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Rifampin Side Effects

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Common Rifampin Side Effects


The most commonly reported Rifampin side effects (click to view or check a box to report):

Alanine Aminotransferase Increased (33)
Aspartate Aminotransferase Increased (32)
Hepatitis (27)
Pyrexia (25)
Hepatocellular Damage (24)
Renal Failure Acute (23)
Nausea (23)
Vomiting (18)
Blood Bilirubin Increased (15)
Rash (14)
Thrombocytopenia (13)
Diarrhoea (13)
Asthenia (13)
Dyspnoea (13)
Fatigue (13)
Hypotension (12)
Erythema (11)
Headache (10)
Hepatic Failure (10)
Myalgia (9)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Rifampin Side Effects Reported to FDA



Rifampin Side Effect Report#9431182
Coma, Hepatic Encephalopathy
This is a report of a 60-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: tuberculosis, who was treated with Rifampin (dosage: 600 Mg, 1x/day, start time: NS), combined with:
  • Isoniazid (300 Mg, 1x/day)
  • Pyrazinamide (1.5 G, 1x/day)
and developed a serious reaction and side effect(s): Coma, Hepatic Encephalopathy after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in female patients, resulting in Coma side effect. The patient was hospitalized.
Rifampin Side Effect Report#9422264
Nausea, Headache, Fatigue, Myalgia, Dyspnoea
This report suggests a potential Rifampin Nausea side effect(s) that can have serious consequences. A 34-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: staphylococcal infection and used Rifampin (dosage: NA) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Nausea, Headache, Fatigue, Myalgia, DyspnoeaAdditional drugs used concurrently: NA. Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Nausea, may still occur.
Rifampin Side Effect Report#9417100
Mitochondrial Neurogastrointestinal Encephalopathy, Anaemia, Mitochondrial Toxicity
This Mitochondrial Neurogastrointestinal Encephalopathy problem was reported by a health professional from BG. A 28-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pulmonary tuberculosis. On NS this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Mitochondrial Neurogastrointestinal Encephalopathy, Anaemia, Mitochondrial ToxicityAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Mitochondrial Neurogastrointestinal Encephalopathy, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9378621
Pyrexia, Dyspnoea, Chest Pain, Rash Maculo-papular, Alanine Aminotransferase Increased
This Pyrexia side effect was reported by a health professional from TN. A 41-year-old female patient (weight:NA) experienced the following symptoms/conditions: tuberculosis.The patient was prescribed Rifampin (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
.After starting to take Rifampin the consumer reported adverse symptoms, such as: Pyrexia, Dyspnoea, Chest Pain, Rash Maculo-papular, Alanine Aminotransferase IncreasedThese side effects may potentially be related to Rifampin. The patient was hospitalized.
Rifampin Side Effect Report#9372074
Mycobacterium Ulcerans Infection, Condition Aggravated, Skin Graft
This is a report of a 19-year-old male patient (weight: NA) from AU, suffering from the following health symptoms/conditions: mycobacterium ulcerans infection, who was treated with Rifampin (dosage: NA, start time: NS), combined with:
  • Moxifloxacin
and developed a serious reaction and side effect(s): Mycobacterium Ulcerans Infection, Condition Aggravated, Skin Graft after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in male patients, resulting in Mycobacterium Ulcerans Infection side effect.
Rifampin Side Effect Report#9370149
Heart Rate Increased, Hypotension
This report suggests a potential Rifampin Heart Rate Increased side effect(s) that can have serious consequences. A 64-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: infection prophylaxis,anaesthesia and used Rifampin (dosage: X2) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Heart Rate Increased, HypotensionAdditional drugs used concurrently:
  • Propofol
  • Atorvastatin
  • Esomeprazole
  • Naproxen
  • Acetaminophen Plus Hydrocodone
  • Multivitamins
  • Midazolam
  • Fentanyl
Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Heart Rate Increased, may still occur.
Rifampin Side Effect Report#9356214
Pyrexia, Rash, Product Quality Issue
