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Proactiv Side Effects

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Common Proactiv Side Effects


The most commonly reported Proactiv side effects (click to view or check a box to report):

Swelling Face (95)
Urticaria (66)
Dyspnoea (61)
Pruritus (50)
Erythema (50)
Eye Swelling (45)
Hypersensitivity (36)
Rash (28)
Swelling (23)
Burning Sensation (23)
Lip Swelling (21)
Throat Tightness (20)
Local Swelling (14)
Pharyngeal Oedema (11)
Dry Skin (10)
Blister (6)
Swollen Tongue (6)
Rash Erythematous (6)
Paraesthesia (5)
Pyrexia (5)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Proactiv Side Effects Reported to FDA



Proactiv Side Effect Report#9994678
Erythema, Pruritus, Swelling
This is a report of a 22-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: acne, who was treated with Proactiv Renewing Cleanser (dosage: Once Daily Dermal, start time:
Feb 08, 2014), combined with:
  • Proactiv Repairing Treatment (Once Daily Dermal)
and developed a serious reaction and side effect(s): Erythema, Pruritus, Swelling after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Proactiv Renewing Cleanser treatment in female patients, resulting in Erythema side effect.
Proactiv Side Effect Report#9989187
Rash, Lip Swelling
This report suggests a potential Proactiv Renewing Cleanser Rash side effect(s) that can have serious consequences. A 14-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: acne and used Proactiv Renewing Cleanser (dosage: Dermal) starting
Sep 05, 2013. After starting Proactiv Renewing Cleanser the patient began experiencing various side effects, including: Rash, Lip SwellingAdditional drugs used concurrently:
  • Proactiv Repairing Treatment (Dermal)
  • Proactiv Deep Cleansing Wash (Dermal)
  • Proactiv Advanced Blemish Treatment (Dermal)
  • Proactiv Refining Mask (Dermal)
Although Proactiv Renewing Cleanser demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Rash, may still occur.
Proactiv Side Effect Report#9925693
Swelling Face, Urticaria
This Swelling Face problem was reported by a consumer or non-health professional from US. A 31-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: acne. On
Dec 01, 2013 this consumer started treatment with Proactiv Renewing Cleanser (dosage: Dermal). The following drugs were being taken at the same time:
  • Proactiv Repairing Treatment (Dermal)
  • Fish Oil
When using Proactiv Renewing Cleanser, the patient experienced the following unwanted symptoms/side effects: Swelling Face, UrticariaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Swelling Face, may become evident only after a product is in use by the general population.
Proactiv Side Effect Report#9912635
Erythema, Swelling, Rash
This Erythema side effect was reported by a consumer or non-health professional from US. A 18-year-old female patient (weight:NA) experienced the following symptoms/conditions: acne.The patient was prescribed Proactiv + Skin Smoothing Exfoliator (drug dosage: NA), which was initiated on
Oct 28, 2013. Concurrently used drugs:
  • Proactiv Plus Pore Targeting Treatment
  • Proactiv + Complexion Perfecting Hydrator
  • Proactiv + Eye Brightening Serum
  • Proactiv+mark Fading Pads
.After starting to take Proactiv + Skin Smoothing Exfoliator the consumer reported adverse symptoms, such as: Erythema, Swelling, RashThese side effects may potentially be related to Proactiv + Skin Smoothing Exfoliator.
Proactiv Side Effect Report#9870352
Swelling Face, Eye Swelling, Hypersensitivity
This is a report of a 24-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: acne, who was treated with Proactiv+ Skin Exfoliator (dosage: Twice Daily Dermal, start time:
Jan 03, 2014), combined with:
  • Pore Targeting Treatment
  • Proactiv+ Complexion Perfecting Hydrator (Twice Daily Dermal)
  • Mark Fading Pads (Twice Daily Dermal)
  • Cosmetics (Twice Daily Dermal)
  • Skin Purifying Mask (Twice Daily Dermal)
and developed a serious reaction and side effect(s): Swelling Face, Eye Swelling, Hypersensitivity after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Proactiv+ Skin Exfoliator treatment in female patients, resulting in Swelling Face side effect.
Proactiv Side Effect Report#9820172
Hypersensitivity
This report suggests a potential Proactiv Acne Cleanser Hypersensitivity side effect(s) that can have serious consequences. A 28-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Proactiv Acne Cleanser (dosage: NA) starting
Jan 09, 2014. After starting Proactiv Acne Cleanser the patient began experiencing various side effects, including: HypersensitivityAdditional drugs used concurrently: NA. Although Proactiv Acne Cleanser demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypersensitivity, may still occur.
Proactiv Side Effect Report#9813606
Swelling Face, Eye Swelling, Dyspnoea, Throat Tightness, Erythema, Pruritus
