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Pergolide Side Effects

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Common Pergolide Side Effects


The most commonly reported Pergolide side effects (click to view or check a box to report):

Aortic Valve Incompetence (20)
Cardiac Failure (16)
Mitral Valve Incompetence (16)
Dyspnoea (12)
Mitral Valve Disease (12)
Pleural Effusion (8)
Condition Aggravated (7)
Pathological Gambling (6)
Tricuspid Valve Incompetence (6)
Aortic Valve Disease (6)
Cardiac Valve Disease (5)
Oedema Peripheral (5)
Pleural Fibrosis (5)
Pulmonary Hypertension (5)
Cardiac Murmur (5)
Aortic Valve Sclerosis (4)
Fall (4)
Anxiety (4)
Tricuspid Valve Disease (4)
Aortic Dilatation (4)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Pergolide Side Effects Reported to FDA



Pergolide Side Effect Report#9321112
Suicide Attempt, Pathological Gambling, Depression, Hypokinesia
This is a report of a 50-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: parkinson^s disease, who was treated with Pergolide (dosage: 3.5 Mg, Daily (1/d), start time: NS), combined with:
  • Tolcapone (600 Mg, Daily (1/d))
  • L-dopa (800 Mg, Daily (1/d))
  • Entacapone (800 Mg, Daily (1/d))
and developed a serious reaction and side effect(s): Suicide Attempt, Pathological Gambling, Depression, Hypokinesia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Pergolide treatment in male patients, resulting in Suicide Attempt side effect.
Pergolide Side Effect Report#9166911
Paraphilia, Dopamine Dysregulation Syndrome, Pathological Gambling, Hypersexuality, Fetishism, Dyskinesia, Dysphoria
This report suggests a potential Pergolide Paraphilia side effect(s) that can have serious consequences. A 48-year-old male patient (weight: NA) from IT was diagnosed with the following symptoms/conditions: parkinson^s disease and used Pergolide (dosage: 3 Mg, Unk) starting NS. After starting Pergolide the patient began experiencing various side effects, including: Paraphilia, Dopamine Dysregulation Syndrome, Pathological Gambling, Hypersexuality, Fetishism, Dyskinesia, DysphoriaAdditional drugs used concurrently:
  • Levodopa+carbidopa (1000/250 Mg/day)
  • Levodopa (2000 Mg, Unk)
  • Levodopa (600 Mg, Unk)
Although Pergolide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Paraphilia, may still occur.
Pergolide Side Effect Report#8318516-4
Depressed Mood, Nausea, Pathological Gambling, Food Craving, Aggression, Hypersexuality, Suicidal Ideation, Suicide Attempt
This Depressed Mood problem was reported by a physician from France. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: parkinsonism. On
Sep 15, 2001 this consumer started treatment with Pergolide Mesylate (dosage: NA). The following drugs were being taken at the same time:
  • Sinemet
  • Athymil (20mg At Night)
  • Requip
  • L-dopa
  • Modopar
  • Pramipexole Dihydrochloride
  • Motilium (1tab Three Times Per Day)
When using Pergolide Mesylate, the patient experienced the following unwanted symptoms/side effects: Depressed Mood, Nausea, Pathological Gambling, Food Craving, Aggression, Hypersexuality, Suicidal Ideation, Suicide AttemptThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Depressed Mood, may become evident only after a product is in use by the general population.
Pergolide Side Effect Report#7640938-5
Dyskinesia, Dystonia, Pain, Chorea, Balance Disorder
This Dyskinesia side effect was reported by a health professional from Japan. A 45-year-old male patient (weight:NA) experienced the following symptoms/conditions: parkinson's disease.The patient was prescribed Pergolide Mesylate (drug dosage: 1000 Ug, Qd), which was initiated on NS. Concurrently used drugs:
  • Carbidopa And Levodopa (300 Mg, Qd, Po)
.After starting to take Pergolide Mesylate the consumer reported adverse symptoms, such as: Dyskinesia, Dystonia, Pain, Chorea, Balance DisorderThese side effects may potentially be related to Pergolide Mesylate.
