Sustiva Safety Questions, Sustiva Answers
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Sustiva Safety Reports
Total Sustiva reports: 139.Sustiva FDA safety alerts: 2005 .
Reported deaths: 9 Reported hospitalizations: 47.
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Reported Sustiva Side Effects: pregnancy, dizziness, balance disorder, cytomegalovirus infection, anaemia, kaposi's sarcoma, pyrexia, nervous system disorder, confusional state, foetal growth retardation, oxygen saturation decreased.
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Sustiva Side Effects Report #5151634-0Health Professional from UNITED STATES reported SUSTIVA problem on Aug 17, 2006. Male patient was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: abnormal dreams. SUSTIVA dosage: unknown. During the same period patient was treated with TRIZIVIR. Patient recovered.
Sustiva Side Effects Report #5151636-4
SUSTIVA problem was reported by a Physician from UNITED STATES on Aug 23, 2006. Female patient, 43 years of age, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: hepatitis, liver function test abnormal. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, PROPECIA, VALIUM. Patient recovered.
Sustiva Side Effects Report #5155336-6
Health Professional from UNITED KINGDOM reported SUSTIVA problem on Aug 16, 2006. Male patient, 46 years of age, was diagnosed with hiv infection, infection prophylaxis, lower respiratory tract infection, pneumocystis jiroveci pneumonia, oral candidiasis and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: body temperature increased, hypotension, liver function test abnormal, lung injury, malaise, oxygen saturation decreased, tachycardia, tachypnoea. SUSTIVA dosage: unknown. During the same period patient was treated with ABACAVIR, SEPTRIN, DOXYCYCLINE, COTRIM D, FLUCONAZOLE. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5155337-8
SUSTIVA problem was reported by a Consumer or non-health professional from UNITED KINGDOM on June 30, 2006. Male patient, 46 years of age, weighting 110.2 lb, was diagnosed with hiv infection, infection prophylaxis, lower respiratory tract infection, pneumocystis jiroveci pneumonia, oral candidiasis and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: hypotension, hypoxia, liver function test abnormal, lung injury, oxygen saturation decreased, pyrexia, tachycardia, tachypnoea. SUSTIVA dosage: unknown. During the same period patient was treated with ABACAVIR, SEPTRIN, DOXYCYCLINE, COTRIM D, FLUCONAZOLE. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5156380-5
Consumer or non-health professional from GERMANY reported SUSTIVA problem on May 15, 2006. Male patient, 35 years of age, weighting 127.9 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: anaemia, balance disorder, cytomegalovirus chorioretinitis, cytomegalovirus infection, dizziness, glioma. SUSTIVA dosage: unknown. During the same period patient was treated with ZERIT, VIREAD, EPIVIR, COTRIM, ZIDOVUDINE. Patient was hospitalized and became disabled. Patient recovered.
Sustiva Side Effects Report #5158947-7
SUSTIVA problem was reported by a Consumer or non-health professional from UNITED STATES on Nov 16, 2006. Male patient, 48 years of age, weighting 134.5 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: pancreatic insufficiency. SUSTIVA dosage: unknown. During the same period patient was treated with DIDANOSINE, COUMADIN, POTASSIUM ACETATE, PANCREASE, SPIRONOLACTONE, NEXIUM. Patient recovered.
Sustiva Side Effects Report #5163371-7
Physician from UNITED KINGDOM reported SUSTIVA problem on Sept 29, 2006. Female patient, 24 years of age, weighting 105.8 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: lower respiratory tract infection, psychotic disorder, renal impairment, sepsis. SUSTIVA dosage: DOSE REDUCED TO 400 MG ONCE DAILY ON 02-OCT-2006. During the same period patient was treated with ABACAVIR. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5164000-9
SUSTIVA problem was reported by a Health Professional from UNITED STATES on May 06, 2002. Male patient, weighting 6.61 lb, was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: blood lactate dehydrogenase increased, hypocalcaemia, lactic acidosis, lipase increased, metabolic acidosis, muscle twitching, pregnancy, tonic clonic movements. SUSTIVA dosage: unknown. During the same period patient was treated with RETROVIR, VIRACEPT, COMBIVIR, ZOVIRAX, INSULIN. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5164483-4
Health Professional from FRANCE reported SUSTIVA problem on June 15, 2001. Female patient, weighting 6.61 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: hepatosplenomegaly, hypertriglyceridaemia, neutropenia. SUSTIVA dosage: unknown. During the same period patient was treated with VIDEX, INVIRASE, NORVIR, VIRAMUNE, VIRACEPT, RETROVIR, PREVISCAN. Patient recovered.
