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Primperan Side Effects

PatientsVille

Common Primperan Side Effects


The most commonly reported Primperan side effects (click to view or check a box to report):

Nausea (8)
Renal Failure (6)
Decreased Appetite (6)
Aspartate Aminotransferase Increased (5)
Alanine Aminotransferase Increased (5)
Blood Bilirubin Increased (5)
Pneumonia (5)
Thrombocytopenia (5)
Platelet Count Decreased (5)
Anaemia (4)
Erythema Multiforme (3)
Disseminated Intravascular Coagulation (3)
Blood Alkaline Phosphatase Increased (3)
Blood Lactate Dehydrogenase Increased (3)
White Blood Cell Count Decreased (3)
Vomiting (3)
Haemoglobin Decreased (3)
Rash (3)
Renal Failure Acute (3)
Febrile Neutropenia (3)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Primperan Side Effects Reported to FDA



Primperan Side Effect Report#9416974
Agranulocytosis, Febrile Neutropenia
This is a report of a 67-year-old male patient (weight: NA) from ES, suffering from the following health symptoms/conditions: nausea,hepatitis c, who was treated with Primperan (dosage: NA, start time:
Apr 01, 2013), combined with:
  • Ribavirin
  • Bi 207127
  • Bi 201335
and developed a serious reaction and side effect(s): Agranulocytosis, Febrile Neutropenia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Primperan treatment in male patients, resulting in Agranulocytosis side effect. The patient was hospitalized.
Primperan Side Effect Report#9407378
Cardiac Failure, Bronchitis, Congestive Cardiomyopathy, Aortic Stenosis
This report suggests a potential Primperan Cardiac Failure side effect(s) that can have serious consequences. A 66-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Primperan (dosage: NA) starting 201212. After starting Primperan the patient began experiencing various side effects, including: Cardiac Failure, Bronchitis, Congestive Cardiomyopathy, Aortic StenosisAdditional drugs used concurrently:
  • Arava
  • Aranesp
  • Herceptin
  • Taxol
  • Solumedrol
  • Ondansetron
  • Sectral
  • Mopral
The patient was hospitalized. Although Primperan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Cardiac Failure, may still occur.
Primperan Side Effect Report#9265249
Rheumatoid Arthritis
This Rheumatoid Arthritis problem was reported by a health professional from JP. A 53-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Apr 23, 2012 this consumer started treatment with Primperan (dosage: 5 Mg, Prn). The following drugs were being taken at the same time:
  • Takepron (15 Mg, Qd)
  • Takepron (15 Mg, Prn)
  • Calonal (400 Mg, Prn)
  • Hirudoid (5 G, Qd)
  • Restamin (5 G, Qd)
  • Vx-950 (telaprevir) (2250 Mg, Qd)
  • Rebetol (800 Mg, Qd)
  • Rebetol (400 Mg, Qd)
When using Primperan, the patient experienced the following unwanted symptoms/side effects: Rheumatoid ArthritisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Rheumatoid Arthritis, may become evident only after a product is in use by the general population.
Primperan Side Effect Report#8478660-8
Erythema Multiforme, Disseminated Intravascular Coagulation
This Erythema Multiforme side effect was reported by a consumer or non-health professional from Japan. A 53-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Primperan Tab (drug dosage: NA), which was initiated on
Dec 21, 2011. Concurrently used drugs:
  • Selbex
  • Meilax
  • Zoloft
  • Maglax
  • Betamethasone Sodium Phosphate
  • Ribavirin
  • Telavic (telaprevir)
  • Voltaren
.After starting to take Primperan Tab the consumer reported adverse symptoms, such as: Erythema Multiforme, Disseminated Intravascular CoagulationThese side effects may potentially be related to Primperan Tab. The patient was hospitalized.
Primperan Side Effect Report#8464650-8
Erythema Multiforme, Disseminated Intravascular Coagulation
This is a report of a 53-year-old female patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: NA, who was treated with Primperan Tab (dosage: NA, start time:
Dec 21, 2011), combined with:
  • Peginterferon Alfa-2b
  • Ribavirin
  • Voltaren
  • Loxonin
  • Selbex
  • Betamethasone Sodium Phosphate
  • Zoloft
  • Maglax
and developed a serious reaction and side effect(s): Erythema Multiforme, Disseminated Intravascular Coagulation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Primperan Tab treatment in female patients, resulting in Erythema Multiforme side effect.
