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Headache (5)
Burning (2)
Burning Eyes (1)
Burning, Painful Rash, Swollen Red Face (1)
Infected Blackhead (1)
Irritated Burning Sensation (1)
Painful Rash (1)
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Proactiv Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 35 

Urticaria, Dyspnoea, Blood Disorder, Pruritus, Rash Macular, Swelling (8445946-2)
on May 22, 2012 Female from UNITED STATES , 19 years of age, was diagnosed with
  • acne
and was treated with Proactiv 30 Day Kit. Directly after, patient experienced the unwanted or unexpected Proactiv side effects: urticaria, dyspnoea, blood disorder, pruritus, rash macular, swelling. Proactiv 30 Day Kit dosage: Twice Daily Dermal.
Associated medications used:
  • Folic Acid
Patient was hospitalized.

Hypersensitivity (8444355-X)
Patient was taking Proactiv 30 Day Kit. Patient felt the following Proactiv side effects: hypersensitivity on May 14, 2012 from UNITED STATES Additional patient health information: Male , 30 years of age, was diagnosed with
  • acne
and. Proactiv 30 Day Kit dosage: Twice Daily Dermal.
Multiple prescriptions taken:
  • Multi-vitamins
  • Ativan
  • Lisinopril
  • Zoloft


Urticaria (8444351-2)
Adverse event was reported on May 11, 2012 by a Female taking Proactiv 30 Day Kit (Dosage: Once Dermal) was diagnosed with
  • acne
and. Location: UNITED STATES , 66 years of age, After Proactiv was administered, patient encountered several Proactiv side effects: urticaria.
Multiple concurrent drugs taken:
  • Allegra
  • Insulin
  • Singulair


Urticaria, Erythema, Dyspnoea, Burning Sensation (8444344-5)
on May 14, 2012 Female from UNITED STATES , 28 years of age, was diagnosed with
  • acne
and was treated with Proactiv 90 Day Kit. Directly after, patient experienced the unwanted or unexpected Proactiv side effects: urticaria, erythema, dyspnoea, burning sensation. Proactiv 90 Day Kit dosage: Once Daily Dermal.


Swelling Face, Eye Swelling, Dyspnoea (8444168-9)
on May 17, 2012 Female from UNITED STATES , 52 years of age, was diagnosed with
  • acne
and was treated with Proactiv Refining Mask. Patient felt the following Proactiv side effects: swelling face, eye swelling, dyspnoea. Proactiv Refining Mask dosage: Once Dermal.

Urticaria, Oedema Peripheral, Swelling Face, Hypersensitivity, Lip Swelling (8397572-1)
Patient was taking Proactiv. After Proactiv was administered, patient encountered several Proactiv side effects: urticaria, oedema peripheral, swelling face, hypersensitivity, lip swelling on May 01, 2012 from UNITED STATES Additional patient health information: Female , 14 years of age, was diagnosed with
  • acne
and. Proactiv dosage: One Dose Dermal.
Multiple concurrent drugs taken:
  • Birth Control Pills


Chemical Injury (8392007-7)
Adverse event was reported on May 25, 2012 by a Female taking Proactive, Cleanser Benzoyl Peroxide 2.5% Guthy/renker (Dosage: Daily, Topical) was diagnosed with
  • acne
and. Location: UNITED STATES , 23 years of age, Directly after, patient experienced the unwanted or unexpected Proactiv side effects: chemical injury. Patient was hospitalized.

Blister, Pain, Eye Swelling, Swelling Face, Rash, Pruritus, Dry Skin, Skin Tightness, Scab (8376465-X)
on Apr 29, 2012 Female from UNITED STATES , 61 years of age, was diagnosed with
  • acne
and was treated with Proactiv. Patient felt the following Proactiv side effects: blister, pain, eye swelling, swelling face, rash, pruritus, dry skin, skin tightness, scab. Proactiv dosage: Once Dermal Daily. Patient was hospitalized.

