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Rifampicin Side Effects

Common Rifampicin Side Effects


The most commonly reported Rifampicin side effects (click to view or check a box to report):

Pyrexia (66)
Vomiting (41)
Dyspnoea (39)
Jaundice (34)
Renal Failure Acute (33)
Nausea (27)
Acute Hepatic Failure (24)
Rash (23)
Hepatitis (22)
Lymphadenopathy (21)
Abdominal Pain (20)
Condition Aggravated (20)
Hyponatraemia (20)
Toxic Epidermal Necrolysis (20)
Asthenia (19)
Eosinophilia (18)
Anaemia (18)
Hepatic Function Abnormal (17)
Blood Creatinine Increased (16)
International Normalised Ratio Increased (16)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Rifampicin Side Effects Reported to FDA

The following Rifampicin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Rifampicin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Dermatitis Exfoliative, Lymphadenopathy, Pyrexia, Face Oedema, Eosinophilia, Hepatitis, Papule
This is a report of a 34-year-old male patient (weight: NA) from ZA, suffering from the following symptoms/conditions: tuberculosis, who was treated with Rifampicin (dosage: NA, start time: NS), combined with:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
  • Co-trimoxazole
and developed a serious reaction and side effect(s). The consumer presented with:
  • Dermatitis Exfoliative
  • Lymphadenopathy
  • Pyrexia
  • Face Oedema
  • Eosinophilia
  • Hepatitis
  • Papule
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampicin treatment in male patients, resulting in dermatitis exfoliative side effect. The patient was hospitalized.

Mycobacterium Avium Complex Infection, Condition Aggravated, Gastrointestinal Disorder, Feeling Abnormal
This report suggests a potential Rifampicin Sandoz Mycobacterium Avium Complex Infection, Condition Aggravated, Gastrointestinal Disorder, Feeling Abnormal side effect(s) that can have serious consequences. A 63-year-old female patient (weight: NA) from JP was diagnosed with the following symptoms/conditions: mycobacterium avium complex infection and used Rifampicin Sandoz (dosage: 150 Mg, Unk) starting NS. Soon after starting Rifampicin Sandoz the patient began experiencing various side effects, including:
  • Mycobacterium Avium Complex Infection
  • Condition Aggravated
  • Gastrointestinal Disorder
  • Feeling Abnormal
Drugs used concurrently:
  • Ethambutol
  • Clarithromycin (200 Mg, Unk)
  • Levofloxacin
The patient was hospitalized. Although Rifampicin Sandoz demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as mycobacterium avium complex infection, may still occur.

Pseudolymphoma, Rash Papulosquamous, Pruritus, Rash Maculo-papular, Face Oedema, Rash Pustular, Blister, Pyrexia, Eczema
This Pseudolymphoma, Rash Papulosquamous, Pruritus, Rash Maculo-papular, Face Oedema, Rash Pustular, Blister, Pyrexia, Eczema problem was reported by a health professional from CA. A 19-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Rifampicin (dosage: NA). The following drugs were being taken at the same time:
  • Vancomycin
  • Heparin Sodium
  • Acetylsalicylic Acid
  • Thiamine
  • Pantoprazole
  • Magnesium Oxide
  • Tramadol
  • Senna
When commencing Rifampicin, the patient experienced the following unwanted symptoms/side effects:
  • Pseudolymphoma
  • Rash Papulosquamous
  • Pruritus
  • Rash Maculo-papular
  • Face Oedema
  • Rash Pustular
  • Blister
  • Pyrexia
  • Eczema
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as pseudolymphoma, may become evident only after a product is in use by the general population.

Hepatitis, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased
This is a report of a 66-year-old female patient (weight: NA) from FR. The patient developed the following symptoms/conditions: NA and was treated with Rifampicin (dosage: NA) starting Jan 09, 2014. Concurrently used drugs:
  • Flagyl
  • Tavanic
  • Lasilix
  • Seretide
  • Kardegic
  • Umuline
  • Cardensiel
  • Inexium
Soon after that, the consumer experienced the following side effects:
  • Hepatitis
  • Alanine Aminotransferase Increased
  • Aspartate Aminotransferase Increased
This opens a possibility that Rifampicin treatment could cause the above reactions, including hepatitis, and some female subjects may be more susceptible.


Lupus-like Syndrome, Leukopenia
A 17-year-old female patient (weight: NA) from GR with the following symptoms/conditions: pulmonary tuberculosis started Rifampicin treatment (dosage: NA) on NS. Soon after starting Rifampicin treatment, the subject experienced various side effects, including:
  • Lupus-like Syndrome
  • Leukopenia
Concurrently used drugs:
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
  • Antibiotics
This finding indicates that some female patients could be more vulnerable to Rifampicin.

