Sirolimus Safety Questions, Sirolimus Answers
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Sirolimus Safety Reports
Total Sirolimus reports: 168.Sirolimus FDA safety alerts: 2002 2003 2007 .
Reported deaths: 11 Reported hospitalizations: 118.
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Reported Sirolimus Side Effects: focal glomerulosclerosis, kidney transplant rejection, condition aggravated, proteinuria, anaemia, liver transplant rejection, pneumonia, asthenia, blood creatinine increased, haemodialysis, complications of transplanted kidney.
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Showing 1-50 of 168 Next >
Sirolimus Side Effects Report #5317081-3Physician from NETHERLANDS reported SIROLIMUS problem on Apr 30, 2007. Male patient, weighting 165.3 lb, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: hyperglycaemia, impaired healing, inferior vena caval occlusion, proteinuria, pulmonary embolism, removal of renal transplant, renal haemorrhage, wound infection. SIROLIMUS dosage: LOADING DOSE OF 15 MG. During the same period patient was treated with METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, DACLIZUMAB. Patient was hospitalized and became disabled. Patient recovered.
Sirolimus Side Effects Report #5318244-3
SIROLIMUS problem was reported by a Physician from BELGIUM on May 04, 2007. Female patient, weighting 164.9 lb, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: nephrectomy, ureterectomy, urinary incontinence, urinary tract infection. SIROLIMUS dosage: unknown. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5320327-9
Physician from BELGIUM reported SIROLIMUS problem on Apr 27, 2007. Male patient, 43 years of age, weighting 172.0 lb, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: disease recurrence, focal glomerulosclerosis, transplant rejection. SIROLIMUS dosage: unknown. During the same period patient was treated with DACLIZUMAB, TACROLIMUS. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5321152-5
SIROLIMUS problem was reported by a Physician from GERMANY on May 02, 2007. Male patient, 60 years of age, weighting 178.6 lb, was diagnosed with prophylaxis against transplant rejection, hypercholesterolaemia, hypertension, pain management and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: concomitant disease progression, osteoarthritis, osteonecrosis. SIROLIMUS dosage: 6 MG. During the same period patient was treated with FLUVASTATIN, BISOPROLOL FUMARATE, AMLODIPINE, PANTOPRAZOLE, METAMIZOLE. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5327819-7
Physician from SPAIN reported SIROLIMUS problem on May 14, 2007. Male patient, weighting 174.2 lb, was diagnosed with prophylaxis against transplant rejection, prostatism, hyperuricaemia and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: prostate cancer. SIROLIMUS dosage: 2 MG/FREQUENCY NOT PROVIDED. During the same period patient was treated with INDAPAMIDE, TEBETANE COMPUESTO, ALLOPURINOL. Patient recovered.
Sirolimus Side Effects Report #5331385-X
SIROLIMUS problem was reported by a Physician from BELGIUM on May 18, 2007. Male patient, 43 years of age, weighting 172.0 lb, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: disease recurrence, focal glomerulosclerosis, transplant rejection. SIROLIMUS dosage: unknown. During the same period patient was treated with DACLIZUMAB, TACROLIMUS. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5333074-4
Physician from UNITED STATES reported SIROLIMUS problem on May 14, 2007. Male patient, weighting 190.5 lb, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: hyperglycaemia. SIROLIMUS dosage: unknown. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5333791-6
SIROLIMUS problem was reported by a Physician from FRANCE on May 15, 2007. Male patient, 34 years of age, was diagnosed with chronic allograft nephropathy, immunosuppression and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL. Patient recovered.
Sirolimus Side Effects Report #5333851-X
Physician from FRANCE reported SIROLIMUS problem on May 15, 2007. Female patient, 51 years of age, was diagnosed with chronic allograft nephropathy and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. Patient recovered.
Sirolimus Side Effects Report #5333860-0
SIROLIMUS problem was reported by a Physician from FRANCE on May 15, 2007. Female patient, 40 years of age, was diagnosed with chronic allograft nephropathy, immunosuppression and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. During the same period patient was treated with AZATHIOPRINE. Patient recovered.