Pergolide Side Effect Report#7591996-8
Agitation, Renal Impairment, Blood Calcium Decreased, Dizziness, Rash, Hypercalcaemia, Hypotension, Pancreatitis, Delirium
This is a report of a 82-year-old male patient (weight: NA) from Netherlands, suffering from the following health symptoms/conditions: NA, who was treated with Pergolide (dosage: NA, start time: NS), combined with:
  • Selegiline
  • Carbidopa
  • Haloperidol Lactate
  • Levodopa
and developed a serious reaction and side effect(s): Agitation, Renal Impairment, Blood Calcium Decreased, Dizziness, Rash, Hypercalcaemia, Hypotension, Pancreatitis, Delirium after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Pergolide treatment in male patients, resulting in Agitation side effect. The patient was hospitalized.
Pergolide Side Effect Report#7399399-6
Compulsive Shopping
This report suggests a potential Pergolide Mesylate Compulsive Shopping side effect(s) that can have serious consequences. A female patient (weight: NA) from France was diagnosed with the following symptoms/conditions: NA and used Pergolide Mesylate (dosage: NA) starting
Jan 01, 1995. After starting Pergolide Mesylate the patient began experiencing various side effects, including: Compulsive ShoppingAdditional drugs used concurrently:
  • Modopar
  • Modopar (125 Dispersible, 3 Times Per Day)
  • Modopar
  • Parlodel (Unk)
  • Modopar (250 Mg, Tid)
  • Modopar (125 Lp One Tablet At Bedtime)
Although Pergolide Mesylate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Compulsive Shopping, may still occur.
Pergolide Side Effect Report#7332462-4
Pathological Gambling, Hypersexuality, Delusion, Psychomotor Hyperactivity
This Pathological Gambling problem was reported by a consumer or non-health professional from France. A 49-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: parkinson's disease. On
Nov 01, 2000 this consumer started treatment with Pergolide Mesylate (dosage: NA). The following drugs were being taken at the same time:
  • Sinemet
When using Pergolide Mesylate, the patient experienced the following unwanted symptoms/side effects: Pathological Gambling, Hypersexuality, Delusion, Psychomotor HyperactivityAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pathological Gambling, may become evident only after a product is in use by the general population.
Pergolide Side Effect Report#7036212-0
Dopamine Dysregulation Syndrome
This Dopamine Dysregulation Syndrome side effect was reported by a health professional from United Kingdom. A 48-year-old female patient (weight:NA) experienced the following symptoms/conditions: parkinson's disease.The patient was prescribed Pergolide (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Ropinirole
  • Levodopa
  • Levodopa
  • Cabergoline
  • Entacapone
.After starting to take Pergolide the consumer reported adverse symptoms, such as: Dopamine Dysregulation SyndromeThese side effects may potentially be related to Pergolide.
Pergolide Side Effect Report#6681874-0
Condition Aggravated, Parkinson's Disease, Torticollis
This is a report of a 68-year-old female patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: parkinson's disease, who was treated with Pergolide Mesylate (dosage: 750 Ug/d, start time: NS), combined with:
  • Pramipexole Dihydrochloride (3 Mg, Qd)
  • Levodopa W/benserazide (benserazide, Levodopa)
and developed a serious reaction and side effect(s): Condition Aggravated, Parkinson's Disease, Torticollis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Pergolide Mesylate treatment in female patients, resulting in Condition Aggravated side effect. The patient was hospitalized.
Pergolide Side Effect Report#6680246-2
Aortic Valve Incompetence, Mitral Valve Incompetence
