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From simple mix-ups to fatal overdoses, medication mistakes happen, on average, once a day to every hospital patient, a new report says. Nationwide, at least 1.5 million people annually are harmed from drug errors, more than half of them in nursing homes.
Many Unfavorable Drug Studies Aren’t Published. Nearly a third of antidepressant drug studies are never published in the medical literature, and nearly all of those happen to show that the drug being tests failed to work.
Only Drugs That are Safe Should be put on the Market. Drug developers are just beginning to come to grips with recent FDA oversight reforms and how they will affect drug safety. But, it appears that industry and consumer advocates are not together on how well the overhaul will be able to prevent future drug safety scandals.

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Review Permax Safety Reports submitted to FDA

Total Permax reports: 37.
Permax FDA safety alerts: 2003 2004 2007 .
Reported deaths: 4    Reported hospitalizations: 25.
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FDA Reported Permax Side Effects: depressed level of consciousness, loss of consciousness, interstitial lung disease, atrioventricular block complete, acanthoma, depression, condition aggravated, neuroleptic malignant syndrome, pulmonary alveolar haemorrhage, pleurisy, pleural effusion.
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Permax Side Effects Report #5216925-3
Consumer or non-health professional from reported PERMAX problem on Jan 03, 2007. Male patient, 55 years of age, was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: gastrointestinal haemorrhage. PERMAX dosage: unknown. During the same period patient was treated with MADOPAR, LEVODOPA. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5248217-0
PERMAX problem was reported by a Physician from DENMARK on Jan 26, 2007. Female patient, 61 years of age, weighting 154.3 lb, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: hydronephrosis, retroperitoneal fibrosis. PERMAX dosage: 3 MG; QD; PO. During the same period patient was treated with CARBIDOPA AND LEVODOPA, ENDO LEVODOPA, PRAMIPEXOLE DIHYDROCHLORIDE. Patient recovered.

Permax Side Effects Report #5248586-1
Health Professional from JAPAN reported PERMAX problem on Feb 09, 2007. Female patient, 76 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: activities of daily living impaired, biliary tract infection, cholangitis, cholecystitis, gait disturbance, hepatic function abnormal, oral intake reduced, pneumonia, pyelonephritis. PERMAX dosage: unknown. During the same period patient was treated with SYMMETREL, MADOPAR. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5250098-6
PERMAX problem was reported by a Pharmacist from JAPAN on Feb 09, 2007. Male patient, 55 years of age, was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: gastrointestinal haemorrhage. PERMAX dosage: unknown. During the same period patient was treated with MADOPAR. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5260735-8
Physician from NETHERLANDS reported PERMAX problem on Feb 09, 2007. Male patient, 78 years of age, weighting 154.3 lb, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: apnoea, bradycardia, depressed level of consciousness, hyperkinesia, hyperthermia. PERMAX dosage: 1 MG; QID; 0.5 MG;BID. During the same period patient was treated with COMTAN, SELEGILNE HYDROCHLORIDE, SYMMETREL, FLUDROCORTISONE ACETATE, OXAZEPAM, PANTOZOL, MAALOX FAST BLOCKER. Patient died on 01/02/2007.

Permax Side Effects Report #5266722-8
PERMAX problem was reported by a Physician from NETHERLANDS on Feb 23, 2007. Male patient, 78 years of age, weighting 154.3 lb, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: apnoea, autonomic failure syndrome, blood culture positive, bradycardia, colon cancer, constipation, depressed level of consciousness, endocarditis, hepatic function abnormal. PERMAX dosage: unknown. During the same period patient was treated with COMTAN, SELEGILINE HYDROCHLORIDE, SYMMETREL, FLUDROCORTISONE ACETATE, OXAZEPAM, PANTOZOL, MAALOX FAST BLOCKER. Patient died on 01/20/2007.

Permax Side Effects Report #5278392-3
Pharmacist from JAPAN reported PERMAX problem on Mar 09, 2007. Male patient, 53 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: gastrointestinal haemorrhage, neuroleptic malignant syndrome, treatment noncompliance. PERMAX dosage: unknown. During the same period patient was treated with MADOPAR, OXETACAINE, ATARAX, VITANEURIN, PANTOL. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5281143-X
PERMAX problem was reported by a Physician from JAPAN on Mar 09, 2007. Male patient, 72 years of age, weighting 132.3 lb, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: asthenia, blood creatine phosphokinase increased, fatigue, vitamin b12 decreased, vitamin b12 deficiency. PERMAX dosage: unknown. During the same period patient was treated with NAUZELIN. Patient recovered.