Sirolimus Side Effects Report #5333861-2
Physician from FRANCE reported SIROLIMUS problem on May 15, 2007. Female patient, 48 years of age, was diagnosed with chronic allograft nephropathy, renal transplant and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL. Patient recovered.
Sirolimus Side Effects Report #5333862-4
SIROLIMUS problem was reported by a Physician from FRANCE on May 15, 2007. Male patient, 29 years of age, was diagnosed with chronic allograft nephropathy, renal transplant and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL. Patient recovered.
Sirolimus Side Effects Report #5338791-8
Physician from MEXICO reported SIROLIMUS problem on May 23, 2007. Female patient, weighting 132.7 lb, was diagnosed with prophylaxis against transplant rejection, hypertension, hyperuricaemia, hypercholesterolaemia, hyperlipidaemia, gastritis and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: azotaemia. SIROLIMUS dosage: unknown. During the same period patient was treated with DILTIAZEM, ENALAPRIL MALEATE, CANDESARTAN, ALLOPURINOL, MACRODANTIN, PRAVASTATINE, BEZAFIBRATE, OMEPRAZOLE. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5340244-8
SIROLIMUS problem was reported by a Physician from SPAIN on May 22, 2007. Male patient, weighting 168.7 lb, was diagnosed with prophylaxis against transplant rejection, hypertension, hypercholesterolaemia, intermittent claudication and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: prostate cancer. SIROLIMUS dosage: unknown. During the same period patient was treated with AMLODIPINE, PREDNISONE, DOXAZOSIN MESYLATE, ATORVASTATIN, MYCOPHENOLATE MOFETIL, LOSARTAN POSTASSIUM. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5342119-7
Physician from SPAIN reported SIROLIMUS problem on May 28, 2007. Male patient, weighting 209.4 lb, was diagnosed with prophylaxis against transplant rejection, antiviral prophylaxis, infection prophylaxis, pain prophylaxis, hypertension and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: renal failure chronic. SIROLIMUS dosage: 1 AND 2 MG EVERY OTHER DAY. During the same period patient was treated with LAMIVUDINE, SULFAMETHOXAZOLE AND TRIMETHOPRIM, GABAPENTIN, AMLODIPINE, IMMUNOGLOBULIN ANTIHEPATITIS B, DOXAZOSIN MESYLATE, CANDESARTAN CILEXETIL, HYDROCHLOROTHIAZIDE. Patient recovered.
Sirolimus Side Effects Report #5350503-0
SIROLIMUS problem was reported by a Physician from SPAIN on June 01, 2007. Male patient, weighting 168.7 lb, was diagnosed with prophylaxis against transplant rejection, hypertension, hypercholesterolaemia, intermittent claudication and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: prostate cancer. SIROLIMUS dosage: unknown. During the same period patient was treated with AMLODIPINE, PREDNISONE, DOXAZOSIN MESYLATE, ATORVASTATIN, MYCOPHENOLATE MOFETIL, LOSARTAN POTASSIUM. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5352178-3
Physician from SWITZERLAND reported SIROLIMUS problem on May 31, 2007. Male patient, weighting 176.4 lb, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: convulsion. SIROLIMUS dosage: 2 MG; FREQUENCY NOT SPECIFIED. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5353494-1
SIROLIMUS problem was reported by a Physician from ARGENTINA on June 01, 2007. Male patient, weighting 160.9 lb, was diagnosed with prophylaxis against transplant rejection, hyperparathyroidism, hypertension, hyperlipidaemia and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: pneumonia. SIROLIMUS dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL, CALCITRIOL, LOSARTAN, ATORVASTATIN CALCIUM, MEPREDNISONE, ENALAPRIL MALEATE. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5353596-X
Physician from UNITED STATES reported SIROLIMUS problem on May 31, 2007. Male patient, weighting 191.2 lb, was diagnosed with prophylaxis against transplant rejection, hyperlipidaemia, hypertension and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: pancreatic carcinoma metastatic. SIROLIMUS dosage: unknown. During the same period patient was treated with ZOCOR, LANTUS, COZAAR, SEPTRA, NOVOLOG. Patient recovered.
