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From simple mix-ups to fatal overdoses, medication mistakes happen, on average, once a day to every hospital patient, a new report says. Nationwide, at least 1.5 million people annually are harmed from drug errors, more than half of them in nursing homes.
Many Unfavorable Drug Studies Aren’t Published. Nearly a third of antidepressant drug studies are never published in the medical literature, and nearly all of those happen to show that the drug being tests failed to work.
Only Drugs That are Safe Should be put on the Market. Drug developers are just beginning to come to grips with recent FDA oversight reforms and how they will affect drug safety. But, it appears that industry and consumer advocates are not together on how well the overhaul will be able to prevent future drug safety scandals.

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Review Pioglitazone Safety Reports submitted to FDA

Total Pioglitazone reports: 94.
Pioglitazone FDA safety alerts: 2002 2007 .
Reported deaths: 15    Reported hospitalizations: 67.
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FDA Reported Pioglitazone Side Effects: fall, myocardial infarction, chest pain, condition aggravated, cardiac failure congestive, bladder cancer recurrent, fibula fracture, loss of consciousness, hyperglycaemia, ankle fracture, dyspnoea exertional.
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Pioglitazone Side Effects Report #5205358-1
Physician from UNITED STATES reported PIOGLITAZONE problem on Dec 21, 2006. Female patient was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: angioedema, urticaria. PIOGLITAZONE dosage: unknown. During the same period patient was treated with SITAGLIPTIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5209175-8
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Jan 08, 2007. Female patient, 65 years of age, weighting 177.3 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: cystocele, stress urinary incontinence. PIOGLITAZONE dosage: unknown. During the same period patient was treated with NEXIUM, PAXIL, VITAMIN B12ECTION, VYTORIN, LEVOXYL, ACTONEL. Patient recovered.

Pioglitazone Side Effects Report #5219047-0
Physician from UNITED STATES reported PIOGLITAZONE problem on Jan 16, 2007. Male patient, 60 years of age, weighting 201.7 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: catheterisation cardiac, chest pain, dyspnoea, stent placement. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ASPIRIN, TERAZOSIN, INDOPROMIDE, ATENOLOL, ZOCOR, ALLOPURINOL, DICLOFENAC, SIMVASTATIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5221096-3
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Jan 16, 2007. Male patient, 59 years of age, weighting 183.2 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: intermittent claudication, muscle spasms, pain in extremity. PIOGLITAZONE dosage: unknown. During the same period patient was treated with SIMVASTATIN, ATENOLOL, ASPIRIN, FISH OIL, ASCORBIC ACID, ZINC. Patient recovered.

Pioglitazone Side Effects Report #5225101-X
Physician from UNITED STATES reported PIOGLITAZONE problem on Jan 19, 2007. Female patient, 44 years of age, weighting 194.4 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: anoxic encephalopathy, cardiac arrest, fall, gastrointestinal haemorrhage, hyperglycaemia, loss of consciousness, respiratory arrest, sinus tachycardia. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ZOLOFT, SYNTHROID, AMBIEN, SONATA. Patient was hospitalized. Patient died on 08/15/2006.

Pioglitazone Side Effects Report #5228759-4
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Jan 24, 2007. Male patient, 66 years of age, weighting 201.7 lb, was diagnosed with investigation and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: activated partial thromboplastin time prolonged, deep vein thrombosis, international normalised ratio increased, prothrombin time prolonged. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ALLEGRA, COUMADIN, LIPITOR, NEURONTIN, QUINAPRIL, NIACIN, ASPIRIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5228761-2
Physician from UNITED STATES reported PIOGLITAZONE problem on Jan 19, 2007. Female patient, 56 years of age, weighting 270.1 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: musculoskeletal chest pain. PIOGLITAZONE dosage: unknown. During the same period patient was treated with LIPITOR, ASPIRIN, NORVASC, LASIX, TRAMADOL, LISINOPRIL, CITALOPRAM. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5235055-8
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Jan 26, 2007. Female patient, 44 years of age, weighting 194.4 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: anoxic encephalopathy, cardiac arrest, contusion, fall, gastrointestinal haemorrhage, hyperglycaemia, metabolic acidosis, refusal of treatment by relative, sinus tachycardia. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ZOLOFT, SYNTHROID, AMBIEN, SONATA, FIORINAL, ADVIL, XANAX. Patient was hospitalized. Patient died on 08/16/2006.

Pioglitazone Side Effects Report #5242152-X
Physician from UNITED STATES reported PIOGLITAZONE problem on Feb 05, 2007. Female patient, 66 years of age, was diagnosed with glucose tolerance decreased and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: anorexia, chest pain, dyspnoea, stress, thyroid mass, weight decreased. PIOGLITAZONE dosage: unknown. During the same period patient was treated with NIFEDIPINE ER, CENTRUM SILVER, SEVEN SEAS CAPSULES. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5246496-7
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Feb 07, 2007. Female patient, 58 years of age, weighting 184.5 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: arrhythmia, palpitations, supraventricular tachycardia. PIOGLITAZONE dosage: 45 MG, 1 IN 1 D; PER ORAL, 45 MG, 1 IN 1 D, PER ORAL. During the same period patient was treated with HYDROCHLOROTHIAZIDE, ASPIRIN, NIFEDIPINE ER, ZOCOR, POTASSIUM CHLORIDE, FLONASE. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5283924-5
Physician from UNITED STATES reported PIOGLITAZONE problem on Mar 14, 2007. Female patient, 52 years of age, weighting 180.1 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: gastrooesophageal reflux disease, oesophagogastric fundoplasty. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ZOLOFT, SYNTHROID, PREMARIN CREAM, ACTIVELLA, MUCINEX, NASONEX, ASPIRIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5302053-5
PIOGLITAZONE problem was reported by a Health Professional from INDONESIA on Apr 10, 2007. Female patient was diagnosed with insulin-requiring type ii diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: hypoglycaemic coma. PIOGLITAZONE dosage: 15 MG (15 MG, 1 IN 1 D). During the same period patient was treated with AMARLY, HYDROCHLOROTHIAZIDE, PLAVIX. Patient recovered.

