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Tacrolimus Safety Reports
Total Tacrolimus reports: 260.Tacrolimus FDA safety alerts: 2003 2005 2006 .
Reported deaths: 93 Reported hospitalizations: 156.
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Reported Tacrolimus Side Effects: condition aggravated, interstitial lung disease, blood creatinine increased, cardiac arrest, septic shock, blood urea increased, sepsis, pyrexia, cerebral infarction, renal impairment, enterococcal infection.
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Tacrolimus Side Effects Report #5353676-9Physician from JAPAN reported TACROLIMUS problem on May 30, 2007. Male patient, 53 years of age, weighting 143.3 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. TACROLIMUS dosage: 1 MG, UID/QD, ORAL. During the same period patient was treated with PREDNISOLONE, AZULFIDINE EN, TICLOPIDINE, CALTAN, LANSOPRAZOLE, ADALATLET, SEVELAMER HYDROCHLORIDE, BARACLUDELET. Patient died on 03/26/2007.
Tacrolimus Side Effects Report #5353698-8
TACROLIMUS problem was reported by a Physician from JAPAN on May 28, 2007. Male patient, 68 years of age, weighting 145.5 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: arthritis bacterial, culture positive, osteomyelitis bacterial, staphylococcal infection. TACROLIMUS dosage: unknown. During the same period patient was treated with PREDNISOLONE, VOLTAREN, INDACIN, GLYCOL SALICYLATE, LANSOPRAZOLE. Patient recovered.
Tacrolimus Side Effects Report #5354880-6
Consumer or non-health professional from UNITED STATES reported TACROLIMUS problem on Apr 27, 2007. Male patient, child 5 years of age, was diagnosed with dermatitis atopic and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: pneumonia. TACROLIMUS dosage: unknown. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5356564-7
TACROLIMUS problem was reported by a Health Professional from UNITED KINGDOM on May 27, 2007. Male patient, 53 years of age, was diagnosed with liver transplant and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: cardiac failure, complications of transplanted liver, continuous haemodiafiltration, enterococcal infection, gastric perforation, hepatic failure, hyperglycaemia, large intestine perforation. TACROLIMUS dosage: 4.00 MG, BID, IV BOLUS. During the same period patient was treated with METHYLPREDNISOLONE, ARTERENOL, MYCOPHENOLATE MOFETIL, HYDROCORTISONE, ANTIBIOTICS, MERONEM, CIPROFLOXACIN. Patient was hospitalized and became disabled. Patient died on 09/07/2004.
Tacrolimus Side Effects Report #5363054-4
Physician from JAPAN reported TACROLIMUS problem on June 06, 2007. Female patient, 75 years of age, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: blood pressure increased, haematemesis. TACROLIMUS dosage: 1 MG, D, ORAL. During the same period patient was treated with PREDNISOLONE, OLMETEC, HYPOCA, GASTER. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5363055-6
TACROLIMUS problem was reported by a Physician from GERMANY on May 31, 2007. Male patient, 50 years of age, weighting 183.0 lb, was diagnosed with liver transplant and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: retinal vein occlusion, retinitis, venous thrombosis. TACROLIMUS dosage: 17 MG, D, ORAL. During the same period patient was treated with SIMULECT. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5363088-X
Health Professional from SPAIN reported TACROLIMUS problem on June 04, 2007. Male patient, 59 years of age, was diagnosed with liver transplant and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: angiodysplasia, human herpesvirus 8 infection, liver transplant rejection, meningitis cryptococcal, multi-organ failure, primary effusion lymphoma, rectal haemorrhage. TACROLIMUS dosage: 3.00 MG, UID/QD, ORAL. During the same period patient was treated with PREDNISONE, METHYLPREDNISOLONE, INSULIN, MORPHINE, PANTOPRAZOLE, RAPAMYCIN, PIPERACILLIN, TAZOBACTAM. Patient was hospitalized. Patient died on 09/15/2005.
