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Hair Loss (25)
Nausea (17)
Dry Mouth (14)
Hair Loss/texturechange (11)
Vertigo (10)
Achey Legs (9)
Bad Acid Rflux After The First Pill (5)
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Protonix Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 1180 

Dyspepsia, Gastrooesophageal Reflux Disease (8448175-1)
on Jun 12, 2012 Female from UNITED STATES , 56 years of age, was treated with Protonix. Directly after, patient experienced the unwanted or unexpected Protonix side effects: dyspepsia, gastrooesophageal reflux disease. Protonix dosage: N/A.
Associated medications used:
  • Nexium
  • Symbicort
  • Gaviscon


Mantle Cell Lymphoma (8446548-4)
Patient was taking Protonix. Patient felt the following Protonix side effects: mantle cell lymphoma on Jun 13, 2012 from UNITED STATES Additional patient health information: Male , weighting 157.0 lb, . Protonix dosage: Unk.
Multiple prescriptions taken:
  • Ddavp (0.1 Mg, Unk)
  • Lantus
  • Zantac (200)
  • Xanax
  • Somatropin (0.5 Mg, Daily (1/d))
  • Multi-vitamin
  • Prednisone (10 Mg, Unk)
  • Levothyroxine Sodium (0.75 Mg, Unk)


Cardiac Murmur, Pyrexia, Decreased Appetite, Tinnitus, Fungal Sepsis, Foot Operation, Dehydration, Goitre, Chills (8446323-0)
Adverse event was reported on Apr 04, 2012 by a Female taking Protonix (Dosage: Unk) . Location: UNITED STATES , weighting 212.0 lb, After Protonix was administered, patient encountered several Protonix side effects: cardiac murmur, pyrexia, decreased appetite, tinnitus, fungal sepsis, foot operation, dehydration, goitre, chills.
Multiple concurrent drugs taken:
  • Methotrexate Sodium
  • Synthroid (Unk)
  • Norvasc (Unk)
  • Restoril (Unk)
  • Enbrel (50 Mg, Qwk)
  • Premarin (Unk)
  • Enbrel
  • Celexa (Unk)
Patient was hospitalized.

Cardiovascular Disorder, Coronary Artery Disease (8445702-5)
on Jun 12, 2012 Male from UNITED STATES , 56 years of age, was treated with Protonix. Directly after, patient experienced the unwanted or unexpected Protonix side effects: cardiovascular disorder, coronary artery disease. Protonix dosage: N/A.
Associated medications used:
  • Avandia (8mg Per Day)
  • Paxil
  • Lortab
  • Atenolol
  • Metformin Hcl
  • Vytorin
  • Tricor
  • Avandamet
Patient was hospitalized.


Product Quality Issue, Off Label Use (8441102-2)
on Jun 06, 2011 Female from UNITED STATES , weighting 210.0 lb, was diagnosed with
  • gastrooesophageal reflux disease
  • attention deficit/hyperactivity disorder
  • asthma
and was treated with Protonix. Patient felt the following Protonix side effects: product quality issue, off label use. Protonix dosage: 40 Mg, Qd.
Multiple prescriptions taken:
  • Daytrana (10 Mg, Unk)
  • Proair Hfa (Unk)
  • Symbicort (1 Puff)


Anxiety, Micturition Urgency, Vitamin D Deficiency, Slow Speech, Eye Swelling, Diarrhoea, Off Label Use, Road Traffic Accident (8436762-6)
Patient was taking Protonix. After Protonix was administered, patient encountered several Protonix side effects: anxiety, micturition urgency, vitamin d deficiency, slow speech, eye swelling, diarrhoea, off label use, road traffic accident on Jun 05, 2012 from UNITED STATES Additional patient health information: Female , 51 years of age, weighting 104.1 lb, . Protonix dosage: N/A.
Multiple concurrent drugs taken:
  • Nexium


Neoplasm Malignant (8436155-1)
Adverse event was reported on Jun 05, 2012 by a Male taking Protonix (Dosage: 40 Mg, 2x/day) was diagnosed with
  • gastrooesophageal reflux disease
  • atrial fibrillation
and. Location: UNITED STATES , weighting 193.0 lb, Directly after, patient experienced the unwanted or unexpected Protonix side effects: neoplasm malignant.
Associated medications used:
  • Digoxin (Unk)


Osteoarthritis, Thrombophlebitis Superficial (8433553-7)
on Dec 15, 2011 Male from UNITED STATES , 43 years of age, was treated with Protonix. Patient felt the following Protonix side effects: osteoarthritis, thrombophlebitis superficial. Protonix dosage: N/A.
Multiple prescriptions taken:
  • Neurontin
  • Lamictal
  • Seroquel
  • Marinol
  • Valtrex
  • Cymbalta
  • Lomotil
  • Oxycodone Hcl
Patient was hospitalized.