Pioglitazone Side Effects Report #5305725-1
Consumer or non-health professional from KOREA, REPUBLIC OF reported PIOGLITAZONE problem on Apr 12, 2007. Female patient was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: myocardial infarction. PIOGLITAZONE dosage: unknown. Patient died.

Pioglitazone Side Effects Report #5306997-X
PIOGLITAZONE problem was reported by a Consumer or non-health professional from KOREA, REPUBLIC OF on Apr 16, 2007. Female patient was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: myocardial infarction. PIOGLITAZONE dosage: unknown. Patient died.

Pioglitazone Side Effects Report #5307708-4
Physician from UNITED STATES reported PIOGLITAZONE problem on Apr 05, 2007. Female patient, 77 years of age, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: osteoarthritis. PIOGLITAZONE dosage: unknown. During the same period patient was treated with KEFLEX, ZETIA, TYLENOL ES, MOBIC, ROGAINE, NASOCORT NASAL SPRAY, TRAMADOL, ADVIL. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5313182-4
PIOGLITAZONE problem was reported by a Consumer or non-health professional from KOREA, REPUBLIC OF on Apr 19, 2007. Female patient was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: myocardial infarction. PIOGLITAZONE dosage: 15 MG (15 MG, 1 IN 1 D) PER ORAL. During the same period patient was treated with METFORMIN. Patient died.

Pioglitazone Side Effects Report #5319742-9
Consumer or non-health professional from KOREA, REPUBLIC OF reported PIOGLITAZONE problem on May 01, 2007. Female patient was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: myocardial infarction. PIOGLITAZONE dosage: 15 MG (15 MG, 1 IN 1 D) PER ORAL. During the same period patient was treated with METFORMIN. Patient died.

Pioglitazone Side Effects Report #5331780-9
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on May 07, 2007. Female patient was diagnosed with cerebrovascular accident, disease recurrence, myocardial infarction, prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: cerebrovascular accident, fall, femur fracture. PIOGLITAZONE dosage: unknown. Patient was hospitalized and became disabled. Patient recovered.

Pioglitazone Side Effects Report #5331781-0
Physician from UNITED STATES reported PIOGLITAZONE problem on May 07, 2007. Female patient was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident prophylaxis, ischaemic heart disease prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: fall, fibula fracture. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5331782-2
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on May 07, 2007. Female patient was diagnosed with cerebrovascular accident, disease recurrence, myocardial infarction, prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: fall, femoral neck fracture. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5331784-6
Physician from UNITED STATES reported PIOGLITAZONE problem on May 07, 2007. Female patient was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident, myocardial infarction and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: alcohol use, contusion, facial bones fracture, fall, hypokalaemia, neck pain, seroma, treatment failure. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5337666-8
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on May 14, 2007. Female patient, 63 years of age, weighting 184.5 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: adverse event, angle closure glaucoma. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ATENOLOL, PREMARIN, VITAMINS. Patient recovered.

