Tipranavir Side Effects
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Tipranavir Safety Reports reported to FDA
Total Tipranavir reports: 135.Tipranavir FDA safety alerts: 2006 .
Reported deaths: 32 Reported hospitalizations: 81.
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Reported Tipranavir Side Effects: coagulation time prolonged, contusion, alanine aminotransferase increased, diarrhoea, aspartate aminotransferase increased, acute abdomen, activated partial thromboplastin time prolonged, gastrointestinal haemorrhage, dehydration, abdominal pain upper, death.
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Tipranavir Side Effects Report #5139500-8Physician from reported TIPRANAVIR problem on July 05, 2006. Male patient was diagnosed with acquired immunodeficiency syndrome and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: acne. TIPRANAVIR dosage: 500MG TPV BID / 200MG RTV BID. During the same period patient was treated with VIDEX EC, LAMIVUDINE, NORVIR, VFEND, DARAPRIM, LEUCOVORIN CALCIUM. Patient recovered.
Tipranavir Side Effects Report #5146388-8
TIPRANAVIR problem was reported by a Consumer or non-health professional from on Sept 15, 2006. Female patient, weighting 50.00 lb, was diagnosed with hiv infection, retroviral infection, medical diet, antifungal prophylaxis, antibiotic prophylaxis, increased appetite, mineral supplementation and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: arthropod bite, coagulation time prolonged, contusion, injury. TIPRANAVIR dosage: TPV/RTV 510 MG/202 MG. During the same period patient was treated with ABACAVIR, SIDERAL, FOLIC ACID, BACTRIM, ZITHROMAX, PERIACTIN, CALCIUM GLUCONATE. Patient recovered.
Tipranavir Side Effects Report #5147159-9
Consumer or non-health professional from reported TIPRANAVIR problem on Apr 18, 2005. Female patient, weighting 174.4 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: caesarean section, nausea, premature baby, premature rupture of membranes, weight decreased. TIPRANAVIR dosage: TIPR: 2X250MG RIT: 2X100MG. During the same period patient was treated with FUZEON, TRIZIVIR, TENOFOVIR. Patient recovered.
Tipranavir Side Effects Report #5148221-7
TIPRANAVIR problem was reported by a Consumer or non-health professional from UNITED STATES MINOR OUTLYING ISLANDS on Sept 15, 2006. Female patient, weighting 50.00 lb, was diagnosed with hiv infection, retroviral infection, medical diet, antifungal prophylaxis, antibiotic prophylaxis, increased appetite, mineral supplementation and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: coagulation time prolonged, contusion, microcytic anaemia. TIPRANAVIR dosage: TPV/RTV 510 MG/202 MG. During the same period patient was treated with ABACAVIR, SIDERAL, FOLIC ACID, BACTRIM, ZITHROMAX, PERIACTIN, CALCIUM GLUCONATE. Patient recovered.
Tipranavir Side Effects Report #5150901-4
Consumer or non-health professional from BRAZIL reported TIPRANAVIR problem on Feb 14, 2006. Male patient, weighting 165.3 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: nephrotic syndrome. TIPRANAVIR dosage: TIPRANAVIR/RITONAVIR: 1000/400MG AS DAILY DOSE. During the same period patient was treated with ZIDOVUDINE, LAMIVUDINE, ABACAVIR, DIDANOSINE, FUZEON. Patient recovered.
Tipranavir Side Effects Report #5154367-X
TIPRANAVIR problem was reported by a Consumer or non-health professional from on July 15, 2005. Male patient, weighting 116.8 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: gallbladder polyp. TIPRANAVIR dosage: TIPR: 4X250MG RIT: 4X100MG. During the same period patient was treated with TENOFOVIR, NEVIRAPINE, ENFUVIRTIDE, LIPITOR, REQUIP, OMNIC, FLUCONAZOLE, OMEPRAZOLE. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5154369-3
Consumer or non-health professional from reported TIPRANAVIR problem on Oct 26, 2006. Female patient, weighting 27.56 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: diarrhoea, gastrointestinal infection. TIPRANAVIR dosage: unknown. During the same period patient was treated with ZIAGENAVIR, ABACAVIR. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5154372-3
TIPRANAVIR problem was reported by a Consumer or non-health professional from on July 28, 2006. Male patient, 52 years of age, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: blood hiv rna increased, hepatotoxicity, skin reaction, weight decreased. TIPRANAVIR dosage: 1000 MG TIPRANAVIR/400 MG RITONAVIR. During the same period patient was treated with ENFUVIRTIDE, LAMIVUDINE AND ZIDOVUDINE. Patient recovered.
