Sutent Safety Questions, Sutent Answers
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Sutent Safety Reports
Total Sutent reports: 1746.Sutent FDA safety alerts: No.
Reported deaths: 393 Reported hospitalizations: 1149.
Take Sutent Side Effects Survey or Share Your Sutent Story.
Reported Sutent Side Effects: diarrhoea, fatigue, nausea, dehydration, disease progression, vomiting, asthenia, confusional state, thrombocytopenia, pyrexia, death.
Sutent Usage.
Showing 1-50 of 1746 Next >
Sutent Side Effects Report #5221412-2Consumer or non-health professional from CANADA reported SUTENT problem on Jan 16, 2007. Male patient, 60 years of age, was treated with SUTENT. SUTENT dosage: unknown. Patient died on 01/10/2007.
Sutent Side Effects Report #5222934-0
SUTENT problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 17, 2007. Male patient, weighting 153.0 lb, was diagnosed with peritonitis and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: appendicitis, hyperbilirubinaemia, peritonitis. SUTENT dosage: unknown. During the same period patient was treated with ZOSYN, OXYCONTIN, PERCOCET, COLACE, PROTONIX. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5222967-4
Consumer or non-health professional from UNITED STATES reported SUTENT problem on Jan 17, 2007. Male patient, 76 years of age, weighting 152.6 lb, was diagnosed with transitional cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: pneumothorax. SUTENT dosage: unknown. During the same period patient was treated with CELECOXIB, AMBIEN, OMEPRAZOLE. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5222976-5
SUTENT problem was reported by a Physician from UNITED STATES on Jan 17, 2007. Female patient, weighting 134.0 lb, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: lactic acidosis. SUTENT dosage: unknown. Patient recovered.
Sutent Side Effects Report #5223002-4
Physician from UNITED STATES reported SUTENT problem on Jan 17, 2007. Female patient, weighting 156.1 lb, was diagnosed with metastatic renal cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: arrhythmia, blood calcium abnormal, blood calcium decreased, blood chloride increased, blood copper abnormal, cardiac failure congestive, dehydration, diarrhoea, hyperglycaemia. SUTENT dosage: unknown. During the same period patient was treated with WARFARIN, TRICOR, CLONIDINE, COMPAZINE, LOPERAMIDE, LASIX, METOPROLOL TARTRATE, ASPIRIN. Patient was hospitalized. Patient died on 11/01/2006.
Sutent Side Effects Report #5223037-1
SUTENT problem was reported by a Physician from FRANCE on Jan 17, 2007. Female patient, 64 years of age, was diagnosed with sarcoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: brain oedema, depressed level of consciousness, somnolence. SUTENT dosage: unknown. Patient recovered.
Sutent Side Effects Report #5224396-6
Physician from FRANCE reported SUTENT problem on Jan 19, 2007. Female patient, weighting 112.4 lb, was diagnosed with gastrointestinal stromal tumour and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: blood creatine phosphokinase increased, disease progression, gastrointestinal stromal tumour, myalgia, myositis, purpura, stomatitis. SUTENT dosage: unknown. During the same period patient was treated with CEFTRIAXONE, CIPROFLOXACIN. Patient was hospitalized. Patient died on 07/31/2006.
Sutent Side Effects Report #5225489-X
SUTENT problem was reported by a Physician from CANADA on Jan 19, 2007. Male patient, 52 years of age, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis, pulmonary embolism. SUTENT dosage: unknown. Patient died on 12/24/2006.
Sutent Side Effects Report #5225504-3
Pharmacist from CANADA reported SUTENT problem on Jan 19, 2007. Male patient, 57 years of age, was treated with SUTENT. SUTENT dosage: unknown. Patient died.
