Community-reported Tasmar side effects:
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Total Tasmar reports: 24.Tasmar FDA safety alerts: No.
Reported deaths: 10 Reported hospitalizations: 4.
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FDA Reported Tasmar Side Effects: alanine aminotransferase increased, blood alkaline phosphatase increased, fall, aspartate aminotransferase increased, condition aggravated, multi-organ failure, deep vein thrombosis, compartment syndrome, anaemia, parkinson's disease, hepatic enzyme increased.
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Tasmar Side Effects Report #5236716-7
Consumer or non-health professional from IRELAND reported TASMAR problem on Nov 02, 2006. Female patient, 61 years of age, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: hepatitis. TASMAR dosage: 100 MG, PO. During the same period patient was treated with MADOPAR, PRAMIPEXOLE DIHYDROCHLORIDE, SINEMET CR. Patient recovered.
Tasmar Side Effects Report #5236717-9
TASMAR problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Aug 21, 2006. Female patient, 70 years of age, weighting 154.1 lb, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, lung neoplasm malignant. TASMAR dosage: 100 MG, TID;. During the same period patient was treated with PROPRANOLOL, CLONAZEPAM, ZOPICLONE, CLEXANE. Patient recovered.
Tasmar Side Effects Report #5255782-6
Physician from GERMANY reported TASMAR problem on Dec 29, 2006. Female patient, 80 years of age, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: aggression, agitation, arrhythmia, atrial fibrillation, cardiomegaly, cerebral atrophy, dementia, disturbance in attention. TASMAR dosage: unknown. During the same period patient was treated with CANDESARTAN, BISOPROLOL, ACETYLSALICYLIC ACID SRT, CARBIDOPA, LEVODOPA, AMANTADINE. Patient died.
Tasmar Side Effects Report #5270422-8
TASMAR problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Feb 26, 2007. Female patient, 68 years of age, weighting 117.9 lb, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, blood alkaline phosphatase increased, fall, hepatic enzyme increased, influenza, nausea, parkinson's disease, vomiting. TASMAR dosage: 100 MG; TID; PO. During the same period patient was treated with PROPRANOLOL, DOMPERIDONE, CARBIDOPA. Patient recovered.
Tasmar Side Effects Report #5281224-0
Physician from GERMANY reported TASMAR problem on Mar 06, 2007. Male patient, 80 years of age, was diagnosed with parkinsonism and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: anaemia, blood creatine phosphokinase increased, compartment syndrome, deep vein thrombosis, hepatic enzyme increased, multi-organ failure, myocardial infarction. TASMAR dosage: unknown. During the same period patient was treated with ISOCOM, SIFROL, TRAZODONE, SEROQUEL, AMANTADINE. Patient was hospitalized. Patient died on 01/27/2007.
Tasmar Side Effects Report #5291405-8
TASMAR problem was reported by a Physician from GERMANY on Mar 13, 2007. Male patient, 80 years of age, was diagnosed with parkinsonism and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: acute hepatic failure, anaemia, blood creatine phosphokinase increased, cardiovascular disorder, coagulopathy, compartment syndrome, deep vein thrombosis, factor v leiden mutation, multi-organ failure. TASMAR dosage: unknown. During the same period patient was treated with ISOCOM, SIFROL, TRAZODONE, SEROQUEL. Patient was hospitalized. Patient died on 01/27/2007.
Tasmar Side Effects Report #5295740-9
Consumer or non-health professional from UNITED KINGDOM reported TASMAR problem on Mar 30, 2007. Male patient, 68 years of age, weighting 240.3 lb, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: cardiac failure congestive, chronic obstructive pulmonary disease. TASMAR dosage: unknown. During the same period patient was treated with MADOPAR, BUMETANIDE, ATORVASTATIN CALCIUM, PARACETAMOL, ENTACAPONE, PRAMIPEXOLE DIHYDROCHLORIDE, RASAGILINE MESILATE. Patient died on 02/19/2007.
Tasmar Side Effects Report #5306612-5
TASMAR problem was reported by a Physician from GERMANY on Apr 03, 2007. Male patient, 80 years of age, weighting 138.9 lb, was diagnosed with parkinsonism and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: anaemia, compartment syndrome, condition aggravated, deep vein thrombosis, haemorrhage, hepatic failure, international normalised ratio increased, multi-organ failure, myocardial infarction. TASMAR dosage: 100 MG;TID; PO. During the same period patient was treated with ISOCOM, SIFROL, TRAZODONE, SEROQUEL, CARBIDOPA. Patient was hospitalized. Patient died on 01/27/2007.