Tipranavir Side Effects Report #5159076-9
Consumer or non-health professional from reported TIPRANAVIR problem on July 28, 2006. Male patient, 52 years of age, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: blood hiv rna increased, hepatotoxicity, skin reaction, weight decreased. TIPRANAVIR dosage: 1000 MG TIPRANAVIR/400 MG RITONAVIR. During the same period patient was treated with ENFUVIRTIDE, LAMIVUDINE AND ZIDOVUDINE. Patient recovered.
Tipranavir Side Effects Report #5159081-2
TIPRANAVIR problem was reported by a Consumer or non-health professional from UNITED STATES MINOR OUTLYING ISLANDS on Sept 15, 2006. Female patient, weighting 50.00 lb, was diagnosed with hiv infection, retroviral infection, medical diet, antifungal prophylaxis, antibiotic prophylaxis, increased appetite, mineral supplementation and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: coagulation time prolonged, contusion, microcytic anaemia. TIPRANAVIR dosage: TPV/RTV 510 MG/202 MG. During the same period patient was treated with ABACAVIR, SIDERAL, FOLIC ACID, BACTRIM, ZITHROMAX, PERIACTIN, CALCIUM GLUCONATE. Patient recovered.
Tipranavir Side Effects Report #5159091-5
Consumer or non-health professional from reported TIPRANAVIR problem on Oct 26, 2006. Female patient, weighting 27.56 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: diarrhoea haemorrhagic, gastrointestinal infection. TIPRANAVIR dosage: TIP/RTV 375/150 MG/M2/ DAY. During the same period patient was treated with ZIAGENAVIR, ABACAVIR. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5160508-0
TIPRANAVIR problem was reported by a Consumer or non-health professional from on Apr 18, 2005. Male patient, weighting 172.0 lb, was diagnosed with hiv infection, prophylaxis and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: cholestasis, cytolytic hepatitis. TIPRANAVIR dosage: TPV/RTV: 500/200 MG B.I.D.. During the same period patient was treated with LEDERFOLIN, PYRIMETHAMINE, DAPSONE, VIREAD, SUSTIVA, FUZEON. Patient recovered.
Tipranavir Side Effects Report #5165012-1
Consumer or non-health professional from UNITED STATES MINOR OUTLYING ISLANDS reported TIPRANAVIR problem on Sept 15, 2006. Female patient, weighting 50.00 lb, was diagnosed with hiv infection, retroviral infection, medical diet, antifungal prophylaxis, antibiotic prophylaxis, increased appetite, mineral supplementation and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: abdominal injury, activated partial thromboplastin time prolonged, alanine aminotransferase increased, arthropod bite, coagulation time prolonged, contusion, iron deficiency anaemia, prothrombin time prolonged. TIPRANAVIR dosage: TPV/RTV 510 MG/202 MG. During the same period patient was treated with ABACAVIR, SIDERAL, FOLIC ACID, BACTRIM, ZITHROMAX, PERIACTIN, CALCIUM GLUCONATE. Patient recovered.
Tipranavir Side Effects Report #5165932-8
TIPRANAVIR problem was reported by a Consumer or non-health professional from FRANCE on Oct 26, 2006. Male patient, weighting 198.4 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: cerebral haemorrhage. TIPRANAVIR dosage: TPV/RTV: 500/200 MG B.I.D.. During the same period patient was treated with VIREAD, FUZEON, EMTRIVA. Patient was hospitalized. Patient died on 07/11/2005.
Tipranavir Side Effects Report #5169461-7
Consumer or non-health professional from ARGENTINA reported TIPRANAVIR problem on July 14, 2006. Male patient, weighting 88.18 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: abdominal distension, abdominal pain upper, acanthosis, activated partial thromboplastin time prolonged, acute abdomen, alanine aminotransferase increased, aspartate aminotransferase increased, biliary dilatation, bilirubin conjugated increased. TIPRANAVIR dosage: 800 MG/320 MG TPV/RTV. Patient was hospitalized. Patient died on 08/05/2006.