Sutent Side Effects Report #5225513-4
SUTENT problem was reported by a Consumer or non-health professional from on Jan 19, 2007. Male patient, 73 years of age, was diagnosed with hepatic neoplasm malignant and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: dehydration, hyponatraemia, mental status changes. SUTENT dosage: unknown. During the same period patient was treated with ALDACTONE, AVANDIA, QUINAPRIL, TRIAZOLAM, CELEXA, LOPERAMIDE HYDROCHLORIDE, LASIX, LOMOTIL. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5225888-6
Health Professional from UNITED STATES reported SUTENT problem on Jan 30, 2007. Female patient, 52 years of age, weighting 172.4 lb, was diagnosed with leiomyosarcoma metastatic and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: leukocytosis, metabolic acidosis. SUTENT dosage: 50 MG DAILY FOR 28 DAYS PO. During the same period patient was treated with OXYCODONE, PROPOXYPHANE, PROTONIX, TANDEM F, DIETARY SUPPLEMENT. Patient died on 12/29/2006.
Sutent Side Effects Report #5227739-2
SUTENT problem was reported by a Consumer or non-health professional from CANADA on Jan 22, 2007. Male patient, 52 years of age, was treated with SUTENT. SUTENT dosage: unknown. Patient died.
Sutent Side Effects Report #5227822-1
Health Professional from INDIA reported SUTENT problem on Jan 22, 2007. Male patient, 44 years of age, was diagnosed with metastatic renal cell carcinoma and was treated with SUTENT. SUTENT dosage: unknown. Patient died on 01/18/2007.
Sutent Side Effects Report #5227823-3
SUTENT problem was reported by a Health Professional from INDIA on Jan 22, 2007. Male patient, 54 years of age, was diagnosed with metastatic renal cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: adrenal disorder, metastases to bone, metastases to liver. SUTENT dosage: unknown. Patient died on 10/28/2006.
Sutent Side Effects Report #5227829-4
Consumer or non-health professional from UNITED STATES reported SUTENT problem on Jan 22, 2007. Male patient, weighting 177.0 lb, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: blood pressure increased, malaise, platelet count decreased, red blood cell count decreased, unresponsive to stimuli, vomiting, white blood cell count decreased. SUTENT dosage: unknown. Patient was hospitalized. Patient died on 01/15/2007.
Sutent Side Effects Report #5227831-2
SUTENT problem was reported by a Physician from UNITED STATES on Jan 22, 2007. Male patient, weighting 112.4 lb, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: blood cholesterol increased, blood triglycerides increased, very low density lipoprotein increased. SUTENT dosage: unknown. During the same period patient was treated with ATENOLOL, AMLODIPINE. Patient recovered.
Sutent Side Effects Report #5227922-6
Consumer or non-health professional from UNITED STATES reported SUTENT problem on Jan 22, 2007. Female patient, weighting 171.1 lb, was diagnosed with metastatic renal cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, fatigue, hypertension, thrombocytopenia, thrombotic thrombocytopenic purpura. SUTENT dosage: unknown. During the same period patient was treated with CARDIZEM, TYLENOL, SYNTHROID, NEXIUM, ASPIRIN, ATIVAN, VITAMIN CAP, ZOFRAN. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5229723-1
SUTENT problem was reported by a Physician from PHILIPPINES on Jan 24, 2007. Male patient, 49 years of age, was diagnosed with metastasis and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: epistaxis. SUTENT dosage: unknown. Patient died on 12/01/2006.
Sutent Side Effects Report #5229767-X
Physician from GERMANY reported SUTENT problem on Jan 24, 2007. Female patient, weighting 149.9 lb, was diagnosed with gastrointestinal stromal tumour and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: acute prerenal failure, anaemia, constipation, diarrhoea, nausea, neoplasm progression, nutritional condition abnormal, vomiting. SUTENT dosage: unknown. During the same period patient was treated with IMATINIB MESYLATE, RAMIPRIL, HYDROCHLOROTHIAZIDE, ZOFRAN. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5229924-2
SUTENT problem was reported by a Physician from ARGENTINA on Jan 24, 2007. Male patient, 58 years of age, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: alopecia, bronchitis viral, diarrhoea, glossitis, haematoma, palmar-plantar erythrodysaesthesia syndrome, petechiae, phlebitis, pyrexia. SUTENT dosage: DAILY DOSE:50MG. During the same period patient was treated with FUROSEMIDE, MEPREDNISONE, THEOPHYLLINE, SALBUTAMOL, ENALAPRIL MALEATE, PANTOPRAZOLE. Patient recovered.