Pioglitazone Side Effects Report #5343826-2
Physician from UNITED STATES reported PIOGLITAZONE problem on May 22, 2007. Female patient, 73 years of age, was diagnosed with cardiovascular disorder, cerebrovascular accident prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: compression fracture. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5354834-X
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on May 30, 2007. Female patient, 69 years of age, weighting 119.5 lb, was diagnosed with cardiovascular event prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: facial bones fracture, fall, hypokalaemia, polydipsia, spinal fracture. PIOGLITAZONE dosage: 45 MG, 1 IN 1 D, PER ORAL. During the same period patient was treated with ACTONEL, NEXIUM, DILTIAZEM, LIPITOR, ASPIRIN, DETROL. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5354835-1
Physician from UNITED STATES reported PIOGLITAZONE problem on May 30, 2007. Female patient, 73 years of age, was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: compression fracture. PIOGLITAZONE dosage: 45 MG, 1 IN 1 D, PER ORAL. During the same period patient was treated with ASPIRIN, FOSAMAX, PLAVIX, SYNTHROID, REMERON, LIPITOR, OXYCODONE. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5371416-4
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on June 13, 2007. Female patient, 70 years of age, weighting 222.0 lb, was diagnosed with cerebrovascular accident prophylaxis, cardiac disorder and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: fall, fibula fracture. PIOGLITAZONE dosage: 45 MG, 1 IN 1 D, PER ORAL. During the same period patient was treated with SYNTHROID, PROCARDIA, TOPROL, PROTONIX, NEURONTIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5371536-4
Physician from UNITED STATES reported PIOGLITAZONE problem on June 12, 2007. Male patient, 71 years of age, was diagnosed with cardiovascular event prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bladder cancer recurrent. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5377876-7
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on June 19, 2007. Male patient, 70 years of age, weighting 158.0 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: nasal septum deviation, post procedural haemorrhage. PIOGLITAZONE dosage: unknown. During the same period patient was treated with CITALOPRAM HYDROBROMIDE, DICLOFENAC, DOXAZOSIN MESYLATE, FORMOTEROL FUMARATE, LEVALBUTEROL, MOMETASONE FUROATE, OMEPRAZOLE, THEOPHYLLINE. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5378007-X
Physician from UNITED STATES reported PIOGLITAZONE problem on June 19, 2007. Female patient was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: pelvic fracture, wrist fracture. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5050468-5
PIOGLITAZONE problem was reported by a Consumer or non-health professional from CANADA on July 03, 2006. Female patient, 83 years of age, was diagnosed with diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: acute coronary syndrome, clear cell carcinoma of the kidney, myocardial infarction, renal neoplasm. PIOGLITAZONE dosage: 8 MG. During the same period patient was treated with CIPRO. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5054152-3
Consumer or non-health professional from CANADA reported PIOGLITAZONE problem on July 11, 2006. Female patient, 83 years of age, was diagnosed with diabetes mellitus inadequate control and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: coronary artery disease, myocardial infarction. PIOGLITAZONE dosage: 8 MG. During the same period patient was treated with CIPRO. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5056404-X
PIOGLITAZONE problem was reported by a Health Professional from MEXICO on July 12, 2006. Female patient, 69 years of age, was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: blood urea increased, cardiac failure, oedema. PIOGLITAZONE dosage: unknown. During the same period patient was treated with GLYBURIDE. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5059019-2
Physician from UNITED STATES reported PIOGLITAZONE problem on July 10, 2006. Male patient, 66 years of age, weighting 237.4 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bladder cancer, prostate cancer. PIOGLITAZONE dosage: unknown. During the same period patient was treated with GEMFIBROZIL, METOPROLOL TARTRATE, SIMVASTATIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5060342-6
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on July 10, 2006. Male patient, 66 years of age, weighting 237.4 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bladder cancer, haematuria, prostate cancer. PIOGLITAZONE dosage: unknown. During the same period patient was treated with GEMFIBROZIL, METOPROLOL TARTRATE, SIMVASTATIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5086858-4
Health Professional from UNITED STATES reported PIOGLITAZONE problem on Apr 21, 2006. Female patient was diagnosed with hepatic steatosis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, incorrect dose administered, pharyngolaryngeal pain. PIOGLITAZONE dosage: unknown. During the same period patient was treated with YASMIN. Patient recovered.

Pioglitazone Side Effects Report #5097586-3
PIOGLITAZONE problem was reported by a Consumer or non-health professional from INDONESIA on Aug 28, 2006. Male patient, 63 years of age, was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: gangrene, oedema peripheral. PIOGLITAZONE dosage: 15 MG PER ORAL. During the same period patient was treated with AMARYL, METFORMIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5106872-X
Consumer or non-health professional from JAPAN reported PIOGLITAZONE problem on Sept 04, 2006. Male patient, 50 years of age, was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: appendicitis, diverticulum intestinal, enteritis infectious, haematocrit decreased, ileitis. PIOGLITAZONE dosage: unknown. During the same period patient was treated with METFORMIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5113580-8
PIOGLITAZONE problem was reported by a Pharmacist from UNITED STATES on Sept 21, 2006. Female patient, 79 years of age, weighting 172.0 lb, was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: dyspnoea exertional, swelling, weight increased. PIOGLITAZONE dosage: 15 MG PO QD. During the same period patient was treated with CARVEDILOL, GLIPIZIDE, FUROSEMIDE, ATORVASTATIN, ASPIRIN, SPIRONOLACTONE, REPAGLINIDE, QUINAPRIL. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5114931-0
Physician from UNITED STATES reported PIOGLITAZONE problem on Sept 15, 2006. Male patient, 63 years of age, weighting 194.4 lb, was diagnosed with glucose tolerance impaired, hypertension and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: angioneurotic oedema, bronchospasm, choking, cough, dizziness, dyspnoea, postnasal drip, throat tightness. PIOGLITAZONE dosage: 45 MG, 1 IN 1 D, PER ORAL. During the same period patient was treated with LOTREL, LOPID, VERAPAMIL, FLOMAX, ASPIRIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5118837-2
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Sept 19, 2006. Male patient, 77 years of age, weighting 182.8 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bronchitis, haemoptysis, hepatic enzyme increased, pneumonia viral, troponin increased. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ZOCOR, HYDROCHLOROTHIAZIDE, LISINOPRIL, LEVAQUIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5120140-1
Pharmacist from UNITED STATES reported PIOGLITAZONE problem on Oct 02, 2006. Male patient, 42 years of age, was diagnosed with diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: insomnia, pain. PIOGLITAZONE dosage: 30 MG QD PO. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5139043-1
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Oct 16, 2006. Female patient, 80 years of age, weighting 139.3 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: knee arthroplasty. PIOGLITAZONE dosage: unknown. During the same period patient was treated with PROTONIX, DETROL LA, BUMETANIDE, LEVOTHYROXINE, CALCIUM, ACETAMINOPHEN, VITAMIN E, ASPIRIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5139287-9
Physician from UNITED STATES reported PIOGLITAZONE problem on Oct 16, 2006. Female patient, 58 years of age, weighting 266.8 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: glomerulonephritis proliferative, haematuria, renal cyst, scoliosis. PIOGLITAZONE dosage: unknown. During the same period patient was treated with BENICAR HCT, ZOCOR, NIFEDIAC. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5139295-8
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Oct 16, 2006. Female patient, 50 years of age, weighting 231.5 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: atelectasis, blood pressure increased, cholelithiasis, effusion, pancreatic necrosis, pancreatitis acute. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5139368-X
Physician from UNITED STATES reported PIOGLITAZONE problem on Oct 16, 2006. Female patient, 50 years of age, weighting 148.6 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: chest discomfort, chest pain, coronary artery disease, dizziness, mitral valve prolapse, oedema peripheral. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ASPIRIN, ATENOLOL, PREVACID. Patient recovered.