Tipranavir Side Effects Report #5172149-X
TIPRANAVIR problem was reported by a Consumer or non-health professional from AUSTRALIA on Dec 06, 2006. Male patient, weighting 146.8 lb, was diagnosed with hiv infection, antibiotic prophylaxis, antiviral prophylaxis, antifungal prophylaxis, gastrooesophageal reflux prophylaxis, pain and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: abscess drainage. TIPRANAVIR dosage: 1000/400 MG/MG. During the same period patient was treated with CLINDAMYCIN, FAMCICLOVIR, FLUCONAZOLE, LOSEC, OSTELIN. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5172155-5
Consumer or non-health professional from UNITED STATES MINOR OUTLYING ISLANDS reported TIPRANAVIR problem on Sept 15, 2006. Female patient, weighting 50.00 lb, was diagnosed with hiv infection, retroviral infection, medical diet, antifungal prophylaxis, antibiotic prophylaxis, increased appetite, mineral supplementation and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: abdominal injury, activated partial thromboplastin time prolonged, alanine aminotransferase increased, arthropod bite, aspartate aminotransferase increased, coagulation factor viii level increased, coagulation time prolonged, contusion, prothrombin time prolonged. TIPRANAVIR dosage: TPV/RTV 510 MG/202 MG. During the same period patient was treated with ABACAVIR, SIDERAL, FOLIC ACID, BACTRIM, ZITHROMAX, PERIACTIN, CALCIUM GLUCONATE. Patient recovered.
Tipranavir Side Effects Report #5176582-1
TIPRANAVIR problem was reported by a Consumer or non-health professional from AUSTRALIA on Dec 06, 2006. Male patient, weighting 146.8 lb, was diagnosed with hiv infection, antibiotic prophylaxis, antiviral prophylaxis, antifungal prophylaxis, gastrooesophageal reflux prophylaxis, pain and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: abscess drainage, perianal abscess. TIPRANAVIR dosage: 1000/400 MG/MG. During the same period patient was treated with CLINDAMYCIN, FAMCICLOVIR, FLUCONAZOLE, LOSEC, OSTELIN. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5186471-4
Consumer or non-health professional from UNITED STATES MINOR OUTLYING ISLANDS reported TIPRANAVIR problem on Sept 15, 2006. Female patient, weighting 50.00 lb, was diagnosed with hiv infection, retroviral infection, medical diet, antifungal prophylaxis, antibiotic prophylaxis, increased appetite, mineral supplementation and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: activated partial thromboplastin time prolonged, alanine aminotransferase increased, aspartate aminotransferase increased, coagulation time prolonged, contusion, prothrombin time prolonged. TIPRANAVIR dosage: TPV/RTV 510 MG/202 MG. During the same period patient was treated with ABACAVIR, SIDERAL, FOLIC ACID, BACTRIM, ZITHROMAX, PERIACTIN, CALCIUM GLUCONATE. Patient recovered.
Tipranavir Side Effects Report #5188846-6
TIPRANAVIR problem was reported by a Consumer or non-health professional from on Dec 19, 2006. Female patient, weighting 61.73 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: gamma-glutamyltransferase increased. TIPRANAVIR dosage: unknown. During the same period patient was treated with ZIDOVUDINE, DIDANOSINE. Patient recovered.
Tipranavir Side Effects Report #5188882-X
Consumer or non-health professional from reported TIPRANAVIR problem on Dec 15, 2006. Female patient was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: transaminases increased. TIPRANAVIR dosage: 1000 MG TIPRANAVIR + 400 MG RITONAVIR. During the same period patient was treated with BRECANAVIR. Patient recovered.
Tipranavir Side Effects Report #5190952-7
TIPRANAVIR problem was reported by a Consumer or non-health professional from on Oct 05, 2005. Male patient, weighting 181.9 lb, was diagnosed with hiv test positive and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: bile duct stone, pancreatitis. TIPRANAVIR dosage: 1000MG TPV / 400MG RTV. During the same period patient was treated with TENOFOVIR, LAMIVUDINE. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5192388-1
Consumer or non-health professional from UNITED STATES MINOR OUTLYING ISLANDS reported TIPRANAVIR problem on Sept 15, 2006. Female patient, weighting 50.00 lb, was diagnosed with hiv infection, retroviral infection, medical diet, antifungal prophylaxis, antibiotic prophylaxis, increased appetite, mineral supplementation and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: activated partial thromboplastin time prolonged, alanine aminotransferase increased, antiphospholipid syndrome, arthropod bite, cd4 lymphocytes decreased, coagulation time prolonged, contusion, injury, iron deficiency. TIPRANAVIR dosage: TPV/RTV 510 MG/202 MG. During the same period patient was treated with ABACAVIR, SIDERAL, FOLIC ACID, BACTRIM, ZITHROMAX, PERIACTIN, CALCIUM GLUCONATE. Patient recovered.
