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Rohypnol Side Effects

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Common Rohypnol Side Effects


The most commonly reported Rohypnol side effects (click to view or check a box to report):

Hepatic Function Abnormal (5)
Rhabdomyolysis (5)
Convulsion (4)
Interstitial Lung Disease (4)
Pancytopenia (4)
Liver Disorder (4)
Loss Of Consciousness (3)
Blood Alkaline Phosphatase Increased (3)
Malaise (3)
Completed Suicide (3)
Neuroleptic Malignant Syndrome (3)
Off Label Use (3)
Thrombocytopenia (3)
Pyrexia (3)
Red Blood Cell Count Decreased (2)
Somnolence (2)
Platelet Count Decreased (2)
Hypothermia (2)
Hypoglycaemia (2)
Neutrophil Count Decreased (2)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Rohypnol Side Effects Reported to FDA



Rohypnol Side Effect Report#9848583
Neuroleptic Malignant Syndrome, Coma, Delirium
This is a report of a 64-year-old male patient (weight: NA) from JP, suffering from the following health symptoms/conditions: NA, who was treated with Rohypnol (dosage: Dosage Is Uncertain., start time: NS), combined with:
  • Diazepam (Dosage Is Uncertain.)
  • Buprenorphine (Dosage Is Uncertain.)
and developed a serious reaction and side effect(s): Neuroleptic Malignant Syndrome, Coma, Delirium after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rohypnol treatment in male patients, resulting in Neuroleptic Malignant Syndrome side effect.
Rohypnol Side Effect Report#9105121
Altered State Of Consciousness, Rhabdomyolysis, Overdose
This report suggests a potential Rohypnol Altered State Of Consciousness side effect(s) that can have serious consequences. A 31-year-old male patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: NA and used Rohypnol (dosage: NA) starting NS. After starting Rohypnol the patient began experiencing various side effects, including: Altered State Of Consciousness, Rhabdomyolysis, OverdoseAdditional drugs used concurrently:
  • Lamotrigine
  • Diazepam
  • Nitrazepam
  • Carbamazepine
  • Zonisamide
The patient was hospitalized. Although Rohypnol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Altered State Of Consciousness, may still occur.
Rohypnol Side Effect Report#8494302-X
Toxic Skin Eruption, Blood Creatine Phosphokinase Increased, Pruritus, Depression
This Toxic Skin Eruption problem was reported by a physician from Japan. A 46-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Feb 16, 2012 this consumer started treatment with Rohypnol (dosage: NA). The following drugs were being taken at the same time:
  • Telavic (antivirals Nos) (2250 Mg;qd;po)
  • Allopurinol
  • Hirudoid Soft
  • Depakene
  • Peg-intron (1.5 Mcg/kg;qw;sc)
  • Antebate
  • Rebetol (800 Mg;qd;po)
  • Lendormin
When using Rohypnol, the patient experienced the following unwanted symptoms/side effects: Toxic Skin Eruption, Blood Creatine Phosphokinase Increased, Pruritus, DepressionThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Toxic Skin Eruption, may become evident only after a product is in use by the general population.
Rohypnol Side Effect Report#8471112-0
Inappropriate Antidiuretic Hormone Secretion, Water Intoxication, Rhabdomyolysis, Convulsion
This Inappropriate Antidiuretic Hormone Secretion side effect was reported by a physician from Japan. A 47-year-old male patient (weight:NA) experienced the following symptoms/conditions: depression.The patient was prescribed Rohypnol (drug dosage: 1 Mg/day), which was initiated on
Jun 04, 2012. Concurrently used drugs:
  • Zoloft (25 Mg, 2x/day)
.After starting to take Rohypnol the consumer reported adverse symptoms, such as: Inappropriate Antidiuretic Hormone Secretion, Water Intoxication, Rhabdomyolysis, ConvulsionThese side effects may potentially be related to Rohypnol. The patient was hospitalized.
Rohypnol Side Effect Report#8445736-0
Hypoalbuminaemia, Hypothermia, Cardio-respiratory Arrest, Hypoglycaemia, Pancytopenia, Loss Of Consciousness
This is a report of a 56-year-old female patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: NA, who was treated with Rohypnol (dosage: NA, start time:
Dec 01, 2011), combined with:
  • Lamictal (100mg Per Day)
and developed a serious reaction and side effect(s): Hypoalbuminaemia, Hypothermia, Cardio-respiratory Arrest, Hypoglycaemia, Pancytopenia, Loss Of Consciousness after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rohypnol treatment in female patients, resulting in Hypoalbuminaemia side effect.
Rohypnol Side Effect Report#8443719-8
Interstitial Lung Disease, Pneumothorax
This report suggests a potential Rohypnol Interstitial Lung Disease side effect(s) that can have serious consequences. A male patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: insomnia and used Rohypnol (dosage: 1 Mg, Qd) starting
