prevent pregnancy during your treatment with pemetrexed. If you become pregnant while using this medication, call your doctor. Pemetrexed may harm the fetus.
- tell your doctor if you are breast-feeding. You should not breast-feed during your treatment with pemetrexed.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
If you miss an appointment to receive a dose of pemetrexed, call your doctor as soon as possible.
What side effects can this medication cause?
Pemetrexed may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea
- vomiting
- constipation
- loss of appetite
- weight loss
- tiredness
- weakness
- pale skin
- headache
- dizziness
- confusion
- fast heartbeat
- difficulty falling asleep or staying asleep
- changes in mood
- depression
- joint or muscle pain
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- diarrhea
- sores and/or redness in the mouth or throat or on the lips
- unusual bleeding or bruising
- sore throat, fever, chills, cough or other signs of infection
- chest pain
- difficulty breathing or swallowing
- slow or difficult speech
- dizziness or faintness
- weakness or numbness of an arm or leg
- pain, burning, numbness, or tingling in the hands or feet
- hives
- rash
- itching
- decreased urination
Pemetrexed may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- rash
- sores and/or redness in the mouth or throat or on the lips
- unusual bleeding or bruising
- sore throat, fever, chills, cough or other signs of infection
- extreme tiredness
- weakness
- pale skin
- headache
- dizziness
- confusion
- fast heartbeat
- difficulty falling asleep or staying asleep
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to pemetrexed.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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