Cardiovascular Disorder, Cerebrovascular Accident (8433147-3)
on Jun 07, 2012 Male from UNITED STATES , 47 years of age, weighting 178.4 lb, was treated with Protonix. After Protonix was administered, patient encountered several Protonix side effects: cardiovascular disorder, cerebrovascular accident. Protonix dosage: N/A.
Multiple concurrent drugs taken:
  • Lipitor
  • Avandia (4mg Per Day)
  • Diltiazem
  • Lamisil
Patient was hospitalized.

Eye Haemorrhage, Nausea, Bowel Movement Irregularity, Vision Blurred, Gastric Disorder, Dry Mouth (8427190-8)
Patient was taking Protonix. Directly after, patient experienced the unwanted or unexpected Protonix side effects: eye haemorrhage, nausea, bowel movement irregularity, vision blurred, gastric disorder, dry mouth on Jun 05, 2012 from UNITED STATES Additional patient health information: Female , weighting 157.9 lb, was diagnosed with
  • gastritis
and. Protonix dosage: 40 Mg Daily.
Associated medications used:
  • Cyclobenzaprine (10 Mg, 2x/day)
  • Vitamin B-12 (1000 Mg, Monthly)
  • Claritin (10 Mg Daily)
  • Naproxen Sodium (500 Mg, 3x/day)
  • Ibuprofen
  • Gabapentin
  • Lipitor (Unk)
  • Gabapentin (800 Mg, 3x/day)


Atrial Fibrillation, Sick Sinus Syndrome (8422877-5)
Adverse event was reported on May 31, 2012 by a Female taking Protonix (Dosage: N/A) . Location: UNITED STATES , 69 years of age, Patient felt the following Protonix side effects: atrial fibrillation, sick sinus syndrome.
Multiple prescriptions taken:
  • Avandia (2mg Per Day)
  • Synthroid
  • Norvasc
Patient was hospitalized.

Neoplasm Malignant (8420932-7)
on Jun 05, 2012 Male from UNITED STATES , weighting 193.0 lb, was diagnosed with
  • gastrooesophageal reflux disease
  • atrial fibrillation
and was treated with Protonix. After Protonix was administered, patient encountered several Protonix side effects: neoplasm malignant. Protonix dosage: 40 Mg, 2x/day.
Multiple concurrent drugs taken:
  • Digoxin (Unk)


Fracture, Upper Limb Fracture, Radius Fracture, Osteoporosis, Foot Fracture, Periarticular Disorder (8418478-5)
on May 30, 2012 Female from UNITED STATES , 51 years of age, weighting 190.0 lb, was treated with Protonix. Directly after, patient experienced the unwanted or unexpected Protonix side effects: fracture, upper limb fracture, radius fracture, osteoporosis, foot fracture, periarticular disorder. Protonix dosage: N/A.
Associated medications used:
  • Bayer
  • Nexium
  • Pepcid
  • Phenytek
  • Diazepam
  • Nexium
  • Lortab
  • Micardis
Patient was hospitalized.

Respiratory Failure, Hypoxia, Urinary Tract Infection, Dehydration, Peripheral Ischaemia, Sepsis, Pancytopenia, Pulseless Electrical Activity, Arterial Thrombosis Limb (8418035-0)
Patient was taking Protonix. Patient felt the following Protonix side effects: respiratory failure, hypoxia, urinary tract infection, dehydration, peripheral ischaemia, sepsis, pancytopenia, pulseless electrical activity, arterial thrombosis limb on May 28, 2012 from UNITED STATES Additional patient health information: Female , 55 years of age, . Protonix dosage: N/A.
Multiple prescriptions taken:
  • Doxorubicin Hcl
  • Ambien
  • Marinol


