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Rulid Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Hepatitis, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Hepatic Necrosis, Neutropenia (8271468-8)
on Apr 05, 2012 Female from FRANCE , 31 years of age, was diagnosed with
  • pyrexia
  • breast cancer
and was treated with Rulid. Directly after, patient experienced the unwanted or unexpected Rulid side effects: hepatitis, aspartate aminotransferase increased, alanine aminotransferase increased, hepatic necrosis, neutropenia. Rulid dosage: 300 Mg, 1x/day.
Associated medications used:
  • Epirubicin Hydrochloride (135 Mg, Other)
  • Fluorouracil (880 Mg, Other)
  • Cyclophosphamide (880 Mg, Other)
  • Solu-medrol (Unk)
  • Zofran (8 Mg, Unk)
  • Polery Adulte (Unk)
  • Prednisolone (Unk)
  • Fluorouracil (Unk)
Patient was hospitalized.

Hepatic Necrosis, Neutropenia, Hepatitis (8251572-0)
Patient was taking Rulid. Patient felt the following Rulid side effects: hepatic necrosis, neutropenia, hepatitis on Mar 26, 2012 from FRANCE Additional patient health information: Female , 31 years of age, was diagnosed with
  • pyrexia
  • breast cancer
  • cough
and. Rulid dosage: 150 Mg, 2x/day.
Multiple prescriptions taken:
  • Fluorouracil (880 Mg, Other)
  • Codeine/erysimin (Unk)
  • Fluorouracil (Unk)
  • Cyclophosphamide (Unk)
  • Zofran (8 Mg, Unk)
  • Epirubicin Hydrochloride (135 Mg, Other)
  • Desloratadine (Unk)
  • Acetaminophen (500 Mg, Unk)
Patient was hospitalized.

Rhabdomyolysis (8139059-7)
Adverse event was reported on Jan 30, 2012 by a Male taking Rulid (Dosage: 150 Mg, Bid) . Location: FRANCE , 67 years of age, After Rulid was administered, patient encountered several Rulid side effects: rhabdomyolysis.
Multiple concurrent drugs taken:
  • Pravastatin (40 Mg, Qd)
  • Lormetazepam (2 Mg, Qd)
  • Surmontil (100.0 Mg, Bid)
  • Pravastatin
  • Pantoprazole (40 Mg, Qd)
  • Mucomyst (200 Mg, Tid)
  • Bisoprolol Fumarate (2.5 Mg, Bid)
  • Metformin Hcl (280.0 Mg, Bid)
Patient was hospitalized.

Eosinophilia, Eosinophilic Pneumonia (8128888-1)
on Jan 30, 2012 Female from FRANCE , 77 years of age, was diagnosed with
  • chest x-ray abnormal
and was treated with Rulid. Directly after, patient experienced the unwanted or unexpected Rulid side effects: eosinophilia, eosinophilic pneumonia. Rulid dosage: 150 Mg, 2x/day.
Associated medications used:
  • Previscan (Unk)
  • Mixtard Human 70/30
  • Cordarone (200 Mg, 1x/day)
  • Ramipril (Unk)
  • Oxeol (Unk)
  • Bronchodual (Unk)
  • Beclometasone (Unk)
  • Diltiazem Hcl (Unk)
Patient was hospitalized.


Bronchitis, Haemoglobin Decreased, Gallbladder Disorder, Hepatitis Cholestatic, Cholelithiasis (8117105-4)
on Jan 30, 2012 Male from GERMANY , 77 years of age, was diagnosed with
  • bronchitis
  • depression
and was treated with Rulid. Patient felt the following Rulid side effects: bronchitis, haemoglobin decreased, gallbladder disorder, hepatitis cholestatic, cholelithiasis. Rulid dosage: 150mg, Daily.
Multiple prescriptions taken:
  • Sertraline Hydrochloride (50 Mg, Daily)
Patient was hospitalized.

Toxic Epidermal Necrolysis, Stevens-johnson Syndrome (7604592-0)
Patient was taking Rulide. After Rulid was administered, patient encountered several Rulid side effects: toxic epidermal necrolysis, stevens-johnson syndrome on Jun 29, 2011 from AUSTRALIA Additional patient health information: Female , 45 years of age, . Rulide dosage: Unk.
Multiple concurrent drugs taken:
  • Pristiq (Unk)
Patient was hospitalized.