This Swelling Face problem was reported by a consumer or non-health professional from US. A 23-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: acne. On
Dec 04, 2013 this consumer started treatment with Proactiv Repairing Treatment (dosage: Once Daily Dermal). The following drugs were being taken at the same time:
  • Birth Control
When using Proactiv Repairing Treatment, the patient experienced the following unwanted symptoms/side effects: Swelling Face, Eye Swelling, Dyspnoea, Throat Tightness, Erythema, PruritusAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Swelling Face, may become evident only after a product is in use by the general population.
Proactiv Side Effect Report#9813564
Pruritus, Swelling Face, Eye Swelling, Throat Irritation
This Pruritus side effect was reported by a consumer or non-health professional from US. A 19-year-old female patient (weight:NA) experienced the following symptoms/conditions: acne.The patient was prescribed Proactiv+ Skin Smoothing Exfoliator (drug dosage: Twice Daily Dermal), which was initiated on
Dec 17, 2013. Concurrently used drugs:
  • Proactiv+ Pore Targeting Treatment (Twice Daily Dermal)
.After starting to take Proactiv+ Skin Smoothing Exfoliator the consumer reported adverse symptoms, such as: Pruritus, Swelling Face, Eye Swelling, Throat IrritationThese side effects may potentially be related to Proactiv+ Skin Smoothing Exfoliator.
Proactiv Side Effect Report#9786493
Swelling, Pruritus, Eye Pruritus, Blister
This is a report of a 19-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: acne, who was treated with Proactiv Renewing Cleanser (dosage: Once Daily Dermal, start time:
Dec 06, 2013), combined with:
  • Proactiv Repairing Treatment (Once Daily Dermal)
  • Proactiv Advanced Daily Oiil Control (Once Daily Dermal)
  • Proactiv Spf 15 Moisturizer (Once Daily Dermal)
  • Proactiv Refining Mask (Once Daily Dermal)
and developed a serious reaction and side effect(s): Swelling, Pruritus, Eye Pruritus, Blister after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Proactiv Renewing Cleanser treatment in male patients, resulting in Swelling side effect.
Proactiv Side Effect Report#9786476
Urticaria, Dyspnoea, Respiratory Arrest
This report suggests a potential Proactiv Renewing Cleanser Urticaria side effect(s) that can have serious consequences. A 33-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: acne and used Proactiv Renewing Cleanser (dosage: Once Daily Dermal) starting
Jun 13, 2013. After starting Proactiv Renewing Cleanser the patient began experiencing various side effects, including: Urticaria, Dyspnoea, Respiratory ArrestAdditional drugs used concurrently:
  • Proactiv Repairing Treatment (Once Daily Dermal)
  • Proactiv Advanced Daily Oil Control (Once Daily Dermal)
  • Proactiv Spf 15 Moisturizer (Once Daily Dermal)
Although Proactiv Renewing Cleanser demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Urticaria, may still occur.
Proactiv Side Effect Report#9748474
Swelling Face, Dyspnoea
This Swelling Face problem was reported by a health professional from US. A 15-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: acne. On
Nov 21, 2013 this consumer started treatment with Proactiv+ Skin Smoothing Exfoliator (dosage: Once Dermal). The following drugs were being taken at the same time:
  • Daily Multivitamin
When using Proactiv+ Skin Smoothing Exfoliator, the patient experienced the following unwanted symptoms/side effects: Swelling Face, DyspnoeaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Swelling Face, may become evident only after a product is in use by the general population.
Proactiv Side Effect Report#9747587
Swelling Face, Eye Swelling, Skin Haemorrhage, Skin Fissures
This Swelling Face side effect was reported by a consumer or non-health professional from US. A 20-year-old female patient (weight:NA) experienced the following symptoms/conditions: acne.The patient was prescribed Proactiv Renewing Cleanser (drug dosage: Twice Daily Dermal), which was initiated on
Sep 26, 2013. Concurrently used drugs:
  • Proactive Repairing Treatment (Twice Daily Dermal)
  • Proactiv Advanced Daily Oil Control (Twice Daily Dermal)
  • Proactiv Spf 15 Moisturizer (Twice Daily Dermal)
.After starting to take Proactiv Renewing Cleanser the consumer reported adverse symptoms, such as: Swelling Face, Eye Swelling, Skin Haemorrhage, Skin FissuresThese side effects may potentially be related to Proactiv Renewing Cleanser. The patient was hospitalized.
Proactiv Side Effect Report#9747576
Swelling Face, Rash Erythematous, Urticaria
This is a report of a 27-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: acne, who was treated with Proactiv Renewing Cleanser (dosage: Dermal, start time:
Oct 07, 2013), combined with:
  • Proactiv Repairing Treatment (Dermal)
  • Proactiv Advanced Daily Oil Control (Dermal)
  • Proactiv Blackhead Dissolving Gel (Dermal)
