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Targin Side Effects

Common Targin Side Effects


The most commonly reported Targin side effects (click to view or check a box to report):

Diarrhoea (4)
Vomiting (4)
Arrhythmia (3)
Chills (3)
Nausea (3)
Death (2)
Dizziness (2)
Incorrect Dose Administered (2)
Cardiac Disorder (2)
Fall (2)
Dyspnoea (2)
Renal Failure (2)
Intestinal Obstruction (2)
Intestinal Haemorrhage (2)
Pruritus (2)
Intervertebral Disc Protrusion (2)
Somnolence (2)
Weight Decreased (1)
Wound Infection (1)
Withdrawal Syndrome (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Targin Side Effects Reported to FDA

The following Targin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Targin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Fall, Femur Fracture
This is a report of a 85-year-old male patient (weight: NA) from DE, suffering from the following symptoms/conditions: NA, who was treated with Targin Retardtabletten (dosage: 40/20 Mg, Bid, start time: 201308), combined with:
  • Oxygesic 40 Mg (40 Mg, Bid)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Fall
  • Femur Fracture
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Targin Retardtabletten treatment in male patients, resulting in fall side effect.

Post Procedural Haemorrhage
This report suggests a potential Targin 10/5 Post Procedural Haemorrhage side effect(s) that can have serious consequences. A 47-year-old female patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: pain and used Targin 10/5 (dosage: 1 Df, 2x/day) starting Feb 21, 2012. Soon after starting Targin 10/5 the patient began experiencing various side effects, including:
  • Post Procedural Haemorrhage
Drugs used concurrently:
  • Celebrex (200 (units Not Provided), 2x1)
The patient was hospitalized. Although Targin 10/5 demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as post procedural haemorrhage, may still occur.

Erectile Dysfunction
This Erectile Dysfunction problem was reported by a health professional from ES. A 40-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: radiculitis,back pain. On 201209 this consumer started treatment with Targin 40mg/20mg Retardtabletten (dosage: 2 Df, Daily). The following drugs were being taken at the same time:
  • Hydromorphone Hcl (24 Mg, Daily)
  • Tryptizol /00002202/ (10 Mg, Daily)
When commencing Targin 40mg/20mg Retardtabletten, the patient experienced the following unwanted symptoms/side effects:
  • Erectile Dysfunction
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as erectile dysfunction, may become evident only after a product is in use by the general population.

Glomerular Filtration Rate Abnormal, Blood Creatinine Increased
This is a report of a 61-year-old female patient (weight: NA) from DE. The patient developed the following symptoms/conditions: pain and was treated with Targin 40mg/20mg Retardtabletten (dosage: 40/20mg, Bid) starting 201212. Concurrently used drugs:
  • Oxygesic (Unk)
  • Pantozol /01263204/ (40 Mg, Q48h)
  • Verahexal (240 Mg, Daily)
  • Micardis Plus (80 Mg, Unk)
  • Amineurin (Unk, Bid)
  • Simvahexal (40 Mg, Pm)
  • Torasemid (10 Mg, Am)
  • Eucreas (50000 Mg, Unk)
Soon after that, the consumer experienced the following side effects:
  • Glomerular Filtration Rate Abnormal
  • Blood Creatinine Increased
This opens a possibility that Targin 40mg/20mg Retardtabletten treatment could cause the above reactions, including glomerular filtration rate abnormal, and some female subjects may be more susceptible.


Breakthrough Pain, Hyperhidrosis, Chills, Diarrhoea, Incorrect Dose Administered
A 51-year-old female patient (weight: NA) from NORWAY with the following symptoms/conditions: constipation started Targiniq treatment (dosage: NA) on Sep 20, 2011. Soon after starting Targiniq treatment, the subject experienced various side effects, including:
  • Breakthrough Pain
  • Hyperhidrosis
  • Chills
  • Diarrhoea
  • Incorrect Dose Administered
Concurrently used drugs:
  • Acetaminophen (3 G, Daily)
  • Zopiclone (10 Mg, Daily)
  • Diazepam (30 Mg, Daily)
  • Remeron (45 Mg, Daily)
  • Trimeprazine Tab (30 Mg, Daily)
  • Carbamazepine (400 Mg, Daily)
  • Simvastatin (40 Mg, Daily)
  • Morphine Sulfate (10 Mg, Four Times A Day)
This finding indicates that some female patients could be more vulnerable to Targiniq.