Chest Discomfort, Chest Pain (8417865-9)
Adverse event was reported on May 31, 2012 by a Female taking Protonix (Dosage: 40 Mg, 1x/day) was diagnosed with
  • gastrooesophageal reflux disease
and. Location: UNITED STATES , weighting 149.9 lb, After Protonix was administered, patient encountered several Protonix side effects: chest discomfort, chest pain.
Multiple concurrent drugs taken:
  • Fuzeon (Unk)
  • Lamictal (Unk)
  • Lithium (Unk)
  • Advair Diskus 100/50 (Unk, 1x/day)
  • Synthroid (Unk)
  • Lorazepam (Unk)


Pleural Effusion, Electrocardiogram Qrs Complex Prolonged, Cardiomegaly, Rib Fracture, Renal Failure, Chest Pain (8410304-3)
on Jul 28, 2005 Female from UNITED STATES , 68 years of age, was treated with Protonix. Directly after, patient experienced the unwanted or unexpected Protonix side effects: pleural effusion, electrocardiogram qrs complex prolonged, cardiomegaly, rib fracture, renal failure, chest pain. Protonix dosage: N/A.
Associated medications used:
  • Nitrostat
  • Lasix
  • Reglan /usa/ (metoclopramide Hydrochloride)
  • Aldactone
  • Glucotrol Xl
  • Valium /net/ (diazepam)
  • Aspirin
  • Tolvaptan (tolvaptan(v.4.1)) 30mg (30 Mg, Qd, Oral)
Patient was hospitalized.

Blood Pressure Increased, Withdrawal Syndrome, Somnolence, Nausea, Urinary Tract Infection, Heart Rate Increased, Tremor (8408300-5)
on May 31, 2012 Female from UNITED STATES , weighting 145.0 lb, was diagnosed with
  • gastrooesophageal reflux disease
  • back pain
and was treated with Protonix. Patient felt the following Protonix side effects: blood pressure increased, withdrawal syndrome, somnolence, nausea, urinary tract infection, heart rate increased, tremor. Protonix dosage: 40 Mg, Daily.
Multiple prescriptions taken:
  • Tramadol Hydrochloride (Unk, As Needed)
  • Naproxen (aleve) (Unk)
  • Xanax
  • Xanax
  • Xanax (0.5 Mg Daily)


Fracture Nonunion, Foot Fracture, Hypertonic Bladder, Tooth Disorder, Femur Fracture, Fracture Delayed Union, Blood Cholesterol Increased, Adverse Event, Low Turnover Osteopathy (8408066-9)
Patient was taking Protonix. After Protonix was administered, patient encountered several Protonix side effects: fracture nonunion, foot fracture, hypertonic bladder, tooth disorder, femur fracture, fracture delayed union, blood cholesterol increased, adverse event, low turnover osteopathy on May 25, 2012 from UNITED STATES Additional patient health information: Female , 61 years of age, . Protonix dosage: N/A.
Multiple concurrent drugs taken:
  • Nifedipine
  • Fosamax Plus D
  • Fosamax
  • Procardia Xl
  • Nexium
  • Fosamax
  • Prilosec
  • Fosamax
Patient was hospitalized.

Nausea, Abdominal Pain Upper, Vomiting, Malaise (8406217-3)
Adverse event was reported on May 29, 2012 by a Female taking Protonix (Dosage: 40 Mg, 1x/day) was diagnosed with
  • abdominal discomfort
  • anxiety
  • nervousness
and. Location: UNITED STATES , weighting 158.7 lb, Directly after, patient experienced the unwanted or unexpected Protonix side effects: nausea, abdominal pain upper, vomiting, malaise.
Associated medications used:
  • Xanax (1 Mg, As Needed)
  • Xanax


Intervertebral Disc Protrusion, Wrist Fracture, Fall, Weight Increased, Body Height Decreased, Palpitations, Weight Fluctuation, Back Injury, Euphoric Mood (8403007-2)
on May 29, 2012 Female from UNITED STATES , weighting 179.0 lb, was diagnosed with
  • gastrooesophageal reflux disease
  • chronic obstructive pulmonary disease
  • asthma
  • type 2 diabetes mellitus
  • hypertension
  • hypokalaemia
  • emphysema
and was treated with Protonix. Patient felt the following Protonix side effects: intervertebral disc protrusion, wrist fracture, fall, weight increased, body height decreased, palpitations, weight fluctuation, back injury, euphoric mood. Protonix dosage: 40 Mg, 2x/day.
Multiple prescriptions taken:
  • Ipratropium (Unk)
  • Albuterol
  • Amaryl (Unk)
  • Atenolol (5 Unk, Unk)
  • Potassium Chloride (20 Meq, Daily)
  • Ipratropium
  • Albuterol
  • Chlordiazepoxide Hcl W/ Clidinium Bromide (5/2.5 Mg, Unk)