This report suggests a potential Pergolide Mesylate Aortic Valve Incompetence side effect(s) that can have serious consequences. A 69-year-old male patient (weight: NA) from Italy was diagnosed with the following symptoms/conditions: parkinson's disease and used Pergolide Mesylate (dosage: NA) starting NS. After starting Pergolide Mesylate the patient began experiencing various side effects, including: Aortic Valve Incompetence, Mitral Valve IncompetenceAdditional drugs used concurrently: NA. Although Pergolide Mesylate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Aortic Valve Incompetence, may still occur.
Pergolide Side Effect Report#6679316-4
Acute Pulmonary Oedema, Aortic Dilatation, Aortic Valve Calcification, Aortic Valve Incompetence, Cardiac Valve Disease, Dyspnoea Exertional, Dyspnoea Paroxysmal Nocturnal, Ejection Fraction Decreased, Haemodialysis
This Acute Pulmonary Oedema problem was reported by a health professional from Greece. A 68-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: parkinson's disease. On NS this consumer started treatment with Pergolide Mesylate (dosage: 1 Mg, Bid). The following drugs were being taken at the same time: NA. When using Pergolide Mesylate, the patient experienced the following unwanted symptoms/side effects: Acute Pulmonary Oedema, Aortic Dilatation, Aortic Valve Calcification, Aortic Valve Incompetence, Cardiac Valve Disease, Dyspnoea Exertional, Dyspnoea Paroxysmal Nocturnal, Ejection Fraction Decreased, HaemodialysisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Acute Pulmonary Oedema, may become evident only after a product is in use by the general population.
Pergolide Side Effect Report#6635748-1
Aortic Dilatation, Aortic Valve Incompetence, Mitral Valve Incompetence, Renal Failure, Retroperitoneal Fibrosis, Ureteral Disorder
This Aortic Dilatation side effect was reported by a health professional from Greece. A 68-year-old male patient (weight:NA) experienced the following symptoms/conditions: parkinson's disease.The patient was prescribed Pergolide Mesylate (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Pergolide Mesylate the consumer reported adverse symptoms, such as: Aortic Dilatation, Aortic Valve Incompetence, Mitral Valve Incompetence, Renal Failure, Retroperitoneal Fibrosis, Ureteral DisorderThese side effects may potentially be related to Pergolide Mesylate.
Pergolide Side Effect Report#6496315-6
Aortic Valve Sclerosis, Atelectasis, C-reactive Protein Increased, Carbon Monoxide Diffusing Capacity Decreased, Dyspnoea, Pleural Disorder, Pleural Effusion, Pleural Fibrosis, Po2 Decreased
This is a report of a 77-year-old male patient (weight: NA) from United Kingdom, suffering from the following health symptoms/conditions: NA, who was treated with Pergolide Mesylate (dosage: 2 Mg, start time: NS), combined with:
  • Entacapone
  • Co-beneldopa
  • Aspirin
  • Furosemide
and developed a serious reaction and side effect(s): Aortic Valve Sclerosis, Atelectasis, C-reactive Protein Increased, Carbon Monoxide Diffusing Capacity Decreased, Dyspnoea, Pleural Disorder, Pleural Effusion, Pleural Fibrosis, Po2 Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Pergolide Mesylate treatment in male patients, resulting in Aortic Valve Sclerosis side effect.
Pergolide Side Effect Report#6134307-7
Antinuclear Antibody Positive, Cough, Dyspnoea, Lymphadenopathy Mediastinal, Monocytosis, Osteitis Deformans, Pleural Effusion, Pleural Fibrosis, Weight Decreased
This report suggests a potential Pergolide Mesylate Antinuclear Antibody Positive side effect(s) that can have serious consequences. A 54-year-old male patient (weight: NA) from United Kingdom was diagnosed with the following symptoms/conditions: parkinson's disease and used Pergolide Mesylate (dosage: Po ; 1.5 Mg;tid;po) starting NS. After starting Pergolide Mesylate the patient began experiencing various side effects, including: Antinuclear Antibody Positive, Cough, Dyspnoea, Lymphadenopathy Mediastinal, Monocytosis, Osteitis Deformans, Pleural Effusion, Pleural Fibrosis, Weight DecreasedAdditional drugs used concurrently:
  • Co-careldopa
  • Co-beneldopa
  • Antibiotics
The patient was hospitalized. Although Pergolide Mesylate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Antinuclear Antibody Positive, may still occur.
Pergolide Side Effect Report#6112000-4
Dyspnoea, Lymphadenopathy Mediastinal, Monocytosis, Osteitis Deformans, Pleural Effusion, Pleural Fibrosis, Weight Decreased
This Dyspnoea problem was reported by a consumer or non-health professional from United Kingdom. A 54-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: parkinson's disease. On NS this consumer started treatment with Pergolide Mesylate (dosage: 1.5 Mg; Tid;). The following drugs were being taken at the same time:
  • Co-careldopa
  • Madopar
  • Co-beneldopa
When using Pergolide Mesylate, the patient experienced the following unwanted symptoms/side effects: Dyspnoea, Lymphadenopathy Mediastinal, Monocytosis, Osteitis Deformans, Pleural Effusion, Pleural Fibrosis, Weight DecreasedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dyspnoea, may become evident only after a product is in use by the general population.
Pergolide Side Effect Report#6076389-7
Agoraphobia, Anxiety, Aortic Dilatation, Aortic Valve Incompetence, Cardiac Failure, Condition Aggravated, Dyspnoea, Dystonia, Mitral Valve Disease
This Agoraphobia side effect was reported by a health professional from Netherlands. A 58-year-old female patient (weight:NA) experienced the following symptoms/conditions: parkinson's disease,anxiety disorder.The patient was prescribed Pergolide Mesylate (drug dosage: 4.75 Mg;daily;oral ; 6 Mg;daily;oral ; 8 Mg;daily;oral), which was initiated on NS. Concurrently used drugs:
  • Citalopram Hydrobromide (10 Mg;daily;oral ; 20 Mg;daily;oral)
  • Amantadine Hcl
  • Selegiline
  • Levodopa
  • Oxazepam
  • Zolpidem
.After starting to take Pergolide Mesylate the consumer reported adverse symptoms, such as: Agoraphobia, Anxiety, Aortic Dilatation, Aortic Valve Incompetence, Cardiac Failure, Condition Aggravated, Dyspnoea, Dystonia, Mitral Valve DiseaseThese side effects may potentially be related to Pergolide Mesylate. The patient was hospitalized.
Pergolide Side Effect Report#6076385-X
Anxiety, Aortic Valve Incompetence, Cardiac Failure, Condition Aggravated, Dyspnoea, Dystonia, Mitral Valve Disease, Oedema Peripheral, Pulmonary Arterial Pressure Increased
This is a report of a 58-year-old female patient (weight: NA) from Netherlands, suffering from the following health symptoms/conditions: parkinson's disease,anxiety disorder, who was treated with Pergolide Mesylate (dosage: 4.75 Mg, Daily;oral ; 6 Mg;daily;oral ; 8 Mg;daily;oral, start time: NS), combined with:
  • Citalopram Hydrobromide (10 Mg;daily;oral ; 20 Mg;daily;oral)
  • Amantadine Hcl
  • Selegiline
  • Levodopa
  • Oxazepam
  • Zolpidem
and developed a serious reaction and side effect(s): Anxiety, Aortic Valve Incompetence, Cardiac Failure, Condition Aggravated, Dyspnoea, Dystonia, Mitral Valve Disease, Oedema Peripheral, Pulmonary Arterial Pressure Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Pergolide Mesylate treatment in female patients, resulting in Anxiety side effect. The patient was hospitalized.
Pergolide Side Effect Report#6076382-4
Anxiety, Aortic Valve Incompetence, Cardiac Failure, Dyspnoea, Dystonia, Mitral Valve Incompetence, Oedema Peripheral, Tricuspid Valve Disease, Ventricular Hypertrophy
This report suggests a potential Pergolide Mesylate Anxiety side effect(s) that can have serious consequences. A 58-year-old female patient (weight: NA) from Netherlands was diagnosed with the following symptoms/conditions: parkinson's disease,anxiety disorder and used Pergolide Mesylate (dosage: 4.75 Mg;daily;oral ; 6 Mg;daily;oral ; 8 Mg;daily;oral) starting NS. After starting Pergolide Mesylate the patient began experiencing various side effects, including: Anxiety, Aortic Valve Incompetence, Cardiac Failure, Dyspnoea, Dystonia, Mitral Valve Incompetence, Oedema Peripheral, Tricuspid Valve Disease, Ventricular HypertrophyAdditional drugs used concurrently:
