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Prostaglandin Side Effects

Common Prostaglandin Side Effects


The most commonly reported Prostaglandin side effects (click to view or check a box to report):

Hypoxia (4)
Shock (4)
Pyrexia (4)
Pulmonary Oedema (4)
Caesarean Section (3)
Hypotension (3)
Neonatal Asphyxia (3)
Renal Failure Acute (3)
Multi-organ Failure (3)
Cardiac Failure (2)
Cytokine Release Syndrome (2)
Renal Impairment (2)
Feeding Disorder Neonatal (2)
Gangrene (2)
Mitral Valve Stenosis (1)
Lymphocyte Count Increased (1)
Myocarditis (1)
Neonatal Respiratory Distress Syndrome (1)
No Therapeutic Response (1)
Neonatal Cardiac Failure (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Prostaglandin Side Effects Reported to FDA

The following Prostaglandin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Prostaglandin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Priapism
This is a report of a 55-year-old male patient (weight: NA) from UNITED STATES, suffering from the following symptoms/conditions: erectile dysfunction, who was treated with Prostaglandin E1 (dosage: 1 Df, Unk, start time: Sep 01, 2009), combined with:
  • Papaverine
  • Cialis (5 Mg, Qd)
  • Phentolamine Mesylate
and developed a serious reaction and side effect(s). The consumer presented with:
  • Priapism
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Prostaglandin E1 treatment in male patients, resulting in priapism side effect.

Visual Impairment
This report suggests a potential Prostaglandin Visual Impairment side effect(s) that can have serious consequences. A 50-year-old male patient (weight: NA) from JAPAN was diagnosed with the following symptoms/conditions: NA and used Prostaglandin (dosage: Unk) starting NS. Soon after starting Prostaglandin the patient began experiencing various side effects, including:
  • Visual Impairment
Drugs used concurrently:
  • Sanpilo (Unk)
  • Varenicline Tartrate (Unk)
Although Prostaglandin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as visual impairment, may still occur.

Extremity Necrosis, Condition Aggravated, Raynaud's Phenomenon, Prothrombin Time Prolonged, Ischaemia, Gangrene, Multi-organ Failure
This Extremity Necrosis, Condition Aggravated, Raynaud's Phenomenon, Prothrombin Time Prolonged, Ischaemia, Gangrene, Multi-organ Failure problem was reported by a health professional from JAPAN. A 69-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Dec 01, 2008 this consumer started treatment with Prostaglandins(prostaglandins) (dosage: NA). The following drugs were being taken at the same time:
  • Gemcitabine (400.00-mg/m2, 80.00-mg-1.0days)
  • Gemcitabine (400.00-mg/m2, 80.00-mg-1.0days)
When commencing Prostaglandins(prostaglandins), the patient experienced the following unwanted symptoms/side effects:
  • Extremity Necrosis
  • Condition Aggravated
  • Raynaud's Phenomenon
  • Prothrombin Time Prolonged
  • Ischaemia
  • Gangrene
  • Multi-organ Failure
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as extremity necrosis, may become evident only after a product is in use by the general population.

Neonatal Asphyxia, Caesarean Section
This is a report of a female patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: labour induction,premature rupture of membranes,infection prophylaxis and was treated with Prostaglandin F2 Alpha (dosage: 3 Mg, 1x/day) starting Jun 11, 2011. Concurrently used drugs:
  • Cefaclor (250 Mg, 1x/day)
  • Unasyn (1.5 Mg, 1x/day)
Soon after that, the consumer experienced the following side effects:
  • Neonatal Asphyxia
  • Caesarean Section
This opens a possibility that Prostaglandin F2 Alpha treatment could cause the above reactions, including neonatal asphyxia, and some female subjects may be more susceptible.


Renal Disorder, Escherichia Infection, Renal Failure Acute, Fibroma, Septic Shock, Transplant Rejection, Thrombosis
A 34-year-old female patient (weight: NA) from FRANCE with the following symptoms/conditions: NA started Prostaglandins treatment (dosage: NA) on Jul 01, 2007. Soon after starting Prostaglandins treatment, the subject experienced various side effects, including:
  • Renal Disorder
  • Escherichia Infection
  • Renal Failure Acute
  • Fibroma
  • Septic Shock
  • Transplant Rejection
  • Thrombosis
Concurrently used drugs:
  • Mifepristone (mifeprex)
  • Methergine (Unk)
  • Cytotec
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Prostaglandins.