Nov 02, 2011. After starting Rohypnol the patient began experiencing various side effects, including: Interstitial Lung Disease, PneumothoraxAdditional drugs used concurrently:
  • Depas (0.5 Mg, Bid)
  • Cymbalta (20 Mg, Qd)
  • Mexitil (100 Mg, Tid)
  • Humalog (16 Iu, Bid)
  • Lendormin (0.25 Mg, Unk)
  • Depas (0.5 Mg, Qd)
  • Ramelteon (8 Mg, Unk)
The patient was hospitalized. Although Rohypnol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Interstitial Lung Disease, may still occur.
Rohypnol Side Effect Report#8415927-3
Melaena, Colon Cancer, Large Intestinal Haemorrhage
This Melaena problem was reported by a physician from Japan. A 85-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Mar 19, 2010 this consumer started treatment with Rohypnol (dosage: NA). The following drugs were being taken at the same time:
  • Aspirin
  • Amlodipine
  • Atorvastatin Calcium
  • Clopidogrel Bisulfate
  • Myonal
  • Lansoprazole
  • Sermion
When using Rohypnol, the patient experienced the following unwanted symptoms/side effects: Melaena, Colon Cancer, Large Intestinal HaemorrhageAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Melaena, may become evident only after a product is in use by the general population.
Rohypnol Side Effect Report#8341767-X
Interstitial Lung Disease
This Interstitial Lung Disease side effect was reported by a physician from Japan. A 67-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Rohypnol (drug dosage: Unk), which was initiated on
Mar 19, 2012. Concurrently used drugs:
  • Humalog (Unk)
  • Cymbalta (20 Mg, Qd)
  • Depas (Unk)
.After starting to take Rohypnol the consumer reported adverse symptoms, such as: Interstitial Lung DiseaseThese side effects may potentially be related to Rohypnol. The patient was hospitalized.
Rohypnol Side Effect Report#8313401-6
Dyskinesia, Neoplasm Progression, Oxygen Saturation Decreased, Schizophrenia, Interstitial Lung Disease, Mental Disorder, Dyspnoea, Neuropathy Peripheral
This is a report of a female patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: NA, who was treated with Rohypnol (dosage: 1 Mg, Unk, start time:
May 09, 2010), combined with:
  • Lendormin (0.25 Mg, Unk)
  • Gleevec (400 Mg, Daily)
  • Gleevec (300 Mg, Daily)
  • Depakene (300 Mg, Unk)
  • Gleevec (200 Mg, Daily)
  • Risperdal (6 Mg, Daily)
  • Gleevec (100 Mg, Daily)
  • Risperdal (6 Mg, Daily)
and developed a serious reaction and side effect(s): Dyskinesia, Neoplasm Progression, Oxygen Saturation Decreased, Schizophrenia, Interstitial Lung Disease, Mental Disorder, Dyspnoea, Neuropathy Peripheral after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rohypnol treatment in female patients, resulting in Dyskinesia side effect. The patient was hospitalized.
Rohypnol Side Effect Report#8307374-X
Liver Disorder
This report suggests a potential Rohypnol Liver Disorder side effect(s) that can have serious consequences. A 67-year-old female patient (weight: NA) from Denmark was diagnosed with the following symptoms/conditions: NA and used Rohypnol (dosage: 2 Mg) starting
Jan 19, 2012. After starting Rohypnol the patient began experiencing various side effects, including: Liver DisorderAdditional drugs used concurrently:
  • Chlorpromazine Hcl
  • Phenobarbital Tab
  • Bromovalerylurea (0.3 G)
  • Alprazolam (1.2 Mg)
  • Lexapro (10 Mg)
  • Hange-koboku-to
  • Dogmatyl (150 Mg)
Although Rohypnol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Liver Disorder, may still occur.
Rohypnol Side Effect Report#8238106-1
Hypoalbuminaemia, Hypothermia, Loss Of Consciousness, Cardio-respiratory Arrest, Pancytopenia, Hypoglycaemia
This Hypoalbuminaemia problem was reported by a physician from Japan. A 56-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Dec 01, 2011 this consumer started treatment with Rohypnol (dosage: NA). The following drugs were being taken at the same time:
  • Antidepressant
  • Lamictal (100mg Per Day)
  • Quetiapine Fumarate
  • Lithium Carbonate
When using Rohypnol, the patient experienced the following unwanted symptoms/side effects: Hypoalbuminaemia, Hypothermia, Loss Of Consciousness, Cardio-respiratory Arrest, Pancytopenia, HypoglycaemiaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypoalbuminaemia, may become evident only after a product is in use by the general population.
Rohypnol Side Effect Report#8183388-8
Completed Suicide, Intentional Overdose
This Completed Suicide side effect was reported by a physician from Japan. A 25-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Rohypnol (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Halcion
  • Depas
  • Lexotan
.After starting to take Rohypnol the consumer reported adverse symptoms, such as: Completed Suicide, Intentional OverdoseThese side effects may potentially be related to Rohypnol.