  • Citalopram Hydrobromide (10 Mg;daily;oral ; 20 Mg;daily;oral)
  • Amantadine Hcl
  • Selegiline
  • Levodopa
  • Oxazepam
  • Zolpidem
The patient was hospitalized. Although Pergolide Mesylate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Anxiety, may still occur.
Pergolide Side Effect Report#6070266-3
Anxiety Disorder, Aortic Valve Disease, Cardiac Failure, Mitral Valve Disease, Tricuspid Valve Disease
This Anxiety Disorder problem was reported by a health professional from Netherlands. A 58-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: parkinson's disease,anxiety disorder. On NS this consumer started treatment with Pergolide (pergolide) (dosage: NA). The following drugs were being taken at the same time:
  • Citalopram Hydrobromide
When using Pergolide (pergolide), the patient experienced the following unwanted symptoms/side effects: Anxiety Disorder, Aortic Valve Disease, Cardiac Failure, Mitral Valve Disease, Tricuspid Valve DiseaseThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Anxiety Disorder, may become evident only after a product is in use by the general population.
Pergolide Side Effect Report#6070081-0
Aortic Valve Incompetence, Cardiac Failure, Mitral Valve Disease, Tricuspid Valve Incompetence
This Aortic Valve Incompetence side effect was reported by a health professional from Netherlands. A 58-year-old female patient (weight:NA) experienced the following symptoms/conditions: parkinson's disease,anxiety disorder.The patient was prescribed Pergolide Mesylate (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Citalopram Hydrobromide
.After starting to take Pergolide Mesylate the consumer reported adverse symptoms, such as: Aortic Valve Incompetence, Cardiac Failure, Mitral Valve Disease, Tricuspid Valve IncompetenceThese side effects may potentially be related to Pergolide Mesylate. The patient was hospitalized.
Pergolide Side Effect Report#6068420-X
Aortic Valve Disease, Cardiac Failure, Mitral Valve Disease, Tricuspid Valve Disease
This is a report of a 58-year-old female patient (weight: NA) from Netherlands, suffering from the following health symptoms/conditions: parkinson's disease,anxiety disorder, who was treated with Pergolide (pergolide) (dosage: NA, start time: NS), combined with:
  • Citalopram Hydrobromide
and developed a serious reaction and side effect(s): Aortic Valve Disease, Cardiac Failure, Mitral Valve Disease, Tricuspid Valve Disease after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Pergolide (pergolide) treatment in female patients, resulting in Aortic Valve Disease side effect. The patient was hospitalized.
Pergolide Side Effect Report#5732109-4
Alveolitis, Aortic Valve Incompetence, Cough, Mitral Valve Incompetence
This report suggests a potential Pergolide Mesylate Alveolitis side effect(s) that can have serious consequences. A 52-year-old female patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: parkinson's disease and used Pergolide Mesylate (dosage: 4.5 Mg; Qd) starting
Jan 01, 1995. After starting Pergolide Mesylate the patient began experiencing various side effects, including: Alveolitis, Aortic Valve Incompetence, Cough, Mitral Valve IncompetenceAdditional drugs used concurrently:
  • Carbidopa And Levodopa
Although Pergolide Mesylate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Alveolitis, may still occur.
Pergolide Side Effect Report#5732101-X
Aortic Valve Incompetence, Cardiac Failure, Mitral Valve Incompetence, Oedema, Tricuspid Valve Incompetence
This Aortic Valve Incompetence problem was reported by a consumer or non-health professional from Spain. A 77-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: parkinsonism. On