Tacrolimus Side Effects Report #5364296-4
TACROLIMUS problem was reported by a Physician from JAPAN on May 31, 2007. Female patient, weighting 75.84 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: bacteraemia, blood glucose increased, blood pressure increased. TACROLIMUS dosage: 1.5 MG, /D, ORAL. During the same period patient was treated with PREDNISOLONE, LOXONIN, TAKEPRON, KAMAG G, DIOVAN, PRAVASTATIN, ONEALFA, PAXIL. Patient died on 04/03/2007.
Tacrolimus Side Effects Report #5369201-2
Physician from JAPAN reported TACROLIMUS problem on June 11, 2007. Female patient was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: pneumonia. TACROLIMUS dosage: unknown. Patient died.
Tacrolimus Side Effects Report #5369203-6
TACROLIMUS problem was reported by a Physician from JAPAN on June 07, 2007. Female patient, 65 years of age, was diagnosed with rheumatoid arthritis, lumbar spinal stenosis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: aspartate aminotransferase increased, bronchitis, haemoptysis, haemorrhagic diathesis, infection in an immunocompromised host, lung disorder. TACROLIMUS dosage: 1.5 MG, UID/QD, ORAL. During the same period patient was treated with PREDNISOLONE, OPALMON, VOLTAREN, AZULFIDINE ENLET, ROXATIDINE ACETATE, BERIZYM, MUCOSTA. Patient recovered.
Tacrolimus Side Effects Report #5369231-0
Physician from JAPAN reported TACROLIMUS problem on June 07, 2007. Female patient, 80 years of age, weighting 81.35 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: anaemia, angina pectoris, fall, gastric ulcer haemorrhage, muscular weakness, pain, stress. TACROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS CAPSULES, TACROLIMUS CAPSULES, VOLTAREN, PREDNISOLONE, METHOTREXATE. Patient recovered.
Tacrolimus Side Effects Report #5370631-3
TACROLIMUS problem was reported by a Physician from UNITED KINGDOM on June 06, 2007. Female patient, child 2 years of age, weighting 26.46 lb, was diagnosed with psoriasis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: pneumonia parainfluenzae viral, sepsis, varicella. TACROLIMUS dosage: unknown. During the same period patient was treated with DERMOL, CETRABEN. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5371069-5
Physician from JAPAN reported TACROLIMUS problem on June 12, 2007. Female patient, 85 years of age, weighting 83.56 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: fall, femur fracture, myocardial infarction. TACROLIMUS dosage: 1.5 MG, ORAL. During the same period patient was treated with METHYLPREDNISOLONE, MOBIC, ISONIAZID, SELBEX. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5371932-5
TACROLIMUS problem was reported by a Physician from UNITED KINGDOM on June 11, 2007. Female patient, 52 years of age, was diagnosed with liver transplant and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: bradycardia, cardiac arrest, cardiac failure, cerebral atrophy, convulsion, pathogen resistance, septic shock, staphylococcal sepsis. TACROLIMUS dosage: 3 MG, UID/QD, ORAL. During the same period patient was treated with MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE, INSULIN, FUROSEMIDE, BLOOD AND RELATED PRODUCTS, ALBUMIN. Patient died on 08/10/2005.
Tacrolimus Side Effects Report #5371934-9
Health Professional from UNITED KINGDOM reported TACROLIMUS problem on June 15, 2007. Male patient, 58 years of age, was diagnosed with liver transplant and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: abdominal infection, aspiration tracheal abnormal, asthenia, bone marrow failure, candidiasis, cerebral haemorrhage, continuous haemodiafiltration, convulsion, enterococcal infection. TACROLIMUS dosage: 3 MG, BID, ORAL. During the same period patient was treated with MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE, PREDNISONE, ANTITHROMBIN II, TRIMETHOPRIM, CALCIUM, CILASTIN W, METAMIZOLE. Patient was hospitalized. Patient died on 09/07/2005.