Pioglitazone Side Effects Report #5139369-1
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Oct 16, 2006. Female patient, 65 years of age, weighting 84.20 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: condition aggravated, hip arthroplasty, osteoarthritis. PIOGLITAZONE dosage: 45 MG, 1 IN 1 D, PER ORAL. During the same period patient was treated with LASIX, RANITIDINE, POTASSIUM CHLORIDE, HYDROCODONE W, FUROSEMIDE, IODINE, DETROL LA. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5140168-5
Physician from UNITED STATES reported PIOGLITAZONE problem on Oct 16, 2006. Female patient, 66 years of age, weighting 147.7 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: chest pain, lung neoplasm. PIOGLITAZONE dosage: unknown. During the same period patient was treated with AVALIDE, EVISTA, LEVOTHYROXINE, CLARITIN, FLEXERIL, CALCIUM, VITAMIN E. Patient recovered.

Pioglitazone Side Effects Report #5147865-6
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Oct 25, 2006. Male patient, 71 years of age, weighting 206.8 lb, was diagnosed with glucose tolerance test abnormal and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: cardiac stress test abnormal, electrocardiogram st segment abnormal. PIOGLITAZONE dosage: unknown. During the same period patient was treated with LOPRESSOR, LOVASTATIN, CLOPIDOGREL BISULPHATE, VITAMIN, FISH OIL, FOLBEE, ENALAPRIL. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5147866-8
Physician from UNITED STATES reported PIOGLITAZONE problem on Oct 25, 2006. Female patient, 66 years of age, weighting 147.7 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: chest pain, ejection fraction decreased, lung neoplasm. PIOGLITAZONE dosage: unknown. During the same period patient was treated with AVALIDE, EVISTA, LEVOTHYROXINE, CLARITIN, FLEXERIL, CALCIUM, VITAMIN E. Patient recovered.

Pioglitazone Side Effects Report #5147869-3
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Oct 25, 2006. Female patient, 80 years of age, weighting 139.3 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: knee arthroplasty. PIOGLITAZONE dosage: unknown. During the same period patient was treated with PROTONIX, DETROL LA, BUMETANIDE, LEVOTHYROXINE, CALCIUM, TYLENOL, VITAMIN E, ECOTRIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5147870-X
Physician from UNITED STATES reported PIOGLITAZONE problem on Oct 25, 2006. Male patient, 58 years of age, weighting 266.8 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: glomerulonephritis proliferative, haematuria, renal cyst, scoliosis. PIOGLITAZONE dosage: unknown. During the same period patient was treated with BENICAR HCT, ZOCOR, NIFEDIAC. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5147879-6
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Oct 25, 2006. Female patient, 50 years of age, weighting 148.6 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: chest discomfort, chest pain, coronary artery disease, dizziness, flatulence, mitral valve prolapse, oedema peripheral. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ASPIRIN, ATENOLOL, PREVACID, PLAVIX. Patient recovered.

Pioglitazone Side Effects Report #5152633-5
Physician from UNITED STATES reported PIOGLITAZONE problem on Nov 01, 2006. Male patient, 66 years of age, weighting 237.4 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bladder cancer, haematuria, prostate cancer, transitional cell carcinoma. PIOGLITAZONE dosage: 45 MG, 1 IN 1 D, PER ORAL. During the same period patient was treated with GEMFIBROZIL, METOPROLOL TARTRATE, SIMVASTATIN, VITAMIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5166378-9
PIOGLITAZONE problem was reported by a Consumer or non-health professional from UNITED STATES on Nov 14, 2006. Female patient was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: pulmonary oedema. PIOGLITAZONE dosage: 45 MG, 1 IN 1 D, PER ORAL. Patient recovered.

Pioglitazone Side Effects Report #5188091-4
Health Professional from UNITED STATES reported PIOGLITAZONE problem on Dec 14, 2006. Male patient, 76 years of age, weighting 142.0 lb, was diagnosed with diabetes mellitus non-insulin-dependent and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: fluid retention. PIOGLITAZONE dosage: 30 MG PO QD. During the same period patient was treated with VIT B, GLIMEPIRIDE, METOPROLOL SUCCINATE, LISINOPRIL, ASPIRIN, HYDROCHLOROTHIAZIDE. Patient recovered.