Renal Failure Acute, Multi-organ Failure, Lymphocyte Count Increased, Pulmonary Oedema, Pyrexia, Cytokine Release Syndrome, Hypoxia, Shock
A female patient from KOREA, REPUBLIC OF (weight: NA) experienced symptoms, such as: prophylaxis and was treated with Prostaglandin E1(dosage: 10 Mcg, Unk). The treatment was initiated on Jan 12, 2011. After that a consumer reported the following side effect(s):
  • Renal Failure Acute
  • Multi-organ Failure
  • Lymphocyte Count Increased
  • Pulmonary Oedema
  • Pyrexia
  • Cytokine Release Syndrome
  • Hypoxia
  • Shock
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Prostaglandin E1 efficacy:
  • Acetaminophen (Unk)
  • Thymoglobulin (37.5 Mg, Qd)
  • Fludara
  • Corticosteroids (Unk)
  • Sol Medrol (15 Mg, Qd)
  • Thymoglobulin (Unk)
  • Fludara (25 Mg, Qd)
  • Melphalan
The patient was hospitalized.

Shock, Hypoxia, Pulmonary Oedema, Pyrexia, Lymphocyte Count Decreased, Renal Impairment, Hypotension
In this report, Prostaglandin E1 was administered for the following condition: prophylaxis.A female consumer from KOREA, REPUBLIC OF (weight: NA) started Prostaglandin E1 treatment (dosage: 30 Mcg, Unk) on Jan 31, 2011.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Shock
  • Hypoxia
  • Pulmonary Oedema
  • Pyrexia
  • Lymphocyte Count Decreased
  • Renal Impairment
  • Hypotension
A possible interaction with other drugs could have contributed to this reaction:
  • Acetaminophen (Unk)
  • Tylenol (325 Mg, Qd)
  • Thymoglobulin (90 Mg, Qd)
  • Corticosteroids (Unk)
  • Solu-medrol (35 Unk, Unk)
  • Cyclophosphamide (1805 Mg, Qd)
  • Heparin (3600 Iu, Unk)
  • Antihistamines (Unk)
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Prostaglandin E1 treatment could be related to the listed above side effect(s).

Hypoxia, Renal Impairment, Pyrexia, Hypotension, Pulmonary Oedema, Shock
This is a report of the following Prostaglandin E1 side effect(s):
  • Hypoxia
  • Renal Impairment
  • Pyrexia
  • Hypotension
  • Pulmonary Oedema
  • Shock
A female patient from KOREA, REPUBLIC OF (weight: NA) presented with the following condition: prophylaxis and received a treatment with Prostaglandin E1 (dosage: 30 Mcg, Unk) starting: Jan 23, 2011.The following concurrently used drugs could have generated interactions:
  • Thymoglobulin (2.5 Mg/kg, Unk)
  • Thymoglobulin (2.5 Mg/kg, Unk)
  • Heparin (3600 Iu, Unk)
  • Thymoglobulin (2.5 Mg/kg, Unk)
  • Cyclophosphamide (1805 Mg, Qd)
This report suggests that a Prostaglandin E1 treatment could be associated with the listed above side effect(s).

