Common Propafenone Side Effects


The most commonly reported Propafenone side effects (click to view or check a box to report):

Atrial Fibrillation (74)
Dizziness (54)
Product Quality Issue (47)
Hypotension (47)
Bradycardia (38)
Cardiac Arrest (34)
Asthenia (32)
Nausea (32)
Fall (32)
Electrocardiogram Qrs Complex Prolonged (31)
Arrhythmia (27)
Completed Suicide (25)
Syncope (25)
Dyspnoea (24)
Vomiting (23)
Headache (22)
Diarrhoea (21)
Fatigue (21)
Convulsion (20)
Blood Pressure Increased (19)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Propafenone Side Effects Reported to FDA



Propafenone Side Effect Report#9819756
Completed Suicide
This is a report of a 43-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Propafenone Hcl Er (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Completed Suicide after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Propafenone Hcl Er treatment in male patients, resulting in Completed Suicide side effect.
Propafenone Side Effect Report#9819755
Completed Suicide, Cardio-respiratory Arrest
This report suggests a potential Propafenone Hcl Er Completed Suicide side effect(s) that can have serious consequences. A 19-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Propafenone Hcl Er (dosage: NA) starting NS. After starting Propafenone Hcl Er the patient began experiencing various side effects, including: Completed Suicide, Cardio-respiratory ArrestAdditional drugs used concurrently: NA. Although Propafenone Hcl Er demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Completed Suicide, may still occur.
Propafenone Side Effect Report#9745781
Coma, Grand Mal Convulsion, Suicide Attempt, Somnolence, Arrhythmia, Hypotension, Nodal Rhythm, Electrocardiogram Qrs Complex Prolonged
This Coma problem was reported by a physician from Country Not Specified. A 13-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Propafenone (dosage: 13 Tablets Of 150mg: 1950 Mg Taken Once). The following drugs were being taken at the same time: NA. When using Propafenone, the patient experienced the following unwanted symptoms/side effects: Coma, Grand Mal Convulsion, Suicide Attempt, Somnolence, Arrhythmia, Hypotension, Nodal Rhythm, Electrocardiogram Qrs Complex ProlongedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Coma, may become evident only after a product is in use by the general population.
Propafenone Side Effect Report#9736452
Heart Rate Decreased, Abdominal Distension, Fluid Retention, Weight Increased, Heart Rate Increased
This Heart Rate Decreased side effect was reported by a consumer or non-health professional from US. A 34-year-old male patient (weight:NA) experienced the following symptoms/conditions: atrial fibrillation.The patient was prescribed Propafenone Hydrochloride (drug dosage: 225mg Twice Per Day), which was initiated on 201107. Concurrently used drugs:
  • Rythmol Sr (325mg Twice Per Day)
  • Rythmol Sr (425mg Three Times Per Day)
  • Blood Thinner
  • Atenolol
  • Diuretic
.After starting to take Propafenone Hydrochloride the consumer reported adverse symptoms, such as: Heart Rate Decreased, Abdominal Distension, Fluid Retention, Weight Increased, Heart Rate IncreasedThese side effects may potentially be related to Propafenone Hydrochloride.
Propafenone Side Effect Report#9736449
Extrasystoles, Heart Rate Increased
This is a report of a 68-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: arrhythmia, who was treated with Propafenone Hydrochloride (dosage: 150mg Three Times Per Day, start time: 2010), combined with:
  • Metoprolol
  • Simvastatin
  • Coumadin
and developed a serious reaction and side effect(s): Extrasystoles, Heart Rate Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Propafenone Hydrochloride treatment in female patients, resulting in Extrasystoles side effect.
Propafenone Side Effect Report#9723694
Brugada Syndrome, Electrocardiogram St Segment Elevation, Electrocardiogram Qrs Complex Abnormal, Electrocardiogram T Wave Inversion
This report suggests a potential Propafenone Brugada Syndrome side effect(s) that can have serious consequences. A 58-year-old male patient (weight: NA) from GR was diagnosed with the following symptoms/conditions: cardioversion and used Propafenone (dosage: 600mg Per Day) starting NS. After starting Propafenone the patient began experiencing various side effects, including: Brugada Syndrome, Electrocardiogram St Segment Elevation, Electrocardiogram Qrs Complex Abnormal, Electrocardiogram T Wave InversionAdditional drugs used concurrently:
  • Verapamil
Although Propafenone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Brugada Syndrome, may still occur.
Propafenone Side Effect Report#9707175
Atrial Fibrillation
This Atrial Fibrillation problem was reported by a pharmacist from US. A 54-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Propafenone (dosage: NA). The following drugs were being taken at the same time: NA. When using Propafenone, the patient experienced the following unwanted symptoms/side effects: Atrial FibrillationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Atrial Fibrillation, may become evident only after a product is in use by the general population.
Propafenone Side Effect Report#9681168
Lethargy, Somnolence, Abdominal Pain, Diarrhoea
This Lethargy side effect was reported by a physician from US. A 74-year-old female patient (weight:NA) experienced the following symptoms/conditions: atrial fibrillation,prophylaxis,hypercholesterolaemia.The patient was prescribed Propafenone Hydrochloride Tablets 150mg (drug dosage: NA), which was initiated on
Aug 08, 2011. Concurrently used drugs:
  • Asa
  • Crestor
.After starting to take Propafenone Hydrochloride Tablets 150mg the consumer reported adverse symptoms, such as: Lethargy, Somnolence, Abdominal Pain, DiarrhoeaThese side effects may potentially be related to Propafenone Hydrochloride Tablets 150mg.
Propafenone Side Effect Report#9681163
Muscular Weakness