Rohypnol Side Effect Report#8180318-X
Hepatic Function Abnormal
This is a report of a female patient (weight: NA) from Denmark, suffering from the following health symptoms/conditions: NA, who was treated with Rohypnol (dosage: 2 Mg, start time:
Oct 08, 2010), combined with:
  • Reflex (15 Mg)
  • Gasmotin (15 Mg)
  • Risperdal (1 Mg)
  • Lexapro (20 Mg)
  • Gascon (120 Mg)
  • Magmitt (750 Mg)
  • U-pan (1.5 Mg)
and developed a serious reaction and side effect(s): Hepatic Function Abnormal after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rohypnol treatment in female patients, resulting in Hepatic Function Abnormal side effect.
Rohypnol Side Effect Report#8173793-8
Thrombocytopenia, Off Label Use
This report suggests a potential Rohypnol Thrombocytopenia side effect(s) that can have serious consequences. A 45-year-old male patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: prophylaxis and used Rohypnol (dosage: 1 Mg, Qd) starting
May 01, 2011. After starting Rohypnol the patient began experiencing various side effects, including: Thrombocytopenia, Off Label UseAdditional drugs used concurrently:
  • Lexotan (2 Mg, Qd)
  • Zyprexa (2.5 Mg, Tid)
  • Meilax (2 Mg, Bid)
  • Lexotan (2 Mg, Bid)
Although Rohypnol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Thrombocytopenia, may still occur.
Rohypnol Side Effect Report#8141308-6
Off Label Use, Thrombocytopenia
This Off Label Use problem was reported by a physician from Japan. A 45-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: prophylaxis. On
May 01, 2011 this consumer started treatment with Rohypnol (dosage: 1 Mg, Qd). The following drugs were being taken at the same time:
  • Lexotan (2 Mg, Qd)
  • Zyprexa (2.5 Mg, Tid)
  • Meilax (2 Mg, Bid)
  • Lexotan (2 Mg, Bid)
When using Rohypnol, the patient experienced the following unwanted symptoms/side effects: Off Label Use, ThrombocytopeniaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Off Label Use, may become evident only after a product is in use by the general population.
Rohypnol Side Effect Report#8026952
Septic Shock, Neutropenia, Bronchitis, Dermatitis
This Septic Shock side effect was reported by a physician from JP. A 73-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Rohypnol (drug dosage: 1 Milligram), which was initiated on
Mar 17, 2011. Concurrently used drugs:
  • Biofermin R (3 Gram)
  • Monilac (30 Milliliter)
  • Lactec G (500 Milliliter)
  • Pantethine (200 Milligram)
  • Vitamedin
  • Sodium Chloride (20 Milliliter)
  • Cefpirome Sulfate (2 Gram)
  • Fentanyl
.After starting to take Rohypnol the consumer reported adverse symptoms, such as: Septic Shock, Neutropenia, Bronchitis, DermatitisThese side effects may potentially be related to Rohypnol.
Rohypnol Side Effect Report#8019016-1
Thrombocytopenia
This is a report of a 46-year-old male patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: NA, who was treated with Rohypnol (dosage: Unk, start time: NS), combined with:
  • Zyprexa (7.5 Mg, Unk)
  • Lexotan (Unk)
  • Meilax (2 Mg, Unk)
and developed a serious reaction and side effect(s): Thrombocytopenia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rohypnol treatment in male patients, resulting in Thrombocytopenia side effect. The patient was hospitalized.
Rohypnol Side Effect Report#8010936-0
Neuroleptic Malignant Syndrome, Cardiomyopathy
This report suggests a potential Rohypnol Neuroleptic Malignant Syndrome side effect(s) that can have serious consequences. A 54-year-old female patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: schizophrenia and used Rohypnol (dosage: Dosage Is Uncertain.) starting NS. After starting Rohypnol the patient began experiencing various side effects, including: Neuroleptic Malignant Syndrome, CardiomyopathyAdditional drugs used concurrently:
  • Perospirone Hydrochloride (Dosage Is Uncertain.)
  • Milnacipran Hydrochloride (Dosage Is Uncertain.)
  • Chlorpromazine Hydrochloride Tab (Dosage Is Uncertain.)
  • Baclofen (Dosage Is Uncertain.)
  • Clonazepam (Dosage Is Uncertain.)
Although Rohypnol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Neuroleptic Malignant Syndrome, may still occur.
Rohypnol Side Effect Report#7973682-5
Gamma-glutamyltransferase Increased
This Gamma-glutamyltransferase Increased problem was reported by a physician from France. A 39-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Sep 09, 2009 this consumer started treatment with Rohypnol (dosage: NA). The following drugs were being taken at the same time:
  • Xolaam
  • Viraferonpeg (50 Mcg;qw)
  • Methadone Hcl
  • Nexium
  • Omeprazole
  • Ribavirin (600 Mg;bid)
  • Heroin