This Pyrexia problem was reported by a pharmacist from US. A 12-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Dec 22, 2012 this consumer started treatment with Rifampin (dosage: 200 Mg, 3x/day (every 8 Hrs)). The following drugs were being taken at the same time: NA. When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Pyrexia, Rash, Product Quality IssueThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pyrexia, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9349875
Hepatitis, Diarrhoea, Septic Shock, Respiratory Failure, Continuous Haemodiafiltration, Renal Failure Acute
This Hepatitis side effect was reported by a health professional from US. A 53-year-old female patient (weight:NA) experienced the following symptoms/conditions: tuberculosis,pyomyositis.The patient was prescribed Rifampin (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Rifampin the consumer reported adverse symptoms, such as: Hepatitis, Diarrhoea, Septic Shock, Respiratory Failure, Continuous Haemodiafiltration, Renal Failure AcuteThese side effects may potentially be related to Rifampin.
Rifampin Side Effect Report#9326703
Rash, Rash, Loss Of Consciousness, Aphasia, Hemiparesis, Haemoglobin Decreased, White Blood Cell Count Decreased, Petechiae, Ecchymosis
This is a report of a 18-year-old female patient (weight: NA) from TR, suffering from the following health symptoms/conditions: brucellosis, who was treated with Rifampin (dosage: NA, start time: NS), combined with:
  • Doxycycline
and developed a serious reaction and side effect(s): Rash, Rash, Loss Of Consciousness, Aphasia, Hemiparesis, Haemoglobin Decreased, White Blood Cell Count Decreased, Petechiae, Ecchymosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in female patients, resulting in Rash side effect. The patient was hospitalized.
Rifampin Side Effect Report#9326307
Rash Maculo-papular, Post Inflammatory Pigmentation Change, Vasculitis
This report suggests a potential Rifampin Rash Maculo-papular side effect(s) that can have serious consequences. A 62-year-old male patient (weight: NA) from TH was diagnosed with the following symptoms/conditions: tuberculosis and used Rifampin (dosage: NA) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Rash Maculo-papular, Post Inflammatory Pigmentation Change, VasculitisAdditional drugs used concurrently:
  • Isoniazid
  • Ethambutol
  • Amlodipine
  • Metformin
  • Glipizide
Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Rash Maculo-papular, may still occur.
Rifampin Side Effect Report#9314127
Tuberculoma Of Central Nervous System, Optic Nerve Disorder
This Tuberculoma Of Central Nervous System problem was reported by a health professional from IN. A 40-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: tuberculosis. On NS this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
  • Dexamethasone
When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Tuberculoma Of Central Nervous System, Optic Nerve DisorderAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Tuberculoma Of Central Nervous System, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9285978
Dizziness, Abdominal Pain Upper, Pyrexia, Tremor, Malaise, Dehydration, Vomiting
This Dizziness side effect was reported by a consumer or non-health professional from US. A 75-year-old female patient (weight:NA) experienced the following symptoms/conditions: latent tuberculosis.The patient was prescribed Rifampin (drug dosage: NA), which was initiated on
Apr 22, 2013. Concurrently used drugs: NA..After starting to take Rifampin the consumer reported adverse symptoms, such as: Dizziness, Abdominal Pain Upper, Pyrexia, Tremor, Malaise, Dehydration, VomitingThese side effects may potentially be related to Rifampin. The patient was hospitalized.
Rifampin Side Effect Report#9277375
Feeling Hot, Flushing, Respiratory Rate Increased, Rash, Rash, Rash, Fatigue, Unevaluable Event
This is a report of a 30-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Rifampin (dosage: NA, start time:
Apr 01, 2013), combined with: NA. and developed a serious reaction and side effect(s): Feeling Hot, Flushing, Respiratory Rate Increased, Rash, Rash, Rash, Fatigue, Unevaluable Event after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in female patients, resulting in Feeling Hot side effect.
Rifampin Side Effect Report#9249028
Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Blood Bilirubin Increased, Bilirubin Conjugated Increased, Blood Alkaline Phosphatase Increased, Jaundice
