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Headache (16)
Agitated (11)
Red Eyes (10)
Abdominal Pain Nausea (8)
Rash (8)
Anxious (4)
ADEMA (2)
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Targin Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 29 

Breakthrough Pain, Hyperhidrosis, Chills, Diarrhoea, Incorrect Dose Administered (8356707-7)
on May 02, 2012 Female from NORWAY , 51 years of age, was diagnosed with
  • constipation
and was treated with Targiniq. Directly after, patient experienced the unwanted or unexpected Targin side effects: breakthrough pain, hyperhidrosis, chills, diarrhoea, incorrect dose administered. Targiniq dosage: N/A.
Associated medications used:
  • Acetaminophen (3 G, Daily)
  • Zopiclone (10 Mg, Daily)
  • Diazepam (30 Mg, Daily)
  • Remeron (45 Mg, Daily)
  • Trimeprazine Tab (30 Mg, Daily)
  • Carbamazepine (400 Mg, Daily)
  • Simvastatin (40 Mg, Daily)
  • Morphine Sulfate (10 Mg, Four Times A Day)


Abnormal Behaviour, Anger, Hallucination, Auditory, Hostility, Hypertensive Crisis (8094601-X)
Patient was taking Targinact Proonged Release (targin). Patient felt the following Targin side effects: abnormal behaviour, anger, hallucination, auditory, hostility, hypertensive crisis on Jan 19, 2012 from Additional patient health information: Male , 62 years of age, . Targinact Proonged Release (targin) dosage: N/A.
Multiple prescriptions taken:
  • Lansoprazole
  • Diazepam
  • Amlodipine
  • Mirtazapine ((30 Mg), Oral)
  • Ramipril


Stupor (7955158-4)
Adverse event was reported on Nov 19, 2011 by a Female taking Targin (Dosage: N/A) . Location: ISRAEL , 59 years of age, After Targin was administered, patient encountered several Targin side effects: stupor.
Multiple concurrent drugs taken:
  • Vemurafenib
  • Pregabalin
  • Caltrate + D (Reported As Caltrat + Vit D)
  • Vemurafenib
  • Omeprazole
  • Vemurafenib
Patient was hospitalized.

Intestinal Obstruction (7952808-3)
on Nov 21, 2011 Female from GERMANY , 75 years of age, was treated with Targin. Directly after, patient experienced the unwanted or unexpected Targin side effects: intestinal obstruction. Targin dosage: N/A.
Associated medications used:
  • Forteo (Unk, Qd)
  • Novaminsulfon
Patient was hospitalized.


Loss Of Consciousness, Respiratory Rate Decreased (7942007-3)
on Nov 09, 2011 Female from IRELAND , 39 years of age, was treated with Targin (naloxone Hydrochloride, Oxycodone Hydrochloride). Patient felt the following Targin side effects: loss of consciousness, respiratory rate decreased. Targin (naloxone Hydrochloride, Oxycodone Hydrochloride) dosage: N/A.
Multiple prescriptions taken:
  • Methadone Hcl
  • Fentanyl (100 Ug 400 Ug 800 Ug 200 Ug 400 Ug)
  • Fentanyl (100 Ug 400 Ug 800 Ug 200 Ug 400 Ug)
  • Fentanyl (100 Ug 400 Ug 800 Ug 200 Ug 400 Ug)


Renal Failure, Anaemia (7904728-8)
Patient was taking Targin. After Targin was administered, patient encountered several Targin side effects: renal failure, anaemia on Oct 28, 2011 from GERMANY Additional patient health information: Male , weighting 192.9 lb, was diagnosed with
  • back pain
and. Targin dosage: Unk.
Multiple concurrent drugs taken:
  • Voltaren (Unk)
  • Gemcitabine Hydrochloride (2675 Mg, Every 21 Days/cycle)
  • Allopurinol (Unk)
  • Prochlorperazine (Unk)
  • Oxycodone Hydrochloride (Unk)
  • Tepilta (Unk)
  • Cisplatin (158 Mg, Every 21 Days/cycle)
  • Ibuprofen Tablets (Unk Unk, Prn)
Patient was hospitalized.

Breast Cancer (7826198-0)
Adverse event was reported on Oct 11, 2011 by a Female taking Targinact (Dosage: N/A) . Location: BELGIUM , 59 years of age, Directly after, patient experienced the unwanted or unexpected Targin side effects: breast cancer.
Associated medications used:
  • Levothyroxine Sodium
  • Progynova
  • Bromazepam
  • Trazodone Hcl
  • Uricran
  • Lioresal


Wound Infection, Finger Amputation (7590483-0)
on Jun 23, 2011 Female from GERMANY , 47 years of age, weighting 143.3 lb, was treated with Targin. Patient felt the following Targin side effects: wound infection, finger amputation. Targin dosage: 1-1-1 - As Used Dose: 5/10 Mg.
Multiple prescriptions taken:
  • Fraxiparin
  • Ibuprofen (1-1-1)
  • Avelox (1-0-0)
  • Cipro
Patient was hospitalized and became disabled.