and developed a serious reaction and side effect(s): Swelling Face, Rash Erythematous, Urticaria after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Proactiv Renewing Cleanser treatment in female patients, resulting in Swelling Face side effect.
Proactiv Side Effect Report#9747573
Eye Swelling, Rash Erythematous, Hypersensitivity, Rash Pruritic
This report suggests a potential Proactiv Plus Skin Smoothing Exfoliator Eye Swelling side effect(s) that can have serious consequences. A 27-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: acne and used Proactiv Plus Skin Smoothing Exfoliator (dosage: Once Daily Dermal) starting
Nov 11, 2013. After starting Proactiv Plus Skin Smoothing Exfoliator the patient began experiencing various side effects, including: Eye Swelling, Rash Erythematous, Hypersensitivity, Rash PruriticAdditional drugs used concurrently:
  • Pore Targeting Treatment (Once Daily Dermal)
  • Proactiv Plus Complexion Perfecting Hydrator (Once Daily Dermal)
  • Skin Purifying Mask (Once Daily Dermal)
Although Proactiv Plus Skin Smoothing Exfoliator demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Eye Swelling, may still occur.
Proactiv Side Effect Report#9747534
Skin Irritation, Cough, Respiratory Disorder
This Skin Irritation problem was reported by a consumer or non-health professional from US. A 35-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: acne. On
Nov 11, 2013 this consumer started treatment with Proactiv+ Skin Smoothing Exfoliator (dosage: Dermal Twice Daily). The following drugs were being taken at the same time:
  • Proactiv+ Pore Targeting Treatment (Dermal Twice Daily)
  • Proactiv+ Complexion Perfecting Hydrator (Dermal Twice Daily)
  • Proactiv+ Mark Fading Pads (Dermal Twice Daily)
When using Proactiv+ Skin Smoothing Exfoliator, the patient experienced the following unwanted symptoms/side effects: Skin Irritation, Cough, Respiratory DisorderThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Skin Irritation, may become evident only after a product is in use by the general population.
Proactiv Side Effect Report#9747533
Erythema, Urticaria, Pruritus, Burning Sensation
This Erythema side effect was reported by a consumer or non-health professional from US. A 12-year-old female patient (weight:NA) experienced the following symptoms/conditions: acne.The patient was prescribed Proactiv+ Skin Smoothing Exfoliator (drug dosage: Twice Daily Dermal), which was initiated on
Nov 07, 2013. Concurrently used drugs:
  • Proactiv Pore Cleansing System (Once Daily Dermal)
  • Proactiv+ Complexion Perfecting Hydrator (Once Daily Dermal)
.After starting to take Proactiv+ Skin Smoothing Exfoliator the consumer reported adverse symptoms, such as: Erythema, Urticaria, Pruritus, Burning SensationThese side effects may potentially be related to Proactiv+ Skin Smoothing Exfoliator.
Proactiv Side Effect Report#9718953
Pruritus, Rash Erythematous, Purpura, Swelling Face, Burning Sensation
This is a report of a 54-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: acne, who was treated with Proactiv Renewing Cleanser (dosage: Once Daily Dermal, start time:
Oct 25, 2013), combined with:
  • Proactiv Repairing Treatment (Once Daily Dermal)
  • Proactiv Advanced Daily Oil Control (Once Daily Dermal)
  • Proactiv Spf 15 Moisturizer (Once Daily Dermal)
  • Daily Multivitamins
and developed a serious reaction and side effect(s): Pruritus, Rash Erythematous, Purpura, Swelling Face, Burning Sensation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Proactiv Renewing Cleanser treatment in female patients, resulting in Pruritus side effect. The patient was hospitalized.
Proactiv Side Effect Report#9718220
Erythema, Swelling, Urticaria
This report suggests a potential Proactiv Plus Skin Smoothing Exfoliator Erythema side effect(s) that can have serious consequences. A 25-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: acne and used Proactiv Plus Skin Smoothing Exfoliator (dosage: Once Daily Dermal) starting
Nov 05, 2013. After starting Proactiv Plus Skin Smoothing Exfoliator the patient began experiencing various side effects, including: Erythema, Swelling, UrticariaAdditional drugs used concurrently:
  • Proactiv Plus Pore Targeting Treatment (Once Daily Dermal)
  • Proactiv Plus Complexion Perfecting Hydrator
  • Daily Multivitamins
Although Proactiv Plus Skin Smoothing Exfoliator demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Erythema, may still occur.
Proactiv Side Effect Report#9718210
Rash Pruritic, Rash Erythematous, Dyspnoea, Swelling
This Rash Pruritic problem was reported by a consumer or non-health professional from US. A 15-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: acne. On
Jul 13, 2013 this consumer started treatment with Proactiv Renewing Cleanser (dosage: Once Daily Dermal). The following drugs were being taken at the same time:
  • Proactiv Repairing Treatment (Once Daily Dermal)