Primperan Side Effect Report#8444545-6
Maternal Exposure During Pregnancy, Threatened Labour, Off Label Use, Vomiting
This report suggests a potential Primperan Tab Maternal Exposure During Pregnancy side effect(s) that can have serious consequences. A 27-year-old female patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: vomiting and used Primperan Tab (dosage: NA) starting
Dec 13, 2011. After starting Primperan Tab the patient began experiencing various side effects, including: Maternal Exposure During Pregnancy, Threatened Labour, Off Label Use, VomitingAdditional drugs used concurrently:
  • Kamikihitou
  • Ascorbic Acid
  • Depas
  • 5 % Glucose
  • Lorazepam
  • 50% Glucose
  • Blonanserin
  • Physio
The patient was hospitalized. Although Primperan Tab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Maternal Exposure During Pregnancy, may still occur.
Primperan Side Effect Report#8386840-5
Pathogen Resistance, Neoplasm Progression, Angina Pectoris, Troponin Increased, Colon Cancer Metastatic, Dyspnoea, Myocardial Infarction, Blood Creatine Phosphokinase Increased
This Pathogen Resistance problem was reported by a health professional from France. A 70-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Nov 04, 2008 this consumer started treatment with Primperan Tab (dosage: Unk). The following drugs were being taken at the same time:
  • Avastin (Unk)
  • Zofran (Unk)
  • Levofloxacin (Unk)
  • Acupan (3 Df, Unk)
  • Augmentin '125' (Unk)
  • Alfuzosin Hcl
  • Solu-medrol (Unk, Other)
  • Eloxatin (150 Mg)
When using Primperan Tab, the patient experienced the following unwanted symptoms/side effects: Pathogen Resistance, Neoplasm Progression, Angina Pectoris, Troponin Increased, Colon Cancer Metastatic, Dyspnoea, Myocardial Infarction, Blood Creatine Phosphokinase IncreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pathogen Resistance, may become evident only after a product is in use by the general population.
Primperan Side Effect Report#8383079-4
Pneumonia, Altered State Of Consciousness, Abdominal Pain, Anaemia, Staphylococcal Infection, Melaena, Proctalgia, Rectal Discharge, Dehydration
This Pneumonia side effect was reported by a physician from Japan. A male patient (weight:NA) experienced the following symptoms/conditions: crohn's disease.The patient was prescribed Primperan Tab (drug dosage: 15mg-5mg), which was initiated on
Sep 01, 2002. Concurrently used drugs:
  • Remicade (A Total Of 50 Doses Administered)
  • Remicade
  • Pentasa (150-500mg)
  • Levofloxacin
  • Remicade (A Total Of 50 Doses Administered)
  • Bio Three (3 Tab-1 Tab)
  • Remicade
  • Loxonin (As Needed)
.After starting to take Primperan Tab the consumer reported adverse symptoms, such as: Pneumonia, Altered State Of Consciousness, Abdominal Pain, Anaemia, Staphylococcal Infection, Melaena, Proctalgia, Rectal Discharge, DehydrationThese side effects may potentially be related to Primperan Tab. The patient was hospitalized.
Primperan Side Effect Report#8376335-7
Abdominal Sepsis
This is a report of a female patient (weight: NA) from Netherlands, suffering from the following health symptoms/conditions: NA, who was treated with Primperan Tab (dosage: NA, start time:
Sep 30, 2011), combined with:
  • Levothyroxine Sodium (25 Microgram)
  • Pantoprazole (40 Milligram)
  • Oxazepam
  • Dexamethasone
  • Seretid (250/50 Ug)
  • Folic Acid (5 Milligram)
  • Revlimid (25 Milligram)
  • Revlimid (25 Milligram)
and developed a serious reaction and side effect(s): Abdominal Sepsis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Primperan Tab treatment in female patients, resulting in Abdominal Sepsis side effect. The patient was hospitalized.
