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Sleep Disorder (21)
Tiredness (16)
Drowsiness (9)
Hair Loss (8)
Urticaria (7)
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Thyroxine Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Medulloblastoma Recurrent (8027224-9)
on Dec 20, 2011 Male from UNITED KINGDOM , child 11 years of age, was treated with Thyroxine (levothyroxine Sodium0. Directly after, patient experienced the unwanted or unexpected Thyroxine side effects: medulloblastoma recurrent. Thyroxine (levothyroxine Sodium0 dosage: N/A.
Associated medications used:
  • Zomacton (somatropin) Powder And Solvent For Solution For Injection (1 Mg)


Operative Haemorrhage, Serotonin Syndrome, Platelet Count Decreased (7456306-5)
Patient was taking Thyroxine. Patient felt the following Thyroxine side effects: operative haemorrhage, serotonin syndrome, platelet count decreased on Apr 11, 2011 from UNITED KINGDOM Additional patient health information: Female , 60 years of age, . Thyroxine dosage: N/A.
Multiple prescriptions taken:
  • Fentanyl (2545 Mcg;x1;)
  • Propofol
  • Paroxetine (no Pref. Name)
  • Isoflurane In Oxygen And Air


Cerebral Haemorrhage, Idiopathic Thrombocytopenic Purpura (7434794-8)
Adverse event was reported on Mar 30, 2011 by a Male taking Thyroxine (Dosage: N/A) . Location: , 64 years of age, weighting 154.3 lb, After Thyroxine was administered, patient encountered several Thyroxine side effects: cerebral haemorrhage, idiopathic thrombocytopenic purpura.
Multiple concurrent drugs taken:
  • Simvastatin (40mg - Daily - Oral)


Rash, Acne, Urticaria, Pruritus (7432946-4)
on Apr 15, 2011 Female from UNITED STATES , weighting 103.6 lb, was diagnosed with
  • thyroid disorder
  • blood cholesterol abnormal
and was treated with Thyroxine. Directly after, patient experienced the unwanted or unexpected Thyroxine side effects: rash, acne, urticaria, pruritus. Thyroxine dosage: N/A.
Associated medications used:
  • Simvastatin
  • Fish Oil
  • Amlodipine Besylate (10 Mg, 1x/day)
  • Calcium



Cerebral Haemorrhage, Idiopathic Thrombocytopenic Purpura, Thrombocytopenia (7401492-6)
on Mar 30, 2011 Male from UNITED KINGDOM , 64 years of age, weighting 154.3 lb, was diagnosed with
  • hypothyroidism
  • hypercholesterolaemia
and was treated with Thyroxine. Patient felt the following Thyroxine side effects: cerebral haemorrhage, idiopathic thrombocytopenic purpura, thrombocytopenia. Thyroxine dosage: 50 Ug, Unk.
Multiple prescriptions taken:
  • Simvastatin (40 Mg, Qd)


Blood Bilirubin Increased, Rash, Febrile Neutropenia (7395868-3)
Patient was taking Thyroxine. After Thyroxine was administered, patient encountered several Thyroxine side effects: blood bilirubin increased, rash, febrile neutropenia on Apr 04, 2011 from CANADA Additional patient health information: Female , 50 years of age, weighting 116.8 lb, was diagnosed with
  • hypothyroidism
  • colorectal cancer metastatic
and. Thyroxine dosage: N/A. Patient was hospitalized.