Tacrolimus Side Effects Report #5371982-9
TACROLIMUS problem was reported by a Health Professional from JAPAN on June 12, 2007. Female patient, 51 years of age, weighting 154.5 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: cellulitis, hepatic function abnormal, oedema peripheral, pain in extremity, thrombophlebitis. TACROLIMUS dosage: unknown. During the same period patient was treated with RHEUMATREX, FOLIAMIN, VOLTAREN, SOLON, LIDOCAINE, KENACORT, INTEBAN, RINDERON. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5372461-5
Physician from UNITED STATES reported TACROLIMUS problem on June 22, 2007. Male patient, weighting 129.1 lb, was diagnosed with prophylaxis against transplant rejection and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: kidney transplant rejection. TACROLIMUS dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL, PREDNISONE, ZENAPAX. Patient recovered.
Tacrolimus Side Effects Report #5376207-6
TACROLIMUS problem was reported by a Health Professional from UNITED KINGDOM on June 18, 2007. Female patient, 59 years of age, was diagnosed with liver transplant and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: abdominal infection, aspergillosis, blood bilirubin increased, bone marrow failure, candidiasis, cholestasis, complications of transplanted liver, enterococcal infection, fungal sepsis. TACROLIMUS dosage: 4 MG, UID/QD, ORAL. During the same period patient was treated with MYCOPHENOLATE MOFETIL, DACLIZUMAB, METHYLPREDNISOLONE, PREDNISONE, HYDROCORTISONE, NOREPINEPHRINE HYDROCHLORIDE, ANTITHROMBIN III, SULFAMETHOXAZOLE AND TRIMETHOPRIM. Patient was hospitalized. Patient died on 09/28/2005.
Tacrolimus Side Effects Report #5376565-2
Physician from JAPAN reported TACROLIMUS problem on June 18, 2007. Female patient, 51 years of age, weighting 154.5 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: cellulitis, deep vein thrombosis, oedema peripheral, pain in extremity. TACROLIMUS dosage: 3 MG, D, ORAL. During the same period patient was treated with RHEUMATREX, FOLIC ACID, VOLTAREN, SOLON, LIDOCAINE, KENACORT, INDOMETHACIN, RINDERON. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5048816-5
TACROLIMUS problem was reported by a Consumer or non-health professional from FRANCE on June 29, 2006. Female patient, 31 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: arteriovenous fistula, asthenia, dehydration, diarrhoea, escherichia urinary tract infection, pollakiuria, pyelonephritis acute, renal failure. TACROLIMUS dosage: unknown. During the same period patient was treated with APROVEL, CELLCEPT, CORTANCYL, CHLORMADINONE ACETATE. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5050263-7
Physician from JAPAN reported TACROLIMUS problem on June 27, 2006. Female patient, 82 years of age, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: arthralgia, joint swelling, nasopharyngitis, oxygen saturation decreased, pneumocystis jiroveci pneumonia, pneumonia bacterial. TACROLIMUS dosage: 1.5 MG, UID/QD, ORAL. During the same period patient was treated with RHEUMATREX, PREDNISOLONE, MUCOSTA, MOBIC, RISEDRONATE, HEAVY KAMA G, CALBLOCK. Patient died on 02/26/2006.
Tacrolimus Side Effects Report #5050420-X
TACROLIMUS problem was reported by a Health Professional from FRANCE on June 23, 2006. Female patient, 64 years of age, was diagnosed with liver transplant and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: peritoneal effusion. TACROLIMUS dosage: 5 MG, UID/QD, ORAL. During the same period patient was treated with ZENAPAX, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE, PREDNISONE, ZOVIRAX, VALACYCLOVIR, BACTRIM. Patient recovered.
Tacrolimus Side Effects Report #5051753-3
Pharmacist from UNITED STATES reported TACROLIMUS problem on July 13, 2006. Female patient was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: fluid intake reduced, gastroenteritis viral, malaise, mental status changes, pancreatitis acute. TACROLIMUS dosage: 8 MG 2 X/D PO. During the same period patient was treated with PREDNISONE, VALGANCICLOVIR, MYCOPHENOLATE MOFETIL, COTRIMOXAZOLE, ATENOLOL, LUNESTA, AMLODIPINE. Patient recovered.