Weight Decreased, Vomiting, Arrhythmia, Depression (7539542-9)
on May 30, 2011 Female from GERMANY , 66 years of age, was treated with Targin. After Targin was administered, patient encountered several Targin side effects: weight decreased, vomiting, arrhythmia, depression. Targin dosage: Unk, Tid.
Multiple concurrent drugs taken:
  • Levothyroxine Sodium
  • Novaminsulfon (30 Df, Unk)
  • Calcigen D
  • Pantoprazole
  • Procoralan (Unk, Bid)
  • Forteo (Unk)


Hypertension (7501893-1)
Patient was taking Targin. Directly after, patient experienced the unwanted or unexpected Targin side effects: hypertension on May 09, 2011 from GERMANY Additional patient health information: Female , weighting 313.1 lb, . Targin dosage: N/A.
Associated medications used:
  • Morphine
  • Tapentadol
  • Analgesics
  • Muscle Relaxants
  • Duloxetine Hydrochloride
  • Antiemetics
Patient was hospitalized.

Dizziness, Gait Disturbance, Somnolence (7500162-3)
Adverse event was reported on May 11, 2011 by a Female taking Targin (Dosage: N/A) . Location: GERMANY , weighting 127.9 lb, Patient felt the following Targin side effects: dizziness, gait disturbance, somnolence.
Multiple prescriptions taken:
  • Nsaid's
  • Metamizol
  • Jurnista
  • Temgesic


Intervertebral Disc Protrusion, Cauda Equina Syndrome, Sciatica, Pruritus (7434682-7)
on Apr 20, 2011 Female from CANADA , weighting 198.2 lb, was diagnosed with
  • intervertebral disc protrusion
  • rheumatoid arthritis
and was treated with Targin. After Targin was administered, patient encountered several Targin side effects: intervertebral disc protrusion, cauda equina syndrome, sciatica, pruritus. Targin dosage: N/A.
Multiple concurrent drugs taken:
  • Humira
  • Methotrexate
  • Plaquenil
  • Colace
  • Senokot
  • Cymbalta
  • Prevacid
  • Calcium W/vitamin D


Nausea, Diarrhoea, Renal Failure, Abdominal Pain, Vomiting, Urinary Tract Infection, Dehydration (7405807-4)
on Apr 01, 2011 Male from GERMANY , weighting 161.6 lb, was diagnosed with
  • pain
  • metastatic gastric cancer
and was treated with Targin. Directly after, patient experienced the unwanted or unexpected Targin side effects: nausea, diarrhoea, renal failure, abdominal pain, vomiting, urinary tract infection, dehydration. Targin dosage: N/A.
Associated medications used:
  • Folinic Acid
  • Novamin
  • Cisplatin
  • Fluorouracil
  • Trastuzumab
Patient was hospitalized.

Urinary Retention (7365816-0)
Patient was taking Targin. Patient felt the following Targin side effects: urinary retention on Mar 08, 2011 from GERMANY Additional patient health information: Female , 80 years of age, . Targin dosage: N/A.
Multiple prescriptions taken:
  • Palexia Retard (150 Mg, 2/day)


Pruritus, Intervertebral Disc Protrusion (7362443-6)
Adverse event was reported on Mar 16, 2011 by a Female taking Targin (Dosage: N/A) was diagnosed with
  • intervertebral disc protrusion
  • rheumatoid arthritis
and. Location: CANADA , weighting 198.2 lb, After Targin was administered, patient encountered several Targin side effects: pruritus, intervertebral disc protrusion.
Multiple concurrent drugs taken:
  • Plaquenil
  • Folic Acid
  • Colace
  • Prevacid
  • Calcium W/vitamin D
  • Humira
  • Prednisone
  • Senokot


Diarrhoea, Intestinal Obstruction, Malignant Neoplasm Progression (6938188-0)
on Aug 19, 2010 Female from UNITED KINGDOM , 37 years of age, was treated with Targinact. Directly after, patient experienced the unwanted or unexpected Targin side effects: diarrhoea, intestinal obstruction, malignant neoplasm progression. Targinact dosage: 20 Mg, Bid.