Pioglitazone Side Effects Report #5378370-X
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on July 02, 2007. Female patient, 36 years of age, weighting 260.1 lb, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: dehydration, hyperglycaemia, hypokalaemia, loss of consciousness, urinary tract infection. PIOGLITAZONE dosage: unknown. During the same period patient was treated with LANTUS. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5379451-7
Physician from UNITED STATES reported PIOGLITAZONE problem on June 19, 2007. Male patient was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: fall, fibula fracture, tibia fracture. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5379482-7
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on June 21, 2007. Male patient, 71 years of age, weighting 182.0 lb, was diagnosed with cardiovascular event prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bladder cancer, neoplasm recurrence. PIOGLITAZONE dosage: unknown. During the same period patient was treated with PROTONIX, PLAVIX. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5384919-3
Physician from UNITED STATES reported PIOGLITAZONE problem on June 28, 2007. Male patient, 70 years of age, weighting 158.0 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: post procedural haemorrhage. PIOGLITAZONE dosage: unknown. During the same period patient was treated with CITALOPRAM HYDROBROMIDE, DICLOFENAC, DOXAZOSIN MESYLATE, FORMOTEROL FUMARATE, LEVALBUTEROL, MOMETASONE FUROATE, OMEPRAZOLE, THEOPHYLLINE. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5385412-4
PIOGLITAZONE problem was reported by a Physician from ITALY on June 28, 2007. Male patient, 67 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: abdominal pain, anaemia, eructation, flatulence, insomnia, malaise, nausea. PIOGLITAZONE dosage: 45 MG (15 MG, 3 IN 1 D), ORAL. During the same period patient was treated with METFORMIN, SIMVASTIN, ASPIRIN, RAMIPRIL. Patient recovered.

Pioglitazone Side Effects Report #5386071-7
Physician from UNITED STATES reported PIOGLITAZONE problem on June 29, 2007. Female patient, 36 years of age, weighting 260.1 lb, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bacteria urine identified, blood potassium decreased, dehydration, hyperglycaemia, loss of consciousness, trichomoniasis. PIOGLITAZONE dosage: unknown. During the same period patient was treated with LANTUS. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5386073-0
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on June 29, 2007. Female patient was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: fall, pelvic fracture, wrist fracture. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5391815-4
Physician from UNITED STATES reported PIOGLITAZONE problem on July 06, 2007. Male patient, 74 years of age, weighting 234.0 lb, was diagnosed with cerebrovascular accident, disease recurrence, myocardial infarction, prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: fall, femoral neck fracture. PIOGLITAZONE dosage: unknown. During the same period patient was treated with LISINOPRIL, DESYREL, PRILOSEC, THIAMINE, FOLIC ACID. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5391816-6
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on July 06, 2007. Female patient, 81 years of age, weighting 111.0 lb, was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: fall, pelvic fracture, wrist fracture. PIOGLITAZONE dosage: unknown. During the same period patient was treated with NEXIUM, PLAVIX, NORVASC, DIOVAN, ZOCOR, HYDROCHLOROTHIAZIDE. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5392328-6
Consumer or non-health professional from JAPAN reported PIOGLITAZONE problem on July 07, 2007. Male patient, 55 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: myocardial infarction. PIOGLITAZONE dosage: 15 MG (15 MG, 1 IN 1 D) PER ORAL. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5393005-8
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on July 09, 2007. Male patient, 81 years of age, was diagnosed with cardiovascular event prophylaxis, ischaemic heart disease prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: facial bones fracture, fall, radius fracture. PIOGLITAZONE dosage: unknown. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5393783-8
Pharmacist from UNITED STATES reported PIOGLITAZONE problem on July 19, 2007. Female patient, 66 years of age, was diagnosed with type 1 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: cardiac failure congestive, condition aggravated. PIOGLITAZONE dosage: 15MG DAILY PO. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5394838-4
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on July 11, 2007. Female patient, 36 years of age, weighting 260.1 lb, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bacteria urine, blood potassium decreased, dehydration, hyperglycaemia, loss of consciousness, trichomoniasis. PIOGLITAZONE dosage: 15 MG, 2 IN 1 D, PER ORAL. During the same period patient was treated with LANTUS. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5394926-2
Consumer or non-health professional from CANADA reported PIOGLITAZONE problem on July 18, 2007. Male patient was treated with PIOGLITAZONE. PIOGLITAZONE dosage: unknown. Patient died.

Pioglitazone Side Effects Report #5395622-8
PIOGLITAZONE problem was reported by a Consumer or non-health professional from CANADA on July 18, 2007. Female patient was treated with PIOGLITAZONE. PIOGLITAZONE dosage: unknown. Patient died.

Pioglitazone Side Effects Report #5395623-X
Consumer or non-health professional from CANADA reported PIOGLITAZONE problem on July 18, 2007. Male patient was treated with PIOGLITAZONE. PIOGLITAZONE dosage: unknown. Patient died.

Pioglitazone Side Effects Report #5400070-8
PIOGLITAZONE problem was reported by a Consumer or non-health professional from CANADA on July 18, 2007. Male patient, 72 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: acute respiratory distress syndrome, cardio-respiratory arrest. PIOGLITAZONE dosage: 15 MG (15 MG, 1 IN 1 D). During the same period patient was treated with CELEBREX, NITRODUR II, MICARDIS, LIPITOR, LASIX, GLUCOPHAGE, ASPIRIN. Patient died.