Tasmar Side Effects Report #5329748-1
Health Professional from CANADA reported TASMAR problem on Apr 30, 2007. Female patient, 75 years of age, weighting 114.6 lb, was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: aspartate aminotransferase increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, gamma-glutamyltransferase increased, liver function test abnormal. TASMAR dosage: 10 MG; TID; PO. During the same period patient was treated with SINEMET, PERMAX, AMANTADINE, EXELON, DOMPERIDONE, TYLENOL W, AMOXICLAV. Patient recovered.
Tasmar Side Effects Report #5352043-1
TASMAR problem was reported by a Physician from UNITED STATES on May 17, 2007. Male patient was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: agitation, depression, dysarthria, fall, hallucination, homicidal ideation, muscular weakness, suicidal ideation, tremor. TASMAR dosage: unknown. Patient recovered.
Tasmar Side Effects Report #5361234-5
Consumer or non-health professional from UNITED KINGDOM reported TASMAR problem on May 29, 2007. Male patient was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: blood bilirubin increased. TASMAR dosage: 100 MG;TID;. During the same period patient was treated with LEVODOPA, MIRAPIXINE. Patient recovered.
Tasmar Side Effects Report #5050662-3
TASMAR problem was reported by a Physician from UNITED KINGDOM on June 26, 2006. Male patient, 65 years of age, weighting 138.9 lb, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased. TASMAR dosage: 300 MG;QD;PO. During the same period patient was treated with AMITRIPTYLINE, APOMORPHINE, ASPIRIN, MADOPAR. Patient recovered.
Tasmar Side Effects Report #5072947-7
Health Professional from UNITED KINGDOM reported TASMAR problem on July 21, 2006. Male patient, 65 years of age, weighting 138.9 lb, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased. TASMAR dosage: 300 MG; QD; PO. During the same period patient was treated with AMITRIPTYLINE, APOMORPHINE, ASPIRIN, MADOPAR. Patient recovered.
Tasmar Side Effects Report #5085783-2
TASMAR problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Aug 01, 2006. Female patient, 68 years of age, weighting 117.9 lb, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: hepatic failure. TASMAR dosage: 100 MG; TID; PO. During the same period patient was treated with PROPRANOLOL, DOMPERIDONE, CARBIDOPA. Patient recovered.
Tasmar Side Effects Report #5103001-3
Physician from UNITED KINGDOM reported TASMAR problem on Aug 25, 2006. Male patient, 65 years of age, weighting 138.9 lb, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased. TASMAR dosage: 100 MG; TID; PO. During the same period patient was treated with MADOPAR, AMITRIPTYLINE, APOMORPHINE, SALICYLIC ACID, ENTACAPONE. Patient recovered.
Tasmar Side Effects Report #5154553-9
TASMAR problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Oct 30, 2006. Female patient, 68 years of age, weighting 117.9 lb, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, blood alkaline phosphatase increased, condition aggravated, fall, hepatic enzyme increased, hepatic failure, influenza, malaise, parkinson's disease. TASMAR dosage: 100 MG TID PO. During the same period patient was treated with PROPRANOLOL, DOMPERIDONE, CARBIDOPA. Patient recovered.
Tasmar Side Effects Report #5419753-9
Physician from UNITED KINGDOM reported TASMAR problem on May 15, 2007. Female patient, 68 years of age, weighting 117.9 lb, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: condition aggravated, contusion, fall, hepatic failure, parkinson's disease. TASMAR dosage: 100 MG; TID; PO; 100 MG; QD; PO. During the same period patient was treated with PROPRANOLOL, DOMPERIDONE, CARBIDOPA. Patient recovered.
Tasmar Side Effects Report #5449583-3
TASMAR problem was reported by a Physician from CANADA on May 11, 2006. Female patient, 59 years of age, was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: respiratory distress. TASMAR dosage: 100 MG; TID; PO. During the same period patient was treated with SINEMET. Patient died.