  • Urinary Antibiotic
When using Proactiv Renewing Cleanser, the patient experienced the following unwanted symptoms/side effects: Rash Pruritic, Rash Erythematous, Dyspnoea, SwellingAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Rash Pruritic, may become evident only after a product is in use by the general population.
Proactiv Side Effect Report#9698304
Rash Pruritic
This Rash Pruritic side effect was reported by a consumer or non-health professional from PR. A 16-year-old male patient (weight:NA) experienced the following symptoms/conditions: acne.The patient was prescribed Proactiv Renewing Cleanser (drug dosage: Twice Daily Dermal), which was initiated on
Sep 03, 2013. Concurrently used drugs:
  • Proactiv Repairing Treatment (Twice Daily Dermal)
  • Proactiv Deep Cleansing Wash (Twice Daily Dermal)
  • Proactiv Advanced Blemish Treatment
.After starting to take Proactiv Renewing Cleanser the consumer reported adverse symptoms, such as: Rash PruriticThese side effects may potentially be related to Proactiv Renewing Cleanser.
Proactiv Side Effect Report#9698273
Rash, Swelling Face, Sunburn
This is a report of a 12-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: acne, who was treated with Proactiv Solution Renewing Cleanser (dosage: Once Daily Dermal, start time:
Jul 06, 2013), combined with:
  • Proactiv Solution Repairing Treatment (Once Daily Dermal)
  • Proactiv Solution Deep Cleansing Wash (Once Daily Dermal)
  • Proactiv Solution Blackhead Dissolving Gel (Once Daily Dermal)
  • Proactiv Solutions Advanced Blemish Treatment (Once Daily Dermal)
  • Vitaclear Vitamin Supplement
and developed a serious reaction and side effect(s): Rash, Swelling Face, Sunburn after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Proactiv Solution Renewing Cleanser treatment in female patients, resulting in Rash side effect.
Proactiv Side Effect Report#9676172
Swelling Face, Eye Swelling
This report suggests a potential Proactiv Renewing Cleanser Swelling Face side effect(s) that can have serious consequences. A 13-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: acne and used Proactiv Renewing Cleanser (dosage: Once Daily Dermal) starting
Sep 25, 2013. After starting Proactiv Renewing Cleanser the patient began experiencing various side effects, including: Swelling Face, Eye SwellingAdditional drugs used concurrently:
  • Proactiv Repairing Treatment (Once Daily Dermal)
  • Multivitamins
Although Proactiv Renewing Cleanser demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Swelling Face, may still occur.
Proactiv Side Effect Report#9675884
Rash, Swelling Face, Infection, Scratch, Pneumonia, Bacteraemia
This Rash problem was reported by a consumer or non-health professional from US. A 40-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: acne. On
Oct 02, 2013 this consumer started treatment with Proactiv Renewing Cleanser (dosage: Twice Daily Dermal). The following drugs were being taken at the same time:
  • Proactiv Repairing Treatment (Twice Daily Dermal)
When using Proactiv Renewing Cleanser, the patient experienced the following unwanted symptoms/side effects: Rash, Swelling Face, Infection, Scratch, Pneumonia, BacteraemiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Rash, may become evident only after a product is in use by the general population.
Proactiv Side Effect Report#9668146
Swelling Face, Pruritus, Erythema, Dyspnoea, Urticaria, Panic Attack
This Swelling Face side effect was reported by a health professional from US. A 31-year-old female patient (weight:NA) experienced the following symptoms/conditions: acne.The patient was prescribed Proactiv Renewing Cleanser (drug dosage: Once Daily Dermal), which was initiated on
Jul 09, 2013. Concurrently used drugs:
  • Proactiv Repairing Treatment (Once Daily Dermal)
  • Proactiv Deep Cleansing Wash (Once Daily Dermal)
  • Proactiv Advanced Blemish Treatment (Once Daily Dermal)
.After starting to take Proactiv Renewing Cleanser the consumer reported adverse symptoms, such as: Swelling Face, Pruritus, Erythema, Dyspnoea, Urticaria, Panic AttackThese side effects may potentially be related to Proactiv Renewing Cleanser.
Proactiv Side Effect Report#9668117
Swelling Face, Urticaria
This is a report of a 15-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: acne, who was treated with Proactiv Renewing Cleanser (dosage: Once Daily Dermal, start time: 201310), combined with:
  • Proactiv Repairing Treatment (Oce Daily Dermal)
  • Proactiv Deep Cleansing Wash (Once Daily Dermal)
  • Proactiv Advanced Blemish Treatment (Once Daily Dermal)
  • Proactiv Blackhead Dissolving Gel (Once Daily Dermal)
and developed a serious reaction and side effect(s): Swelling Face, Urticaria after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Proactiv Renewing Cleanser treatment in male patients, resulting in Swelling Face side effect.


