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Rifampin Side Effects

Common Rifampin Side Effects


The most commonly reported Rifampin side effects (click to view or check a box to report):

Alanine Aminotransferase Increased (33)
Aspartate Aminotransferase Increased (32)
Hepatitis (27)
Pyrexia (25)
Hepatocellular Damage (24)
Renal Failure Acute (23)
Nausea (23)
Vomiting (18)
Blood Bilirubin Increased (15)
Rash (14)
Thrombocytopenia (13)
Diarrhoea (13)
Asthenia (13)
Dyspnoea (13)
Fatigue (13)
Hypotension (12)
Erythema (11)
Headache (10)
Hepatic Failure (10)
Myalgia (9)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Rifampin Side Effects Reported to FDA

The following Rifampin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Rifampin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Coma, Hepatic Encephalopathy
This is a report of a 60-year-old female patient (weight: NA) from FR, suffering from the following symptoms/conditions: tuberculosis, who was treated with Rifampin (dosage: 600 Mg, 1x/day, start time: NS), combined with:
  • Isoniazid (300 Mg, 1x/day)
  • Pyrazinamide (1.5 G, 1x/day)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Coma
  • Hepatic Encephalopathy
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in female patients, resulting in coma side effect. The patient was hospitalized.

Nausea, Headache, Fatigue, Myalgia, Dyspnoea
This report suggests a potential Rifampin Nausea, Headache, Fatigue, Myalgia, Dyspnoea side effect(s) that can have serious consequences. A 34-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: staphylococcal infection and used Rifampin (dosage: NA) starting NS. Soon after starting Rifampin the patient began experiencing various side effects, including:
  • Nausea
  • Headache
  • Fatigue
  • Myalgia
  • Dyspnoea
Drugs used concurrently: NA. Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as nausea, may still occur.

Mitochondrial Neurogastrointestinal Encephalopathy, Anaemia, Mitochondrial Toxicity
This Mitochondrial Neurogastrointestinal Encephalopathy, Anaemia, Mitochondrial Toxicity problem was reported by a health professional from BG. A 28-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pulmonary tuberculosis. On NS this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
When commencing Rifampin, the patient experienced the following unwanted symptoms/side effects:
  • Mitochondrial Neurogastrointestinal Encephalopathy
  • Anaemia
  • Mitochondrial Toxicity
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as mitochondrial neurogastrointestinal encephalopathy, may become evident only after a product is in use by the general population.

Pyrexia, Dyspnoea, Chest Pain, Rash Maculo-papular, Alanine Aminotransferase Increased
This is a report of a 41-year-old female patient (weight: NA) from TN. The patient developed the following symptoms/conditions: tuberculosis and was treated with Rifampin (dosage: NA) starting NS. Concurrently used drugs:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
Soon after that, the consumer experienced the following side effects:
  • Pyrexia
  • Dyspnoea
  • Chest Pain
  • Rash Maculo-papular
  • Alanine Aminotransferase Increased
The patient was hospitalized. This opens a possibility that Rifampin treatment could cause the above reactions, including pyrexia, and some female subjects may be more susceptible.


Mycobacterium Ulcerans Infection, Condition Aggravated, Skin Graft
A 19-year-old male patient (weight: NA) from AU with the following symptoms/conditions: mycobacterium ulcerans infection started Rifampin treatment (dosage: NA) on NS. Soon after starting Rifampin treatment, the subject experienced various side effects, including:
  • Mycobacterium Ulcerans Infection
  • Condition Aggravated
  • Skin Graft
Concurrently used drugs:
  • Moxifloxacin
This finding indicates that some male patients could be more vulnerable to Rifampin.

Heart Rate Increased, Hypotension
A 64-year-old female patient from US (weight: NA) experienced symptoms, such as: infection prophylaxis,anaesthesia and was treated with Rifampin(dosage: X2). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Heart Rate Increased
  • Hypotension
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Rifampin efficacy:
  • Propofol
  • Atorvastatin
  • Esomeprazole
  • Naproxen
  • Acetaminophen Plus Hydrocodone
  • Multivitamins
  • Midazolam
  • Fentanyl


Pyrexia, Rash, Product Quality Issue
In this report, Rifampin was administered for the following condition: NA.A 12-year-old male consumer from US (weight: NA) started Rifampin treatment (dosage: 200 Mg, 3x/day (every 8 Hrs)) on Dec 22, 2012.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Pyrexia
  • Rash
  • Product Quality Issue
A possible interaction with other drugs could have contributed to this reaction: NA.The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Rifampin treatment could be related to the listed above side effect(s).