This is a report of a 73-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: atrial fibrillation, who was treated with Propafenone Hydrochloride Tablets 225mg (dosage: NA, start time: 201104), combined with: NA. and developed a serious reaction and side effect(s): Muscular Weakness after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Propafenone Hydrochloride Tablets 225mg treatment in female patients, resulting in Muscular Weakness side effect.
Propafenone Side Effect Report#9681162
Palpitations
This report suggests a potential Propafenone Hydrochloride Tablets 225mg Palpitations side effect(s) that can have serious consequences. A 61-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Propafenone Hydrochloride Tablets 225mg (dosage: NA) starting
Jul 16, 2012. After starting Propafenone Hydrochloride Tablets 225mg the patient began experiencing various side effects, including: PalpitationsAdditional drugs used concurrently: NA. Although Propafenone Hydrochloride Tablets 225mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Palpitations, may still occur.
Propafenone Side Effect Report#9681159
Malaise
This Malaise problem was reported by a consumer or non-health professional from US. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: atrial fibrillation,arthritis. On 2012 this consumer started treatment with Propafenone Hydrochloride Tablets 300mg (dosage: NA). The following drugs were being taken at the same time:
  • Cymbalta
When using Propafenone Hydrochloride Tablets 300mg, the patient experienced the following unwanted symptoms/side effects: MalaiseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Malaise, may become evident only after a product is in use by the general population.
Propafenone Side Effect Report#9649226
Suicide Attempt, Cardiac Arrest, Pulse Absent, Loss Of Consciousness, Pupils Unequal, Apnoea, Rhythm Idioventricular, Electrocardiogram Qrs Complex Prolonged, Ventricular Arrhythmia
This Suicide Attempt side effect was reported by a health professional from TR. A 18-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Propafenone (drug dosage: 30 Df, Unk), which was initiated on NS. Concurrently used drugs:
  • Captopril (20 Df, Unk)
.After starting to take Propafenone the consumer reported adverse symptoms, such as: Suicide Attempt, Cardiac Arrest, Pulse Absent, Loss Of Consciousness, Pupils Unequal, Apnoea, Rhythm Idioventricular, Electrocardiogram Qrs Complex Prolonged, Ventricular ArrhythmiaThese side effects may potentially be related to Propafenone. The patient was hospitalized.
Propafenone Side Effect Report#9648576
Anaphylactic Shock
This is a report of a 68-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: arrhythmia, who was treated with Propafenone Hydrochloride Tablets (propafenone Hydrochloride) (tablets) (dosage: Unk, start time: 2010), combined with: NA. and developed a serious reaction and side effect(s): Anaphylactic Shock after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Propafenone Hydrochloride Tablets (propafenone Hydrochloride) (tablets) treatment in female patients, resulting in Anaphylactic Shock side effect.
Propafenone Side Effect Report#9646289
Ventricular Arrhythmia, Electrocardiogram Qrs Complex Prolonged, Cardiac Arrest, Haemodynamic Instability, Toxicity To Various Agents, Intentional Overdose
This report suggests a potential Propafenone Ventricular Arrhythmia side effect(s) that can have serious consequences. A 18-year-old female patient (weight: NA) from TR was diagnosed with the following symptoms/conditions: intentional overdose and used Propafenone (dosage: 30 X 300mg) starting NS. After starting Propafenone the patient began experiencing various side effects, including: Ventricular Arrhythmia, Electrocardiogram Qrs Complex Prolonged, Cardiac Arrest, Haemodynamic Instability, Toxicity To Various Agents, Intentional OverdoseAdditional drugs used concurrently:
  • Captopril (20 X 50mg)
The patient was hospitalized. Although Propafenone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Ventricular Arrhythmia, may still occur.
Propafenone Side Effect Report#9643612
Hepatotoxicity, Jaundice
This Hepatotoxicity problem was reported by a physician from LB. A 67-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: atrial fibrillation. On NS this consumer started treatment with Propafenone (dosage: 300mg Per Day). The following drugs were being taken at the same time: NA. When using Propafenone, the patient experienced the following unwanted symptoms/side effects: Hepatotoxicity, JaundiceAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hepatotoxicity, may become evident only after a product is in use by the general population.
Propafenone Side Effect Report#9571324
Vision Blurred
This Vision Blurred side effect was reported by a consumer or non-health professional from US. A 58-year-old male patient (weight:NA) experienced the following symptoms/conditions: atrial fibrillation.The patient was prescribed Propafenone Hcl Er (drug dosage: NA), which was initiated on 201112. Concurrently used drugs: NA..After starting to take Propafenone Hcl Er the consumer reported adverse symptoms, such as: Vision BlurredThese side effects may potentially be related to Propafenone Hcl Er.
Propafenone Side Effect Report#9518401
Cardiac Failure Congestive, Blood Pressure Increased
This is a report of a 71-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: arrhythmia, who was treated with Propafenone (dosage: 150mg Tid Po, start time:
Jun 19, 2013), combined with:
  • Flecainide (50 Mg Bid Po)
  • Advair
  • Proair
  • Warfarin
and developed a serious reaction and side effect(s): Cardiac Failure Congestive, Blood Pressure Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Propafenone treatment in male patients, resulting in Cardiac Failure Congestive side effect.
Propafenone Side Effect Report#9441210