Tacrolimus Side Effects Report #5054105-5
TACROLIMUS problem was reported by a Physician from JAPAN on June 29, 2006. Female patient, 69 years of age, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: sepsis. TACROLIMUS dosage: 1 MG, ORAL. During the same period patient was treated with METHOTREXATE, PREDNISOLONE, MOBIC, MUCOSTA, ONEALFA, PANALDINE, BAYASPIRIN PER ORAL NOS. Patient died on 04/18/2006.
Tacrolimus Side Effects Report #5054126-2
Physician from JAPAN reported TACROLIMUS problem on June 26, 2006. Male patient, 73 years of age, weighting 119.0 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: lumbar vertebral fracture, pneumonia bacterial. TACROLIMUS dosage: 2 MG, D, ORAL. During the same period patient was treated with PREDNISOLONE, ENBREL. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5054127-4
TACROLIMUS problem was reported by a Physician from JAPAN on July 05, 2006. Male patient, 64 years of age, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: interstitial lung disease, pneumocystis jiroveci pneumonia. TACROLIMUS dosage: 2 MG, D, ORAL; 3 MG, D, ORAL. During the same period patient was treated with TACROLIMUS CAPSULES, PREDNISOLONE, GASTER PER ORAL NOS, MOBIC, NORVASC, LOXONIN, LIPITOR, OMEPRAZON. Patient died on 07/05/2006.
Tacrolimus Side Effects Report #5054131-6
Physician from JAPAN reported TACROLIMUS problem on June 29, 2006. Female patient, 25 years of age, weighting 72.75 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: condition aggravated, depression, mental disorder, persecutory delusion, suicide attempt, vomiting. TACROLIMUS dosage: 1 MG, UID/QD, ORAL; 2 MG UID/QD, ORAL; 54 DF D, ORAL. During the same period patient was treated with TACROLIMUS CAPSULES, TACROLIMUS CAPSULES, RHEUMATREX, VOLTAREN, LENDORMIN, PREDNISOLONE, RIMATIL. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5059962-4
TACROLIMUS problem was reported by a Consumer or non-health professional from MEXICO on July 06, 2006. Female patient, 16 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, kidney transplant rejection. TACROLIMUS dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL, VERAPAMIL. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5060128-2
Consumer or non-health professional from GERMANY reported TACROLIMUS problem on July 10, 2006. Female patient, 56 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: blood creatine increased, transplant rejection. TACROLIMUS dosage: unknown. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5066413-2
TACROLIMUS problem was reported by a Consumer or non-health professional from UNITED STATES on July 14, 2006. Female patient, 35 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: abdominal pain, chest pain, computerised tomogram abdomen abnormal, condition aggravated, hypertension, nausea, oesophagitis, tachycardia, vomiting. TACROLIMUS dosage: 2 MG 2X PER 1 DAY, ORAL; SEE IMAGE. During the same period patient was treated with CELLCEPT, PREDNISONE, ZENAPAX, CLONIDINE. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5070376-3
Physician from JAPAN reported TACROLIMUS problem on July 18, 2006. Male patient, 64 years of age, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: condition aggravated, immunosuppression, interstitial lung disease, pneumocystis jiroveci pneumonia, respiratory failure. TACROLIMUS dosage: 2 MG ORAL. During the same period patient was treated with PREDNISOLONE, GASTER, MOBIC, NORVASC, LOXONIN, LIPITOR, OMEPRAZOLE, PROMAC. Patient died on 07/05/2006.
Tacrolimus Side Effects Report #5079951-3
TACROLIMUS problem was reported by a Physician from JAPAN on July 27, 2006. Male patient, 64 years of age, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: condition aggravated, interstitial lung disease, pneumocystis jiroveci pneumonia, respiratory failure. TACROLIMUS dosage: 2 MG, D, ORAL; 3 MG, D, ORAL. During the same period patient was treated with TACROLIMUS CAPSULES, PREDNISOLONE, GASTER, MOBIC, NORVASC, LOXONIN, LIPITOR, OMEPRAZOLE. Patient died on 07/05/2006.