Hepatitis, Diarrhoea, Septic Shock, Respiratory Failure, Continuous Haemodiafiltration, Renal Failure Acute
This is a report of the following Rifampin side effect(s):
  • Hepatitis
  • Diarrhoea
  • Septic Shock
  • Respiratory Failure
  • Continuous Haemodiafiltration
  • Renal Failure Acute
A 53-year-old female patient from US (weight: NA) presented with the following condition: tuberculosis,pyomyositis and received a treatment with Rifampin (dosage: NA) starting: NS.The following concurrently used drugs could have generated interactions: NA.This report suggests that a Rifampin treatment could be associated with the listed above side effect(s).

Rash, Loss Of Consciousness, Aphasia, Hemiparesis, Haemoglobin Decreased, White Blood Cell Count Decreased, Petechiae, Ecchymosis
This Rifampin report was submitted by a 18-year-old female consumer from TR (weight: NA). The patient was diagnosed with: brucellosis and Rifampin was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Rash
  • Loss Of Consciousness
  • Aphasia
  • Hemiparesis
  • Haemoglobin Decreased
  • White Blood Cell Count Decreased
  • Petechiae
  • Ecchymosis
Other drugs used simultaneously:
  • Doxycycline
The patient was hospitalized.Those unexpected symptoms could be linked to a Rifampin treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Rash Maculo-papular, Post Inflammatory Pigmentation Change, Vasculitis
This is a report of a possible correlation between Rifampin use and the following symptoms/side effect(s):
  • Rash Maculo-papular
  • Post Inflammatory Pigmentation Change
  • Vasculitis
which could contribute to an assessment of Rifampin risk profile.A 62-year-old male consumer from TH (weight: NA) was suffering from tuberculosis and was treated with Rifampin (dosage: NA) starting NS.Other concurrent medications:
  • Isoniazid
  • Ethambutol
  • Amlodipine
  • Metformin
  • Glipizide


Tuberculoma Of Central Nervous System, Optic Nerve Disorder
A 40-year-old male patient from IN (weight: NA) presented with the following symptoms: tuberculosis and after a treatment with Rifampin (dosage: NA) experienced the following side effect(s):
  • Tuberculoma Of Central Nervous System
  • Optic Nerve Disorder
The treatment was started on NS. Rifampin was used in combination with the following drugs:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
  • Dexamethasone
This report could alert potential Rifampin consumers.

Dizziness, Abdominal Pain Upper, Pyrexia, Tremor, Malaise, Dehydration, Vomiting
In this report, a 75-year-old female patient from US (weight: NA) was affected by a possible Rifampin side effect.The patient was diagnosed with latent tuberculosis. After a treatment with Rifampin (dosage: NA, start date: Apr 22, 2013), the patient experienced the following side effect(s):
  • Dizziness
  • Abdominal Pain Upper
  • Pyrexia
  • Tremor
  • Malaise
  • Dehydration
  • Vomiting
The following simultaneously used drugs could have led to this reaction: NA.The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Rifampin treatment.

Feeling Hot, Flushing, Respiratory Rate Increased, Rash, Fatigue, Unevaluable Event
This is a report of a 30-year-old female patient from US (weight: NA), who used Rifampin (dosage: NA) for a treatment of NA. After starting a treatment on Apr 01, 2013, the patient experienced the following side effect(s):
  • Feeling Hot
  • Flushing
  • Respiratory Rate Increased
  • Rash
  • Fatigue
  • Unevaluable Event
The following drugs could possibly have interacted with the Rifampin treatment NA.Taken together, these observations suggest that a Rifampin treatment could be related to side effect(s), such as Feeling Hot, Flushing, Respiratory Rate Increased, Rash, Fatigue, Unevaluable Event.

Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Blood Bilirubin Increased, Bilirubin Conjugated Increased, Blood Alkaline Phosphatase Increased, Jaundice
This aspartate aminotransferase increased side effect was reported by a pharmacist from US. A 64-year-old male patient (weight:NA) experienced the following symptoms/conditions: staphylococcal abscess,bacterial abscess central nervous system. The patient was prescribed Rifampin (dosage: NA), which was started on Nov 02, 2012. Concurrently used drugs: NA. When starting to take Rifampin the consumer reported the following symptoms:
  • Aspartate Aminotransferase Increased
  • Alanine Aminotransferase Increased
  • Blood Bilirubin Increased
  • Bilirubin Conjugated Increased
  • Blood Alkaline Phosphatase Increased
  • Jaundice
The patient was hospitalized. These side effects may potentially be related to Rifampin.

Thrombocytopenia, Anaemia, Renal Failure Acute, Blood Alkaline Phosphatase Increased, Blood Bilirubin Increased
This is a Rifampin side effect report of a 31-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: tuberculosis, who was treated with Rifampin (dosage:NA, start time: Mar 15, 2013), combined with: NA., and developed a serious reaction and a thrombocytopenia side effect. The patient presented with:
  • Thrombocytopenia
  • Anaemia
  • Renal Failure Acute
  • Blood Alkaline Phosphatase Increased
  • Blood Bilirubin Increased
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Rifampin treatment in female patients suffering from tuberculosis, resulting in thrombocytopenia.

Systemic Lupus Erythematosus, Pericarditis, Pleurisy
This report suggests a potential Rifampin systemic lupus erythematosus side effect(s) that can have serious consequences. A 50-year-old male patient from CN (weight:NA) was diagnosed with the following health condition(s): pulmonary tuberculosis and used Rifampin (dosage: NA) starting NS. Soon after starting Rifampin the patient began experiencing various side effects, including:
  • Systemic Lupus Erythematosus
  • Pericarditis
  • Pleurisy
Drugs used concurrently:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as systemic lupus erythematosus, may still occur.

Pneumonitis
This pneumonitis problem was reported by a health professional from JP. A 84-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): disseminated tuberculosis.On 201202 a consumer started treatment with Rifampin (dosage: NA). The following drugs/medications were being taken at the same time:
  • Isoniazid
  • Ethambutol
  • Prednisolone
When commencing Rifampin, the patient experienced the following unwanted symptoms /side effects:
  • Pneumonitis
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as pneumonitis, may become evident only after a product is in use by the general population.

Respiratory Disorder, Heart Rate Decreased, Procedural Complication, Apnoea, Cardiac Arrest, Tuberculoma Of Central Nervous System
This is a Rifampin side effect report of a 13-year-old female patient (weight: NA) from CN. The patient developed the following symptoms/conditions: meningitis tuberculous and was treated with Rifampin (dosage: NA) starting NS. Concurrently used drugs:
  • Isoniazid (3 Month)
  • Pyrazinamide (3 Month)
Soon after that, the consumer experienced the following of symptoms:
  • Respiratory Disorder
  • Heart Rate Decreased
  • Procedural Complication
  • Apnoea
  • Cardiac Arrest
  • Tuberculoma Of Central Nervous System
The patient was hospitalized. This opens a possibility that Rifampin could cause respiratory disorder and that some female patients may be more susceptible.

Product Quality Issue
A 38-year-old female patient (weight: NA) from US with the following symptoms: lyme disease started Rifampin treatment (dosage: Unk) on Dec 11, 2012. Soon after starting Rifampin treatment, the consumer experienced several side effects, including:
  • Product Quality Issue
. Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Rifampin side effects, such as product quality issue.

Product Quality Issue
This product quality issue side effect was reported by a consumer or non-health professional from US. A 16-year-old female patient (weight:NA) experienced the following symptoms/conditions: lyme disease.The patient was prescribed Rifampin (dosage: Unk), which was started on NS. Concurrently used drugs: NA..When starting to take Rifampin the consumer reported symptoms, such as:
  • Product Quality Issue
These side effects may potentially be related to Rifampin.