Brugada Syndrome, Hypotension, Bundle Branch Block Right, Electrocardiogram St Segment Elevation, Electrocardiogram St Segment Depression, Chest Pain, Palpitations, Atrial Fibrillation
This report suggests a potential Propafenone Hydrochloride Brugada Syndrome side effect(s) that can have serious consequences. A 62-year-old male patient (weight: NA) from TR was diagnosed with the following symptoms/conditions: atrial fibrillation and used Propafenone Hydrochloride (dosage: NA) starting NS. After starting Propafenone Hydrochloride the patient began experiencing various side effects, including: Brugada Syndrome, Hypotension, Bundle Branch Block Right, Electrocardiogram St Segment Elevation, Electrocardiogram St Segment Depression, Chest Pain, Palpitations, Atrial FibrillationAdditional drugs used concurrently: NA.The patient was hospitalized. Although Propafenone Hydrochloride demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Brugada Syndrome, may still occur.
Propafenone Side Effect Report#9321077
Palpitations, Tachycardia, Electrocardiogram Abnormal
This Palpitations problem was reported by a pharmacist from US. A 66-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: atrial fibrillation. On
Feb 17, 2009 this consumer started treatment with Propafenone (dosage: 225 Mg Tid Po). The following drugs were being taken at the same time: NA. When using Propafenone, the patient experienced the following unwanted symptoms/side effects: Palpitations, Tachycardia, Electrocardiogram AbnormalThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Palpitations, may become evident only after a product is in use by the general population.
Propafenone Side Effect Report#9286265
Cardiac Failure, Atrial Fibrillation
This Cardiac Failure side effect was reported by a physician from CZ. A 66-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Propafenone (drug dosage: 600mg Per Day), which was initiated on NS. Concurrently used drugs:
  • Metoprolol (200mg Per Day)
  • Losartan (100mg Per Day)
  • Rilmenidine
  • Furosemide
  • Captopril
  • Acetylsalicylic Acid
  • Isosorbide Mononitrate
  • Amlodipine
.After starting to take Propafenone the consumer reported adverse symptoms, such as: Cardiac Failure, Atrial FibrillationThese side effects may potentially be related to Propafenone. The patient was hospitalized.
Propafenone Side Effect Report#9284356
Intentional Overdose, Suicide Attempt, Coma, Acidosis, Depressed Level Of Consciousness, Muscular Weakness, Condition Aggravated, Hyperhidrosis, Pupillary Light Reflex Tests Abnormal
This is a report of a 28-year-old male patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: NA, who was treated with Propafenone (dosage: NA, start time: NS), combined with:
  • Verapamil
  • Benzodiazepine Bromazepamum
and developed a serious reaction and side effect(s): Intentional Overdose, Suicide Attempt, Coma, Acidosis, Depressed Level Of Consciousness, Muscular Weakness, Condition Aggravated, Hyperhidrosis, Pupillary Light Reflex Tests Abnormal after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Propafenone treatment in male patients, resulting in Intentional Overdose side effect. The patient was hospitalized.
Propafenone Side Effect Report#9248152
Arrhythmia, Cardiac Failure, Circulatory Collapse, Cytogenetic Abnormality
This report suggests a potential Propafenone Arrhythmia side effect(s) that can have serious consequences. A male patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: supraventricular extrasystoles and used Propafenone (dosage: NA) starting NS. After starting Propafenone the patient began experiencing various side effects, including: Arrhythmia, Cardiac Failure, Circulatory Collapse, Cytogenetic AbnormalityAdditional drugs used concurrently: NA. Although Propafenone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Arrhythmia, may still occur.
Propafenone Side Effect Report#9217077
Arrhythmia, Cardiac Failure, Circulatory Collapse
This Arrhythmia problem was reported by a physician from DE. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: supraventricular extrasystoles. On NS this consumer started treatment with Propafenone (dosage: NA). The following drugs were being taken at the same time: NA. When using Propafenone, the patient experienced the following unwanted symptoms/side effects: Arrhythmia, Cardiac Failure, Circulatory CollapseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Arrhythmia, may become evident only after a product is in use by the general population.
Propafenone Side Effect Report#9130018
Haematemesis
This Haematemesis side effect was reported by a health professional from US. A 75-year-old male patient (weight:NA) experienced the following symptoms/conditions: atrial fibrillation,blood pressure abnormal,blood cholesterol abnormal,heart rate abnormal.The patient was prescribed Propafenone (drug dosage: 450 Mg, Qd), which was initiated on
Feb 01, 2008. Concurrently used drugs:
  • Clonidine (.2 Mg, Unk)
  • Livalo (2 Mg, Qd)
  • Bystolic (2.5 Mg, Qd)
  • Tekturna (Unk Unk, Qd)
  • Amoxicillin
  • Xarelto (20 Mg, Qd)
  • Xarelto
  • Acetylsalicylic Acid({=100 Mg) (81 Mg, Qd)
.After starting to take Propafenone the consumer reported adverse symptoms, such as: HaematemesisThese side effects may potentially be related to Propafenone.
Propafenone Side Effect Report#9095557
Abdominal Pain, Blood Urine Present, Porphyria Acute, Inappropriate Antidiuretic Hormone Secretion
This is a report of a 40-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: atrial fibrillation, who was treated with Propafenone Hydrochloride Tablets (propafenone Hydrochloride) (tablets) (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Abdominal Pain, Blood Urine Present, Porphyria Acute, Inappropriate Antidiuretic Hormone Secretion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Propafenone Hydrochloride Tablets (propafenone Hydrochloride) (tablets) treatment in male patients, resulting in Abdominal Pain side effect. The patient was hospitalized.