Tacrolimus Side Effects Report #5080491-6
Physician from UNITED KINGDOM reported TACROLIMUS problem on July 28, 2006. Male patient, 64 years of age, was diagnosed with liver transplant and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: blood potassium increased, cardiac arrest, lung infection pseudomonal. TACROLIMUS dosage: 3 MG, UID/QD, ORAL. During the same period patient was treated with ZENAPAX, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL, HYDROCORTISONE. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5081960-5
TACROLIMUS problem was reported by a Physician from JAPAN on July 31, 2006. Male patient, 50 years of age, weighting 134.5 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: thrombophlebitis. TACROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS CAPSULES, TACROLIMUS CAPSULES, TACROLIMUS CAPSULES, TACROLIMUS CAPSULES, PREDNISOLONE. Patient recovered.
Tacrolimus Side Effects Report #5086204-6
Physician from JAPAN reported TACROLIMUS problem on Aug 09, 2006. Female patient, 69 years of age, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: sepsis. TACROLIMUS dosage: unknown. During the same period patient was treated with METHOTREXATE, PREDNISOLONE, MOBIC, MUCOSTA, ONEALFA, TICLOPIDINE, BAYASPIRINE. Patient died on 04/18/2006.
Tacrolimus Side Effects Report #5088352-3
TACROLIMUS problem was reported by a Physician from JAPAN on Aug 10, 2006. Female patient, 72 years of age, weighting 111.3 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: condition aggravated, diabetes mellitus, dyskinesia, fall, fracture, haemorrhage, platelet count decreased, tremor. TACROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS CAPSULES, TACROLIMUS CAPSULES, PREDNISOLONE, LOXOPROFEN, VOLTAREN. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5095552-5
Pharmacist from UNITED STATES reported TACROLIMUS problem on Aug 31, 2006. Female patient, 13 years of age, was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: tremor. TACROLIMUS dosage: unknown. Patient recovered.
Tacrolimus Side Effects Report #5096715-5
TACROLIMUS problem was reported by a Physician from JAPAN on Aug 21, 2006. Male patient, 73 years of age, weighting 119.0 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: lumbar vertebral fracture, pathological fracture, pneumonia bacterial. TACROLIMUS dosage: 2 MG, ORAL. During the same period patient was treated with PREDNISOLONE. Patient was hospitalized and became disabled. Patient recovered.
Tacrolimus Side Effects Report #5096752-0
Physician from JAPAN reported TACROLIMUS problem on Aug 21, 2006. Female patient, weighting 110.2 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: arthritis bacterial, decubitus ulcer. TACROLIMUS dosage: 1 MG, ORAL; SEE IMAGE. During the same period patient was treated with TACROLIMUS CAPSULES, TACROLIMUS CAPSULES, PREDNISOLONE, VOLTAREN. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5099948-7
TACROLIMUS problem was reported by a Physician from JAPAN on Aug 25, 2006. Male patient, 80 years of age, weighting 135.6 lb, was diagnosed with myasthenia gravis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: infection, pneumonia. TACROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS CAPSULES, PREDNISOLONE, MESTINON, LANSOPRAZOLE, NEUROTROPIN, DIART. Patient died.
Tacrolimus Side Effects Report #5099963-3
Physician from JAPAN reported TACROLIMUS problem on Aug 25, 2006. Female patient, 65 years of age, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: dyspnoea, haemorrhagic cerebral infarction, loss of consciousness, stress ulcer. TACROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS CAPSULES, PREDNISOLONE, AZULFIDINE, MOBIC, ALFAROL, VOLTAREN. Patient died on 08/23/2006.
