Common Prilosec Side Effects


The most commonly reported Prilosec side effects (click to view or check a box to report):

Gastrooesophageal Reflux Disease (274)
Dyspepsia (211)
Nausea (183)
Abdominal Pain Upper (163)
Malaise (151)
Pain (140)
Diarrhoea (134)
Vomiting (132)
Headache (119)
Dyspnoea (115)
Dizziness (115)
Chest Pain (112)
Anxiety (97)
Fatigue (85)
Weight Decreased (79)
Abdominal Discomfort (79)
Off Label Use (74)
Asthenia (73)
Abdominal Pain (69)
Injury (64)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Prilosec Side Effects Reported to FDA



Prilosec Side Effect Report#9981252
Stress Fracture, Lower Limb Fracture
This is a report of a 33-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: gastrooesophageal reflux disease, who was treated with Prilosec Otc (dosage: NA, start time:
Jan 15, 2013), combined with: NA. and developed a serious reaction and side effect(s): Stress Fracture, Lower Limb Fracture after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Prilosec Otc treatment in male patients, resulting in Stress Fracture side effect.
Prilosec Side Effect Report#9956324
Nasal Septum Deviation, Cough, Vomiting, Wheezing
This report suggests a potential Prilosec Nasal Septum Deviation side effect(s) that can have serious consequences. A 57-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease,rhinitis,multiple allergies,asthma and used Prilosec (dosage: NA) starting 2013. After starting Prilosec the patient began experiencing various side effects, including: Nasal Septum Deviation, Cough, Vomiting, WheezingAdditional drugs used concurrently:
  • Rhinocort Aqua (2 Sprays Per Nostril Daily)
  • Rhinocort Aqua (2 Sprays Per Nostril Daily)
  • Ventolin (2 Sprays Prn)
  • Loratidine
  • Ultram (Prn)
  • Advil (Prn)
Although Prilosec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Nasal Septum Deviation, may still occur.
Prilosec Side Effect Report#9924818
Anxiety, Depression, Insomnia, Thinking Abnormal, Self-injurious Ideation
This Anxiety problem was reported by a consumer or non-health professional from US. A 13-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease. On
Nov 27, 2013 this consumer started treatment with Prilosec (dosage: 2 Pills Once Daily). The following drugs were being taken at the same time: NA. When using Prilosec, the patient experienced the following unwanted symptoms/side effects: Anxiety, Depression, Insomnia, Thinking Abnormal, Self-injurious IdeationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Anxiety, may become evident only after a product is in use by the general population.
Prilosec Side Effect Report#9893871
Cataract, Glaucoma, Sleep Paralysis, Panic Attack, Pain, Gastric Disorder, Memory Impairment, Skin Wrinkling, Confusional State
This Cataract side effect was reported by a consumer or non-health professional from US. A 58-year-old female patient (weight:NA) experienced the following symptoms/conditions: gastric ulcer.The patient was prescribed Prilosec (drug dosage: NA), which was initiated on 1995. Concurrently used drugs: NA..After starting to take Prilosec the consumer reported adverse symptoms, such as: Cataract, Glaucoma, Sleep Paralysis, Panic Attack, Pain, Gastric Disorder, Memory Impairment, Skin Wrinkling, Confusional StateThese side effects may potentially be related to Prilosec.
Prilosec Side Effect Report#9871512
Dyspnoea, Dysphagia, Haematochezia, Mucous Stools
This is a report of a 38-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Prilosec (dosage: NA, start time: NS), combined with:
  • Lisinopril
and developed a serious reaction and side effect(s): Dyspnoea, Dysphagia, Haematochezia, Mucous Stools after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Prilosec treatment in female patients, resulting in Dyspnoea side effect.
Prilosec Side Effect Report#9867080
Headache, Palpitations, Abdominal Pain Upper
This report suggests a potential Prilosec Headache side effect(s) that can have serious consequences. A 40-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: cough and used Prilosec (dosage: NA) starting
Jan 10, 2014. After starting Prilosec the patient began experiencing various side effects, including: Headache, Palpitations, Abdominal Pain UpperAdditional drugs used concurrently:
  • Imitrex
  • Vit D
  • Vit B
  • Calcium
  • Nasonex
  • Migrelief
  • Naproxen
Although Prilosec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Headache, may still occur.
Prilosec Side Effect Report#9856113
Renal Cyst, Splenomegaly, Hepatomegaly, Polyp, Nephrolithiasis, Gastrointestinal Disorder, Psoriatic Arthropathy, Osteoarthritis, Back Pain
This Renal Cyst problem was reported by a consumer or non-health professional from US. A 50-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease,ulcer. On
Aug 27, 2013 this consumer started treatment with Prilosec (dosage: NA). The following drugs were being taken at the same time: NA. When using Prilosec, the patient experienced the following unwanted symptoms/side effects: Renal Cyst, Splenomegaly, Hepatomegaly, Polyp, Nephrolithiasis, Gastrointestinal Disorder, Psoriatic Arthropathy, Osteoarthritis, Back PainAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Renal Cyst, may become evident only after a product is in use by the general population.
Prilosec Side Effect Report#9850456
Nausea, Condition Aggravated
This Nausea side effect was reported by a consumer or non-health professional from US. A female patient (weight:NA) experienced the following symptoms/conditions: gastrooesophageal reflux disease.The patient was prescribed Prilosec (drug dosage: NA), which was initiated on 201203. Concurrently used drugs:
  • Protonix
.After starting to take Prilosec the consumer reported adverse symptoms, such as: Nausea, Condition AggravatedThese side effects may potentially be related to Prilosec.
Prilosec Side Effect Report#9831809
Colectomy Total