This report suggests a potential Rifampin Aspartate Aminotransferase Increased side effect(s) that can have serious consequences. A 64-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: staphylococcal abscess,bacterial abscess central nervous system and used Rifampin (dosage: NA) starting
Nov 02, 2012. After starting Rifampin the patient began experiencing various side effects, including: Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Blood Bilirubin Increased, Bilirubin Conjugated Increased, Blood Alkaline Phosphatase Increased, JaundiceAdditional drugs used concurrently: NA.The patient was hospitalized. Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Aspartate Aminotransferase Increased, may still occur.
Rifampin Side Effect Report#9238834
Thrombocytopenia, Anaemia, Renal Failure Acute, Blood Alkaline Phosphatase Increased, Blood Bilirubin Increased
This Thrombocytopenia problem was reported by a pharmacist from US. A 31-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: tuberculosis. On
Mar 15, 2013 this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time: NA. When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Thrombocytopenia, Anaemia, Renal Failure Acute, Blood Alkaline Phosphatase Increased, Blood Bilirubin IncreasedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Thrombocytopenia, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9225082
Systemic Lupus Erythematosus, Pericarditis, Pleurisy
This Systemic Lupus Erythematosus side effect was reported by a health professional from CN. A 50-year-old male patient (weight:NA) experienced the following symptoms/conditions: pulmonary tuberculosis.The patient was prescribed Rifampin (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
.After starting to take Rifampin the consumer reported adverse symptoms, such as: Systemic Lupus Erythematosus, Pericarditis, PleurisyThese side effects may potentially be related to Rifampin.
Rifampin Side Effect Report#9225053
Pneumonitis
This is a report of a 84-year-old female patient (weight: NA) from JP, suffering from the following health symptoms/conditions: disseminated tuberculosis, who was treated with Rifampin (dosage: NA, start time: 201202), combined with:
  • Isoniazid
  • Ethambutol
  • Prednisolone
and developed a serious reaction and side effect(s): Pneumonitis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in female patients, resulting in Pneumonitis side effect. The patient was hospitalized.
Rifampin Side Effect Report#9222295
Respiratory Disorder, Heart Rate Decreased, Procedural Complication, Apnoea, Cardiac Arrest, Tuberculoma Of Central Nervous System
This report suggests a potential Rifampin Respiratory Disorder side effect(s) that can have serious consequences. A 13-year-old female patient (weight: NA) from CN was diagnosed with the following symptoms/conditions: meningitis tuberculous and used Rifampin (dosage: NA) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Respiratory Disorder, Heart Rate Decreased, Procedural Complication, Apnoea, Cardiac Arrest, Tuberculoma Of Central Nervous SystemAdditional drugs used concurrently:
  • Isoniazid (3 Month)
  • Pyrazinamide (3 Month)
The patient was hospitalized. Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Respiratory Disorder, may still occur.
Rifampin Side Effect Report#9199173
Product Quality Issue
This Product Quality Issue problem was reported by a consumer or non-health professional from US. A 38-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: lyme disease. On
Dec 11, 2012 this consumer started treatment with Rifampin (dosage: Unk). The following drugs were being taken at the same time: NA. When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Product Quality IssueAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Product Quality Issue, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9199088
Product Quality Issue
This Product Quality Issue side effect was reported by a consumer or non-health professional from US. A 16-year-old female patient (weight:NA) experienced the following symptoms/conditions: lyme disease.The patient was prescribed Rifampin (drug dosage: Unk), which was initiated on NS. Concurrently used drugs: NA..After starting to take Rifampin the consumer reported adverse symptoms, such as: Product Quality IssueThese side effects may potentially be related to Rifampin.