Tacrolimus Side Effects Report #5099966-9
TACROLIMUS problem was reported by a Physician from JAPAN on Aug 22, 2006. Female patient, 76 years of age, weighting 106.3 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: adjustment disorder, pyelonephritis. TACROLIMUS dosage: unknown. During the same period patient was treated with PREDNISOLONE, CALONAL, MAGMITT, GASLON, LEVOFLOXACIN, GASMOTIN, MEILAX, TETRAMIDE. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5104069-0
Physician from JAPAN reported TACROLIMUS problem on Sept 04, 2006. Female patient, 74 years of age, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: blood pressure systolic increased, condition aggravated, interstitial lung disease, lower respiratory tract infection bacterial, lower respiratory tract infection fungal, lung disorder, pneumocystis jiroveci infection, pulmonary tuberculosis. TACROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS CAPSULES, METALCAPTASE CAPSULE, PREDNISOLONE, LOXONIN, CLINORIL, MUCOSTA, AMARYL. Patient died on 08/13/2006.
Tacrolimus Side Effects Report #5107916-1
TACROLIMUS problem was reported by a Pharmacist from UNITED KINGDOM on Sept 01, 2006. Female patient, 16 years of age, weighting 94.80 lb, was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: biliary tract disorder, c-reactive protein increased, gallbladder non-functioning, pyrexia. TACROLIMUS dosage: 2 MG, BID, ORAL. During the same period patient was treated with AZATHIOPRINE, METHYLPREDNISOLONE, SUCRALFATE. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5107937-9
Physician from JAPAN reported TACROLIMUS problem on Aug 30, 2006. Female patient, weighting 110.2 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: arthritis bacterial, decubitus ulcer, staphylococcal infection, suture related complication. TACROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS CAPSULES, TACROLIMUS CAPSULES, PREDNISOLONE, VOLTAREN, VANCOMYCIN, HABEKACIN. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5107938-0
TACROLIMUS problem was reported by a Physician from JAPAN on Sept 06, 2006. Female patient, 64 years of age, weighting 81.57 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: haemorrhagic cerebral infarction, loss of consciousness, pneumonia bacterial, stress ulcer. TACROLIMUS dosage: unknown. During the same period patient was treated with TACROLIMUS CAPSULES, PREDNISOLONE, AZULFIDINE, MOBIC, VOLTAREN, ALFAROL, WARFARIN. Patient was hospitalized. Patient died on 08/23/2006.
Tacrolimus Side Effects Report #5108499-2
Consumer or non-health professional from ARGENTINA reported TACROLIMUS problem on Sept 07, 2006. Female patient, 23 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: anaemia, gastrointestinal stromal tumour, immunosuppression, renal atrophy. TACROLIMUS dosage: 1MG 1X PER 12 HR. During the same period patient was treated with MYCOPHENOLATE MOFETIL, PREDNISONE, ACYCLOVIR, LOSARTAN POTASSIUM, ATORVASTATIN CALCIUM. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5113400-1
TACROLIMUS problem was reported by a Physician from JAPAN on Sept 08, 2006. Female patient, 64 years of age, weighting 108.0 lb, was diagnosed with rheumatoid arthritis and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: interstitial lung disease. TACROLIMUS dosage: 1.5 MG, UID/QD, ORAL. During the same period patient was treated with RHEUMATREX, PREDNISOLONE, KETOPROFEN SUPPOSITORY, DICLOFENAC, GAMOFA ORODISPERSABLE CRLET, CYTOTEC, ALFACALCIDOL, ACTONEL. Patient died on 08/14/2006.
Tacrolimus Side Effects Report #5113677-2
Consumer or non-health professional from UNITED STATES reported TACROLIMUS problem on Sept 21, 2006. Male patient, 57 years of age, weighting 206.1 lb, was diagnosed with renal disorder, atrial fibrillation and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: asthenia, hypotension, reversible posterior leukoencephalopathy syndrome, tremor. TACROLIMUS dosage: 0.5 MG PO BID. During the same period patient was treated with AMIODARONE, WARFARIN, GABAPENTIN, LOSARTAN POSTASSIUM, PRAVASTATIN, ALLOPURINOL, TRAZODONE, FOLIC ACID. Patient was hospitalized. Patient recovered.