Abnormal Behaviour, Anger, Hallucination, Auditory, Hostility, Hypertensive Crisis
A 62-year-old male patient from (weight: NA) experienced symptoms, such as: NA and was treated with Targinact Proonged Release (targin)(dosage: NA). The treatment was initiated on Nov 08, 2011. After that a consumer reported the following side effect(s):
  • Abnormal Behaviour
  • Anger
  • Hallucination, Auditory
  • Hostility
  • Hypertensive Crisis
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Targinact Proonged Release (targin) efficacy:
  • Lansoprazole
  • Diazepam
  • Amlodipine
  • Mirtazapine ((30 Mg), Oral)
  • Ramipril


Stupor
In this report, Targin was administered for the following condition: NA.A 59-year-old female consumer from ISRAEL (weight: NA) started Targin treatment (dosage: NA) on Jul 04, 2011.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Stupor
A possible interaction with other drugs could have contributed to this reaction:
  • Vemurafenib
  • Pregabalin
  • Caltrate + D (Reported As Caltrat + Vit D)
  • Vemurafenib
  • Omeprazole
  • Vemurafenib
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Targin treatment could be related to the listed above side effect(s).

Intestinal Obstruction
This is a report of the following Targin side effect(s):
  • Intestinal Obstruction
A 75-year-old female patient from GERMANY (weight: NA) presented with the following condition: NA and received a treatment with Targin (dosage: NA) starting: Apr 28, 2011.The following concurrently used drugs could have generated interactions:
  • Forteo (Unk, Qd)
  • Novaminsulfon
The patient was hospitalized.This report suggests that a Targin treatment could be associated with the listed above side effect(s).

Loss Of Consciousness, Respiratory Rate Decreased
This Targin (naloxone Hydrochloride, Oxycodone Hydrochloride) report was submitted by a 39-year-old female consumer from IRELAND (weight: NA). The patient was diagnosed with: NA and Targin (naloxone Hydrochloride, Oxycodone Hydrochloride) was administered (dosage: NA) starting: Sep 19, 2011. The consumer developed a set of symptoms:
  • Loss Of Consciousness
  • Respiratory Rate Decreased
Other drugs used simultaneously:
  • Methadone Hcl
  • Fentanyl (100 Ug 400 Ug 800 Ug 200 Ug 400 Ug)
  • Fentanyl (100 Ug 400 Ug 800 Ug 200 Ug 400 Ug)
  • Fentanyl (100 Ug 400 Ug 800 Ug 200 Ug 400 Ug)
Those unexpected symptoms could be linked to a Targin (naloxone Hydrochloride, Oxycodone Hydrochloride) treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Renal Failure, Anaemia
This is a report of a possible correlation between Targin use and the following symptoms/side effect(s):
  • Renal Failure
  • Anaemia
which could contribute to an assessment of Targin risk profile.A male consumer from GERMANY (weight: NA) was suffering from back pain and was treated with Targin (dosage: Unk) starting May 10, 2011.Other concurrent medications:
  • Voltaren (Unk)
  • Gemcitabine Hydrochloride (2675 Mg, Every 21 Days/cycle)
  • Allopurinol (Unk)
  • Prochlorperazine (Unk)
  • Oxycodone Hydrochloride (Unk)
  • Tepilta (Unk)
  • Cisplatin (158 Mg, Every 21 Days/cycle)
  • Ibuprofen Tablets (Unk Unk, Prn)
The patient was hospitalized.

Breast Cancer
A 59-year-old female patient from BELGIUM (weight: NA) presented with the following symptoms: NA and after a treatment with Targinact (dosage: NA) experienced the following side effect(s):
  • Breast Cancer
The treatment was started on Sep 29, 2008. Targinact was used in combination with the following drugs:
  • Levothyroxine Sodium
  • Progynova
  • Bromazepam
  • Trazodone Hcl
  • Uricran
  • Lioresal
This report could alert potential Targinact consumers.

Wound Infection, Finger Amputation
In this report, a 47-year-old female patient from GERMANY (weight: NA) was affected by a possible Targin side effect.The patient was diagnosed with NA. After a treatment with Targin (dosage: 1-1-1 - As Used Dose: 5/10 Mg, start date: Feb 06, 2008), the patient experienced the following side effect(s):
  • Wound Infection
  • Finger Amputation
The following simultaneously used drugs could have led to this reaction:
  • Fraxiparin
  • Ibuprofen (1-1-1)
  • Avelox (1-0-0)
  • Cipro
The patient was hospitalized and became disabled.The findings here stress that side effects should be taken into consideration when evaluating a Targin treatment.