Sustiva Side Effects Report #5168281-7
SUSTIVA problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Nov 30, 2006. Male patient, 37 years of age, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: balance disorder, confusional state, dizziness, hemiplegia, tuberculosis. SUSTIVA dosage: unknown. During the same period patient was treated with COMBIVIR. Patient recovered.
Sustiva Side Effects Report #5169416-2
Physician from FRANCE reported SUSTIVA problem on Jan 16, 2006. Female patient, 27 years of age, weighting 123.5 lb, was diagnosed with hiv test positive and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, agitation, condition aggravated, delirium, depression, mental disorder, transaminases increased. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5171712-X
SUSTIVA problem was reported by a Health Professional from FRANCE on Dec 18, 2000. Male patient, weighting 6.61 lb, was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: abortion induced, anaemia macrocytic, blood creatine phosphokinase increased, blood lactic acid increased, caesarean section, platelet count increased, retrognathia. SUSTIVA dosage: unknown. During the same period patient was treated with RETROVIR, EPIVIR, VIRAMUNE, COMBIVIR, VITAMIN, PEVARYL, GINKOR. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5177176-4
Consumer or non-health professional from UNITED KINGDOM reported SUSTIVA problem on Dec 08, 2006. Male patient was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: nervous system disorder. SUSTIVA dosage: REDUCED TO 400MG DAILY. Patient recovered.
Sustiva Side Effects Report #5192350-9
SUSTIVA problem was reported by a Physician from FRANCE on Mar 27, 2006. Female patient, 43 years of age, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: abortion, metrorrhagia, pregnancy. SUSTIVA dosage: unknown. During the same period patient was treated with COMBIVIR, VIRAMUNE. Patient recovered.
Sustiva Side Effects Report #5379117-3
Consumer or non-health professional from GERMANY reported SUSTIVA problem on July 02, 2007. Male patient, 35 years of age, weighting 127.9 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: anaemia, balance disorder, cytomegalovirus infection, dizziness, glioma, kaposi's sarcoma. SUSTIVA dosage: unknown. During the same period patient was treated with ZERIT, VIREAD, EPIVIR, COTRIM, ZIDOVUDINE. Patient was hospitalized and became disabled. Patient recovered.
Sustiva Side Effects Report #5379139-2
SUSTIVA problem was reported by a Physician from SPAIN on June 29, 2007. Male patient, 47 years of age, weighting 176.4 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: hepatitis, hepatorenal syndrome, renal impairment. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, CIALIS, ANTIDEPRESSANT NOS. Patient died on 01/04/2006.
Sustiva Side Effects Report #5379143-4
Physician from GERMANY reported SUSTIVA problem on June 29, 2007. Male patient, 41 years of age, weighting 141.1 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: gingivitis, periodontitis. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA. Patient recovered.
Sustiva Side Effects Report #5382916-5
SUSTIVA problem was reported by a Physician from SPAIN on July 06, 2007. Male patient, 45 years of age, was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: maculopathy. SUSTIVA dosage: unknown. Patient recovered.
Sustiva Side Effects Report #5386362-X
Health Professional from UNITED STATES reported SUSTIVA problem on July 06, 2007. Female patient, 31 years of age, was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: breech presentation, dandy-walker syndrome, foetal growth retardation, foetal malformation, oligohydramnios, stillbirth, umbilical cord abnormality. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, VIRAMUNE. Patient recovered.
Sustiva Side Effects Report #5391475-2
SUSTIVA problem was reported by a Consumer or non-health professional from UNITED STATES on July 18, 2007. Male patient, 34 years of age, weighting 154.3 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: immune reconstitution syndrome, polyarthritis. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA. Patient was hospitalized and became disabled. Patient recovered.
Sustiva Side Effects Report #5392455-3
Physician from GERMANY reported SUSTIVA problem on July 17, 2007. Female patient, 22 years of age, weighting 121.3 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: pregnancy, talipes. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, KALETRA, COMBIVIR. Patient recovered.