Pioglitazone Side Effects Report #5402116-X
Physician from UNITED STATES reported PIOGLITAZONE problem on July 20, 2007. Female patient, 66 years of age, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: anorexia, chest pain, dyspnoea, mediastinal mass, stress, tracheal deviation, weight decreased. PIOGLITAZONE dosage: unknown. During the same period patient was treated with NIFEDIPINE ER, CENTRUM SILVER, SEVEN SEAS CAPSULES. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5402117-1
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on July 18, 2007. Male patient, 80 years of age, weighting 160.0 lb, was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: facial bones fracture, fall, radius fracture, ulna fracture. PIOGLITAZONE dosage: unknown. During the same period patient was treated with SIMVASTATIN, PREDNISONE, OMEPRAZOLE, METOPROLOL TARTRATE, ALLOPURINOL. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5402853-7
Consumer or non-health professional from CANADA reported PIOGLITAZONE problem on July 25, 2007. Male patient was diagnosed with diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: lymphoma, recurrent cancer. PIOGLITAZONE dosage: 30 MG (30 MG, 1 IN 1 D); PER ORAL. Patient died.

Pioglitazone Side Effects Report #5404949-2
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on June 11, 2007. Female patient, 74 years of age, weighting 146.5 lb, was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bundle branch block left, cardiac failure congestive, condition aggravated, road traffic accident, subarachnoid haemorrhage, urinary tract infection. PIOGLITAZONE dosage: unknown. During the same period patient was treated with PRILOSEC, ASPIRIN, PRAVASTATIN, CLOPIDOGREL, SOTALOL, AGGRENOX, NEXIUM. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5405830-5
Physician from UNITED STATES reported PIOGLITAZONE problem on July 26, 2007. Male patient, 60 years of age, weighting 178.4 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: avulsion fracture, hand fracture. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ATENOLOL, POTASSIUM CHLORIDE, CRESTOR, PLAVIX, INDAPAMIDE, DICLOFENAC, ZOCOR, LISINOPRIL. Patient recovered.

Pioglitazone Side Effects Report #5406171-2
PIOGLITAZONE problem was reported by a Health Professional from CANADA on July 25, 2007. Female patient, 78 years of age, was diagnosed with diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: atrioventricular block, cardiac failure congestive, chills, dyspnoea exertional, lung consolidation, pleural effusion, pyrexia, ventricular hypertrophy. PIOGLITAZONE dosage: 30 MG (30 MG, 1 IN 1 D) PER ORAL. During the same period patient was treated with METFORMIN, GLYBURIDE, FOSINOPRIL, NORVASC, PRAVACHOL, ASPIRIN. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5407418-9
Consumer or non-health professional from CANADA reported PIOGLITAZONE problem on July 30, 2007. Male patient, 78 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: rectal cancer metastatic. PIOGLITAZONE dosage: 15 MG (15 MG, 1 IN 1 D), PER ORAL, 30 MG (30 MG, 1 IN 1 D) PER ORAL. During the same period patient was treated with METOPROLOL SUCCINATE, IMIPRAMINE, GLICLAZIDE, ENALAPRIL MALEATE, METFORMIN, MAGNESIUM OXIDE, TRENTAL. Patient died.

Pioglitazone Side Effects Report #5408966-8
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on July 26, 2007. Female patient, 47 years of age, weighting 238.1 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: ankle fracture, fall, fibula fracture, hand fracture. PIOGLITAZONE dosage: unknown. During the same period patient was treated with SYNTHROID, CELEXA. Patient recovered.

Pioglitazone Side Effects Report #5413295-2
Health Professional from AUSTRALIA reported PIOGLITAZONE problem on Aug 03, 2007. Female patient, weighting 165.3 lb, was diagnosed with ill-defined disorder and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: lactic acidosis, renal failure acute. PIOGLITAZONE dosage: unknown. During the same period patient was treated with PERINDOPRIL ERBUMINE, METFORMIN HYDROCHLORIDE, ASPIRIN, LEVOTHYROXINE, PANTAPROZOLE, ATORVASTATIN CALCIUM, PARACETAMOL. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5413549-X
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on July 31, 2007. Female patient, 74 years of age, weighting 323.0 lb, was diagnosed with cardiovascular event prophylaxis, cerebrovascular accident prophylaxis and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: aneurysm, aortic stenosis, atrial fibrillation, cardiac failure congestive, cerebral arteriovenous malformation haemorrhagic, condition aggravated, dyspnoea exertional, dyspnoea paroxysmal nocturnal, fluid overload. PIOGLITAZONE dosage: unknown. During the same period patient was treated with PRILOSEC, ASPIRIN, PRAVASTATIN, CLOPIDOGREL, SOTALOL, AGGRENOX, NEXIUM. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5413676-7
Consumer or non-health professional from GERMANY reported PIOGLITAZONE problem on July 30, 2007. Male patient, 51 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: condition aggravated, hepatic steatosis. PIOGLITAZONE dosage: 15 MG PIOGLITAZONE AND 850 MG METFORMIN PER ORAL. During the same period patient was treated with ATORVASTATIN CALCIUM, URSO FALK, BLOPRESS, SERUMLIPIDREDUCING AGENTS, RENIN, ACOMPLIA. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5420633-3
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Aug 06, 2007. Female patient, 28 years of age, weighting 315.0 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: accident, ankle fracture. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ZOLOFT, TOPROL, HYDROCHLOROTHIAZIDE, BACLOFEN, FERROUS SULPHATE. Patient recovered.