Permax Side Effects Report #5291395-8
Health Professional from ITALY reported PERMAX problem on Mar 26, 2007. Male patient, 62 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, dyskinesia, incorrect dose administered, mood swings, paedophilia. PERMAX dosage: 1 MG; TID. During the same period patient was treated with LEVODOPA, CARBIDOPA, LEVODOPA W, CLOZAPINE. Patient recovered.

Permax Side Effects Report #5294374-X
PERMAX problem was reported by a Consumer or non-health professional from UNITED STATES on Apr 10, 2007. Female patient, 58 years of age, weighting 185.0 lb, was diagnosed with dyskinesia, movement disorder and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: aortic valve disease, somnolence. PERMAX dosage: unknown. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5300423-2
Consumer or non-health professional from JAPAN reported PERMAX problem on Mar 26, 2007. Male patient, 64 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: bradycardia, condition aggravated. PERMAX dosage: unknown. Patient recovered.

Permax Side Effects Report #5337875-8
PERMAX problem was reported by a Consumer or non-health professional from UNITED STATES on Feb 22, 2006. Male patient, 58 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: affect lability, antisocial personality disorder, bereavement reaction, cellulitis gangrenous, chest pain, depression, diabetes mellitus, dizziness, dyskinesia. PERMAX dosage: unknown. During the same period patient was treated with SINEMET, PRAMIPEXOLE DIHYDROCHLORIDE, COMTAN, ROPINIROLE, VICODIN. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5326893-1
Consumer or non-health professional from JAPAN reported PERMAX problem on Apr 24, 2007. Male patient, 64 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: sinus bradycardia. PERMAX dosage: unknown. During the same period patient was treated with ACINON, NEO DOPASTON, THYRADIN, ZANTAC, SERMION, GASCON. Patient recovered.

Permax Side Effects Report #5336370-X
PERMAX problem was reported by a Consumer or non-health professional from UNITED STATES on May 07, 2007. Female patient, 45 years of age, was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: acanthoma, antinuclear antibody positive, atrioventricular block complete, cardiac murmur, cardiomegaly, chondroplasty, coronary artery disease, hyperkeratosis, interstitial lung disease. PERMAX dosage: unknown. During the same period patient was treated with NARBALEK, ULTRAM, PRAMIPEXOLE DIHYDROCHLORIDE, PREDNISONE. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5363044-1
Consumer or non-health professional from UNITED STATES reported PERMAX problem on May 31, 2007. Female patient, 45 years of age, was diagnosed with restless legs syndrome and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: acanthoma, alanine aminotransferase increased, antinuclear antibody positive, arthropathy, aspartate aminotransferase increased, atrioventricular block complete, blood alkaline phosphatase increased, blood bilirubin increased, bursitis. PERMAX dosage: unknown. During the same period patient was treated with NARBALEK, ULTRAM, PRAMIPEXOLE DIHYDROCHLORIDE. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5055299-8
PERMAX problem was reported by a Pharmacist from JAPAN on July 05, 2006. Male patient, 64 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: cardiac disorder, condition aggravated, depressed level of consciousness, neuroleptic malignant syndrome. PERMAX dosage: unknown. During the same period patient was treated with LEVODOPA, PRAMIPEXOLE DIHYDROCHLORIDE, SELEGILINE HYDROCHLORIDE, AMANTADINE. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5065158-2
Consumer or non-health professional from JAPAN reported PERMAX problem on July 10, 2006. Female patient, 76 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: anxiety, cardiomyopathy, chest pain, depressed mood, depression, gait disturbance, insomnia. PERMAX dosage: unknown. During the same period patient was treated with LEVODOPA, TOLEDOMIN. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5066258-3
PERMAX problem was reported by a Consumer or non-health professional from UNITED STATES on July 13, 2006. Female patient, 42 years of age, weighting 238.0 lb, was diagnosed with muscle twitching and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, anaemia, anxiety, aortic valve sclerosis, breast cyst, cardiac hypertrophy, cardiac ventricular disorder, depression, dilatation atrial. PERMAX dosage: unknown. During the same period patient was treated with WELLBUTRIN, LORAZEPAM, CLONAZEPAM, GABAPENTIN, TRAMADOL, TEMAZEPAM, TRAZODONE. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5072789-2
Pharmacist from JAPAN reported PERMAX problem on July 19, 2006. Male patient, 64 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, basedow's disease, blood creatine phosphokinase increased, congestive cardiomyopathy, depressed level of consciousness, diabetes mellitus, dyspnoea, ejection fraction decreased, neuroleptic malignant syndrome. PERMAX dosage: unknown. During the same period patient was treated with LEVODOPA, PRAMIPEXOLE DIHYDROCHLORIDE, SELEGILINE HYDROCHLORIDE, AMANTADINE. Patient was hospitalized. Patient died on 07/03/2006.