When using Rohypnol, the patient experienced the following unwanted symptoms/side effects: Gamma-glutamyltransferase IncreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Gamma-glutamyltransferase Increased, may become evident only after a product is in use by the general population.
Rohypnol Side Effect Report#7953116-7
Diabetic Ketoacidosis, Off Label Use
This Diabetic Ketoacidosis side effect was reported by a physician from Japan. A male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Rohypnol (drug dosage: NA), which was initiated on
Jun 11, 2007. Concurrently used drugs:
  • Allopurinol
  • Desyrel
  • Seroquel
  • Paxil
  • Livalo
.After starting to take Rohypnol the consumer reported adverse symptoms, such as: Diabetic Ketoacidosis, Off Label UseThese side effects may potentially be related to Rohypnol.
Rohypnol Side Effect Report#7917591-6
Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Hepatic Function Abnormal
This is a report of a 58-year-old female patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: NA, who was treated with Rohypnol (dosage: NA, start time:
Sep 29, 2010), combined with:
  • Magmitt
  • Temodal (100 Mg;qd;indrp, 150 Mg/m2; Po)
  • Temodal (100 Mg;qd;indrp, 150 Mg/m2; Po)
  • Famotidine
  • Pramipexole Dihydrochloride
  • Prednisolone
  • Clonazepam
and developed a serious reaction and side effect(s): Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Hepatic Function Abnormal after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rohypnol treatment in female patients, resulting in Aspartate Aminotransferase Increased side effect.
Rohypnol Side Effect Report#7904050-X
Haemorrhage Subcutaneous
This report suggests a potential Rohypnol Haemorrhage Subcutaneous side effect(s) that can have serious consequences. A 81-year-old female patient (weight: NA) from Japan was diagnosed with the following symptoms/conditions: NA and used Rohypnol (dosage: NA) starting NS. After starting Rohypnol the patient began experiencing various side effects, including: Haemorrhage SubcutaneousAdditional drugs used concurrently:
  • Medrol
  • Mucosta
  • Rheumatrex (6 Mg, Weekly)
  • Rabeprazole Sodium
  • Adalat
Although Rohypnol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Haemorrhage Subcutaneous, may still occur.
Rohypnol Side Effect Report#7879829-3
Interstitial Lung Disease
This Interstitial Lung Disease problem was reported by a pharmacist from Japan. A 80-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Sep 26, 2011 this consumer started treatment with Rohypnol (dosage: NA). The following drugs were being taken at the same time:
  • Depakene
  • Seroquel
  • Ovulanze Taiyo
  • Seroquel
  • Brotizolam
  • Lobu
When using Rohypnol, the patient experienced the following unwanted symptoms/side effects: Interstitial Lung DiseaseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Interstitial Lung Disease, may become evident only after a product is in use by the general population.
Rohypnol Side Effect Report#7835124-X
Neutrophil Count Decreased, Enterobacter Sepsis, Disseminated Intravascular Coagulation
This Neutrophil Count Decreased side effect was reported by a physician from Japan. A male patient (weight:NA) experienced the following symptoms/conditions: schizophrenia.The patient was prescribed Rohypnol (drug dosage: 2 Mg, Qd), which was initiated on
Sep 06, 2011. Concurrently used drugs:
  • Zyprexa (10 Mg, Qd)
  • Risperdal (2 Mg, Tid)
  • Depromel (25 Mg, Tid)
  • Promazine Hydrochloride (25 Mg, Qd)
  • Zyprexa (5 Mg, Qd)
  • Selbex (50 Mg, Tid)
  • Lexotan (5 Mg, Tid)
  • Seroquel (200 Mg, Tid)
.After starting to take Rohypnol the consumer reported adverse symptoms, such as: Neutrophil Count Decreased, Enterobacter Sepsis, Disseminated Intravascular CoagulationThese side effects may potentially be related to Rohypnol.
Rohypnol Side Effect Report#7810703-4
Ileus Paralytic, Pyrexia, Rhabdomyolysis
This is a report of a 47-year-old female patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: schizophrenia, who was treated with Rohypnol (dosage: Tabs, start time: NS), combined with:
  • Abilify (Abilify Tabs 6mg)
and developed a serious reaction and side effect(s): Ileus Paralytic, Pyrexia, Rhabdomyolysis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rohypnol treatment in female patients, resulting in Ileus Paralytic side effect. The patient was hospitalized.


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The appearance of Rohypnol on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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    Rohypnol reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
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    Side Effects reported to FDA: 54

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    Reported deaths: 8

    Reported hospitalizations: 25

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