Rulid Side Effects

Common Rulid Side Effects

The most commonly reported Rulid side effects (click to view or check a box to report):

Renal Failure Acute (3)
Aspartate Aminotransferase Increased (2)
Blood Alkaline Phosphatase Increased (2)
Alanine Aminotransferase Increased (2)
Neutropenia (2)
Hepatitis (2)
Hepatic Necrosis (2)
Pharyngolaryngeal Pain (1)
Rash (1)
Pyrexia (1)
Respiratory Tract Infection (1)
Nephritis Interstitial (1)
Rhabdomyolysis (1)
Hyperhidrosis (1)
Jaundice Cholestatic (1)
Liver Function Test Abnormal (1)
Hepatitis Cholestatic (1)
Hepatic Enzyme Abnormal (1)
Haemoglobin Decreased (1)
Gamma-glutamyltransferase Increased (1)

➢ More

If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Rulid Side Effects Reported to FDA

The following Rulid reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

The appearance of Rulid on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Hepatitis, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Hepatic Necrosis, Neutropenia
This is a report of a 31-year-old female patient (weight: NA) from FRANCE, suffering from the following symptoms/conditions: pyrexia,breast cancer, who was treated with Rulid (dosage: 300 Mg, 1x/day, start time: May 17, 2004), combined with:
  • Epirubicin Hydrochloride (135 Mg, Other)
  • Fluorouracil (880 Mg, Other)
  • Cyclophosphamide (880 Mg, Other)
  • Solu-medrol (Unk)
  • Zofran (8 Mg, Unk)
  • Polery Adulte (Unk)
  • Prednisolone (Unk)
  • Fluorouracil (Unk)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Hepatitis
  • Aspartate Aminotransferase Increased
  • Alanine Aminotransferase Increased
  • Hepatic Necrosis
  • Neutropenia
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rulid treatment in female patients, resulting in hepatitis side effect. The patient was hospitalized.

Hepatic Necrosis, Neutropenia, Hepatitis
This report suggests a potential Rulid Hepatic Necrosis, Neutropenia, Hepatitis side effect(s) that can have serious consequences. A 31-year-old female patient (weight: NA) from FRANCE was diagnosed with the following symptoms/conditions: pyrexia,breast cancer,cough and used Rulid (dosage: 150 Mg, 2x/day) starting Apr 19, 2004. Soon after starting Rulid the patient began experiencing various side effects, including:
  • Hepatic Necrosis
  • Neutropenia
  • Hepatitis
Drugs used concurrently:
  • Fluorouracil (880 Mg, Other)
  • Codeine/erysimin (Unk)
  • Fluorouracil (Unk)
  • Cyclophosphamide (Unk)
  • Zofran (8 Mg, Unk)
  • Epirubicin Hydrochloride (135 Mg, Other)
  • Desloratadine (Unk)
  • Acetaminophen (500 Mg, Unk)
The patient was hospitalized. Although Rulid demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hepatic necrosis, may still occur.

This Rhabdomyolysis problem was reported by a health professional from FRANCE. A 67-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Jan 01, 2002 this consumer started treatment with Rulid (dosage: 150 Mg, Bid). The following drugs were being taken at the same time:
  • Pravastatin (40 Mg, Qd)
  • Lormetazepam (2 Mg, Qd)
  • Surmontil (100.0 Mg, Bid)
  • Pravastatin
  • Pantoprazole (40 Mg, Qd)
  • Mucomyst (200 Mg, Tid)
  • Bisoprolol Fumarate (2.5 Mg, Bid)
  • Metformin Hcl (280.0 Mg, Bid)
When commencing Rulid, the patient experienced the following unwanted symptoms/side effects:
  • Rhabdomyolysis
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as rhabdomyolysis, may become evident only after a product is in use by the general population.