Pioglitazone Side Effects Report #5444189-4
Consumer or non-health professional from CANADA reported PIOGLITAZONE problem on Aug 17, 2007. Male patient, 74 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: cerebrovascular accident. PIOGLITAZONE dosage: 45 MG (45 MG, 1 IN 1 D) PER ORAL. During the same period patient was treated with PREVACID, LOPRESSOR, COLCHICINE, LIPITOR, ELAVIL, PLAVIX, PENTASA, DIABETA. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5444271-1
PIOGLITAZONE problem was reported by a Consumer or non-health professional from GERMANY on Aug 16, 2007. Female patient, 70 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: acute hepatic failure, asthenia, base excess increased, bundle branch block, cardiac failure, condition aggravated, confusional state, diabetes mellitus. PIOGLITAZONE dosage: unknown. During the same period patient was treated with TAMOXIFEN CITRATE, OPIPRAMOL, SILYMARIN, OXAZEPAM. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5445788-6
Consumer or non-health professional from UNITED KINGDOM reported PIOGLITAZONE problem on Aug 23, 2007. Male patient, 60 years of age, was diagnosed with diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: cardiac failure congestive, treatment noncompliance. PIOGLITAZONE dosage: 4 MG. During the same period patient was treated with BYETTA, EXENATIDE, METFORMIN, INSULIN GLARGINE. Patient was hospitalized. Patient died.

Pioglitazone Side Effects Report #5445790-4
PIOGLITAZONE problem was reported by a Consumer or non-health professional from CANADA on Aug 20, 2007. Male patient, 63 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: inappropriate antidiuretic hormone secretion, iron deficiency anaemia, rectal cancer stage ii, urinary retention. PIOGLITAZONE dosage: 20 MG (30 MG,1 IN 1 D), PER ORAL. During the same period patient was treated with DILANTIN, TEGRETOL, METFORMIN, GLYBURIDE, CORGARD, ACCUPRIL, FOLIC ACID, VITAMIN B12. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5449490-6
Consumer or non-health professional from GERMANY reported PIOGLITAZONE problem on Aug 22, 2007. Female patient, 62 years of age, was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: bradykinesia, disturbance in attention, fall, headache, hemiparesis, hyperreflexia, hypoglycaemia, loss of consciousness, malaise. PIOGLITAZONE dosage: unknown. During the same period patient was treated with RAMIPRIL, METOPROLOL TARTRATE, HYDROCHLOROTHIAZIDE. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5449548-1
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Aug 23, 2007. Male patient, 77 years of age, weighting 237.7 lb, was diagnosed with glucose tolerance impaired and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: dysstasia, excoriation, fall, gait disturbance, intermittent claudication, muscular weakness, pain in extremity, peripheral sensorimotor neuropathy. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ASPIRIN, MONOPRIL, GABAPENTIN, ZESTORETIC. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5449599-7
Consumer or non-health professional from CANADA reported PIOGLITAZONE problem on Aug 30, 2007. Male patient was diagnosed with diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: non-hodgkin's lymphoma recurrent. PIOGLITAZONE dosage: 45 MG (45 MG, 1 IN 1 D) PER ORAL. During the same period patient was treated with REPAGLINIDE, METFORMIN. Patient died.

Pioglitazone Side Effects Report #5453475-3
PIOGLITAZONE problem was reported by a Health Professional from UNITED STATES on Sept 03, 2007. Female patient, 53 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: ankle fracture, fall, fibula fracture, joint dislocation. PIOGLITAZONE dosage: unknown. During the same period patient was treated with METFORMIN, GLYBURIDE, BUTABITAL, LISINOPRIL, TEMAZEPAM, DIPHENHYDRAMINE HYDROCHLORIDE, IBUPROFEN, VENLAFAXINE. Patient was hospitalized. Patient recovered.

Pioglitazone Side Effects Report #5460648-2
Consumer or non-health professional from CANADA reported PIOGLITAZONE problem on Sept 13, 2007. Female patient was diagnosed with diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: pancreatic carcinoma. PIOGLITAZONE dosage: unknown. During the same period patient was treated with ASPIRIN, LOSARTAN POSTASSIUM, ALPRAZOLAM, ATORVASTATIN CALCIUM, OLANZAPINE. Patient died.

Pioglitazone Side Effects Report #5463798-X
PIOGLITAZONE problem was reported by a Physician from UNITED STATES on Sept 12, 2007. Female patient, 53 years of age, was diagnosed with type 2 diabetes mellitus and was treated with PIOGLITAZONE. After drug was administered, patient experienced the following problems/side effects: ankle fracture, fall, joint dislocation. PIOGLITAZONE dosage: unknown. During the same period patient was treated with METFORMIN, GLYBURIDE, BUTALBITAL, LISINOPRIL, TEMAZEPAM, DIPHENHYDRAMINE HYDROCHLORIDE, IBUPROFEN, VENLAFAXINE. Patient was hospitalized. Patient recovered.


Drug Information: Pioglitazone

URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a699016.html

(pye oh gli' ta zone)

IMPORTANT WARNING:

Pioglitazone and other similar medications for diabetes may cause or worsen congestive heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body). Before you start to take pioglitazone, tell your doctor if you have or have ever had congestive heart failure, especially if your heart failure is so severe that you must limit your activity and are only comfortable when you are at rest or you must remain in a chair or bed. Also tell your doctor if you were born with a heart defect, and if you have or have ever had swelling of the arms, hands, feet, ankles, or lower legs; heart disease; high cholesterol or fats in the blood; high blood pressure; coronary artery disease (narrowing of the blood vessels that lead to the heart); a heart attack; or an irregular heartbeat. Your doctor may tell you not to take pioglitazone or may monitor you carefully during your treatment.If you develop congestive heart failure, you may experience certain symptoms. Tell your doctor immediately if you have any of the following symptoms, especially when you first start taking pioglitazone or after your dose is increased: large weight gain in a short period of time; shortness of breath; swelling of the arms, hands, feet, ankles, or lower legs; swelling or pain in the stomach; waking up short of breath during the night; needing to sleep with extra pillows in order to breathe while lying down; frequent dry cough; or increased tiredness.Talk to your doctor about the risks of taking pioglitazone.