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The appearance of Proactiv on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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What are common Proactiv Side Effects for Women?

Women Side EffectsReports
Swelling Face 82
Urticaria 55
Dyspnoea 51
Pruritus 46
Erythema 42
Eye Swelling 42
Hypersensitivity 26
Rash 23
Swelling 20
Burning Sensation 19

What are common Proactiv Side Effects for Men?

Men Side EffectsReports
Swelling Face 13
Urticaria 11
Dyspnoea 10
Hypersensitivity 9
Erythema 8
Dizziness 5
Burning Sensation 4
Pruritus 4
Rash 4
Eye Swelling 3

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Proactiv reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Discuss Proactiv Side Effects

    Did You Have a Proactiv Side Effect?

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    How Effective is Proactiv for You?

    Exceeded Expectations
    Effective
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    Not Effective

    Proactiv Safety Alerts, Active Ingredients, Usage Information

    NDC11118-1209
    TypeHUMAN OTC DRUG
    Proprietary NameProactive Solution Cleaning Bar
    NameSALICYLIC ACID
    Dosage FormSOAP
    RouteTOPICAL
    On market since20100901
    LabelerBradford Soap Works, Inc.
    Active Ingredient(s)SALICYLIC ACID
    Strength(s)1
    Unit(s)g/100g
    Pharma Class

    More About Proactiv

    Side Effects reported to FDA: 209

    Proactiv safety alerts: No

    Reported hospitalizations: 19

    Latest Proactiv clinical trials