Back Pain, Body Temperature Decreased, Chest Pain, Constipation, Defaecation Urgency, Diarrhoea, Feeling Cold, Parosmia, Withdrawal Syndrome (6466778-0)
on Nov 23, 2009 Male from UNITED KINGDOM , weighting 132.3 lb, was diagnosed with
  • cancer pain
and was treated with Targinact. Patient felt the following Targin side effects: back pain, body temperature decreased, chest pain, constipation, defaecation urgency, diarrhoea, feeling cold, parosmia, withdrawal syndrome. Targinact dosage: 2 Df, Bid.
Multiple prescriptions taken:
  • Mxl Capsules
  • Oxycontin (20 Mg, Bid)
  • Co-danthramer Capsules (15 Ml, Tid)
  • Cyclizine (50 Mg, Tid)
  • Fexofenadine (180 Mg, Daily)
  • Haloperidol (1.5 Mg, Daily)
  • Indoramin (20 Mg, Bid)
  • Seretide /01420901/ (Unk)


Enamel Anomaly, Tooth Injury (6332569-4)
Patient was taking Targin 20/10 Mg Retardtabletten. After Targin was administered, patient encountered several Targin side effects: enamel anomaly, tooth injury on Aug 20, 2009 from GERMANY Additional patient health information: Female , weighting 132.3 lb, was diagnosed with
  • pain
and. Targin 20/10 Mg Retardtabletten dosage: 20 Mg, Tid.
Multiple concurrent drugs taken:
  • Lyrica
  • Arcoxia
  • Clomipramine Hcl


Dyspnoea, Myalgia, Restlessness, Skin Burning Sensation (5546147-8)
Adverse event was reported on Nov 29, 2007 by a Male taking Targin 20/10 Mg Retardtabletten (Dosage: 20 Mg, Single) was diagnosed with
  • pain
and. Location: GERMANY , 85 years of age, weighting 134.5 lb, Directly after, patient experienced the unwanted or unexpected Targin side effects: dyspnoea, myalgia, restlessness, skin burning sensation.
Associated medications used:
  • Oxygesic 20 Mg (20 Mg, Unk)
  • Symbicort
  • Torsemide
  • Oxaloacetic Acid


Chest Discomfort, Dizziness, Dyspnoea, Malaise, Pulmonary Embolism (5519639-5)
on Nov 06, 2007 Male from GERMANY , 72 years of age, weighting 220.5 lb, was diagnosed with
  • back pain
and was treated with Targin 10/5 Mg Retardtabletten. Patient felt the following Targin side effects: chest discomfort, dizziness, dyspnoea, malaise, pulmonary embolism. Targin 10/5 Mg Retardtabletten dosage: 10 Mg, Single.
Multiple prescriptions taken:
  • Oxygesic 20 Mg (20 Mg, Bid)
  • Bisoprolol Fumarate
Patient was hospitalized.

Arrhythmia, Chills, Incorrect Dose Administered, Nausea, Vomiting (5394403-9)
on Jul 10, 2007 Male from , 58 years of age, was diagnosed with
  • constipation
and was treated with Targin Retardtabletten. After Targin was administered, patient encountered several Targin side effects: arrhythmia, chills, incorrect dose administered, nausea, vomiting. Targin Retardtabletten dosage: 20 Mg, Tid.
Multiple concurrent drugs taken:
  • Oxygesic 10 Mg (10 Mg, Bid)


Arrhythmia, Chills, Nausea, Vomiting (5333726-6)
Patient was taking Targin Retardtabletten. Directly after, patient experienced the unwanted or unexpected Targin side effects: arrhythmia, chills, nausea, vomiting on May 14, 2007 from Additional patient health information: Male , 58 years of age, . Targin Retardtabletten dosage: Unk, Unk.
Associated medications used:
  • Oxygesic (Unk, Unk)


Cervicobrachial Syndrome (5221106-3)
Adverse event was reported on Jan 15, 2007 by a Female taking Targin 10/5 Mg Retardtabletten (Dosage: 10 Mg, Bid) was diagnosed with
  • pain
and. Location: , 60 years of age, Patient felt the following Targin side effects: cervicobrachial syndrome. Patient was hospitalized.

Colitis, Colitis Ulcerative, Intestinal Haemorrhage (5194060-0)
on Nov 13, 2006 Male from , 62 years of age, was diagnosed with
  • pain
and was treated with Targin 10/5 Mg Retardtabletten. After Targin was administered, patient encountered several Targin side effects: colitis, colitis ulcerative, intestinal haemorrhage. Targin 10/5 Mg Retardtabletten dosage: 10 Mg, Bid.
Multiple concurrent drugs taken:
  • Diclofenac ^ratiopharm^ (Unk, See Text)
  • Aspirin
  • Metoprolol Succinate
  • Co-diovan
  • Allopurinol Sodium
Patient was hospitalized.

Cardiac Disorder, Musculoskeletal Pain (5179244-X)
on Nov 17, 2006 Female from , 60 years of age, was diagnosed with
  • pain
and was treated with Targin 10/5 Mg Retardtabletten. Directly after, patient experienced the unwanted or unexpected Targin side effects: cardiac disorder, musculoskeletal pain. Targin 10/5 Mg Retardtabletten dosage: 10 Mg, Bid. Patient was hospitalized.

Showing 1-25 of 29 

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Targin Information

More About Targin

Side Effects reported to FDA: 29. View Targin Adverse Reports

Targin safety alerts: No

Reported deaths: 2

Reported hospitalizations: 6

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