Tacrolimus Side Effects Report #5113730-3
TACROLIMUS problem was reported by a Pharmacist from UNITED STATES on Sept 21, 2006. Male patient, 21 years of age, weighting 183.0 lb, was diagnosed with renal transplant and was treated with TACROLIMUS. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, hypertension, thrombotic microangiopathy. TACROLIMUS dosage: 8 MG PO BID. During the same period patient was treated with MYCOPHENOLATE MOFETIL, PREDNISONE, ACYCLOVIR, SULFAMETHOXAZOLE, CLONIDINE, NIFEDIPINE. Patient was hospitalized. Patient recovered.
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Drug Information: Tacrolimus
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601117.html
(ta kroe' li mus)IMPORTANT WARNING:
| Tacrolimus increases your risk of getting infections. Avoid people with contagious diseases, such as the flu and colds. Keep cuts and scratches clean. Use good personal hygiene, especially for your mouth, teeth, skin, hair, and hands. Tacrolimus also may increase your risk of getting certain types of cancer. Talk to your doctor about this risk. |
Why is this medication prescribed?
Tacrolimus is used to prevent rejection of liver transplants. Sometimes it is used to prevent rejection of other types of transplants.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Tacrolimus comes as a capsule to take by mouth and in an injectable form. It usually is taken twice a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tacrolimus exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take tacrolimus even if you feel well. Do not stop taking tacrolimus without talking to your doctor. You will probably take tacrolimus for a long time.
What special precautions should I follow?
Before taking tacrolimus,
- tell your doctor and pharmacist if you are allergic to tacrolimus or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially amiloride (Midamor, Moduretic), bromocriptine (Parlodel), carbamazepine (Tegretol), cimetidine (Tagamet), cisapride (Propulsid), clarithromycin (Biaxin), clotrimazole (Mycelex, Lotrimin), cyclosporine (Neoral, Sandimmune), danazol (Danocrine), diltiazem (Cardizem), erythromycin (E-Mycin), fluconazole (Diflucan), ganciclovir (Cytovene), HIV protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir), itraconazole (Sporanox), ketoconazole (Nizoral), methylprednisolone (Medrol), metoclopramide (Reglan), nefazodone (Serzone), nicardipine (Cardene), nifedipine (Adalat, Procardia), omeprazole (Prilosec), oral contraceptives (birth control pills), phenobarbital, phenytoin (Dilantin), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane), spironolactone (Aldactone), triamterene-containing drugs (Dyazide, Dyrenium, Maxzide), troleandomycin (Tao), verapamil (Calan, Isoptin), and vitamins. Do not take antacids within 2 hours of taking tacrolimus.
- tell your doctor and pharmacist what herbal products you are taking, especially St. John's wort and products containing St. John's Wort.
- tell your doctor if you have or have ever had heart or kidney disease or diabetes.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking tacrolimus, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tacrolimus.
What special dietary instructions should I follow?
Avoid drinking grapefruit juice while taking tacrolimus.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Tacrolimus may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea
- upset stomach
- vomiting
- stomach pain
- loss of appetite
- insomnia
If you experience any of the following symptoms, call your doctor immediately:
- fever
- sore throat
- chills
- frequent or painful urination
- decreased urination
- severe or continued headaches
- swelling of the feet, ankles, lower legs, and hands
- weight gain
- tremor
- weakness
- unusual bleeding or bruising
- skin rash
- itching
- hives
- difficulty breathing
- wheezing
- yellowing of the skin or eyes
- seizures
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to tacrolimus and do blood tests to see how your liver and kidneys are working.
Tacrolimus can raise your blood pressure. Talk to your doctor about checking your blood pressure regularly.
Before receiving any vaccinations, tell your doctor that you are taking tacrolimus.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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