Eosinophilia, Eosinophilic Pneumonia
This is a report of a 77-year-old female patient (weight: NA) from FRANCE. The patient developed the following symptoms/conditions: chest x-ray abnormal and was treated with Rulid (dosage: 150 Mg, 2x/day) starting Jun 01, 2005. Concurrently used drugs:
  • Previscan (Unk)
  • Mixtard Human 70/30
  • Cordarone (200 Mg, 1x/day)
  • Ramipril (Unk)
  • Oxeol (Unk)
  • Bronchodual (Unk)
  • Beclometasone (Unk)
  • Diltiazem Hcl (Unk)
Soon after that, the consumer experienced the following side effects:
  • Eosinophilia
  • Eosinophilic Pneumonia
The patient was hospitalized. This opens a possibility that Rulid treatment could cause the above reactions, including eosinophilia, and some female subjects may be more susceptible.

Bronchitis, Haemoglobin Decreased, Gallbladder Disorder, Hepatitis Cholestatic, Cholelithiasis
A 77-year-old male patient (weight: NA) from GERMANY with the following symptoms/conditions: bronchitis,depression started Rulid treatment (dosage: 150mg, Daily) on Aug 01, 2001. Soon after starting Rulid treatment, the subject experienced various side effects, including:
  • Bronchitis
  • Haemoglobin Decreased
  • Gallbladder Disorder
  • Hepatitis Cholestatic
  • Cholelithiasis
Concurrently used drugs:
  • Sertraline Hydrochloride (50 Mg, Daily)
The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Rulid.

Toxic Epidermal Necrolysis, Stevens-johnson Syndrome
A 45-year-old female patient from AUSTRALIA (weight: NA) experienced symptoms, such as: NA and was treated with Rulide(dosage: Unk). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Toxic Epidermal Necrolysis
  • Stevens-johnson Syndrome
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Rulide efficacy:
  • Pristiq (Unk)
The patient was hospitalized.

Renal Failure Acute, Clostridium Difficile Colitis, Sepsis, Diarrhoea, Dehydration
In this report, Rulid was administered for the following condition: tracheobronchitis.A 90-year-old female consumer from GERMANY (weight: NA) started Rulid treatment (dosage: 300 Mg, Qd) on Dec 28, 2010.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Renal Failure Acute
  • Clostridium Difficile Colitis
  • Sepsis
  • Diarrhoea
  • Dehydration
A possible interaction with other drugs could have contributed to this reaction:
  • Unacid Pd Oral (750 Mg, Bid)
  • Humalog (14 Iu, Qd)
  • Norvasc (10 Mg, Qd)
  • Corangin ^ciba-geigy^ (40 Mg, Bid)
  • Torsemide (10 Mg, Qd)
  • Fentanyl (4.125 Mg, Q72h)
  • Pantoprazole (40 Mg, Qd)
  • Metronidazole (500 Mg, Tid)
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Rulid treatment could be related to the listed above side effect(s).

Cardiac Arrest, Renal Failure Acute
This is a report of the following Rulid side effect(s):
  • Cardiac Arrest
  • Renal Failure Acute
A 39-year-old male patient from KOREA, REPUBLIC OF (weight: NA) presented with the following condition: NA and received a treatment with Rulid (dosage: Unk) starting: Aug 07, 2008.The following concurrently used drugs could have generated interactions:
  • Ciprofloxacin Hydrochloride (2250 Mg Daily Dosage)
  • Teicoplanin (Unk)
  • Meropenem (Unk)
  • Ativan (Unk)
  • Lasix (Unk)
  • Voriconazole (200 Mg, 2x/day)
  • K-contin Continus (Unk)
  • Vitamin K Tab (Unk)
This report suggests that a Rulid treatment could be associated with the listed above side effect(s).