Sutent Side Effects Report #5229972-2
Health Professional from CANADA reported SUTENT problem on Jan 24, 2007. Female patient, 70 years of age, was treated with SUTENT. SUTENT dosage: unknown. Patient died.
Sutent Side Effects Report #5230306-8
SUTENT problem was reported by a Physician from UNITED STATES on Jan 24, 2007. Female patient, weighting 175.0 lb, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: cardiac failure congestive, cardiomyopathy, pericardial effusion. SUTENT dosage: unknown. Patient recovered.
Sutent Side Effects Report #5230317-2
Consumer or non-health professional from UNITED STATES reported SUTENT problem on Jan 24, 2007. Male patient, weighting 194.0 lb, was diagnosed with hypertension, depression and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: disorientation, hypertension, psychotic disorder, rash. SUTENT dosage: unknown. During the same period patient was treated with NORVASC, ZOLOFT, MORPHINE, HYDROCODONE BITARTRATE. Patient recovered.
Sutent Side Effects Report #5231828-6
SUTENT problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 25, 2007. Male patient, weighting 119.9 lb, was diagnosed with gastrointestinal stromal tumour and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: cellulitis, perianal abscess. SUTENT dosage: unknown. Patient was hospitalized and became disabled. Patient recovered.
Sutent Side Effects Report #5231884-5
Consumer or non-health professional from CANADA reported SUTENT problem on Jan 25, 2007. Female patient, 50 years of age, was treated with SUTENT. SUTENT dosage: unknown. Patient died on 01/10/2007.
Sutent Side Effects Report #5231924-3
SUTENT problem was reported by a Consumer or non-health professional from PERU on Jan 25, 2007. Male patient, weighting 145.5 lb, was diagnosed with renal cancer metastatic and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: cellulitis. SUTENT dosage: unknown. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5231972-3
Physician from GREECE reported SUTENT problem on Jan 25, 2007. Female patient, 69 years of age, was diagnosed with renal cancer metastatic and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, blood pressure decreased, epistaxis, fatigue, influenza like illness, pyrexia, red blood cell sedimentation rate increased, thrombocytopenia. SUTENT dosage: unknown. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5231975-9
SUTENT problem was reported by a Pharmacist from CANADA on Jan 25, 2007. Female patient, 74 years of age, was treated with SUTENT. SUTENT dosage: unknown. Patient died.
Sutent Side Effects Report #5233029-4
Consumer or non-health professional from UNITED STATES reported SUTENT problem on Jan 26, 2007. Male patient, 76 years of age, weighting 152.6 lb, was diagnosed with transitional cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: pneumothorax. SUTENT dosage: unknown. During the same period patient was treated with CELECOXIB, AMBIEN, OMEPRAZOLE. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5233038-5
SUTENT problem was reported by a Physician from AUSTRIA on Jan 26, 2007. Male patient, weighting 242.5 lb, was diagnosed with metastatic renal cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: dyspnoea, rhabdomyolysis, urinary retention. SUTENT dosage: unknown. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5233084-1
Physician from GERMANY reported SUTENT problem on Jan 26, 2007. Male patient, weighting 194.0 lb, was diagnosed with metastatic renal cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: adrenocortical insufficiency acute, hyponatraemia, renal failure acute. SUTENT dosage: unknown. During the same period patient was treated with METOPROLOL SUCCINATE, RAMIPRIL, THYROXIN, HYDROCORTISONE, CALCITRIOL, CALCIUM, POTASSIUM ACETATE, MAGNESIUM. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5233114-7
SUTENT problem was reported by a Physician from FRANCE on Jan 26, 2007. Male patient, weighting 202.8 lb, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: blood thyroid stimulating hormone decreased, hyperthyroidism. SUTENT dosage: unknown. Patient recovered.