Sustiva Side Effects Report #5401630-0
SUSTIVA problem was reported by a Health Professional from FRANCE on July 27, 2007. Male patient, 39 years of age, weighting 167.6 lb, was diagnosed with hiv infection, tuberculosis, prophylaxis, epilepsy and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: brain stem syndrome, inflammation, intracranial pressure increased, nervous system disorder. SUSTIVA dosage: unknown. During the same period patient was treated with AMIKLIN, TRUVADA, PIRILENE, MYAMBUTOL, RIMIFON, IZILOX, BACTRIM, DEPAKENE. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5409412-0
Health Professional from FRANCE reported SUSTIVA problem on Aug 07, 2007. Male patient, 39 years of age, weighting 167.6 lb, was diagnosed with hiv infection, tuberculosis, prophylaxis, epilepsy and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: brain stem syndrome, immune reconstitution syndrome, inflammation, intracranial pressure increased, nervous system disorder. SUSTIVA dosage: unknown. During the same period patient was treated with AMIKLIN, TRUVADA, PIRILENE, MYAMBUTOL, RIMIFON, IZILOX, BACTRIM, DEPAKENE. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5412473-6
SUSTIVA problem was reported by a Health Professional from FRANCE on Aug 08, 2007. Female patient, 39 years of age, was diagnosed with hiv infection, chlamydial infection, hypertension, gastrointestinal disorder and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: hepatitis fulminant. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, RULID, HYTACAND, INIPOMP. Patient was hospitalized. Patient died on 06/26/2007.
Sustiva Side Effects Report #5417028-5
Health Professional from UNITED STATES reported SUSTIVA problem on July 20, 2007. Female patient, 31 years of age, was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: breech presentation, dandy-walker syndrome, foetal growth retardation, foetal malformation, oligohydramnios, pregnancy, stillbirth, umbilical cord abnormality. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, VIRAMUNE. Patient recovered.
Sustiva Side Effects Report #5422562-8
SUSTIVA problem was reported by a Health Professional from UNITED STATES on Aug 15, 2007. Female patient, weighting 6.61 lb, was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: congenital anomaly, pregnancy, skin disorder. SUSTIVA dosage: unknown. During the same period patient was treated with STAVUDINE. Patient recovered.
Sustiva Side Effects Report #5423492-8
Health Professional from UNITED STATES reported SUSTIVA problem on Aug 09, 2007. Female patient, 31 years of age, was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: breech presentation, dandy-walker syndrome, foetal growth retardation, foetal malformation, oligohydramnios, pregnancy, stillbirth, umbilical cord abnormality. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, VIRAMUNE, BACTRIM. Patient recovered.
Sustiva Side Effects Report #5427043-3
SUSTIVA problem was reported by a Pharmacist from UNITED STATES on Aug 24, 2007. Female patient, 29 years of age, weighting 92.00 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: anger, depression, mood altered, suicide attempt. SUSTIVA dosage: ORAL;600.0 MILLIGRAM. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5427239-0
Physician from UNITED KINGDOM reported SUSTIVA problem on Aug 24, 2007. Female patient, 40 years of age, weighting 158.7 lb, was diagnosed with acquired immunodeficiency syndrome, hiv infection, contraception, hypertension, nephropathy and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: foetal growth retardation, normal newborn, pregnancy. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, CONDOM, PERINDOPRIL ERBUMINE, PERINDOPRIL ERBUMINE, LABETALOL, INDAPAMIDE, COMBIVIR. Patient recovered.
Sustiva Side Effects Report #5429568-3
SUSTIVA problem was reported by a Physician from GERMANY on Aug 24, 2007. Male patient, 52 years of age, weighting 207.2 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: arthralgia, back pain, pain in extremity, tinnitus. SUSTIVA dosage: unknown. During the same period patient was treated with COMBIVIR, TRIZIVIR. Patient recovered.
Sustiva Side Effects Report #5430925-X
Physician from UNITED KINGDOM reported SUSTIVA problem on Aug 28, 2007. Female patient, 40 years of age, weighting 158.7 lb, was diagnosed with acquired immunodeficiency syndrome, hiv infection, contraception, hypertension, nephropathy and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: foetal growth retardation, infant, pregnancy. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, CONDOM, PERINDOPRIL ERBUMINE, PERINDOPRIL ERBUMINE, LABETALOL, INDAPAMIDE, COMBIVIR. Patient recovered.
Sustiva Side Effects Report #5430944-3
SUSTIVA problem was reported by a Physician from GERMANY on Aug 24, 2007. Male patient, 52 years of age, weighting 207.2 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: arthralgia, back pain, pain in extremity, tinnitus. SUSTIVA dosage: unknown. During the same period patient was treated with COMBIVIR, TRIZIVIR. Patient recovered.
Sustiva Side Effects Report #5443594-X
Consumer or non-health professional from UNITED KINGDOM reported SUSTIVA problem on Sept 03, 2007. Male patient, 68 years of age, weighting 121.3 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: hepatic cirrhosis. SUSTIVA dosage: unknown. During the same period patient was treated with VIDEX, ZERIT. Patient recovered.