Renal Failure Acute, Clostridium Difficile Colitis, Sepsis, Diarrhoea, Dehydration (7516775-9)
Adverse event was reported on May 30, 2011 by a Female taking Rulid (Dosage: 300 Mg, Qd) was diagnosed with
  • tracheobronchitis
and. Location: GERMANY , 90 years of age, weighting 123.5 lb, Directly after, patient experienced the unwanted or unexpected Rulid side effects: renal failure acute, clostridium difficile colitis, sepsis, diarrhoea, dehydration.
Associated medications used:
  • Unacid Pd Oral (750 Mg, Bid)
  • Humalog (14 Iu, Qd)
  • Norvasc (10 Mg, Qd)
  • Corangin ^ciba-geigy^ (40 Mg, Bid)
  • Torsemide (10 Mg, Qd)
  • Fentanyl (4.125 Mg, Q72h)
  • Pantoprazole (40 Mg, Qd)
  • Metronidazole (500 Mg, Tid)
Patient was hospitalized.

Cardiac Arrest, Renal Failure Acute (7488827-3)
on May 16, 2011 Male from KOREA, REPUBLIC OF , 39 years of age, weighting 152.8 lb, was treated with Rulid. Patient felt the following Rulid side effects: cardiac arrest, renal failure acute. Rulid dosage: Unk.
Multiple prescriptions taken:
  • Ciprofloxacin Hydrochloride (2250 Mg Daily Dosage)
  • Teicoplanin (Unk)
  • Meropenem (Unk)
  • Ativan (Unk)
  • Lasix (Unk)
  • Voriconazole (200 Mg, 2x/day)
  • K-contin Continus (Unk)
  • Vitamin K Tab (Unk)


Congenital Pyelocaliectasis, Atrial Septal Defect (7329935-7)
on Feb 22, 2011 Male from BELGIUM , weighting 7.56 lb, was treated with Rulid. After Rulid was administered, patient encountered several Rulid side effects: congenital pyelocaliectasis, atrial septal defect. Rulid dosage: N/A.
Multiple concurrent drugs taken:
  • Maxipim
  • Viramune
  • Kaletra
  • Truvada
  • Clamoxyl
  • Rocephin


Hepatic Enzyme Abnormal (6657367-3)
Patient was taking Rulid. Directly after, patient experienced the unwanted or unexpected Rulid side effects: hepatic enzyme abnormal on Mar 25, 2010 from FRANCE Additional patient health information: Male , 75 years of age, . Rulid dosage: N/A.
Associated medications used:
  • Lasix
  • Calcium Carbonate
  • Allopurinol
  • Lexomil
  • Meteoxane
  • Myfortic
  • Hyperium
  • Zeffix
Patient was hospitalized.

Alanine Aminotransferase Increased, Arthralgia, Aspartate Aminotransferase Increased, Blood Alkaline Phosphatase Increased, Blood Bilirubin Increased, Blood Lactate Dehydrogenase Increased, Cough, Decreased Appetite, Gamma-glutamyltransferase Increased (6577064-2)
Adverse event was reported on Jan 29, 2010 by a Male taking Rulid (Dosage: N/A) . Location: FRANCE , 75 years of age, Patient felt the following Rulid side effects: alanine aminotransferase increased, arthralgia, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, blood lactate dehydrogenase increased, cough, decreased appetite, gamma-glutamyltransferase increased.
Multiple prescriptions taken:
  • Lasix
  • Eucalcic
  • Allopurinol
  • Lexomil
  • Meteoxane
  • Myfortic
  • Hyperium
  • Zeffix
Patient was hospitalized.

Abdominal Tenderness, Blood Alkaline Phosphatase Increased, Hyperhidrosis, Jaundice Cholestatic, Liver Function Test Abnormal, Pharyngolaryngeal Pain, Pyrexia, Rash, Respiratory Tract Infection (5074918-3)
on Jul 24, 2000 Female from AUSTRALIA , 30 years of age, was diagnosed with
  • respiratory tract infection
  • schizophrenia, paranoid type
and was treated with Rulide. After Rulid was administered, patient encountered several Rulid side effects: abdominal tenderness, blood alkaline phosphatase increased, hyperhidrosis, jaundice cholestatic, liver function test abnormal, pharyngolaryngeal pain, pyrexia, rash, respiratory tract infection. Rulide dosage: N/A.
Multiple concurrent drugs taken:
  • Clozaril (25 - 125 Mg Daily)
  • Clozaril (75 - 300mg Daily)
  • Sertraline (50 Mg)
  • Flupentixol (Depot)
  • Clonazepam (0.5 Mg, Qd)


Nephritis Interstitial, Renal Failure Acute (5029689-3)
on Jun 14, 2006 Female from , 37 years of age, weighting 136.7 lb, was diagnosed with
  • gastroenteritis
  • nasopharyngitis
and was treated with Rulid. Directly after, patient experienced the unwanted or unexpected Rulid side effects: nephritis interstitial, renal failure acute. Rulid dosage: N/A. Patient was hospitalized.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Rulid Information

More About Rulid

Side Effects reported to FDA: 13. View Rulid Adverse Reports

Rulid safety alerts: No

Reported deaths: 2

Reported hospitalizations: 9

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