Sutent Side Effects Report #5233208-6
Physician from FRANCE reported SUTENT problem on Jan 26, 2007. Male patient, 58 years of age, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: dysgeusia, hypertension, thrombocytopenia. SUTENT dosage: unknown. Patient recovered.
Sutent Side Effects Report #5233975-1
SUTENT problem was reported by a Pharmacist from UNITED STATES on Jan 27, 2007. Male patient, 63 years of age, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: cerebrovascular accident. SUTENT dosage: unknown. Patient recovered.
Sutent Side Effects Report #5234083-6
Pharmacist from CANADA reported SUTENT problem on Jan 29, 2007. Male patient, 54 years of age, was treated with SUTENT. SUTENT dosage: unknown. Patient died on 01/17/2007.
Sutent Side Effects Report #5234739-5
SUTENT problem was reported by a Pharmacist from UNITED STATES on Jan 30, 2007. Male patient, 63 years of age, weighting 142.0 lb, was diagnosed with lung neoplasm malignant and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: convulsion. SUTENT dosage: unknown. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5234829-7
Physician from ARGENTINA reported SUTENT problem on Jan 29, 2007. Male patient, 58 years of age, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: alopecia, bronchitis viral, constipation, diarrhoea, glossitis, haematoma, palmar-plantar erythrodysaesthesia syndrome, petechiae, phlebitis. SUTENT dosage: DAILY DOSE:50MG. During the same period patient was treated with FUROSEMIDE, MEPREDNISONE, THEOPHYLLINE, SALBUTAMOL, ENALAPRIL MALEATE, PANTOPRAZOLE. Patient recovered.
Sutent Side Effects Report #5234863-7
SUTENT problem was reported by a Physician from ARGENTINA on Jan 30, 2007. Female patient, 80 years of age, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: oesophageal ulcer. SUTENT dosage: unknown. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5234901-1
Physician from FRANCE reported SUTENT problem on Jan 29, 2007. Male patient, 65 years of age, was diagnosed with renal cancer metastatic and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: blood amylase increased, cholestasis, lipase increased. SUTENT dosage: DAILY DOSE:50MG. Patient died.
Sutent Side Effects Report #5236184-5
SUTENT problem was reported by a Physician from GERMANY on Jan 31, 2007. Male patient was diagnosed with metastatic renal cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: pancytopenia. SUTENT dosage: DAILY DOSE:50MG. Patient recovered.
Sutent Side Effects Report #5236209-7
Physician from FRANCE reported SUTENT problem on Jan 31, 2007. Male patient, weighting 183.0 lb, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: abdominal pain, alanine aminotransferase increased, aspartate aminotransferase increased, bacillus infection, bacterial infection, bile duct obstruction, biliary tract disorder, blood alkaline phosphatase increased, blood calcium increased. SUTENT dosage: unknown. During the same period patient was treated with ALLOPURINOL, METFORMIN, ASPIRIN. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5236222-X
SUTENT problem was reported by a Consumer or non-health professional from UNITED STATES on Feb 01, 2007. Male patient, weighting 183.0 lb, was diagnosed with pancreatic carcinoma, constipation, fungal infection, restless legs syndrome, pain and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: gastrointestinal haemorrhage, syncope. SUTENT dosage: unknown. During the same period patient was treated with PACLITAXEL, CARBOPLATIN, COLACE, REQUIP, OXYCONTIN, OXYCODONE. Patient was hospitalized. Patient died on 01/01/2007.
Sutent Side Effects Report #5236237-1
Physician from CANADA reported SUTENT problem on Jan 31, 2007. Male patient, 52 years of age, was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis, pulmonary embolism. SUTENT dosage: unknown. During the same period patient was treated with FOLIC ACID, THIAMINE, INSULIN, MORPHINE. Patient died on 12/24/2006.