Sustiva Side Effects Report #5450111-7
SUSTIVA problem was reported by a Health Professional from UNITED STATES on Sept 04, 2007. Female patient, weighting 6.61 lb, was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: pregnancy, skin disorder. SUSTIVA dosage: unknown. During the same period patient was treated with STAVUDINE, ZIDOVUDINE, NELFINAVIR MESYLATE, LAMIVUDINE, ABACAVIR SULPHATE. Patient recovered.
Sustiva Side Effects Report #5453720-4
Health Professional from UNITED STATES reported SUSTIVA problem on Sept 10, 2007. Female patient, weighting 6.61 lb, was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: aplasia cutis congenita, pregnancy. SUSTIVA dosage: unknown. During the same period patient was treated with STAVUDINE, ZIDOVUDINE, NELFINAVIR MESYLATE, LAMIVUDINE, ABACAVIR SULPHATE. Patient recovered.
Sustiva Side Effects Report #5455896-1
SUSTIVA problem was reported by a Physician from GERMANY on Sept 11, 2007. Male patient, 52 years of age, weighting 207.2 lb, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: abdominal pain, arthralgia, chest pain, headache, neck pain, pain in extremity, tinnitus. SUSTIVA dosage: unknown. During the same period patient was treated with COMBIVIR, TRIZIVIR. Patient recovered.
Sustiva Side Effects Report #5463410-X
Physician from UNITED STATES reported SUSTIVA problem on Sept 11, 2007. Female patient, 41 years of age, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: pneumonia. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA. Patient was hospitalized. Patient recovered.
Sustiva Side Effects Report #5469702-2
SUSTIVA problem was reported by a Consumer or non-health professional from ITALY on Sept 25, 2007. Male patient, 40 years of age, was diagnosed with hiv infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: thrombocytopenia. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA. Patient recovered.
Sustiva Side Effects Report #5470893-8
Health Professional from FRANCE reported SUSTIVA problem on Sept 24, 2007. Male patient, 58 years of age, weighting 134.5 lb, was diagnosed with hiv test positive, atypical mycobacterial infection and was treated with SUSTIVA. After drug was administered, patient experienced the following problems/side effects: cryptococcosis, immune reconstitution syndrome, pyrexia, vomiting. SUSTIVA dosage: unknown. During the same period patient was treated with TRUVADA, RIFATER, ETHAMBUTOL HYDROCHLORIDE, ZECLAR, CORTANCYL, ZELITREX, BACTRIM, TRIFLUCAN. Patient was hospitalized. Patient recovered.
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Drug Information: Efavirenz
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a699004.html
(e fa veer' ens)Why is this medication prescribed?
Efavirenz is used with other medications to treat human immunodeficiency virus (HIV) infection in patients with or without acquired immunodeficiency syndrome (AIDS). Efavirenz is in a class of medications called nonnucleoside reverse transcriptase inhibitors (NNRTIs). Efavirenz works by slowing the spread of HIV in the body. Efavirenz does not cure HIV infection and may not prevent you from developing HIV-related illnesses. Efavirenz does not prevent you from spreading HIV to other people.
How should this medicine be used?
Efavirenz comes as a capsule and as a tablet to take by mouth. It is usually taken once a day with plenty of water on an empty stomach. Take efavirenz at around the same time every day. Taking efavirenz at bedtime may make side effects less bothersome. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take efavirenz exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Efavirenz controls HIV infection, but does not cure it. Continue to take efavirenz even if you feel well. Do not stop taking efavirenz without talking to your doctor. When your supply of efavirenz starts to run low, get more from your doctor or pharmacist. If you miss doses or stop taking efavirenz, your condition may become more difficult to treat.
Other uses for this medicine
Efavirenz is also used with another medication to help prevent infection in health care workers or other people who were accidentally exposed to HIV. Talk to your doctor about the possible risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking efavirenz,
- tell your doctor and pharmacist if you are allergic to efavirenz or any other medications.