This is a report of a 22-year-old male patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: NA, who was treated with Prilosec (dosage: NA, start time:
Apr 24, 2013), combined with:
  • Humira
  • Prozac
  • Antibiotics
  • Prednisone
and developed a serious reaction and side effect(s): Colectomy Total after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Prilosec treatment in male patients, resulting in Colectomy Total side effect.
Prilosec Side Effect Report#9829067
Back Injury, Accident, Thirst, Pollakiuria, Glucose Tolerance Impaired, Blood Cholesterol Abnormal, Asthma, Fatigue, Gastrointestinal Sounds Abnormal
This report suggests a potential Prilosec Back Injury side effect(s) that can have serious consequences. A 57-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease and used Prilosec (dosage: NA) starting 2009. After starting Prilosec the patient began experiencing various side effects, including: Back Injury, Accident, Thirst, Pollakiuria, Glucose Tolerance Impaired, Blood Cholesterol Abnormal, Asthma, Fatigue, Gastrointestinal Sounds AbnormalAdditional drugs used concurrently: NA. Although Prilosec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Back Injury, may still occur.
Prilosec Side Effect Report#9826036
Back Pain, Muscle Contractions Involuntary, Spinal Fusion Surgery
This Back Pain problem was reported by a consumer or non-health professional from US. A 34-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease. On
Apr 15, 1987 this consumer started treatment with Prilosec (dosage: 1 Once Daily). The following drugs were being taken at the same time: NA. When using Prilosec, the patient experienced the following unwanted symptoms/side effects: Back Pain, Muscle Contractions Involuntary, Spinal Fusion SurgeryAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Back Pain, may become evident only after a product is in use by the general population.
Prilosec Side Effect Report#9802280
Blood Glucose Increased, Haematemesis, Loss Of Consciousness, Fall, Eructation, Dizziness, Pain In Extremity, Feeling Abnormal, Insomnia
This Blood Glucose Increased side effect was reported by a consumer or non-health professional from US. A 53-year-old male patient (weight:NA) experienced the following symptoms/conditions: nerve injury,diabetic neuropathy,pain in extremity,back pain.The patient was prescribed Prilosec (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Lyrica
  • Lyrica
  • Lyrica
  • Cymbalta
  • Cymbalta
  • Cymbalta
  • Insulin
.After starting to take Prilosec the consumer reported adverse symptoms, such as: Blood Glucose Increased, Haematemesis, Loss Of Consciousness, Fall, Eructation, Dizziness, Pain In Extremity, Feeling Abnormal, InsomniaThese side effects may potentially be related to Prilosec. The patient was hospitalized.
Prilosec Side Effect Report#9788008
Abdominal Pain Upper
This is a report of a 11-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: nausea, who was treated with Prilosec - Omeprazole Varied (dosage: 10 Mg - 40 Mg When Still Pain Once Daily Taken By Mouth?over 1 1/2 Years, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Abdominal Pain Upper after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Prilosec - Omeprazole Varied treatment in male patients, resulting in Abdominal Pain Upper side effect.
Prilosec Side Effect Report#9787754
Fibula Fracture, Bone Pain
This report suggests a potential Prilosec Fibula Fracture side effect(s) that can have serious consequences. A 57-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease and used Prilosec (dosage: Strength: 20.6?quantity: 1-2 Pills Daily?by Mouth) starting 200710. After starting Prilosec the patient began experiencing various side effects, including: Fibula Fracture, Bone PainAdditional drugs used concurrently:
  • Synthroid (124 Mg)
  • Multivitamin
  • Niacin
  • Glucosamine
Although Prilosec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Fibula Fracture, may still occur.
Prilosec Side Effect Report#9785640
Dizziness, Dehydration, Hyperhidrosis, Heart Rate Increased, Flatulence, Dizziness, Retching, Diarrhoea, Headache
This Dizziness problem was reported by a consumer or non-health professional from US. A 49-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: off label use,flatulence. On
Sep 12, 2013 this consumer started treatment with Prilosec Otc (dosage: 2 Pill Sample Packs 1x Daily Before Eating By Mouth). The following drugs were being taken at the same time: NA. When using Prilosec Otc, the patient experienced the following unwanted symptoms/side effects: Dizziness, Dehydration, Hyperhidrosis, Heart Rate Increased, Flatulence, Dizziness, Retching, Diarrhoea, HeadacheAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dizziness, may become evident only after a product is in use by the general population.
Prilosec Side Effect Report#9781153
Throat Irritation, Burning Sensation, Nasal Disorder, Laryngitis, Oropharyngeal Pain, Cough, Wheezing
This Throat Irritation side effect was reported by a consumer or non-health professional from US. A 51-year-old female patient (weight:NA) experienced the following symptoms/conditions: gastrooesophageal reflux disease.The patient was prescribed Prilosec Otc (drug dosage: 1 Pill Once Daily Taken By Mouth), which was initiated on NS. Concurrently used drugs: NA..After starting to take Prilosec Otc the consumer reported adverse symptoms, such as: Throat Irritation, Burning Sensation, Nasal Disorder, Laryngitis, Oropharyngeal Pain, Cough, WheezingThese side effects may potentially be related to Prilosec Otc.
Prilosec Side Effect Report#9777694
Chest Discomfort, Dyspepsia, Eructation
This is a report of a 26-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: gastrooesophageal reflux disease, who was treated with Prilosec (dosage: NA, start time: 2010), combined with:
  • Nexium
  • Levothyroxine
  • Ranitidine