Permax Side Effects Report #5079296-1
PERMAX problem was reported by a Physician from UNITED STATES on July 24, 2006. Male patient, 69 years of age, was diagnosed with parkinson's disease, psychotic disorder and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: abasia, activities of daily living impaired, aggression, agitation, cognitive disorder, condition aggravated, cyclothymic disorder, delusion, dementia. PERMAX dosage: unknown. During the same period patient was treated with CARBIDOPA, LEVODOPA, OLANZAPINE, ZIPRASIDONE, QUETIAPINE FUMARATE. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5079641-7
Physician from JAPAN reported PERMAX problem on July 24, 2006. Male patient, 66 years of age, weighting 114.6 lb, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: balance disorder, fall, loss of consciousness, pericarditis constrictive. PERMAX dosage: unknown. During the same period patient was treated with SELEGILINE, NEO DOPASTON. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5080024-4
PERMAX problem was reported by a Physician from JAPAN on July 31, 2006. Male patient was diagnosed with parkinsonism and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: loss of consciousness. PERMAX dosage: unknown. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5084868-4
Pharmacist from JAPAN reported PERMAX problem on Aug 04, 2006. Male patient, 64 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, basedow's disease, blood creatine phosphokinase increased, congestive cardiomyopathy, depressed level of consciousness, diabetes mellitus, dyspnoea, ejection fraction decreased, neuroleptic malignant syndrome. PERMAX dosage: unknown. During the same period patient was treated with LEVODOPA, PRAMIPEXOLE DIHYDROCHLORIDE, SELEGILINE HYDROCHLORIDE, AMANTADINE. Patient was hospitalized. Patient died on 07/03/2006.

Permax Side Effects Report #5090942-9
PERMAX problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 09, 2006. Female patient, 42 years of age, weighting 238.0 lb, was diagnosed with muscle twitching and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: anaemia, anxiety, aortic valve sclerosis, breast cyst, cardiac hypertrophy, depression, dilatation atrial, dizziness. PERMAX dosage: unknown. During the same period patient was treated with WELLBUTRIN, LORAZEPAM, CLONAZEPAM, GABAPENTIN, TRAMADOL, TEMAZEPAM. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5106921-9
Consumer or non-health professional from UNITED STATES reported PERMAX problem on Aug 29, 2006. Female patient, 42 years of age, weighting 238.0 lb, was diagnosed with muscle twitching and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, anaemia, breast cyst, endocarditis, foot fracture, gambling, hand fracture, marital problem. PERMAX dosage: 0.05 MG; SEE IMAGE. During the same period patient was treated with WELLBUTRIN, LORAZEPAM, CLONAZEPAM, GABAPENTIN, TRAMADOL, TEMAZEPAM. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5115330-8
PERMAX problem was reported by a Physician from JAPAN on Sept 08, 2006. Male patient, 66 years of age, weighting 114.6 lb, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: balance disorder, fall, gait disturbance, loss of consciousness, muscular weakness, pericarditis constrictive, post procedural complication, stress. PERMAX dosage: unknown. During the same period patient was treated with SELEGILINE, NEO DOPASTON. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5129327-5
Physician from DENMARK reported PERMAX problem on Sept 29, 2006. Female patient, 61 years of age, weighting 154.3 lb, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: hydronephrosis, retroperitoneal fibrosis. PERMAX dosage: 3 MG; QD; PO. During the same period patient was treated with CARBIDOPA AND LEVODOPA, ENDO LEVODOPA, PRAMIPEXOLE DIHYDROCHLORIDE. Patient recovered.