- do not take astemizole (Hismanal) (no longer available in the United States); cisapride (Propulsid) (no longer available in the United States); ergot-type medications such as bromocriptine (Parlodel), cabergoline (Dostinex), dihydroergotamine (D.H.E. 45, Migranal), ergoloid mesylates (Germinal, Hydergine), ergonovine (Ergotrate), ergotamine (Bellergal-S, Cafergot, Ergomar, Wigraine), methylergonovine (Methergine), methysergide (Sansert), and pergolide (Permax); midazolam (Versed); triazolam (Halcion); or voriconazole (Vfend) while taking efavirenz.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: acetaminophen (Tylenol, others); anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants; antifungals such as itraconazole (Sporanox), and ketoconazole (Nizoral); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Lexxel, Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular), and verapamil (Calan, Covera, Isoptin, Verelan); chlorpheniramine in over-the-counter cold products; cholesterol-lowering medications (statins); cimetidine (Tagamet); clarithromycin (Biaxin, Prevpac); danazol (Danocrine); dexamethasone (Decadron); erythromycin (E.E.S., E-Mycin, Erythrocin); iron products; isoniazid (INH, Nydrazid); medications for anxiety, mental illness, or pain; medications for HIV or AIDS such as amprenavir (Agenerase), atazanavir (Reyataz); indinavir (Crixivan), lopinavir (in Kaletra); ritonavir (Norvir, in Kaletra) and saquinavir ( Invirase); medications for seizures such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); methotrexate (Rheumatrex); methadone (Dolophine); metronidazole (Flagyl); niacin (nicotinic acid); nonsteroidal anti-inflammatory medications (NSAIDs) such as celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Anaprox, Naprosyn), and piroxicam (Feldene); oral medications for diabetes such as glipizide (Glucotrol, Metaglip) and tolbutamide (Orinase); proton pump inhibitors such as lansoprazole (Prevacid), omeprazole (Prilosec), and pantoprazole (Protonix); quinidine (Quinidex); quinine; rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); sedatives; sertraline (Zoloft); sildenafil (Viagra); sleeping pills; sulfamethoxazole (Bactrim, Septra); tamoxifen (Nolvadex); torsemide (Demadex); tranquilizers; troleandomycin (TAO); or zafirlukast (Accolate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially products that contain kava or St. John's wort.
- tell your doctor if you drink or have ever drunk large amounts of alcohol; if you use or have ever used street drugs or have overused prescription medications; or if you have or have ever had seizures; high cholesterol; depression or other mental illness; or heart, liver,or pancreas disease.
- you should not become pregnant while taking efavirenz. You will have to have a negative pregnancy test before you begin taking this medication and use effective birth control during your treatment. Efavirenz may interfere with the action of hormonal contraceptives (birth control pills, patches, rings, implants, or injections, so you should not use these as your only method of birth control during your treatment. You must use a barrier method of birth control (device that blocks sperm from entering the uterus such as a condom or a diaphragm) along with any other method of birth control you have chosen. Ask your doctor to help you choose a method of birth control that will work for you. If you become pregnant while taking efavirenz, call your doctor. Efavirenz may harm the fetus.
- you should not breastfeed if you are infected with HIV or are taking efavirenz.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking efavirenz.
- you should know that efavirenz may make you drowsy, dizzy, or unable to concentrate. Do not drive a car or operate machinery until you know how this medication affects you.
- ask your doctor about the safe use of alcoholic beverages while you are taking efavirenz. Alcohol can make the side effects from efavirenz worse.
- you should know that your body fat may increase or move to different areas of your body such as your breasts and upper back.
- you should know that efavirenz may cause changes in your thoughts, behavior, or mental health. Call your doctor immediately if you develop any of the following symptoms while you are taking efavirenz: depression, thinking about killing yourself or planning or trying to do so, angry or aggressive behavior, hallucinations (seeing things or hearing voices that do not exist), or loss of touch with reality. Be sure your family knows which symptoms may be serious so that they can call your doctor if you are unable to seek treatment on your own.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Efavirenz may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- upset stomach
- vomiting
- stomach pain
- diarrhea
- indigestion
- drowsiness
- dizziness
- headache
- difficulty concentrating
- confusion
- forgetfulness
- nervousness
- strange thoughts
- abnormally happy mood
- difficulty falling asleep or staying asleep
- unusual dreams
- pain
Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the SPECIAL PRECAUTIONS section, call your doctor immediately:
- sore throat, cough, fever, chills, or other signs of infection
- rash
- itching
- blisters or sores on skin
- peeling skin
- fainting
- extreme tiredness
- lack of energy
- loss of appetite
- pain in the upper right part of the stomach
- unusual bleeding or bruising
- yellowing of the skin or eyes
- flu-like symptoms
- seizures
Efavirenz may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- movements of your body that you cannot control
- dizziness
- headache
- difficulty concentrating
- nervousness
- confusion
- forgetfulness
- difficulty falling asleep or staying asleep
- unusual dreams
- drowsiness
- hallucinations (seeing things or hearing voices that do not exist)
- abnormally happy mood
- strange thoughts
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to efavirenz.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking efavirenz.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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