and developed a serious reaction and side effect(s): Chest Discomfort, Dyspepsia, Eructation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Prilosec treatment in male patients, resulting in Chest Discomfort side effect.
Prilosec Side Effect Report#9772318
Gastrooesophageal Reflux Disease, Disease Recurrence, Diarrhoea, Abdominal Distension
This report suggests a potential Prilosec Gastrooesophageal Reflux Disease side effect(s) that can have serious consequences. A 61-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: barrett^s oesophagus,gastrooesophageal reflux disease and used Prilosec (dosage: NA) starting
Jul 16, 2013. After starting Prilosec the patient began experiencing various side effects, including: Gastrooesophageal Reflux Disease, Disease Recurrence, Diarrhoea, Abdominal DistensionAdditional drugs used concurrently: NA. Although Prilosec demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Gastrooesophageal Reflux Disease, may still occur.
Prilosec Side Effect Report#9748549
Pain, Pancreatitis, Constipation
This Pain problem was reported by a consumer or non-health professional from US. A 55-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease. On 2003 this consumer started treatment with Prilosec (dosage: NA). The following drugs were being taken at the same time:
  • Nexium
  • Lisinopril
  • Lorazepam
  • Lorazepam
  • Hydrocodone (7.5/325mg Prn)
  • Fluticasone (50mcg, 2 Sprays In Each Nos)
  • Loratidine
  • Cymbalta
When using Prilosec, the patient experienced the following unwanted symptoms/side effects: Pain, Pancreatitis, ConstipationThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pain, may become evident only after a product is in use by the general population.
Prilosec Side Effect Report#9744461
Inguinal Hernia, Decreased Appetite, Weight Decreased, Gastritis, Abdominal Pain, Nausea, Vomiting, Off Label Use
This Inguinal Hernia side effect was reported by a consumer or non-health professional from US. A 62-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Prilosec (drug dosage: NA), which was initiated on 2007. Concurrently used drugs:
  • Nexium
  • Cardizem
  • Flomax
  • Simvastatin
  • Fosamax
  • Zofran (One Df Every 8 Hours As Needed)
  • Carafate (1gm/10 Ml Suspension, 2 Teaspoonful Half An Hour Before Breakfast And Dinner)
.After starting to take Prilosec the consumer reported adverse symptoms, such as: Inguinal Hernia, Decreased Appetite, Weight Decreased, Gastritis, Abdominal Pain, Nausea, Vomiting, Off Label UseThese side effects may potentially be related to Prilosec.
Prilosec Side Effect Report#9734727
Thrombosis, Vascular Graft
This is a report of a male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Prilosec (dosage: NA, start time: NS), combined with:
  • Valtrex
  • Androgel
  • Hizentra (Over 1-2 Hours)
  • Kytril (4 Mg/4 Ml)
  • Protonix Dr
  • Fentanyl
  • Acyclovir
  • Morphine Sulfate (10 Mg/0.7 Ml)
and developed a serious reaction and side effect(s): Thrombosis, Vascular Graft after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Prilosec treatment in male patients, resulting in Thrombosis side effect. The patient was hospitalized.
Prilosec Side Effect Report#9720861
Weight Decreased, Chronic Obstructive Pulmonary Disease, Hypophagia, Asthma, Headache, Nausea, Off Label Use
This report suggests a potential Prilosec Otc Weight Decreased side effect(s) that can have serious consequences. A 53-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Prilosec Otc (dosage: NA) starting NS. After starting Prilosec Otc the patient began experiencing various side effects, including: Weight Decreased, Chronic Obstructive Pulmonary Disease, Hypophagia, Asthma, Headache, Nausea, Off Label UseAdditional drugs used concurrently:
  • Pulmicort Respules
  • Rhinocort Aqua
  • Symbicort (160/4.5 Mcg, 2 Puffs Bid)
  • Symbicort (160/4.5 Mcg, 2 Puffs Bid)
Although Prilosec Otc demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Weight Decreased, may still occur.
Prilosec Side Effect Report#9704838
Hiatus Hernia, Dyspepsia, Pain, Adverse Event
This Hiatus Hernia problem was reported by a consumer or non-health professional from US. A 52-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease. On NS this consumer started treatment with Prilosec (dosage: NA). The following drugs were being taken at the same time: NA. When using Prilosec, the patient experienced the following unwanted symptoms/side effects: Hiatus Hernia, Dyspepsia, Pain, Adverse EventAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hiatus Hernia, may become evident only after a product is in use by the general population.
Prilosec Side Effect Report#9698946
Nausea, Vomiting, Multi-organ Failure, Intentional Overdose
This Nausea side effect was reported by a health professional from US. A 31-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Prilosec (drug dosage: 20 Mg 30 Times A Day?), which was initiated on NS. Concurrently used drugs:
  • Colchicine (0.6 Mg 160 Times A Day)
.After starting to take Prilosec the consumer reported adverse symptoms, such as: Nausea, Vomiting, Multi-organ Failure, Intentional OverdoseThese side effects may potentially be related to Prilosec.
Prilosec Side Effect Report#9691794
Gastrooesophageal Reflux Disease, Oropharyngeal Pain, Hiccups, Cough, Increased Upper Airway Secretion, Eating Disorder, Dyspepsia, Dyspnoea, Weight Decreased
This is a report of a 65-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Prilosec (dosage: NA, start time: 2009), combined with:
  • Nexium
  • Tegretol Xr
  • Advair (100/50mg Bid)
  • Synthroid (100mcg Daily)
  • Ca With D
  • Fish Oil
  • Acuvit (1 Cap Daily)
  • Aleve (2 Tabs Prn)
and developed a serious reaction and side effect(s): Gastrooesophageal Reflux Disease, Oropharyngeal Pain, Hiccups, Cough, Increased Upper Airway Secretion, Eating Disorder, Dyspepsia, Dyspnoea, Weight Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Prilosec treatment in female patients, resulting in Gastrooesophageal Reflux Disease side effect.