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The appearance of Propafenone on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Propafenone Side Effects for Women?

Women Side Effects Reports
Atrial Fibrillation 45
Dizziness 39
Product Quality Issue 33
Hypotension 30
Bradycardia 25
Asthenia 23
Nausea 21
Cardiac Arrest 20
Fall 20
Dyspnoea 18

What are common Propafenone Side Effects for Men?

Men Side Effects Reports
Atrial Fibrillation 29
Electrocardiogram Qrs Complex Prolonged 17
Syncope 16
Hypotension 15
Cardiac Arrest 14
Dizziness 14
Product Quality Issue 14
Arrhythmia 13
Bradycardia 13
Brugada Syndrome 12

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Why Your Notes are Important

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  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Propafenone reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Propafenone Safety Alerts, Active Ingredients, Usage Information

    NDC 0591-0582
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name Propafenone HCl
    Name Propafenone hydrochloride
    Dosage Form TABLET, FILM COATED
    Route ORAL
    On market since 20001024
    Labeler Watson Laboratories, Inc.
    Active Ingredient(s) PROPAFENONE HYDROCHLORIDE
    Strength(s) 150
    Unit(s) mg/1
    Pharma Class Antiarrhythmic [EPC]

    More About Propafenone

    Side Effects reported to FDA: 482

    Propafenone safety alerts: 2009 2008

    Reported deaths: 37

    Reported hospitalizations: 185

    Propafenone HCL Tablets

    Audience: Cardiology healthcare professionals, patients

    [Posted 03/25/2009] FDA and Watson Pharmaceuticals notified healthcare professionals and patients of a recall of Propafenone HCL 225 mg tablets, a drug product used to treat cardiac arrhythmias. The drug is being recalled because some tablets may contain slightly higher levels of the active ingredient than specified. Because it has a narrow therapeutic index, some patients who are particularly sensitive to small variations in dose may experience potentially serious side effects, including arrhythmias (irregular heartbeat) or low blood pressure. The affected lot [lot number 112680A, expiration date July 31, 2010] of Propafenone HCL tablets was shipped to customers between October 15, 2008 and November 26, 2008. The Press Release includes instructions for identifying and returning the affected product.

    [March 23, 2009 - Press Release - Watson Pharmaceuticals]

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