Sirolimus Side Effects Report #5356629-X
SIROLIMUS problem was reported by a Physician from BRAZIL on June 06, 2007. Male patient, weighting 160.5 lb, was diagnosed with prophylaxis against transplant rejection, anaemia, hypertension, hypercholesterolaemia and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: renal disorder. SIROLIMUS dosage: unknown. During the same period patient was treated with PREDNISONE, EPOGEN, ATENOLOL, FUROSEMIDE, SIMVASTATIN, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL. Patient recovered.
Sirolimus Side Effects Report #5356673-2
Physician from UNITED KINGDOM reported SIROLIMUS problem on June 08, 2007. Male patient, weighting 213.8 lb, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: hepatic steatosis. SIROLIMUS dosage: unknown. During the same period patient was treated with AZATHIOPRINE. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5356675-6
SIROLIMUS problem was reported by a Physician from MEXICO on June 11, 2007. Female patient, weighting 132.7 lb, was diagnosed with prophylaxis against transplant rejection, hypertension, hyperuricaemia, hypercholesterolaemia, hyperlipidaemia, gastritis and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: azotaemia. SIROLIMUS dosage: unknown. During the same period patient was treated with DILTIAZEM, ENALAPRIL MALEATE, CANDESARTAN, ALLOPURINOL, MACRODANTIN, PRAVASTATINE, BEZAFIBRATE, OMEPRAZOLE. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5356710-5
Physician from FRANCE reported SIROLIMUS problem on June 04, 2007. Female patient, 40 years of age, was diagnosed with chronic allograft nephropathy, immunosuppression and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. During the same period patient was treated with AZATHIOPRINE. Patient recovered.
Sirolimus Side Effects Report #5356711-7
SIROLIMUS problem was reported by a Physician from FRANCE on June 04, 2007. Male patient, 34 years of age, was diagnosed with chronic allograft nephropathy, immunosuppression and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL. Patient recovered.
Sirolimus Side Effects Report #5356712-9
Physician from FRANCE reported SIROLIMUS problem on June 04, 2007. Female patient, 51 years of age, was diagnosed with chronic allograft nephropathy and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. Patient recovered.
Sirolimus Side Effects Report #5357264-X
SIROLIMUS problem was reported by a Physician from FRANCE on June 04, 2007. Male patient, 29 years of age, was diagnosed with chronic allograft nephropathy, renal transplant and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL. Patient recovered.
Sirolimus Side Effects Report #5357267-5
Physician from FRANCE reported SIROLIMUS problem on June 04, 2007. Female patient, 48 years of age, was diagnosed with chronic allograft nephropathy, renal transplant and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis. SIROLIMUS dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL. Patient recovered.
Sirolimus Side Effects Report #5359992-9
SIROLIMUS problem was reported by a Physician from UNITED STATES on June 07, 2007. Male patient, weighting 147.9 lb, was diagnosed with prophylaxis against transplant rejection, hypertension and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: gastroenteritis. SIROLIMUS dosage: unknown. During the same period patient was treated with HYTRIN, INDERAL, ACETYLSALICYLIC ACID SRT, ACETYLSALICYLIC ACID SRT, ASCORBIC ACID, ASCORBIC ACID. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5360737-7
Physician from UNITED STATES reported SIROLIMUS problem on June 14, 2007. Male patient, weighting 174.8 lb, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: epididymitis, hydrocele, hydronephrosis, kidney transplant rejection. SIROLIMUS dosage: unknown. During the same period patient was treated with MEDROL, MAALOX FAST BLOCKER, ALTERNAGEL, ASCORBIC ACID, ADALAT, PROTONIX, VALCYTE, BACTRIM. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5362362-0
SIROLIMUS problem was reported by a Health Professional from GERMANY on June 11, 2007. Female patient, 37 years of age, was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: liver transplant rejection. SIROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS. Patient recovered.