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The appearance of Prilosec on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Prilosec Side Effects for Women?

Women Side Effects Reports
Gastrooesophageal Reflux Disease 196
Dyspepsia 143
Nausea 133
Abdominal Pain Upper 127
Malaise 115
Pain 109
Vomiting 94
Diarrhoea 85
Dyspnoea 82
Headache 79

What are common Prilosec Side Effects for Men?

Men Side Effects Reports
Gastrooesophageal Reflux Disease 78
Dyspepsia 68
Nausea 50
Diarrhoea 49
Dizziness 47
Headache 39
Vomiting 38
Chest Pain 37
Abdominal Pain Upper 36
Malaise 36

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Why Your Notes are Important

Your notes could be helpful in several ways:

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  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Prilosec reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Prilosec Safety Alerts, Active Ingredients, Usage Information

    NDC 0186-0606
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name PRILOSEC
    Name Omeprazole magnesium
    Dosage Form CAPSULE, DELAYED RELEASE
    Route ORAL
    On market since 19951115
    Labeler AstraZeneca LP
    Active Ingredient(s) OMEPRAZOLE MAGNESIUM
    Strength(s) 10
    Unit(s) mg/1
    Pharma Class Proton Pump Inhibitor [EPC],Proton Pump Inhibitors [MoA],Cytochrome P450 2C19 Inhibitors [MoA]