Primperan Side Effect Report#8328529-4
Obstructive Airways Disorder, Sensation Of Pressure, Nervousness, Heart Rate Increased
This report suggests a potential Primperan Tab Obstructive Airways Disorder side effect(s) that can have serious consequences. A 62-year-old female patient (weight: NA) from Sweden was diagnosed with the following symptoms/conditions: NA and used Primperan Tab (dosage: NA) starting
Jul 07, 2011. After starting Primperan Tab the patient began experiencing various side effects, including: Obstructive Airways Disorder, Sensation Of Pressure, Nervousness, Heart Rate IncreasedAdditional drugs used concurrently:
  • Loperamide
  • Tramadol Hydrochloride
  • (alvedon)
  • Docetaxel (Intravenous Drip)
  • Herceptin (Intravenous (not Otherwise Specified))
Although Primperan Tab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Obstructive Airways Disorder, may still occur.
Primperan Side Effect Report#8310066-4
Transaminases Increased, Blood Alkaline Phosphatase Increased, Blood Bilirubin Increased
This Transaminases Increased problem was reported by a physician from Sweden. A 77-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Nov 09, 2011 this consumer started treatment with Primperan Tab (dosage: NA). The following drugs were being taken at the same time:
  • Felodipine
  • Propavan
  • Prednisolone
  • Imovane
  • Arava
  • Alvedon
  • Dimor
When using Primperan Tab, the patient experienced the following unwanted symptoms/side effects: Transaminases Increased, Blood Alkaline Phosphatase Increased, Blood Bilirubin IncreasedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Transaminases Increased, may become evident only after a product is in use by the general population.
Primperan Side Effect Report#8309453-X
Febrile Neutropenia, Sepsis, C-reactive Protein Increased
This Febrile Neutropenia side effect was reported by a health professional from Japan. A female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Primperan Tab (drug dosage: NA), which was initiated on
Nov 20, 2011. Concurrently used drugs:
  • P N Twin-2
  • Albumin (human)
  • Vidaza (75 Milligram/sq. Meter)
  • Irsogladine Maleate
  • Gran
  • Emend
  • Aloxi
  • Minocycline Hydrochloride
.After starting to take Primperan Tab the consumer reported adverse symptoms, such as: Febrile Neutropenia, Sepsis, C-reactive Protein IncreasedThese side effects may potentially be related to Primperan Tab. The patient was hospitalized.
Primperan Side Effect Report#8300226-0
Pulmonary Embolism
This is a report of a 84-year-old male patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: NA, who was treated with Primperan Tab (dosage: Unk, start time:
Jan 31, 2012), combined with:
  • Famotidine (Unk)
  • Estracyt (313.4 Mg, 1x/day)
  • Alendronate Sodium (35 Mg)
  • Calcitriol (Unk)
  • Ebrantil (Unk)
  • Warfarin (5 Mg, 1x/day)
and developed a serious reaction and side effect(s): Pulmonary Embolism after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Primperan Tab treatment in male patients, resulting in Pulmonary Embolism side effect. The patient was hospitalized.
Primperan Side Effect Report#8297261-8
Vomiting, Sinus Bradycardia, Atrioventricular Block Second Degree
This report suggests a potential Primperan Tab Vomiting side effect(s) that can have serious consequences. A 24-year-old male patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: NA and used Primperan Tab (dosage: NA) starting
Mar 06, 2012. After starting Primperan Tab the patient began experiencing various side effects, including: Vomiting, Sinus Bradycardia, Atrioventricular Block Second DegreeAdditional drugs used concurrently:
  • Rebetol (600 Mg;qd;po)
  • Peg-intron (1.5 Mcg/kg;qw;sc)
  • Loxonin
  • Telavic (antivirals Nos) (2250 Mg;qd;po)
  • Mucosta
Although Primperan Tab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Vomiting, may still occur.
Primperan Side Effect Report#8281775-0
Extrapyramidal Disorder, Abasia
This Extrapyramidal Disorder problem was reported by a pharmacist from Japan. A 82-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Nov 15, 2011 this consumer started treatment with Primperan Tab (dosage: NA). The following drugs were being taken at the same time:
  • Pentazocine Lactate
  • Hydroxyzine Pamoate
  • Tramadol Hydrochloride And Acetaminophen
When using Primperan Tab, the patient experienced the following unwanted symptoms/side effects: Extrapyramidal Disorder, AbasiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Extrapyramidal Disorder, may become evident only after a product is in use by the general population.