Multi-organ Failure, Pyrexia, Hypoxia, Blood Pressure Decreased, Renal Failure Acute, Cytokine Release Syndrome, Pulmonary Oedema, Shock
This Prostaglandin E1 report was submitted by a female consumer from KOREA, REPUBLIC OF (weight: NA). The patient was diagnosed with: prophylaxis,bone marrow transplant,acute lymphocytic leukaemia recurrent,bone marrow conditioning regimen and Prostaglandin E1 was administered (dosage: 10 Mcg, Unk) starting: Jan 18, 2011. The consumer developed a set of symptoms:
  • Multi-organ Failure
  • Pyrexia
  • Hypoxia
  • Blood Pressure Decreased
  • Renal Failure Acute
  • Cytokine Release Syndrome
  • Pulmonary Oedema
  • Shock
Other drugs used simultaneously:
  • Thymoglobulin (Unk)
  • Melphalan (90 Mg, Qd)
  • Melphalan
  • Fludara (25 Mg, Qd)
  • Fludara
  • Ranitidine (15 Mg, Q12hr)
  • Thymoglobulin (2.5 Mg/kg, Qd)
  • Heparin (1500 Iu, Unk)
The patient was hospitalized.Those unexpected symptoms could be linked to a Prostaglandin E1 treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Cardiac Failure, Collateral Circulation
This is a report of a possible correlation between Prostaglandin E1 (prostaglandin E1) use and the following symptoms/side effect(s):
  • Cardiac Failure
  • Collateral Circulation
which could contribute to an assessment of Prostaglandin E1 (prostaglandin E1) risk profile.A female consumer from JAPAN (weight: NA) was suffering from hypoplastic left heart syndrome and was treated with Prostaglandin E1 (prostaglandin E1) (dosage: Gradually Increased To 8.0 Ng/kg/min) starting NS.Other concurrent medications:
  • Nitrogen, Liquid


Aorta Hypoplasia, Aortic Stenosis, Cardiac Failure, Cardiac Murmur, Cyanosis Neonatal, Mitral Valve Stenosis, Neonatal Cardiac Failure
A female patient from JAPAN (weight: NA) presented with the following symptoms: hypoplastic left heart syndrome and after a treatment with Prostaglandin E1 (prostaglandin E1) (dosage: (gradually Increased To 8.0 Ng/kg/min)) experienced the following side effect(s):
  • Aorta Hypoplasia
  • Aortic Stenosis
  • Cardiac Failure
  • Cardiac Murmur
  • Cyanosis Neonatal
  • Mitral Valve Stenosis
  • Neonatal Cardiac Failure
The treatment was started on NS. Prostaglandin E1 (prostaglandin E1) was used in combination with the following drugs:
  • Nitrogen, Liquid
This report could alert potential Prostaglandin E1 (prostaglandin E1) consumers.

Enterocolitis
In this report, a female patient from FRANCE (weight: NA) was affected by a possible Prostaglandin E1 (prostaglandin E1) side effect.The patient was diagnosed with heart disease congenital. After a treatment with Prostaglandin E1 (prostaglandin E1) (dosage: (intravenous (not Otherwise Specified) ), start date: NS), the patient experienced the following side effect(s):
  • Enterocolitis
The following simultaneously used drugs could have led to this reaction: NA.The findings here stress that side effects should be taken into consideration when evaluating a Prostaglandin E1 (prostaglandin E1) treatment.

Feeding Disorder Neonatal, Iatrogenic Injury, Neonatal Respiratory Distress Syndrome, Obstruction Gastric, Tachycardia
This is a report of a female patient from POLAND (weight: NA), who used Prostaglandin E1 (prostaglandin) (dosage: (started At 0.05ug/kg/min And Reduced To 0.025ug/kg/min)) for a treatment of heart disease congenital. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Feeding Disorder Neonatal
  • Iatrogenic Injury
  • Neonatal Respiratory Distress Syndrome
  • Obstruction Gastric
  • Tachycardia
The following drugs could possibly have interacted with the Prostaglandin E1 (prostaglandin) treatment NA.Taken together, these observations suggest that a Prostaglandin E1 (prostaglandin) treatment could be related to side effect(s), such as Feeding Disorder Neonatal, Iatrogenic Injury, Neonatal Respiratory Distress Syndrome, Obstruction Gastric, Tachycardia.

Diarrhoea Neonatal, Feeding Disorder Neonatal, Pyloric Stenosis, Vomiting Projectile
This diarrhoea neonatal side effect was reported by a consumer or non-health professional from POLAND. A female patient (weight:NA) experienced the following symptoms/conditions: heart disease congenital. The patient was prescribed Prostaglandin E1 (prostaglandin) (dosage: (0.05ug/kg/min)), which was started on NS. Concurrently used drugs: NA. When starting to take Prostaglandin E1 (prostaglandin) the consumer reported the following symptoms:
  • Diarrhoea Neonatal
  • Feeding Disorder Neonatal
  • Pyloric Stenosis
  • Vomiting Projectile
These side effects may potentially be related to Prostaglandin E1 (prostaglandin).