Gout (8401335-8)
on May 30, 2012 Male from UNITED STATES , 47 years of age, weighting 180.0 lb, was diagnosed with
  • gastrooesophageal reflux disease
and was treated with Protonix. After Protonix was administered, patient encountered several Protonix side effects: gout. Protonix dosage: 40mg 1x Day Oral 047 April - May 2009 (?).
Multiple concurrent drugs taken:
  • Simvastatin


Vitamin D Deficiency, Calcium Deficiency, Osteoporosis, Vomiting (8398081-6)
Patient was taking Protonix. Directly after, patient experienced the unwanted or unexpected Protonix side effects: vitamin d deficiency, calcium deficiency, osteoporosis, vomiting on May 22, 2012 from UNITED STATES Additional patient health information: Female , 48 years of age, weighting 149.0 lb, . Protonix dosage: N/A.
Associated medications used:
  • Ceralafate
  • Kador
  • Zyrtec
  • Nexium
  • Hydroclorazazide
  • Nizatidizine
  • Zofren
  • Propo N/apap (100-650)


Renal Failure, Rash (8395204-X)
Adverse event was reported on Feb 28, 2011 by a Female taking Protonix (Dosage: N/A) . Location: UNITED STATES , 84 years of age, Patient felt the following Protonix side effects: renal failure, rash.
Multiple prescriptions taken:
  • Revlimid (5 Mg, 21/7, Po)
  • Clonidine
  • Megace
  • Coreg
  • Nephro-vit E (nephrovite)
Patient was hospitalized and became disabled.

Thrombocytopenia, Pneumonia (8394246-8)
on Oct 20, 2011 Female from UNITED STATES , 84 years of age, weighting 127.6 lb, was treated with Protonix. After Protonix was administered, patient encountered several Protonix side effects: thrombocytopenia, pneumonia. Protonix dosage: N/A.
Multiple concurrent drugs taken:
  • Magnesium Gluconate (magnesium Gluconate)
  • Premarin
  • Zithromax
  • Coumadin
  • Prednisone Tab
  • Coreg
  • Allopurinol
  • Gabapentin
Patient was hospitalized.

Platelet Count Decreased, White Blood Cell Count Decreased, Red Blood Cell Count Decreased, Full Blood Count Decreased (8391625-X)
on Jun 17, 2011 Female from UNITED STATES , 85 years of age, weighting 180.0 lb, was treated with Protonix. Directly after, patient experienced the unwanted or unexpected Protonix side effects: platelet count decreased, white blood cell count decreased, red blood cell count decreased, full blood count decreased. Protonix dosage: N/A.
Associated medications used:
  • Revlimid (10 Mg, 1 In 1 D, Po ; 5 Mg, 1 In 1 D, Po)
  • Revlimid (10 Mg, 1 In 1 D, Po ; 5 Mg, 1 In 1 D, Po)
  • Potassium Gluconate Tab
  • Extra Strength Tylenol
  • Fortical
  • Fish Oil (fish Oil)
  • Caltrate 600 + Vitamin D3 (calcite D)
  • Vitamin B6


Showing 1-25 of 1180 

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It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Protonix Information

Alternative PROTONIX Names:PANTOPRAZ

Active Ingredient: PANTOPRAZ

Protonix Dosage, Warnings, Usage.

Side Effects reported to FDA: 1180. View Protonix Adverse Reports

Protonix safety alerts: 2004

Reported deaths: 43

Reported hospitalizations: 371

Protonix I.V. (pantoprazole sodium)

Audience: Pharmacists, nurses and other healthcare professionals in institutional settings

Wyeth and FDA informed healthcare professionals of reports of glass vial breakage of Protonix I.V. during attempts to connect vials to spiked intravenous system adaptors. This may be a safety issue for pharmacists or nurses when preparing Protonix I.V. for Injection vials in combination with spiked intravenous system adaptors, both during manual assembly and while utilizing mechanical assistance.

[August 2004 - Letter - Wyeth]

Managing Your Medicines

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