Sutent Side Effects Report #5236248-6
SUTENT problem was reported by a Consumer or non-health professional from UNITED STATES on Feb 06, 2007. Male patient, weighting 158.1 lb, was diagnosed with pancreatic carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: thrombosis. SUTENT dosage: unknown. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5236297-8
Physician from GERMANY reported SUTENT problem on Jan 31, 2007. Female patient, weighting 127.9 lb, was diagnosed with neuroendocrine tumour and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: pericardial effusion. SUTENT dosage: DAILY DOSE:37.5MG. During the same period patient was treated with IBANDRONATE. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5236427-8
SUTENT problem was reported by a Physician from SWEDEN on Jan 31, 2007. Male patient, weighting 202.8 lb, was diagnosed with metastatic renal cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: leukopenia, sepsis. SUTENT dosage: unknown. During the same period patient was treated with MORPHINE, DOLCONTIN, DULCOLAX, LAXOBERAL, GASTROGRAFIN, CHLORIDE, EUFUSOL, CITODON. Patient was hospitalized. Patient died on 12/18/2006.
Sutent Side Effects Report #5237462-6
Consumer or non-health professional from ARGENTINA reported SUTENT problem on Feb 01, 2007. Male patient was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: abdominal pain upper, blister, dysphonia, red blood cell count decreased, white blood cell count decreased. SUTENT dosage: DAILY DOSE:50MG. Patient recovered.
Sutent Side Effects Report #5237538-3
SUTENT problem was reported by a Physician from UNITED STATES on Feb 01, 2007. Female patient, weighting 134.9 lb, was diagnosed with metastatic neoplasm and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: angioedema, dysphagia, glossodynia, hypersensitivity, oral pain, pain in jaw, swollen tongue, tongue oedema. SUTENT dosage: DAILY DOSE:50MG. During the same period patient was treated with ACCUPRIL, ZETIA, ARTHROTEC, LOZOL, WARFARIN. Patient recovered.
Sutent Side Effects Report #5237552-8
Consumer or non-health professional from UNITED STATES reported SUTENT problem on Feb 01, 2007. Female patient, weighting 158.1 lb, was diagnosed with breast cancer and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: chest pain, dyspnoea, nausea. SUTENT dosage: unknown. During the same period patient was treated with MAXZIDE, TOPROL, DIGOXIN, ASPIRIN, ACTONEL, PROZAC, AVAPRO. Patient was hospitalized. Patient recovered.
Sutent Side Effects Report #5237558-9
SUTENT problem was reported by a Physician from GREECE on Feb 01, 2007. Male patient, 63 years of age, was diagnosed with metastatic renal cell carcinoma and was treated with SUTENT. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis. SUTENT dosage: unknown. During the same period patient was treated with ANTIHYPERTENSIVES. Patient died on 02/01/2007.
Showing 1-50 of 1746 Next >
Drug Information: Sunitinib
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a607052.html
soo ni' ti nibWhy is this medication prescribed?
Sunitinib is used to treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the stomach, intestine (bowel), or esophagus (tube that connects the throat with the stomach) in people with tumors that were not treated successfully with imatinib (Gleevec) or people who cannot take imatinib. Sunitinib is also used to treat advanced renal cell carcinoma (RCC, a type of cancer that begins in the cells of the kidneys). Sunitinib is in a class of medications called multikinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells and may help shrink tumors.
How should this medicine be used?
Sunitinib comes as a capsule to take by mouth with or without food. It is usually taken once a day for 4 weeks (28 days) followed by a 2-week break before beginning the next dosing cycle. Take sunitinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sunitinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsules whole; do not split, chew, or crush them.Do not open the capsules.
You may need to take one or more capsules at a time depending on your dose of sunitinib.