Addison^s Disease, Skin Hyperpigmentation, Asthenia, Dizziness, Hyponatraemia, Depression
A 45-year-old female patient from BR (weight: NA) experienced symptoms, such as: erythema induratum and was treated with Rifampicin(dosage: Unk). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Addison^s Disease
  • Skin Hyperpigmentation
  • Asthenia
  • Dizziness
  • Hyponatraemia
  • Depression
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Rifampicin efficacy:
  • Isoniazid
  • Pyrazinamide
  • Nph Insulin
  • Enalapril
The patient was hospitalized.

Intentional Overdose, Cardiogenic Shock, Pulmonary Oedema, Acute Coronary Syndrome, Electrocardiogram St Segment Elevation, Dyspnoea, Pruritus, Red Man Syndrome
In this report, Rifampicin was administered for the following condition: NA.A 19-year-old male consumer from PL (weight: NA) started Rifampicin treatment (dosage: Unk) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Intentional Overdose
  • Cardiogenic Shock
  • Pulmonary Oedema
  • Acute Coronary Syndrome
  • Electrocardiogram St Segment Elevation
  • Dyspnoea
  • Pruritus
  • Red Man Syndrome
A possible interaction with other drugs could have contributed to this reaction:
  • Isoniazid (Unk)
  • Pyrazinamide (Unk)
  • Ketoprofen (Unk)
  • Alcohol (Unk)
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Rifampicin treatment could be related to the listed above side effect(s).

Haemorrhage, Haematuria, International Normalised Ratio Increased
This is a report of the following Rifampicin side effect(s):
  • Haemorrhage
  • Haematuria
  • International Normalised Ratio Increased
A 59-year-old female patient from BR (weight: NA) presented with the following condition: pulmonary tuberculosis,atrial fibrillation and received a treatment with Rifampicin (dosage: 600 Mg, Per Day) starting: NS.The following concurrently used drugs could have generated interactions:
  • Warfarin (52.5 Mg, Per Week)
  • Warfarin (45 Mg, Per Week)
  • Warfarin (80 Mg, Per Week)
  • Warfarin (77.5 Mg, Unk)
  • Warfarin (37.5 Mg, Unk)
  • Pyrazinamide (2 G, Per Day)
  • Isoniazid (400 Mg, Per Day)
  • Ferrous Sulfate
This report suggests that a Rifampicin treatment could be associated with the listed above side effect(s).

Diabetes Mellitus Inadequate Control
This Rifampicin Sandoz report was submitted by a 75-year-old male consumer from JP (weight: NA). The patient was diagnosed with: tuberculous pleurisy and Rifampicin Sandoz was administered (dosage: NA) starting: Dec 21, 2012. The consumer developed a set of symptoms:
  • Diabetes Mellitus Inadequate Control
Other drugs used simultaneously:
  • Isoniazid
  • Ethambutol Hydrochloride
  • Pyrazinamide
The patient was hospitalized.Those unexpected symptoms could be linked to a Rifampicin Sandoz treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Intracranial Pressure Increased
This is a report of a possible correlation between Rifampicin use and the following symptoms/side effect(s):
  • Intracranial Pressure Increased
which could contribute to an assessment of Rifampicin risk profile.A 55-year-old female consumer from JP (weight: NA) was suffering from meningitis tuberculous and was treated with Rifampicin (dosage: 600 Mg, Daily) starting NS.Other concurrent medications:
  • Isoniazid (500 Mg, Daily)
  • Ethambutol (750 Mg, Daily)
  • Pyrazinamide (1.5 G, Daily)
  • Prednisolone (40 Mg, Daily)
  • Prednisolone (20 Mg, Daily)
  • Meropenem (6 G, Daily)
  • Meropenem
  • Acyclovir (1.5 G, Daily)
The patient was hospitalized.

Inappropriate Antidiuretic Hormone Secretion, Hyponatraemia, Blood Osmolarity Decreased, Urine Sodium Decreased, Hyperaldosteronism, Hypokalaemia, Blood Aldosterone Increased, Renin Increased, Pulmonary Tuberculosis
A 49-year-old female patient from DE (weight: NA) presented with the following symptoms: pulmonary tuberculosis and after a treatment with Rifampicin (dosage: NA) experienced the following side effect(s):
  • Inappropriate Antidiuretic Hormone Secretion
  • Hyponatraemia
  • Blood Osmolarity Decreased
  • Urine Sodium Decreased
  • Hyperaldosteronism
  • Hypokalaemia
  • Blood Aldosterone Increased
  • Renin Increased
  • Pulmonary Tuberculosis
The treatment was started on NS. Rifampicin was used in combination with the following drugs:
  • Isoniazid
  • Ethambutol
  • Pyrazinamide
  • Tolvaptan
The patient was hospitalized.This report could alert potential Rifampicin consumers.