Sirolimus Side Effects Report #5365203-0
Physician from UNITED STATES reported SIROLIMUS problem on June 11, 2007. Male patient was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: liver transplant rejection. SIROLIMUS dosage: 2 MG DAILY. During the same period patient was treated with CYCLOSPORINE, BACTRIM, EFFEXOR, REMERON, RESTORIL, CALCIUM PHOSPHATE, KEFLEX, LEVAQUIN. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5371580-7
SIROLIMUS problem was reported by a Physician from BRAZIL on June 19, 2007. Female patient was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: liver transplant rejection. SIROLIMUS dosage: unknown. Patient recovered.
Sirolimus Side Effects Report #5371581-9
Physician from BRAZIL reported SIROLIMUS problem on June 19, 2007. Female patient was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: liver transplant rejection. SIROLIMUS dosage: unknown. Patient recovered.
Sirolimus Side Effects Report #5373350-2
SIROLIMUS problem was reported by a Physician from UNITED STATES on June 19, 2007. Male patient, 19 years of age, was diagnosed with kidney transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: focal glomerulosclerosis, kidney transplant rejection, nephrotic syndrome, proteinuria. SIROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS, METHYLPREDNISOLONE. Patient recovered.
Sirolimus Side Effects Report #5046538-8
Pharmacist from UNITED STATES reported SIROLIMUS problem on July 05, 2006. Male patient, 57 years of age, weighting 191.8 lb, was diagnosed with renal transplant and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: haemorrhage, pneumonia, pulmonary alveolar haemorrhage, staphylococcal infection. SIROLIMUS dosage: 4MG Q AM. During the same period patient was treated with PREDNISONE, METOPROLOL TARTRATE, COLCHICINE, SIMVASTATIN, OMEPRAZOLE, CACO, IMDUR. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5050783-5
SIROLIMUS problem was reported by a Consumer or non-health professional from FRANCE on June 29, 2006. Female patient, 49 years of age, was diagnosed with renal transplant and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: dialysis, renal failure acute. SIROLIMUS dosage: 5 MG 1X PER 1 DAY; 15 MG 1X PER 1 DAY. During the same period patient was treated with THYMOGLOBULIN, MYCOPHENOLATE MOFETIL. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5053134-5
Health Professional from BELGIUM reported SIROLIMUS problem on July 03, 2006. Male patient was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, disease recurrence, focal glomerulosclerosis, proteinuria. SIROLIMUS dosage: 15 + 4 + 5MG 1X PER 1 DAY ORAL - SEE IMAGE. During the same period patient was treated with TACROLIMUS, ZENAPAX, CORTICOSTEROIDS. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5053614-2
SIROLIMUS problem was reported by a Consumer or non-health professional from SPAIN on July 03, 2006. Male patient, 44 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: abdominal hernia, post procedural complication. SIROLIMUS dosage: unknown. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5053954-7
Physician from BELGIUM reported SIROLIMUS problem on July 03, 2006. Male patient was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: disease recurrence, focal glomerulosclerosis. SIROLIMUS dosage: 15 MG 1X PER 1 DAY ORAL; SEE IMAGE. During the same period patient was treated with TACROLIMUS, ZENAPAX, CORTICOSTEROIDS. Patient was hospitalized. Patient died.
Sirolimus Side Effects Report #5055118-X
SIROLIMUS problem was reported by a Consumer or non-health professional from FRANCE on July 06, 2006. Female patient, 40 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: anaemia, anastomotic complication, arteriovenous fistula, condition aggravated, effusion, haemodialysis, infarction, kidney fibrosis, kidney transplant rejection. SIROLIMUS dosage: 15 MG DAILY FOR 2 DAYS AND THEN 8 MG DAILY ORAL. During the same period patient was treated with MYCOPHENOLATE MOFETIL. Patient recovered.