Weight Decreased, Vomiting, Arrhythmia, Depression
This is a report of a 66-year-old female patient from GERMANY (weight: NA), who used Targin (dosage: Unk, Tid) for a treatment of NA. After starting a treatment on Apr 05, 2011, the patient experienced the following side effect(s):
  • Weight Decreased
  • Vomiting
  • Arrhythmia
  • Depression
The following drugs could possibly have interacted with the Targin treatment
  • Levothyroxine Sodium
  • Novaminsulfon (30 Df, Unk)
  • Calcigen D
  • Pantoprazole
  • Procoralan (Unk, Bid)
  • Forteo (Unk)
Taken together, these observations suggest that a Targin treatment could be related to side effect(s), such as Weight Decreased, Vomiting, Arrhythmia, Depression.

Hypertension
This hypertension side effect was reported by a physician from GERMANY. A female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Targin (dosage: NA), which was started on Nov 05, 2010. Concurrently used drugs:
  • Morphine
  • Tapentadol
  • Analgesics
  • Muscle Relaxants
  • Duloxetine Hydrochloride
  • Antiemetics
When starting to take Targin the consumer reported the following symptoms:
  • Hypertension
The patient was hospitalized. These side effects may potentially be related to Targin.

Dizziness, Gait Disturbance, Somnolence
This is a Targin side effect report of a female patient (weight:NA) from GERMANY, suffering from the following symptoms/conditions: NA, who was treated with Targin (dosage:NA, start time: Oct 14, 2010), combined with:
  • Nsaid's
  • Metamizol
  • Jurnista
  • Temgesic
, and developed a serious reaction and a dizziness side effect. The patient presented with:
  • Dizziness
  • Gait Disturbance
  • Somnolence
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Targin treatment in female patients suffering from NA, resulting in dizziness.

Intervertebral Disc Protrusion, Cauda Equina Syndrome, Sciatica, Pruritus
This report suggests a potential Targin intervertebral disc protrusion side effect(s) that can have serious consequences. A female patient from CANADA (weight:NA) was diagnosed with the following health condition(s): intervertebral disc protrusion,rheumatoid arthritis and used Targin (dosage: NA) starting Jan 01, 2005. Soon after starting Targin the patient began experiencing various side effects, including:
  • Intervertebral Disc Protrusion
  • Cauda Equina Syndrome
  • Sciatica
  • Pruritus
Drugs used concurrently:
  • Humira
  • Methotrexate
  • Plaquenil
  • Colace
  • Senokot
  • Cymbalta
  • Prevacid
  • Calcium W/vitamin D
Although Targin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as intervertebral disc protrusion, may still occur.

Nausea, Diarrhoea, Renal Failure, Abdominal Pain, Vomiting, Urinary Tract Infection, Dehydration
This nausea problem was reported by a physician from GERMANY. A male patient (weight: NA) was diagnosed with the following medical condition(s): pain,metastatic gastric cancer.On NS a consumer started treatment with Targin (dosage: NA). The following drugs/medications were being taken at the same time:
  • Folinic Acid
  • Novamin
  • Cisplatin
  • Fluorouracil
  • Trastuzumab
When commencing Targin, the patient experienced the following unwanted symptoms /side effects:
  • Nausea
  • Diarrhoea
  • Renal Failure
  • Abdominal Pain
  • Vomiting
  • Urinary Tract Infection
  • Dehydration
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as nausea, may become evident only after a product is in use by the general population.

Urinary Retention
This is a Targin side effect report of a 80-year-old female patient (weight: NA) from GERMANY. The patient developed the following symptoms/conditions: NA and was treated with Targin (dosage: NA) starting NS. Concurrently used drugs:
  • Palexia Retard (150 Mg, 2/day)
Soon after that, the consumer experienced the following of symptoms:
  • Urinary Retention
This opens a possibility that Targin could cause urinary retention and that some female patients may be more susceptible.

Pruritus, Intervertebral Disc Protrusion
A female patient (weight: NA) from CANADA with the following symptoms: intervertebral disc protrusion,rheumatoid arthritis started Targin treatment (dosage: NA) on Jan 01, 2005. Soon after starting Targin treatment, the consumer experienced several side effects, including:
  • Pruritus
  • Intervertebral Disc Protrusion
. Concurrently used drugs:
  • Plaquenil
  • Folic Acid
  • Colace
  • Prevacid
  • Calcium W/vitamin D
  • Humira
  • Prednisone
  • Senokot
This finding indicates that some patients can be more vulnerable to developing Targin side effects, such as pruritus.