Ventricular Septal Defect, Atrial Septal Defect, Small For Dates Baby
In this report, a male patient from DE (weight: NA) was affected by a possible Rifampicin side effect.The patient was diagnosed with pulmonary tuberculosis. After a treatment with Rifampicin (dosage: Unk, start date: NS), the patient experienced the following side effect(s):
  • Ventricular Septal Defect
  • Atrial Septal Defect
  • Small For Dates Baby
The following simultaneously used drugs could have led to this reaction:
  • Pyrazinamid
  • Ethambutol
  • Truvada (Unk)
  • Lopinavir + Ritonavir (Unk)
  • Isoniazid (Unk)
The findings here stress that side effects should be taken into consideration when evaluating a Rifampicin treatment.

Neutropenia
This is a report of a 73-year-old male patient from IT (weight: NA), who used Rifampicin (dosage: NA) for a treatment of tuberculosis. After starting a treatment on Dec 18, 2013, the patient experienced the following side effect(s):
  • Neutropenia
The following drugs could possibly have interacted with the Rifampicin treatment
  • Nicozid
  • Etapiam
  • Pyrazinamide
  • Levopraid
  • Rifabutin
The patient was hospitalized.Taken together, these observations suggest that a Rifampicin treatment could be related to side effect(s), such as Neutropenia.

Angioedema, Periorbital Oedema, Lip Oedema
This angioedema side effect was reported by a health professional from ES. A 54-year-old female patient (weight:NA) experienced the following symptoms/conditions: tuberculin test positive. The patient was prescribed Rifampicin (dosage: NA), which was started on NS. Concurrently used drugs:
  • Isoniazid
When starting to take Rifampicin the consumer reported the following symptoms:
  • Angioedema
  • Periorbital Oedema
  • Lip Oedema
These side effects may potentially be related to Rifampicin.

Acute Respiratory Distress Syndrome
This is a Rifampicin side effect report of a 16-year-old female patient (weight:NA) from PH, suffering from the following symptoms/conditions: lymph node tuberculosis, who was treated with Rifampicin (dosage:Unk, start time: NS), combined with:
  • Pyrazinamide (Unk)
  • Ethambutol (Unk)
  • Isoniazid (Unk)
, and developed a serious reaction and a acute respiratory distress syndrome side effect. The patient presented with:
  • Acute Respiratory Distress Syndrome
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Rifampicin treatment in female patients suffering from lymph node tuberculosis, resulting in acute respiratory distress syndrome.

Diabetes Mellitus
This report suggests a potential Rifampicin diabetes mellitus side effect(s) that can have serious consequences. A 61-year-old male patient from JP (weight:NA) was diagnosed with the following health condition(s): pulmonary tuberculosis and used Rifampicin (dosage: Unk) starting NS. Soon after starting Rifampicin the patient began experiencing various side effects, including:
  • Diabetes Mellitus
Drugs used concurrently:
  • Isoniazid (Unk)
  • Ethambutol (Unk)
  • Pyrazinamide (Unk)
Although Rifampicin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as diabetes mellitus, may still occur.

Cerebral Infarction, Post Gastric Surgery Syndrome
This cerebral infarction problem was reported by a health professional from JP. A 59-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): pulmonary tuberculosis.On NS a consumer started treatment with Rifampicin (dosage: Unk). The following drugs/medications were being taken at the same time:
  • Isoniazid (Unk)
  • Ethambutol (Unk)
  • Pyrazinamide (Unk)
When commencing Rifampicin, the patient experienced the following unwanted symptoms /side effects:
  • Cerebral Infarction
  • Post Gastric Surgery Syndrome
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as cerebral infarction, may become evident only after a product is in use by the general population.

Overdose
This is a Rifampicin side effect report of a 24-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: tuberculosis,rheumatic heart disease,atrial thrombosis and was treated with Rifampicin (dosage: 450 Mg/day) starting NS. Concurrently used drugs:
  • Warfarin (5 Mg/day)
  • Warfarin (5.8 Mg/day)
  • Furosemide
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
  • Enalapril
  • Carvedilol
Soon after that, the consumer experienced the following of symptoms:
  • Overdose
This opens a possibility that Rifampicin could cause death and that some female patients may be more susceptible.

Hepatitis, Renal Failure Chronic
A 74-year-old male patient (weight: NA) from JP with the following symptoms: pulmonary tuberculosis started Rifampicin treatment (dosage: Unk) on NS. Soon after starting Rifampicin treatment, the consumer experienced several side effects, including:
  • Hepatitis
  • Renal Failure Chronic
. Concurrently used drugs:
  • Isoniazid (Unk)
  • Ethambutol (Unk)
  • Pyrazinamide (Unk)
This finding indicates that some patients can be more vulnerable to developing Rifampicin side effects, such as hepatitis.