Rifampin Side Effect Report#9160155
Mycobacterium Ulcerans Infection, Anaemia, Treatment Failure, Condition Aggravated
This is a report of a 4-year-old patient (weight: NA) from ZA, suffering from the following health symptoms/conditions: NA, who was treated with Rifampin (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Mycobacterium Ulcerans Infection, Anaemia, Treatment Failure, Condition Aggravated after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in patients, resulting in Mycobacterium Ulcerans Infection side effect.
Rifampin Side Effect Report#9160147
Tubulointerstitial Nephritis, Fanconi Syndrome, Paralysis, Hypokalaemia, Metabolic Acidosis, Renal Tubular Acidosis, Iga Nephropathy
This report suggests a potential Rifampin Tubulointerstitial Nephritis side effect(s) that can have serious consequences. A 42-year-old male patient (weight: NA) from KR was diagnosed with the following symptoms/conditions: pulmonary tuberculosis and used Rifampin (dosage: NA) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Tubulointerstitial Nephritis, Fanconi Syndrome, Paralysis, Hypokalaemia, Metabolic Acidosis, Renal Tubular Acidosis, Iga NephropathyAdditional drugs used concurrently:
  • Isoniazid
  • Ethambutol
The patient was hospitalized. Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Tubulointerstitial Nephritis, may still occur.
Rifampin Side Effect Report#9155085
Hypertension
This Hypertension problem was reported by a health professional from IN. A 52-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: pulmonary tuberculosis. On NS this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time:
  • Amlodipine
When using Rifampin, the patient experienced the following unwanted symptoms/side effects: HypertensionThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypertension, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9155068
Accelerated Hypertension, Acute Left Ventricular Failure, Hypertension
This Accelerated Hypertension side effect was reported by a health professional from IN. A 48-year-old male patient (weight:NA) experienced the following symptoms/conditions: peritoneal tuberculosis.The patient was prescribed Rifampin (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Amlodipine
  • Losartan
  • Isoniazid
  • Ethambutol
  • Pyrazinamide
.After starting to take Rifampin the consumer reported adverse symptoms, such as: Accelerated Hypertension, Acute Left Ventricular Failure, HypertensionThese side effects may potentially be related to Rifampin. The patient was hospitalized.
Rifampin Side Effect Report#9135749
Shock, Respiratory Distress, Vomiting, Grand Mal Convulsion, Coma, Metabolic Acidosis, Lactic Acidosis, Rhabdomyolysis, Liver Disorder
This is a report of a 31-year-old male patient (weight: NA) from IN, suffering from the following health symptoms/conditions: NA, who was treated with Rifampin (dosage: 6075 Gms, start time: NS), combined with:
  • Isoniazid
and developed a serious reaction and side effect(s): Shock, Respiratory Distress, Vomiting, Grand Mal Convulsion, Coma, Metabolic Acidosis, Lactic Acidosis, Rhabdomyolysis, Liver Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in male patients, resulting in Shock side effect.


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The appearance of Rifampin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Rifampin Side Effects for Women?

Women Side EffectsReports
Nausea 14
Alanine Aminotransferase Increased 12
Aspartate Aminotransferase Increased 11
Hepatitis 11
Pyrexia 11
Rash 10
Vomiting 10
Fatigue 8
Diarrhoea 7
Erythema 7

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Rifampin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Rifampin Safety Alerts, Active Ingredients, Usage Information

    NDC0069-0112
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameRifampin
    NameRifampin
    Dosage FormINJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
    RouteINTRAVENOUS
    On market since20110510
    LabelerPfizer Laboratories Div Pfizer Inc
    Active Ingredient(s)RIFAMPIN
    Strength(s)600
    Unit(s)mg/10mL
    Pharma ClassRifamycin Antibacterial [EPC],Rifamycins [Chemical/Ingredient]

    Rifampin Dosage, Warnings, Usage.

    Side Effects reported to FDA: 305

    Rifampin safety alerts: 2003

    Reported deaths: 61

    Reported hospitalizations: 125

    Latest Rifampin clinical trials