Why is this medication prescribed?

Pioglitazone is used with a diet and exercise program and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Pioglitazone is in a class of medications called thiazolidinediones. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels. Pioglitazone is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated).

How should this medicine be used?

Pioglitazone comes as a tablet to take by mouth. It is usually taken once daily with or without meals. Take pioglitazone at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pioglitazone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of pioglitazone and gradually increase your dose.

Pioglitazone controls type 2 diabetes but does not cure it. It may take 2 weeks for your blood sugar to decrease and several weeks longer for you to feel the full effect of pioglitazone. Continue to take pioglitazone even if you feel well. Do not stop taking pioglitazone without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking pioglitazone,

  • tell your doctor and pharmacist if you are allergic to pioglitazone or any other medications.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention any of the following: atorvastatin (Lipitor), gemfibrozil (Lopid), hormonal contraceptives (birth control pills, patches, rings, implants, and injections), ketoconazole (Nizoral), midazolam, montelukast (Singulair), nifedipine (Procardia), and rifampin (Rifadin, Rifater, in Rifamate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking pioglitazone, call your doctor. Do not breastfeed while you are taking pioglitazone.
  • if you have not yet experienced menopause (change of life; end of monthly periods) you should know that pioglitazone may increase the chance that you will become pregnant even if you do not have regular monthly periods or you have a condition that prevents you from ovulating (releasing an egg from the ovaries). Talk to your doctor about methods of birth control that will work for you.
  • if you will be having surgery, including dental surgery, tell the doctor or dentist that you are taking pioglitazone.
  • ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of pioglitazone you may need.

What special dietary instructions should I follow?

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet, exercise regularly, and lose weight if necessary. This will help to control your diabetes and help pioglitazone work more effectively.

Alcohol may cause a decrease in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are taking pioglitazone.

What should I do if I forget a dose?

If you remember that same day, take the missed dose as soon as your remember it. However, if you do not remember until the next day, skip the missed dose and continue your regular dosing schedule. Do not take more than one dose in one day and do not take a double dose to make up for a missed one.

What side effects can this medication cause?

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

You may experience hypoglycemia (low blood sugar) if you are taking this medication in combination with other medications used to treat diabetes. Your doctor will tell you what you should do if you develop hypoglycemia. He or she may tell you to check your blood sugar, eat or drink a food or beverage that contains sugar, such as hard candy or fruit juice, or get medical care. Follow these directions carefully if you have any of the following symptoms of hypoglycemia:

  • shakiness
  • dizziness or lightheadedness
  • sweating
  • nervousness or irritability
  • sudden changes in behavior or mood
  • headache
  • numbness or tingling around the mouth
  • weakness
  • pale skin
  • hunger
  • clumsy or jerky movements

If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately.

  • confusion
  • seizures
  • loss of consciousness

Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):

  • extreme thirst
  • frequent urination
  • extreme hunger
  • weakness
  • blurred vision

If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of these symptoms:

  • dry mouth
  • upset stomach and vomiting
  • shortness of breath
  • breath that smells fruity
  • decreased consciousness

Pioglitazone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • runny nose and other cold symptoms
  • headache
  • muscle pain
  • tooth or mouth pain
  • sore throat

Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately:

  • nausea
  • vomiting
  • loss of appetite
  • excessive tiredness
  • dark urine
  • yellowing of the skin or whites of the eyes
  • blurred vision
  • vision loss

In clinical studies, more people who took pioglitazone developed bladder cancer than people who did not take pioglitazone. Talk to your doctor about the risk of taking this medication.

In clinical studies, more women who took pioglitazone developed fractures, especially of the hands, arms, feet, ankles, and lower legs than women who did not take pioglitazone. Men who took pioglitazone did not have a greater risk of developing fractures than men who did not take the medication. If you are a woman, talk to your doctor about the risk of taking this medication.

Pioglitazone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Keep all appointments with your doctor, your eye doctor, and the laboratory. Your doctor will probably order regular eye examinations and certain laboratory tests to check your body's response to pioglitazone. Your blood sugar and glycosolated hemoglobin should be checked regularly to determine your response to pioglitazone. Your doctor will also tell you how to check your response to pioglitazone by measuring your blood or urine sugar levels at home. Follow these directions carefully.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand name(s):

  • Actos®

Brand name(s) of combination products:

  • ActoPLUSMet® (containing pioglitazone and metformin)
  • Duetact® (containing pioglitazone and glimepiride)

Ask Our Patient Community about Pioglitazone

PatientsVille.com does not provide medical advice, diagnosis or treatment. The information contained on PatientsVille.com site has not been scientifically or otherwise verified as to a cause and effect relationship and cannot be used to estimate the incidence of adverse drug reactions or for establishing or changing of patient treatments.


Thank you for visiting Patientsville.com. We hope you found our information about prescription drug side effects helpful. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Thank you for visiting Patientsville.net. Hope you enjoyed finding Pioglitazone safety information and found answers to Your Questions about Pioglitazone side effects

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