Sirolimus Side Effects Report #5062112-1
Consumer or non-health professional from FRANCE reported SIROLIMUS problem on July 18, 2006. Male patient, 75 years of age, was diagnosed with neoplasm prophylaxis and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: anaemia, asthenia, atrial flutter, diarrhoea, pleural effusion, pneumonia, proteinuria. SIROLIMUS dosage: 3 MG 1X PER 1 DAY ORAL. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5064982-X
SIROLIMUS problem was reported by a Consumer or non-health professional from SPAIN on July 18, 2006. Male patient, 44 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: abdominal hernia. SIROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5072854-X
Health Professional from FRANCE reported SIROLIMUS problem on July 28, 2006. Male patient, 75 years of age, was diagnosed with neoplasm prophylaxis and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: anaemia, atrial flutter, blood creatinine increased, diarrhoea, pleural effusion, pneumonia, proteinuria. SIROLIMUS dosage: 3 MG 1X PER 1 DAY ORAL. Patient was hospitalized and became disabled. Patient recovered.
Sirolimus Side Effects Report #5074396-4
SIROLIMUS problem was reported by a Consumer or non-health professional from ITALY on July 25, 2006. Male patient, 54 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: kidney transplant rejection. SIROLIMUS dosage: unknown. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5074440-4
Consumer or non-health professional from SPAIN reported SIROLIMUS problem on July 26, 2006. Male patient, 44 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: abdominal hernia, procedural complication. SIROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS, CELLCEPT, SEPTRA, COZAAR, ATORVASTATIN CALCIUM, ZETIA. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5074449-0
SIROLIMUS problem was reported by a Consumer or non-health professional from SPAIN on July 26, 2006. Male patient, 44 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: abdominal hernia, post procedural complication. SIROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS, CELLCEPT, SEPTRA, COZAAR, ATORVASTATIN CALCIUM, ZETIA. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5094454-8
Consumer or non-health professional from ITALY reported SIROLIMUS problem on Aug 22, 2006. Female patient, 59 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: anaemia, haemodialysis, iatrogenic injury, kidney transplant rejection, leukopenia, nephroangiosclerosis, nephropathy toxic, renal tubular necrosis. SIROLIMUS dosage: unknown. During the same period patient was treated with CYCLOSPORINE. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5094456-1
SIROLIMUS problem was reported by a Consumer or non-health professional from ITALY on Aug 23, 2006. Female patient, 65 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: cerebral haemorrhage, hepatic failure, leukopenia, multi-organ failure, platelet count decreased, pulmonary oedema, sepsis. SIROLIMUS dosage: 1 MG 1X PER 1 DAY, ORAL; 3 MG 1X PER 1 DAY, ORAL. Patient was hospitalized. Patient died.
Sirolimus Side Effects Report #5096644-7
Consumer or non-health professional from ITALY reported SIROLIMUS problem on Aug 24, 2006. Female patient, 40 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, blood triglycerides increased, blood urea increased, complications of transplanted kidney, platelet count decreased. SIROLIMUS dosage: 4 MG 1X PER 1 DAY ORAL. During the same period patient was treated with CYCLOSPORINE. Patient was hospitalized. Patient recovered.
Sirolimus Side Effects Report #5124717-9
SIROLIMUS problem was reported by a Consumer or non-health professional from FRANCE on Sept 29, 2006. Female patient, 37 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with SIROLIMUS. After drug was administered, patient experienced the following problems/side effects: complications of transplanted kidney, kidney transplant rejection. SIROLIMUS dosage: 5 MG 1X PER 1 DAY ORAL. During the same period patient was treated with CELLCEPT, ZENAPAX. Patient was hospitalized. Patient recovered.
Showing 1-50 of 168 Next >
Drug Information: Sirolimus
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a602026.html
(sir oh' li mus)IMPORTANT WARNING:
| Sirolimus may increase the risk of infection and lymphoma. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, chills, frequent or painful urination, or other signs of infection.Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to sirolimus.Talk to your doctor about the risks of taking sirolimus. |
Why is this medication prescribed?
Sirolimus is used in combination with other medications to prevent rejection of kidney transplants. Sirolimus is in a class of medications called immunosuppressants. It works by suppressing the body's immune system.