Permax Side Effects Report #5165186-2
PERMAX problem was reported by a Physician from JAPAN on Nov 14, 2006. Male patient, 66 years of age, weighting 114.6 lb, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: balance disorder, cardiac failure, fall, hypotension, loss of consciousness, muscular weakness, pericarditis constrictive, post procedural complication, shock. PERMAX dosage: unknown. During the same period patient was treated with SELEGILINE, NEO DOPASTON. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5385246-0
Consumer or non-health professional from UNITED STATES reported PERMAX problem on June 15, 2007. Female patient, 45 years of age, was diagnosed with restless legs syndrome and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: acanthoma, antinuclear antibody positive, arthropathy, atrioventricular block complete, blood iron increased, bursitis, cardiac murmur, carotid bruit, cervical cyst. PERMAX dosage: unknown. During the same period patient was treated with NARBALEK, ULTRAM, PRAMIPEXOLE DIHYDROCHLORIDE. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5386011-0
PERMAX problem was reported by a Health Professional from JAPAN on July 03, 2007. Male patient was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: disseminated intravascular coagulation, interstitial lung disease, platelet count decreased, pleural effusion, pleurisy, pulmonary alveolar haemorrhage, systemic lupus erythematosus. PERMAX dosage: unknown. Patient recovered.

Permax Side Effects Report #5387178-0
Consumer or non-health professional from UNITED STATES reported PERMAX problem on July 02, 2007. Female patient, 45 years of age, was diagnosed with restless legs syndrome and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: acanthoma, alanine aminotransferase increased, aspartate aminotransferase increased, atrioventricular block complete, blood alkaline phosphatase increased, blood bilirubin increased, blood iron increased, carotid bruit, cervical cyst. PERMAX dosage: unknown. During the same period patient was treated with NARBALEK, ULTRAM, PRAMIPEXOLE DIHYDROCHLORIDE, PREDNISONE. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5394924-9
PERMAX problem was reported by a Physician from JAPAN on July 10, 2007. Male patient, 73 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: ascites. PERMAX dosage: unknown. During the same period patient was treated with BROMOCRIPTINE MESYLATE. Patient recovered.

Permax Side Effects Report #5397254-4
Health Professional from JAPAN reported PERMAX problem on July 16, 2007. Male patient was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: disseminated intravascular coagulation, interstitial lung disease, pleural effusion, pleurisy, pulmonary alveolar haemorrhage, systemic lupus erythematosus. PERMAX dosage: unknown. Patient recovered.

Permax Side Effects Report #5404725-0
PERMAX problem was reported by a Health Professional from JAPAN on July 26, 2007. Male patient was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: disseminated intravascular coagulation, interstitial lung disease, lupus-like syndrome, platelet count decreased, pleural effusion, pleurisy, pulmonary alveolar haemorrhage. PERMAX dosage: unknown. During the same period patient was treated with SYMMETREL, MADOPAR. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5416523-2
Physician from JAPAN reported PERMAX problem on Aug 02, 2007. Male patient, 73 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: ascites, colon operation. PERMAX dosage: unknown. During the same period patient was treated with BROMOCRIPTINE MESYLATE, NEO DOPASTON, SELEGILINE HYDROCHLORIDE, DEPAS, PURSENNID, LAXOBERON, MAGNESIUM OXIDE. Patient was hospitalized. Patient recovered.

Permax Side Effects Report #5451968-6
PERMAX problem was reported by a Health Professional from JAPAN on Aug 29, 2007. Male patient, 75 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: blepharospasm, condition aggravated, parkinson's disease, visual acuity reduced. PERMAX dosage: unknown. During the same period patient was treated with CABERGOLINE, SIFROL. Patient recovered.

Permax Side Effects Report #5473234-5
Consumer or non-health professional from ITALY reported PERMAX problem on Sept 18, 2007. Male patient, 54 years of age, was diagnosed with parkinson's disease and was treated with PERMAX. After drug was administered, patient experienced the following problems/side effects: retroperitoneal fibrosis, urethral stenosis. PERMAX dosage: 4 MG; QD; PO. Patient was hospitalized. Patient recovered.


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gastrointestinal haemorrhage hydronephrosis, retroperitoneal fibrosis activities of daily living impaired, biliary tract infection, cholangitis, cholecystitis, gait disturbance, hepatic function abnormal, oral intake reduced, pneumonia, pyelonephritis, was diagnosed with parkinson's disease and was diagnosed with parkinson's disease and was diagnosed with parkinson's disease and