Primperan Side Effect Report#8278019-2
Disseminated Intravascular Coagulation, Multi-organ Failure, Rhabdomyolysis, Gastroenteritis
This Disseminated Intravascular Coagulation side effect was reported by a physician from Japan. A 75-year-old male patient (weight:NA) experienced the following symptoms/conditions: gastroenteritis.The patient was prescribed Primperan Tab (drug dosage: 30 Mg, 1x/day), which was initiated on
Nov 11, 2011. Concurrently used drugs:
  • Eplerenone (Once Daily)
  • Carvedilol (2.5 Mg, 1x/day)
  • Acardi (2.5 Mg, 1x/day)
  • Medicon (30 Mg, 1x/day)
  • Mucosta (300 Mg, 1x/day)
  • Eplerenone (Once Daily)
  • Eplerenone (Once Daily)
  • Allopurinol (100 Mg, 1x/day)
.After starting to take Primperan Tab the consumer reported adverse symptoms, such as: Disseminated Intravascular Coagulation, Multi-organ Failure, Rhabdomyolysis, GastroenteritisThese side effects may potentially be related to Primperan Tab. The patient was hospitalized.
Primperan Side Effect Report#8263586-5
White Blood Cell Count Decreased, Platelet Count Decreased, Neutrophil Count Decreased
This is a report of a male patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: NA, who was treated with Primperan Tab (dosage: NA, start time:
May 30, 2011), combined with:
  • Gasmotin
  • Vidaza (75 Milligram/sq. Meter)
  • Vidaza (75 Milligram/sq. Meter)
and developed a serious reaction and side effect(s): White Blood Cell Count Decreased, Platelet Count Decreased, Neutrophil Count Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Primperan Tab treatment in male patients, resulting in White Blood Cell Count Decreased side effect.
Primperan Side Effect Report#8261354-1
Irritability, Suspiciousness, Anosognosia, Agitation, Bipolar Disorder, Logorrhoea, Flight Of Ideas, Depression
This report suggests a potential Primperan Tab Irritability side effect(s) that can have serious consequences. A 73-year-old female patient (weight: NA) from France was diagnosed with the following symptoms/conditions: nausea,anxiety,insomnia,pain and used Primperan Tab (dosage: 1 Df 3 Times Daily As Needed) starting
Jan 11, 2012. After starting Primperan Tab the patient began experiencing various side effects, including: Irritability, Suspiciousness, Anosognosia, Agitation, Bipolar Disorder, Logorrhoea, Flight Of Ideas, DepressionAdditional drugs used concurrently:
  • Xanax (Unk)
  • Trimeprazine Tartrate (15 Drops, 1x/day)
  • Acupan (1 Df 6 Times Daily As Needed)
  • Acetaminophen And Tramadol Hcl (Unk)
  • Quetiapine Fumarate (300 Mg, 1x/day)
  • Tramadol Hcl (Unk)
The patient was hospitalized. Although Primperan Tab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Irritability, may still occur.
Primperan Side Effect Report#8249699-2
Nausea, Tremor, Sepsis, Infection, Hyperuricaemia, Erythema Multiforme, Injection Site Reaction, Haemorrhoids, Connective Tissue Disorder
This Nausea problem was reported by a consumer or non-health professional from Japan. A 53-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Dec 21, 2011 this consumer started treatment with Primperan Tab (dosage: NA). The following drugs were being taken at the same time:
  • Magnesium Sulfate
  • Nitrazepam
  • Telavic (telaprevir)
  • Peginterferon
  • Ribavirin
  • Rinderon-vg
  • Zoloft
  • Loxonin
When using Primperan Tab, the patient experienced the following unwanted symptoms/side effects: Nausea, Tremor, Sepsis, Infection, Hyperuricaemia, Erythema Multiforme, Injection Site Reaction, Haemorrhoids, Connective Tissue DisorderThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Nausea, may become evident only after a product is in use by the general population.