Mycobacterium Ulcerans Infection, Anaemia, Treatment Failure, Condition Aggravated
This is a report of a 4-year-old patient (weight: NA) from ZA, suffering from the following symptoms/conditions: NA, who was treated with Rifampin (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Mycobacterium Ulcerans Infection
  • Anaemia
  • Treatment Failure
  • Condition Aggravated
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in patients, resulting in mycobacterium ulcerans infection side effect.

Tubulointerstitial Nephritis, Fanconi Syndrome, Paralysis, Hypokalaemia, Metabolic Acidosis, Renal Tubular Acidosis, Iga Nephropathy
This report suggests a potential Rifampin Tubulointerstitial Nephritis, Fanconi Syndrome, Paralysis, Hypokalaemia, Metabolic Acidosis, Renal Tubular Acidosis, Iga Nephropathy side effect(s) that can have serious consequences. A 42-year-old male patient (weight: NA) from KR was diagnosed with the following symptoms/conditions: pulmonary tuberculosis and used Rifampin (dosage: NA) starting NS. Soon after starting Rifampin the patient began experiencing various side effects, including:
  • Tubulointerstitial Nephritis
  • Fanconi Syndrome
  • Paralysis
  • Hypokalaemia
  • Metabolic Acidosis
  • Renal Tubular Acidosis
  • Iga Nephropathy
Drugs used concurrently:
  • Isoniazid
  • Ethambutol
The patient was hospitalized. Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as tubulointerstitial nephritis, may still occur.

Hypertension
This Hypertension problem was reported by a health professional from IN. A 52-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: pulmonary tuberculosis. On NS this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time:
  • Amlodipine
When commencing Rifampin, the patient experienced the following unwanted symptoms/side effects:
  • Hypertension
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as hypertension, may become evident only after a product is in use by the general population.

Accelerated Hypertension, Acute Left Ventricular Failure
This is a report of a 48-year-old male patient (weight: NA) from IN. The patient developed the following symptoms/conditions: peritoneal tuberculosis and was treated with Rifampin (dosage: NA) starting NS. Concurrently used drugs:
  • Amlodipine
  • Losartan
  • Isoniazid
  • Ethambutol
  • Pyrazinamide
Soon after that, the consumer experienced the following side effects:
  • Accelerated Hypertension
  • Acute Left Ventricular Failure
The patient was hospitalized. This opens a possibility that Rifampin treatment could cause the above reactions, including accelerated hypertension, and some male subjects may be more susceptible.

Shock, Respiratory Distress, Vomiting, Grand Mal Convulsion, Coma, Metabolic Acidosis, Lactic Acidosis, Rhabdomyolysis, Liver Disorder
A 31-year-old male patient (weight: NA) from IN with the following symptoms/conditions: NA started Rifampin treatment (dosage: 6075 Gms) on NS. Soon after starting Rifampin treatment, the subject experienced various side effects, including:
  • Shock
  • Respiratory Distress
  • Vomiting
  • Grand Mal Convulsion
  • Coma
  • Metabolic Acidosis
  • Lactic Acidosis
  • Rhabdomyolysis
  • Liver Disorder
Concurrently used drugs:
  • Isoniazid
This finding indicates that some male patients could be more vulnerable to Rifampin.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Rifampin Side Effects

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    How Effective is Rifampin for You?

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    Rifampin Safety Alerts, Active Ingredients, Usage Information

    NDC0069-0112
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameRifampin
    NameRifampin
    Dosage FormINJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
    RouteINTRAVENOUS
    On market since20110510
    LabelerPfizer Laboratories Div Pfizer Inc
    Active Ingredient(s)RIFAMPIN
    Strength(s)600
    Unit(s)mg/10mL
    Pharma ClassRifamycin Antibacterial [EPC],Rifamycins [Chemical/Ingredient]

    Rifampin Dosage, Warnings, Usage.

    Side Effects reported to FDA: 305

    Rifampin safety alerts: 2003

    Reported deaths: 61

    Reported hospitalizations: 125

    Latest Rifampin clinical trials