Cerebral Infarction, Chlamydial Infection, Disseminated Intravascular Coagulation, Finger Amputation, Gangrene, Haemorrhage, Heart Rate Increased, Myocarditis, Respiratory Rate Increased
This is a Prostaglandin E1 side effect report of a 43-year-old female patient (weight:NA) from CHINA, suffering from the following symptoms/conditions: cyanosis, who was treated with Prostaglandin E1 (dosage:NA, start time: NS), combined with: NA., and developed a serious reaction and a cerebral infarction side effect. The patient presented with:
  • Cerebral Infarction
  • Chlamydial Infection
  • Disseminated Intravascular Coagulation
  • Finger Amputation
  • Gangrene
  • Haemorrhage
  • Heart Rate Increased
  • Myocarditis
  • Respiratory Rate Increased
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Prostaglandin E1 treatment in female patients suffering from cyanosis, resulting in cerebral infarction.

Arteriospasm Coronary, Atrioventricular Block, Bradycardia, Cardiac Arrest, Electrocardiogram St Segment Depression, Electrocardiogram St Segment Elevation, Electrocardiogram T Wave Inversion, Hypotension, No Therapeutic Response
This report suggests a potential Prostaglandin E1 (prostaglandin E1) arteriospasm coronary side effect(s) that can have serious consequences. A 60-year-old female patient from JAPAN (weight:NA) was diagnosed with the following health condition(s): hypotensive anaesthesia procedure and used Prostaglandin E1 (prostaglandin E1) (dosage: (0.03 Ug/kg/min Intravenous (not Otherwise Specified)) starting NS. Soon after starting Prostaglandin E1 (prostaglandin E1) the patient began experiencing various side effects, including:
  • Arteriospasm Coronary
  • Atrioventricular Block
  • Bradycardia
  • Cardiac Arrest
  • Electrocardiogram St Segment Depression
  • Electrocardiogram St Segment Elevation
  • Electrocardiogram T Wave Inversion
  • Hypotension
  • No Therapeutic Response
Drugs used concurrently:
  • Propofol ((intravenous (not Otherwise Specified)), (4 Mg/kg/h Intravenous (not Otherwise Specified))
  • Propranolol ((intravenous (not Otherwise Specified))
  • Fentanyl
  • Vecuronium Bromide
The patient was hospitalized. Although Prostaglandin E1 (prostaglandin E1) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as arteriospasm coronary, may still occur.

Caesarean Section, Foetal Heart Rate Decreased, Hypotonia Neonatal, Neonatal Asphyxia
This caesarean section problem was reported by a consumer or non-health professional from GERMANY. A female patient (weight: NA) was diagnosed with the following medical condition(s): labour induction.On NS a consumer started treatment with Prostaglandin (pge2) (prostaglandin (pge2)) (dosage: 3 Mg Once Vg). The following drugs/medications were being taken at the same time:
  • Oxytocin
When commencing Prostaglandin (pge2) (prostaglandin (pge2)), the patient experienced the following unwanted symptoms /side effects:
  • Caesarean Section
  • Foetal Heart Rate Decreased
  • Hypotonia Neonatal
  • Neonatal Asphyxia
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as caesarean section, may become evident only after a product is in use by the general population.

Caesarean Section, Neonatal Asphyxia
This is a Prostaglandin side effect report of a patient (weight: NA) from GERMANY. The patient developed the following symptoms/conditions: labour induction and was treated with Prostaglandin (dosage: 3 Mg Once Transplacental) starting NS. Concurrently used drugs:
  • Oxytocin
Soon after that, the consumer experienced the following of symptoms:
  • Caesarean Section
  • Neonatal Asphyxia
The patient was hospitalized. This opens a possibility that Prostaglandin could cause caesarean section and that some patients may be more susceptible.



Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    More About Prostaglandin

    Side Effects reported to FDA: 18

    Prostaglandin safety alerts: No

    Reported deaths: 3

    Reported hospitalizations: 2

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