How should this medicine be used?
Sirolimus comes as a tablet and a solution (liquid) to take by mouth. It is usually taken once a day, either always with food or always without food. To help you remember to take sirolimus, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sirolimus exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take sirolimus even if you feel well. Do not stop taking sirolimus without talking to your doctor.
To use the bottles of solution, follow these steps:
- Open the solution bottle. On first use, insert the plastic tube with stopper tightly into the bottle until it is even with the top of the bottle. Do not remove from the bottle.
- For each use, tightly insert one of the amber syringes with the plunger fully pushed in into the opening in the plastic tube.
- Draw up the amount of solution your doctor has prescribed by gently pulling out the plunger of the syringe until the bottom of the black line of the plunger is even with the correct mark on the syringe. Keep the bottle upright. If bubbles form in the syringe, empty the syringe into the bottle and repeat this step.
- Empty the syringe into a glass or plastic cup containing at least 2 ounces (1/4 cup) of water or orange juice. Do not use apple juice, grapefruit juice, or other liquids. Stir vigorously for 1 minute and drink immediately.
- Refill the cup with at least 4 ounces (1/2 cup) of water or orange juice. Stir vigorously and drink the rinse solution.
- Throw away the used syringe.
If you need to carry a filled syringe with you, snap a cap onto the syringe and put the syringe in the carrying case. Use the medication in the syringe within 24 hours.
To use the pouches of solution, follow these steps:
- Before opening the pouch, squeeze the pouch from the neck area to push the contents into the lower part of the pouch.
- Fold the marked area on the pouch and carefully cut with scissors.
- Squeeze the entire contents of the pouch into a glass or plastic cup containing at least 2 ounces (1/4 cup) of water or orange juice. Do not use apple juice, grapefruit juice, or other liquids. Stir vigorously for 1 minute and drink immediately.
- Refill the cup with at least 4 ounces (1/2 cup) of water or orange juice. Stir vigorously and drink the rinse solution.
Other uses for this medicine
Sirolimus also is used sometimes to treat psoriasis. Talk to your doctor about the possible risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking sirolimus,
- tell your doctor and pharmacist if you are allergic to sirolimus or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: amphotericin B (Abelcet, AmBisome, Amphocin, Fungizone); antifungals such as clotrimazole (Lotrimin), fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); bromocriptine (Parlodel); cimetidine (Tagamet); cisapride (Propulsid); clarithromycin (Biaxin); danazol (Danocrine); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir); medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); metoclopramide (Reglan); nicardipine (Cardene); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); rifapentine (Priftin); troleandomycin (TAO); and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking cyclosporine (Neoral) soft gelatin capsules or solution, take them 4 hours before sirolimus.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had high cholesterol or triglycerides or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should use an effective method of birth control before starting to take sirolimus, while taking sirolimus, and for 12 weeks after stopping sirolimus. If you become pregnant while taking sirolimus, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking sirolimus.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Sirolimus may increase your risk for skin cancer.
- do not have any vaccinations (e.g., measles or flu shots) without talking to your doctor.
What special dietary instructions should I follow?
Avoid drinking large amounts of grapefruit juice while taking this medicine.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Sirolimus may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- stomach pain
- weakness
- back pain
- headache
- constipation
- diarrhea
- upset stomach
- vomiting
- swelling of the hands, feet, ankles, or lower legs
- weight gain
- joint pain
- difficulty falling asleep or staying asleep
- tremor
- rash
- fever
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them or those listed in the IMPORTANT WARNING section, call your doctor immediately:
- pale skin
- unusual bleeding or bruising
- cough
- shortness of breath
Sirolimus may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store tablets at room temperature and away from excess heat and moisture (not in the bathroom). Keep liquid medication in the refrigerator, closed tightly, and throw away any unused medication one month after the bottle is opened. Do not freeze. If needed, you may store the pouches for up to 24 hours and the bottles for up to 15 days at room temperature. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to sirolimus.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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