Primperan Side Effect Report#8237407-0
Gastrointestinal Perforation
This Gastrointestinal Perforation side effect was reported by a consumer or non-health professional from Japan. A 85-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Primperan Tab (drug dosage: NA), which was initiated on
Dec 01, 2010. Concurrently used drugs:
  • Gemzar
  • Miya-bm (3 D/f, 3/d)
.After starting to take Primperan Tab the consumer reported adverse symptoms, such as: Gastrointestinal PerforationThese side effects may potentially be related to Primperan Tab.
Primperan Side Effect Report#8218470-X
Syncope
This is a report of a female patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: NA, who was treated with Primperan Tab (dosage: 20 Milligram;, start time:
Sep 15, 2011), combined with:
  • Pursennid
  • Emend (80 Milligram;)
  • Lasix (10 Milligram;)
  • Domperidone
  • Pemetrexed (760mg ,every 3 Weeks)
  • Cisplatin (114mg Every 3 Weeks)
  • Panvitan (1 Gram;)
  • Emend (125 Milligram;)
and developed a serious reaction and side effect(s): Syncope after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Primperan Tab treatment in female patients, resulting in Syncope side effect. The patient was hospitalized.
Primperan Side Effect Report#8198194-8
Rhabdomyolysis, Incontinence, Nausea
This report suggests a potential Primperan Tab Rhabdomyolysis side effect(s) that can have serious consequences. A 53-year-old female patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: NA and used Primperan Tab (dosage: Once A Day) starting
Jan 23, 2012. After starting Primperan Tab the patient began experiencing various side effects, including: Rhabdomyolysis, Incontinence, NauseaAdditional drugs used concurrently: NA. Although Primperan Tab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Rhabdomyolysis, may still occur.
Primperan Side Effect Report#8193021-7
Renal Failure Acute, Renal Failure Chronic, Asthenia, Anaemia, Confusional State, Nephrotic Syndrome, Hyperkalaemia, Paraesthesia
This Renal Failure Acute problem was reported by a health professional from France. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Oct 02, 2009 this consumer started treatment with Primperan Tab (dosage: 3 Tablespoon). The following drugs were being taken at the same time:
  • Ventolin
  • Previscan
  • Truvada (.5 Tablet)
  • Rabeprazole Sodium (40 Milligram)
  • Isentress
  • Cymbalta (30 Milligram)
  • Folic Acid (25 Milligram)
  • Oxycodone Hcl (120 Milligram)
When using Primperan Tab, the patient experienced the following unwanted symptoms/side effects: Renal Failure Acute, Renal Failure Chronic, Asthenia, Anaemia, Confusional State, Nephrotic Syndrome, Hyperkalaemia, ParaesthesiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Renal Failure Acute, may become evident only after a product is in use by the general population.
Primperan Side Effect Report#8181291-0
Decreased Appetite
This Decreased Appetite side effect was reported by a physician from Japan. A 59-year-old female patient (weight:NA) experienced the following symptoms/conditions: nausea,cancer pain,non-small cell lung cancer.The patient was prescribed Primperan Tab (drug dosage: 5 Mg, 3x/day), which was initiated on
Sep 27, 2011. Concurrently used drugs:
  • Oxycontin (5 Mg, 2x/day)
  • Crizotinib (250 Mg, 2x/day)
  • Oxycodone Hydrochloride (2.5 Mg, As Needed)
.After starting to take Primperan Tab the consumer reported adverse symptoms, such as: Decreased AppetiteThese side effects may potentially be related to Primperan Tab. The patient was hospitalized.
Primperan Side Effect Report#8170558-8
Arrhythmia, Toxicity To Various Agents, Electrocardiogram Qt Prolonged
This is a report of a 69-year-old female patient (weight: NA) from Denmark, suffering from the following health symptoms/conditions: nausea,atrial fibrillation, who was treated with Primperan Tab (dosage: Unk, start time:
Mar 12, 2009), combined with:
  • Cordarone (200 Mg, Daily)
and developed a serious reaction and side effect(s): Arrhythmia, Toxicity To Various Agents, Electrocardiogram Qt Prolonged after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Primperan Tab treatment in female patients, resulting in Arrhythmia side effect.


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The appearance of Primperan on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Primperan reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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