Tasmar Side Effects Report #5449584-5
Physician from CANADA reported TASMAR problem on May 11, 2006. Female patient, 74 years of age, was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: antinuclear antibody positive, biliary cirrhosis, blood fibrinogen decreased, blood glucose increased, blood iron increased, blood lactate dehydrogenase increased, blood urea increased, depressed level of consciousness, diarrhoea. TASMAR dosage: 300 MG; QD; PO. During the same period patient was treated with IBUPROFEN, TYLENOL NO, ARTANE, PROVERA, PERMAX, PREMARIN, ASPIRIN, SINEMET. Patient died.
Tasmar Side Effects Report #5449585-7
TASMAR problem was reported by a Physician from CANADA on May 11, 2006. Female patient was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: muscle rigidity, parkinsonism. TASMAR dosage: unknown. Patient recovered.
Tasmar Side Effects Report #5449586-9
Physician from CANADA reported TASMAR problem on May 11, 2006. Female patient, 82 years of age, was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: cerebrovascular accident. TASMAR dosage: 100 MG; TID; PO. Patient died.
Tasmar Side Effects Report #5449587-0
TASMAR problem was reported by a Physician from CANADA on May 11, 2006. Male patient, 81 years of age, was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: pneumonia. TASMAR dosage: 100 MG; TID; PO. Patient died.
Tasmar Side Effects Report #5449588-2
Physician from CANADA reported TASMAR problem on May 11, 2006. Male patient, 58 years of age, was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: pulmonary oedema. TASMAR dosage: 200 MG; TID; PO. During the same period patient was treated with SINEMET, BROMOCRIPTINE MESYLATE, AMANTADINE. Patient died.
Tasmar Side Effects Report #5454995-8
TASMAR problem was reported by a Consumer or non-health professional from FRANCE on Aug 30, 2007. Female patient, 47 years of age, was diagnosed with parkinson's disease and was treated with TASMAR. After drug was administered, patient experienced the following problems/side effects: parkinsonism, rash erythematous. TASMAR dosage: unknown. During the same period patient was treated with MADOPAR, COZAAR. Patient was hospitalized. Patient recovered.
Drug Information: Tolcapone
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a698036.html
(tole' ka pone)IMPORTANT WARNING:
| Tolcapone may cause life threatening liver damage. Tell your doctor if you have or have ever had liver disease. Keep all appointments with your doctor and the laboratory. Your doctor will order certain laboratory tests before and during treatment to check your response to tolcapone.If you experience any of the following symptoms, call your doctor immediately: upset stomach that does not go away, extreme tiredness, lack of energy, yellowing of the skin or whites of eyes, tenderness on the right upper side of the stomach, itching, loss of appetite, pale stools, or dark urine. |
Why is this medication prescribed?
Tolcapone is used in combination with levodopa and carbidopa to treat the signs and symptoms of Parkinson's disease.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Tolcapone comes as a tablet to take by mouth. It is usually taken three times a day. Your doctor will most likely prescribe this in addition to levodopa and carbidopa (Sinemet). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tolcapone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Tolcapone controls symptoms of Parkinson's disease but does not cure it. Continue to take tolcapone even if you feel well. Do not stop taking tolcapone without talking to your doctor. Abrupt discontinuation of tolcapone may cause high fever and confusion.
What special precautions should I follow?
Before taking tolcapone,
- tell your doctor and pharmacist if you are allergic to tolcapone or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants (''blood thinners'') such as warfarin (Coumadin), desipramine (Norpramin), dobutamine (Dobutrex), drugs that cause drowsiness (sedatives, tranquilizers, and sleeping pills), isoproterenol (Isuprel), MAO inhibitors [phenelzine (Nardil) or tranylcypromine (Parnate)], methyldopa (Aldomet), and vitamins.
- in addition to the condition listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had heart or kidney disease or rhabdomyolysis (skeletal muscle disease).
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking tolcapone, call your doctor.
- if you are having surgery, including dental surgery, tell your doctor or dentist that you are taking tolcapone.
- you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how tolcapone will affect you.
- remember that alcohol can add to the drowsiness caused by this drug.
What special dietary instructions should I follow?
Tolcapone may cause an upset stomach. Tolcapone may be taken with food to reduce nausea.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Tolcapone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- sleep disturbances
- excessive dreaming
- diarrhea
- dizziness
- vomiting
- increased sweating
If you experience any of the following symptoms, or any of those listed in the IMPORTANT WARNING section, call your doctor immediately:
- hallucinations
- confusion
- irregular heartbeat
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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