Diarrhoea, Intestinal Obstruction, Malignant Neoplasm Progression
This diarrhoea side effect was reported by a physician from UNITED KINGDOM. A 37-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Targinact (dosage: 20 Mg, Bid), which was started on Jan 13, 2010. Concurrently used drugs: NA..When starting to take Targinact the consumer reported symptoms, such as:
  • Diarrhoea
  • Intestinal Obstruction
  • Malignant Neoplasm Progression
These side effects may potentially be related to Targinact.

Back Pain, Body Temperature Decreased, Chest Pain, Constipation, Defaecation Urgency, Diarrhoea, Feeling Cold, Parosmia, Withdrawal Syndrome
This is a report of a male patient (weight: NA) from UNITED KINGDOM, suffering from the following symptoms/conditions: cancer pain, who was treated with Targinact (dosage: 2 Df, Bid, start time: Jan 01, 2004), combined with:
  • Mxl Capsules
  • Oxycontin (20 Mg, Bid)
  • Co-danthramer Capsules (15 Ml, Tid)
  • Cyclizine (50 Mg, Tid)
  • Fexofenadine (180 Mg, Daily)
  • Haloperidol (1.5 Mg, Daily)
  • Indoramin (20 Mg, Bid)
  • Seretide /01420901/ (Unk)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Back Pain
  • Body Temperature Decreased
  • Chest Pain
  • Constipation
  • Defaecation Urgency
  • Diarrhoea
  • Feeling Cold
  • Parosmia
  • Withdrawal Syndrome
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Targinact treatment in male patients, resulting in back pain side effect.

Enamel Anomaly, Tooth Injury
This report suggests a potential Targin 20/10 Mg Retardtabletten Enamel Anomaly, Tooth Injury side effect(s) that can have serious consequences. A female patient (weight: NA) from GERMANY was diagnosed with the following symptoms/conditions: pain and used Targin 20/10 Mg Retardtabletten (dosage: 20 Mg, Tid) starting Aug 22, 2007. Soon after starting Targin 20/10 Mg Retardtabletten the patient began experiencing various side effects, including:
  • Enamel Anomaly
  • Tooth Injury
Drugs used concurrently:
  • Lyrica
  • Arcoxia
  • Clomipramine Hcl
Although Targin 20/10 Mg Retardtabletten demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as enamel anomaly, may still occur.

Dyspnoea, Myalgia, Restlessness, Skin Burning Sensation
This Dyspnoea, Myalgia, Restlessness, Skin Burning Sensation problem was reported by a physician from GERMANY. A 85-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pain. On Nov 08, 2007 this consumer started treatment with Targin 20/10 Mg Retardtabletten (dosage: 20 Mg, Single). The following drugs were being taken at the same time:
  • Oxygesic 20 Mg (20 Mg, Unk)
  • Symbicort
  • Torsemide
  • Oxaloacetic Acid
When commencing Targin 20/10 Mg Retardtabletten, the patient experienced the following unwanted symptoms/side effects:
  • Dyspnoea
  • Myalgia
  • Restlessness
  • Skin Burning Sensation
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as dyspnoea, may become evident only after a product is in use by the general population.

Chest Discomfort, Dizziness, Dyspnoea, Malaise, Pulmonary Embolism
This is a report of a 72-year-old male patient (weight: NA) from GERMANY. The patient developed the following symptoms/conditions: back pain and was treated with Targin 10/5 Mg Retardtabletten (dosage: 10 Mg, Single) starting May 01, 2007. Concurrently used drugs:
  • Oxygesic 20 Mg (20 Mg, Bid)
  • Bisoprolol Fumarate
Soon after that, the consumer experienced the following side effects:
  • Chest Discomfort
  • Dizziness
  • Dyspnoea
  • Malaise
  • Pulmonary Embolism
The patient was hospitalized. This opens a possibility that Targin 10/5 Mg Retardtabletten treatment could cause the above reactions, including chest discomfort, and some male subjects may be more susceptible.

Arrhythmia, Chills, Incorrect Dose Administered, Nausea, Vomiting
A 58-year-old male patient (weight: NA) from with the following symptoms/conditions: constipation started Targin Retardtabletten treatment (dosage: 20 Mg, Tid) on Apr 06, 2007. Soon after starting Targin Retardtabletten treatment, the subject experienced various side effects, including:
  • Arrhythmia
  • Chills
  • Incorrect Dose Administered
  • Nausea
  • Vomiting
Concurrently used drugs:
  • Oxygesic 10 Mg (10 Mg, Bid)
This finding indicates that some male patients could be more vulnerable to Targin Retardtabletten.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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