Your doctor may gradually increase or decrease your dose of sunitinib during your treatment. This depends on how well the medication works for you and the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take sunitinib even if you feel well. Do not stop taking sunitinib without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking sunitinib,
- tell your doctor and pharmacist if you are allergic to sunitinib, mannitol, or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: certain antibiotics such as clarithromycin (Biaxin, in Prevpac), erythromycin (E.E.S., E-Mycin, Erythrocin), moxifloxacin (Avelox), rifampin (Rifadin, Rimactane), rifabutin (Mycobutin), rifapentine (Priftin), sparfloxacin (Zagam) (not available in the US), telithromycin (Ketek), and troleandomycin (TAO) (not available in the US); anticoagulants ('blood thinners') such as warfarin (Coumadin); antifungals such as itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); certain calcium channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac, others) and verapamil (Calan, Isoptin, Verelan); cimetidine (Tagamet); cisapride (Propulsid); dexamethasone (Mymethasone); certain medications for depression such as fluvoxamine and nefazodone; certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); medications for irregular heartbeat including amiodarone (Cordarone), disopyramide (Norpace), dofetilide (Tikosyn)procainamide (Procanbid, Pronestyl), quinidine (Quinidex), and sotalol (Betapace, Betapace AF); certain medications for seizures such as carbamazepine (Equetro, Carbatrol, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); pimozide (Orap); and thioridazine (Mellaril). Other medications may also interact with sunitinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor and pharmacist what herbal products you are taking, especially St. John's wort. Your doctor will probably tell you not to take St. John's wort while taking sunitinib.
- tell your doctor if you have or have ever had a bleeding problem;angina (chest pain); arrhythmias (slow, fast, or irregular heart beat);a heart attack; heart bypass surgery; heart failure; high blood pressure; pulmonary embolism (PE; blood clot in the lungs); seizures; a stroke or transient ischemic attack (TIA, mini-stroke); or heart, kidney, liver, or thyroid disease.
- tell your doctor if you are pregnant, could be pregnant, or plan to become pregnant. You should not become pregnant while you are taking sunitinib. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking sunitinib, call your doctor immediately Sunitinib may harm the fetus.
- tell your doctor if you are breast-feeding. You should not breast-feed while you are taking sunitinib.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking sunitinib.
- you should know that sunitinib may cause your skin to turn yellow and your hair to lighten and lose color. This is probably caused by the yellow color of the medication and is not harmful or painful. Your natural skin and hair color will likely return after you stop taking sunitinib.
- you should know that sunitinib may cause high blood pressure. Your blood pressure should be checked regularly while you are taking sunitinib.
What special dietary instructions should I follow?
Do not eat grapefruit or drink grapefruit juice while taking this medication.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Tell your doctor or nurse about the missed dose.
What side effects can this medication cause?
Sunitinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- extreme tiredness
- weakness
- nausea
- vomiting
- diarrhea
- constipation
- heartburn
- gas
- white patches or sores on the lips or in the mouth and throat
- pain, irritation, or burning sensation of the lips, tongue, mouth or throat
- dry mouth
- change in the way things taste
- loss of appetite
- weight loss
- hair loss
- thin, brittle fingernails or hair
- slow speech
- depression
- dryness, thickness, cracking, or blistering of skin on the palms of the hands and the soles of the feet
- rash
- muscle or limb pain
- pain, burning, numbness, or tingling in the hands or feet
- unusual discomfort in cold temperatures
Some side effects can be serious. If you experience any of these symptoms,call your doctor immediately:
- unusual bruising or bleeding
- black and tarry stools
- red blood in stools
- bloody vomit
- vomiting material that looks like coffee grounds
- stomach pain or swelling
- fever
- chills
- swelling, tenderness, warmth, or redness of a leg
- swelling of the feet or ankles
- rapid, irregular, or pounding heartbeat
- chest pain
- shortness of breath
- weight gain
- difficulty falling asleep or staying asleep
- coughing up pink or bloody mucus
- increased urination, especially at night
- sudden severe back, stomach, or leg pain
Sunitinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to sunitinib.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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