Diabetes Mellitus, Cerebral Infarction
This diabetes mellitus side effect was reported by a health professional from JP. A 62-year-old male patient (weight:NA) experienced the following symptoms/conditions: pulmonary tuberculosis.The patient was prescribed Rifampicin (dosage: Unk), which was started on NS. Concurrently used drugs:
  • Isoniazid (Unk)
  • Ethambutol (Unk)
  • Pyrazinamide (Unk)
.When starting to take Rifampicin the consumer reported symptoms, such as:
  • Diabetes Mellitus
  • Cerebral Infarction
These side effects may potentially be related to Rifampicin.

Acute Hepatic Failure, Renal Failure Acute, Respiratory Failure, Hepatic Encephalopathy, Coagulopathy, Distributive Shock, Altered State Of Consciousness
This is a report of a 94-year-old male patient (weight: NA) from TW, suffering from the following symptoms/conditions: pulmonary tuberculosis, who was treated with Rifampicin (dosage: 600 Mg, Daily, start time: NS), combined with:
  • Isoniazid (400 Mg, Daily)
  • Pyrazinamide (750 Mg, Daily)
  • Ethambutol (800 Mg, Daily)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Acute Hepatic Failure
  • Renal Failure Acute
  • Respiratory Failure
  • Hepatic Encephalopathy
  • Coagulopathy
  • Distributive Shock
  • Altered State Of Consciousness
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampicin treatment in male patients, resulting in acute hepatic failure side effect. The patient was hospitalized.

Influenza Like Illness, Rash, Leukocytosis, Eosinophilia, Hepatocellular Injury, Pruritus, Rash Maculo-papular, Macule
This report suggests a potential Rifampicin Influenza Like Illness, Rash, Leukocytosis, Eosinophilia, Hepatocellular Injury, Pruritus, Rash Maculo-papular, Macule side effect(s) that can have serious consequences. A 16-year-old female patient (weight: NA) from PH was diagnosed with the following symptoms/conditions: lymph node tuberculosis and used Rifampicin (dosage: NA) starting NS. Soon after starting Rifampicin the patient began experiencing various side effects, including:
  • Influenza Like Illness
  • Rash
  • Leukocytosis
  • Eosinophilia
  • Hepatocellular Injury
  • Pruritus
  • Rash Maculo-papular
  • Macule
Drugs used concurrently:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
Although Rifampicin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as influenza like illness, may still occur.

Anaemia, Neutropenia, Agranulocytosis
This Anaemia, Neutropenia, Agranulocytosis problem was reported by a health professional from FR. A 7-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: meningitis staphylococcal. On Dec 07, 2012 this consumer started treatment with Rifampicin (dosage: NA). The following drugs were being taken at the same time:
  • Claforan
  • Vancomycine
  • Nalbuphine
  • Paracetamol
  • Fosfocine
When commencing Rifampicin, the patient experienced the following unwanted symptoms/side effects:
  • Anaemia
  • Neutropenia
  • Agranulocytosis
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as anaemia, may become evident only after a product is in use by the general population.

Pneumonia, Suffocation Feeling
This is a report of a 48-year-old male patient (weight: NA) from JP. The patient developed the following symptoms/conditions: tuberculosis and was treated with Rifampicin Sandoz (dosage: 750 Mg, Daily) starting Dec 02, 2013. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Pneumonia
  • Suffocation Feeling
This opens a possibility that Rifampicin Sandoz treatment could cause the above reactions, including pneumonia, and some male subjects may be more susceptible.

Jaundice Cholestatic, Asthenia, Dysentery
A 48-year-old male patient (weight: NA) from IT with the following symptoms/conditions: pulmonary tuberculosis started Rifampicin treatment (dosage: NA) on Oct 04, 2013. Soon after starting Rifampicin treatment, the subject experienced various side effects, including:
  • Jaundice Cholestatic
  • Asthenia
  • Dysentery
Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Rifampicin.

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Top 10 Rifampicin Side Effects for Women

Women Side EffectsReports
Pyrexia 26
Vomiting 22
Nausea 16
Dyspnoea 15
Hyponatraemia 15
Jaundice 14
Lymphadenopathy 13
Abdominal Pain 12
Acute Hepatic Failure 12
Condition Aggravated 11

Top 10 Rifampicin Side Effects for Men

Men Side EffectsReports
Pyrexia 38
Dyspnoea 23
Renal Failure Acute 21
Jaundice 18
Vomiting 16
Anaemia 15
Rash 14
Toxic Epidermal Necrolysis 14
Eosinophilia 13
Acute Hepatic Failure 12

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    More About Rifampicin

    Side Effects reported to FDA: 674

    Rifampicin safety alerts: No

    Reported deaths: 134

    Reported hospitalizations: 323

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