Jan 01, 1995 this consumer started treatment with Pergolide Mesylate (dosage: 3 Mg; Qd; Po). The following drugs were being taken at the same time: NA. When using Pergolide Mesylate, the patient experienced the following unwanted symptoms/side effects: Aortic Valve Incompetence, Cardiac Failure, Mitral Valve Incompetence, Oedema, Tricuspid Valve IncompetenceThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Aortic Valve Incompetence, may become evident only after a product is in use by the general population.
Pergolide Side Effect Report#5727303-2
Arterial Disorder, Atrophy, Cardiac Murmur, Cardiac Valve Disease, Coronary Artery Disease, Fibrosis, Joint Swelling, Mitral Valve Incompetence, Oedema Peripheral
This Arterial Disorder side effect was reported by a consumer or non-health professional from Spain. A 74-year-old male patient (weight:NA) experienced the following symptoms/conditions: parkinson's disease.The patient was prescribed Pergolide Mesylate (drug dosage: 1 Mg; Tid;, 1 Mg; Qid;), which was initiated on
Jan 01, 1997. Concurrently used drugs: NA..After starting to take Pergolide Mesylate the consumer reported adverse symptoms, such as: Arterial Disorder, Atrophy, Cardiac Murmur, Cardiac Valve Disease, Coronary Artery Disease, Fibrosis, Joint Swelling, Mitral Valve Incompetence, Oedema PeripheralThese side effects may potentially be related to Pergolide Mesylate. The patient was hospitalized.
Pergolide Side Effect Report#5632881-8
Cardiomegaly, Condition Aggravated, Congestive Cardiomyopathy, Coronary Artery Stenosis, Dyspnoea, Ejection Fraction Decreased, Hypokinesia, Left Ventricular Dysfunction, Mitral Valve Incompetence
This is a report of a 67-year-old male patient (weight: NA) from Germany, suffering from the following health symptoms/conditions: parkinson's disease, who was treated with Pergolide Mesylate (dosage: 2 Mg; Qd; Po, start time:
Jan 01, 2003), combined with:
  • Madopar
  • Pk-merz
  • Pk-levo
  • Torem
  • Acetylsalicylic Acid Lisinopril
  • Novodigal
  • Querto
  • Aldactone
and developed a serious reaction and side effect(s): Cardiomegaly, Condition Aggravated, Congestive Cardiomyopathy, Coronary Artery Stenosis, Dyspnoea, Ejection Fraction Decreased, Hypokinesia, Left Ventricular Dysfunction, Mitral Valve Incompetence after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Pergolide Mesylate treatment in male patients, resulting in Cardiomegaly side effect. The patient was hospitalized.


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The appearance of Pergolide on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Pergolide reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Pergolide Safety Alerts, Active Ingredients, Usage Information

    More About Pergolide

    Side Effects reported to FDA: 74

    Pergolide safety alerts: 2007 2003

    Reported deaths: 5

    Reported hospitalizations: 39

    Permax (pergolide) and generic equivalents

    Audience: Neurologists, other healthcare professionals, consumers

    [Posted 03/29/2007] FDA notified healthcare professionals and patients that companies that manufacture and distribute pergolide have agreed to withdraw the drug from the market. Pergolide is a dopamine agonist (DA) used with levodopa and carbidopa to manage the signs and symptoms of Parkinson's disease. Results of two new studies showed that some patients with Parkinson's disease treated with pergolide had serious damage to their heart valves when compared to patients who did not receive the drug. These two studies confirm earlier studies that also describe this problem. Patients currently taking pergolide should contact their healthcare professional about alternate treatments and not abruptly stop taking their medication. Healthcare professionals should assess their patient's need for DA therapy. If continued treatment with a DA is needed, another DA should be substituted for pergolide.

    [March 29, 2007 - Public Health Advisory - FDA]

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