Eye Swelling, Hypersensitivity, Dyspnoea, Swelling Face, Pruritus, Pharyngeal Oedema (8348823-0)
on Apr 25, 2012 Female from UNITED STATES , 31 years of age, was diagnosed with
  • acne
and was treated with Proactiv90 Day Kit. After Proactiv was administered, patient encountered several Proactiv side effects: eye swelling, hypersensitivity, dyspnoea, swelling face, pruritus, pharyngeal oedema. Proactiv90 Day Kit dosage: Once Daily Oral. Patient was hospitalized.

Swelling Face, Eye Swelling, Nausea, Pruritus (8348821-7)
Patient was taking Proactiv 30. Directly after, patient experienced the unwanted or unexpected Proactiv side effects: swelling face, eye swelling, nausea, pruritus on Apr 22, 2012 from UNITED STATES Additional patient health information: Female , 16 years of age, was diagnosed with
  • acne
and. Proactiv 30 dosage: One Dose Dermal.

Burning Sensation, Urticaria, Hypersensitivity, Erythema (8348817-5)
Adverse event was reported on May 08, 2012 by a Male taking Proactiv (Dosage: 2 Doses Dermally) was diagnosed with
  • acne
and. Location: UNITED STATES , 20 years of age, Patient felt the following Proactiv side effects: burning sensation, urticaria, hypersensitivity, erythema.

Eye Swelling, Swelling Face (8348814-X)
on Apr 18, 2012 Female from UNITED STATES , 21 years of age, was diagnosed with
  • acne
and was treated with Proactiv 90 Day Kit. After Proactiv was administered, patient encountered several Proactiv side effects: eye swelling, swelling face. Proactiv 90 Day Kit dosage: Twice Daily Dermal.

Dyspnoea, Swelling Face, Anaphylactic Shock (8348812-6)
on Apr 14, 2012 Female from UNITED STATES , 18 years of age, was diagnosed with
  • acne
and was treated with Proactiv 90 Day Kit. Directly after, patient experienced the unwanted or unexpected Proactiv side effects: dyspnoea, swelling face, anaphylactic shock. Proactiv 90 Day Kit dosage: One Dose Dermal.

Hypersensitivity, Lip Swelling, Urticaria, Throat Tightness (8322610-1)
Patient was taking Proactiv 30 Day Kit. Patient felt the following Proactiv side effects: hypersensitivity, lip swelling, urticaria, throat tightness on Mar 27, 2012 from UNITED STATES Additional patient health information: Female , 78 years of age, was diagnosed with
  • acne
and. Proactiv 30 Day Kit dosage: Once Daily Dermally.

Swelling Face, Erythema, Rash, Pruritus (8322601-0)
Adverse event was reported on Apr 07, 2012 by a Female taking Proactiv 90 Day Kit (Dosage: Once Daily, Dermal) was diagnosed with
  • acne
and. Location: UNITED STATES , 40 years of age, After Proactiv was administered, patient encountered several Proactiv side effects: swelling face, erythema, rash, pruritus. Patient was hospitalized.

Pharyngeal Oedema, Swelling Face, Urticaria (8322597-1)
on Apr 05, 2012 Female from UNITED STATES , 30 years of age, was diagnosed with
  • acne
and was treated with Proactiv 30 Day Kit. Directly after, patient experienced the unwanted or unexpected Proactiv side effects: pharyngeal oedema, swelling face, urticaria. Proactiv 30 Day Kit dosage: One Dose Dermal.

Weight Decreased, Blood Count Abnormal, Burning Sensation, Malaise, Erythema, Pyrexia (8322592-2)
on Apr 14, 2012 Male from UNITED STATES , 50 years of age, was diagnosed with
  • acne
and was treated with Proactiv. Patient felt the following Proactiv side effects: weight decreased, blood count abnormal, burning sensation, malaise, erythema, pyrexia. Proactiv dosage: 1 Dcose Dermal Bid. Patient was hospitalized.

Application Site Pain, Application Site Urticaria (8282529-1)
Patient was taking Proactiv 90day Kit. After Proactiv was administered, patient encountered several Proactiv side effects: application site pain, application site urticaria on Mar 21, 2012 from UNITED STATES Additional patient health information: Female , 31 years of age, was diagnosed with
  • acne
and. Proactiv 90day Kit dosage: One Use Dermal.