Platelet Count Decreased, Cerebral Haemorrhage (7368211-3)
Adverse event was reported on Feb 24, 2011 by a Male taking Thyroxine (Dosage: N/A) . Location: UNITED KINGDOM , 64 years of age, weighting 154.3 lb, Directly after, patient experienced the unwanted or unexpected Thyroxine side effects: platelet count decreased, cerebral haemorrhage.
Associated medications used:
  • Simvastatin (40 Mg, Daily, Oral)


Lymphocytosis (7363521-8)
on Mar 08, 2011 Female from UNITED KINGDOM , 68 years of age, weighting 121.3 lb, was diagnosed with
  • hypothyroidism
  • rheumatoid arthritis
and was treated with Thyroxine. Patient felt the following Thyroxine side effects: lymphocytosis. Thyroxine dosage: 100 Ug, 1x/day.
Multiple prescriptions taken:
  • Meloxicam (7.5 Mg, 1x/day)
  • Enbrel (50 Mg, Weekly)
  • Prednisolone (7.5 Mg, 1x/day)


Cerebral Haemorrhage, Idiopathic Thrombocytopenic Purpura, Thrombocytopenia (7341231-0)
on Feb 24, 2011 Male from UNITED KINGDOM , 64 years of age, weighting 154.3 lb, was diagnosed with
  • hypothyroidism
  • hypercholesterolaemia
and was treated with Thyroxine. After Thyroxine was administered, patient encountered several Thyroxine side effects: cerebral haemorrhage, idiopathic thrombocytopenic purpura, thrombocytopenia. Thyroxine dosage: N/A.
Multiple concurrent drugs taken:
  • Simvastatin (40 Mg, Daily)


Cerebral Haemorrhage, Idiopathic Thrombocytopenic Purpura (7321818-1)
Patient was taking Thyroxine. Directly after, patient experienced the unwanted or unexpected Thyroxine side effects: cerebral haemorrhage, idiopathic thrombocytopenic purpura on Feb 01, 2011 from Additional patient health information: Male , 64 years of age, weighting 154.3 lb, . Thyroxine dosage: N/A.
Associated medications used:
  • Simvastatin (40mg - Daily - Oral)


Swelling Face, Urticaria (4877351-X)
Adverse event was reported on Jan 03, 2006 by a Patient taking Thyroxine (Dosage: N/A) . Location: UNITED KINGDOM , 69 years of age, Patient felt the following Thyroxine side effects: swelling face, urticaria.
Multiple prescriptions taken:
  • Aspirin
  • Lisinopril
  • Bendrofluazide
  • Ferrous Sulfate Tab
  • Diclofenac (75mg Daily)


Leukocytoclastic Vasculitis (4818964-0)
on Oct 05, 2005 Female from AUSTRALIA , weighting 154.3 lb, was diagnosed with
  • hypothyroidism
  • depression
and was treated with Thyroxine. After Thyroxine was administered, patient encountered several Thyroxine side effects: leukocytoclastic vasculitis. Thyroxine dosage: Daily Dose: 100 Microgram(s).
Multiple concurrent drugs taken:
  • Luvox (Daily Dose: 50 Milligram(s))


Leukocytoclastic Vasculitis (4801392-1)
on Oct 05, 2005 Female from AUSTRALIA , weighting 154.3 lb, was diagnosed with
  • ill-defined disorder
  • depression
and was treated with Thyroxine. Directly after, patient experienced the unwanted or unexpected Thyroxine side effects: leukocytoclastic vasculitis. Thyroxine dosage: N/A.
Associated medications used:
  • Luvox (Daily Dose: 50 Milligram(s))


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Record and Track Your Side Effects

It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Thyroxine Information

Alternative THYROXINE Names:LEVOTHYRO

Active Ingredient: LEVOTHYRO

More About Thyroxine

Side Effects reported to FDA: 13. View Thyroxine Adverse Reports

Thyroxine safety alerts: 2004

Reported deaths: 5

Reported hospitalizations: 1

Levoxyl (levothyroxine sodium)

Audience: Endocrinologists and other healthcare professionals

FDA and King Pharmaceuticals notified healthcare professionals of revisions to the PRECAUTIONS, ADVERSE REACTIONS and DOSAGE AND ADMINISTRATION sections of labeling, describing reports of choking, gagging, tablets stuck in throat and dysphagia while taking Levoxyl. These reports have predominately occurred when Levoxyl tablets were not taken with water. It is recommended that Levoxyl tablets be taken with a full glass of water.

[September 17, 2004 - Letter - King Pharmaceuticals]

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