Congenital Pyelocaliectasis, Atrial Septal Defect
This Rulid report was submitted by a male consumer from BELGIUM (weight: NA). The patient was diagnosed with: NA and Rulid was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Congenital Pyelocaliectasis
  • Atrial Septal Defect
Other drugs used simultaneously:
  • Maxipim
  • Viramune
  • Kaletra
  • Truvada
  • Clamoxyl
  • Rocephin
Those unexpected symptoms could be linked to a Rulid treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Hepatic Enzyme Abnormal
This is a report of a possible correlation between Rulid use and the following symptoms/side effect(s):
  • Hepatic Enzyme Abnormal
which could contribute to an assessment of Rulid risk profile.A 75-year-old male consumer from FRANCE (weight: NA) was suffering from NA and was treated with Rulid (dosage: NA) starting Apr 01, 2008.Other concurrent medications:
  • Lasix
  • Calcium Carbonate
  • Allopurinol
  • Lexomil
  • Meteoxane
  • Myfortic
  • Hyperium
  • Zeffix
The patient was hospitalized.

Alanine Aminotransferase Increased, Arthralgia, Aspartate Aminotransferase Increased, Blood Alkaline Phosphatase Increased, Blood Bilirubin Increased, Blood Lactate Dehydrogenase Increased, Cough, Decreased Appetite, Gamma-glutamyltransferase Increased
A 75-year-old male patient from FRANCE (weight: NA) presented with the following symptoms: NA and after a treatment with Rulid (dosage: NA) experienced the following side effect(s):
  • Alanine Aminotransferase Increased
  • Arthralgia
  • Aspartate Aminotransferase Increased
  • Blood Alkaline Phosphatase Increased
  • Blood Bilirubin Increased
  • Blood Lactate Dehydrogenase Increased
  • Cough
  • Decreased Appetite
  • Gamma-glutamyltransferase Increased
The treatment was started on Apr 01, 2008. Rulid was used in combination with the following drugs:
  • Lasix
  • Eucalcic
  • Allopurinol
  • Lexomil
  • Meteoxane
  • Myfortic
  • Hyperium
  • Zeffix
The patient was hospitalized.This report could alert potential Rulid consumers.

Abdominal Tenderness, Blood Alkaline Phosphatase Increased, Hyperhidrosis, Jaundice Cholestatic, Liver Function Test Abnormal, Pharyngolaryngeal Pain, Pyrexia, Rash, Respiratory Tract Infection
In this report, a 30-year-old female patient from AUSTRALIA (weight: NA) was affected by a possible Rulide side effect.The patient was diagnosed with respiratory tract infection,schizophrenia, paranoid type. After a treatment with Rulide (dosage: NA, start date: Sep 11, 1997), the patient experienced the following side effect(s):
  • Abdominal Tenderness
  • Blood Alkaline Phosphatase Increased
  • Hyperhidrosis
  • Jaundice Cholestatic
  • Liver Function Test Abnormal
  • Pharyngolaryngeal Pain
  • Pyrexia
  • Rash
  • Respiratory Tract Infection
The following simultaneously used drugs could have led to this reaction:
  • Clozaril (25 - 125 Mg Daily)
  • Clozaril (75 - 300mg Daily)
  • Sertraline (50 Mg)
  • Flupentixol (Depot)
  • Clonazepam (0.5 Mg, Qd)
The findings here stress that side effects should be taken into consideration when evaluating a Rulide treatment.

Nephritis Interstitial, Renal Failure Acute
This is a report of a 37-year-old female patient from (weight: NA), who used Rulid (dosage: NA) for a treatment of gastroenteritis,nasopharyngitis. After starting a treatment on Apr 05, 2006, the patient experienced the following side effect(s):
  • Nephritis Interstitial
  • Renal Failure Acute
The following drugs could possibly have interacted with the Rulid treatment NA.The patient was hospitalized.Taken together, these observations suggest that a Rulid treatment could be related to side effect(s), such as Nephritis Interstitial, Renal Failure Acute.

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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    More About Rulid

    Side Effects reported to FDA: 13

    Rulid safety alerts: No

    Reported deaths: 2

    Reported hospitalizations: 9

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