Burning Sensation, Pruritus, Hypersensitivity, Rash, Chemical Injury (8257191-4)
Adverse event was reported on Mar 30, 2012 by a Female taking Proactiv Solution Katie Rodan + Kathy Fields (Dosage: Small Once A Day 049) was diagnosed with
  • acne
and. Location: UNITED STATES , weighting 105.0 lb, Directly after, patient experienced the unwanted or unexpected Proactiv side effects: burning sensation, pruritus, hypersensitivity, rash, chemical injury.

Throat Tightness, Face Oedema (8220425-6)
on Feb 27, 2012 Male from UNITED STATES , 21 years of age, was diagnosed with
  • acne
and was treated with Proactiv 90 Day Kit. Patient felt the following Proactiv side effects: throat tightness, face oedema. Proactiv 90 Day Kit dosage: Daily. Patient was hospitalized.

Cellulitis (8158411-7)
on Jan 03, 2012 Male from UNITED STATES , 34 years of age, was diagnosed with
  • acne
and was treated with Proactiv Cleanser 2.5% Benzoyl Peroxide Guthy/renker. After Proactiv was administered, patient encountered several Proactiv side effects: cellulitis. Proactiv Cleanser 2.5% Benzoyl Peroxide Guthy/renker dosage: Daily, Topical.
Multiple concurrent drugs taken:
  • Proactiv Lotion 2.5% Benzoyl Peroxide Buthy|renker (Daily, Topical)


Swelling, Convulsion, Urticaria (8158365-3)
Patient was taking Proactiv 90 Day Kit (pa90). Directly after, patient experienced the unwanted or unexpected Proactiv side effects: swelling, convulsion, urticaria on Feb 07, 2012 from UNITED STATES Additional patient health information: Male , 14 years of age, was diagnosed with
  • acne
and. Proactiv 90 Day Kit (pa90) dosage: Daily. Patient was hospitalized.

Urticaria (8158359-8)
Adverse event was reported on Jan 07, 2012 by a Female taking Proactiv 30 Day Kit (Dosage: N/A) was diagnosed with
  • acne
and. Location: UNITED STATES , 14 years of age, Patient felt the following Proactiv side effects: urticaria. Patient was hospitalized.

Chemical Injury (8048551-5)
on Jan 13, 2012 Female from UNITED STATES , 23 years of age, was diagnosed with
  • acne
and was treated with Proactiv,cleanser Benzoyl Peroxide 2.5% Guthy|renker. After Proactiv was administered, patient encountered several Proactiv side effects: chemical injury. Proactiv,cleanser Benzoyl Peroxide 2.5% Guthy|renker dosage: Daily, Topical.
Multiple concurrent drugs taken:
  • Proactiv,lotion Benzoyl Peroxide 2.5% Guthy|renker (Daily, Topical)
Patient was hospitalized.

Incoherent, Confusional State, Feeling Drunk, Disorientation (7678308-6)
on Aug 02, 2011 Female from UNITED STATES , weighting 59.99 lb, was diagnosed with
  • gastric disorder
  • pain in extremity
and was treated with Proactive Enzymes. Directly after, patient experienced the unwanted or unexpected Proactiv side effects: incoherent, confusional state, feeling drunk, disorientation. Proactive Enzymes dosage: Unk, Daily.

Showing 1-25 of 35 

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It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Proactiv Information

Alternative PROACTIV Names:AVOBENZON BENZOYL P HYDROCORT HYDROQUIN OCTINOXAT PYRITHION SALICYLIC SULFUR

Active Ingredient: AVOBENZON BENZOYL P HYDROCORT HYDROQUIN OCTINOXAT PYRITHION SALICYLIC SULFUR

More About Proactiv

Side Effects reported to FDA: 35. View Proactiv Adverse Reports

Proactiv safety alerts: No

Reported hospitalizations: 2

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