Tipranavir Side Effects Report #5194247-7
TIPRANAVIR problem was reported by a Consumer or non-health professional from BRAZIL on Dec 19, 2006. Female patient, weighting 61.73 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: gamma-glutamyltransferase increased. TIPRANAVIR dosage: unknown. During the same period patient was treated with ZIDOVUDINE, DIDANOSINE. Patient recovered.
Tipranavir Side Effects Report #5377711-7
Consumer or non-health professional from UNITED STATES reported TIPRANAVIR problem on June 27, 2007. Male patient, weighting 156.5 lb, was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: asthma, hypersensitivity. TIPRANAVIR dosage: TPV/R 1000/400MG. During the same period patient was treated with ROSUVASTATIN. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5382322-3
TIPRANAVIR problem was reported by a Consumer or non-health professional from ARGENTINA on July 05, 2007. Female patient, weighting 117.7 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: fallopian tube obstruction, uterine haemorrhage. TIPRANAVIR dosage: TPV/RTV 1000/400 MG. During the same period patient was treated with TENOFOVIR, LAMIVUDINE. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5384633-4
Consumer or non-health professional from ARGENTINA reported TIPRANAVIR problem on July 10, 2007. Female patient, weighting 117.7 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: ectopic pregnancy, fallopian tube obstruction, post abortion haemorrhage. TIPRANAVIR dosage: TPV/RTV 1000/400 MG. During the same period patient was treated with TENOFOVIR, LAMIVUDINE. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5384637-1
TIPRANAVIR problem was reported by a Consumer or non-health professional from ARGENTINA on July 10, 2007. Female patient, weighting 111.3 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: abortion spontaneous. TIPRANAVIR dosage: TPV/RTV 1000/400 MG. During the same period patient was treated with ABACAVIR, DIDANOSINE. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5384642-5
Consumer or non-health professional from UNITED STATES reported TIPRANAVIR problem on July 09, 2007. Male patient, weighting 156.5 lb, was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: asthma, hypersensitivity. TIPRANAVIR dosage: TPV/R 1000/400MG. During the same period patient was treated with ROSUVASTATIN. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5386839-7
TIPRANAVIR problem was reported by a Consumer or non-health professional from ARGENTINA on July 12, 2007. Female patient, weighting 111.3 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: abortion spontaneous. TIPRANAVIR dosage: TPV/RTV 1000/400 MG. During the same period patient was treated with ABACAVIR, DIDANOSINE. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5397008-9
Consumer or non-health professional from AUSTRALIA reported TIPRANAVIR problem on July 23, 2007. Male patient, weighting 172.0 lb, was diagnosed with hiv infection, antibiotic prophylaxis, aortic valve incompetence, addison's disease, insomnia and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: dehydration, dry skin, faeces discoloured, gastrointestinal haemorrhage, hypotension, malaise, pyrexia, renal failure acute, renal impairment. TIPRANAVIR dosage: TPV/RTV 1000/400 MG/MG. During the same period patient was treated with WARFARIN, AUGMENTIN, FLUCONAZOLE, LAMIVUDINE, CARVEDILOL, FLUDROCORTISONE ACETATE, PRAVASTATIN, MIRTAZAPINE. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5400953-9
TIPRANAVIR problem was reported by a Consumer or non-health professional from ARGENTINA on July 27, 2007. Female patient, weighting 117.7 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: ectopic pregnancy, fallopian tube obstruction, haematosalpinx. TIPRANAVIR dosage: TPV/RTV 1000/400 MG. During the same period patient was treated with TENOFOVIR, LAMIVUDINE. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5447983-9
Physician from ITALY reported TIPRANAVIR problem on Aug 30, 2007. Male patient, weighting 158.7 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: hemiparesis. TIPRANAVIR dosage: 1000MG TIPRANAVIR + 400MG RITONAVIR. During the same period patient was treated with DIDANOSINE, TENOFOVIR DISOPROXIL FUMARATE. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5450522-X
TIPRANAVIR problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 04, 2007. Male patient, weighting 156.5 lb, was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: asthma, hypersensitivity. TIPRANAVIR dosage: TPV/R 1000/400MG. During the same period patient was treated with ROSUVASTATIN. Patient was hospitalized. Patient recovered.
Tipranavir Side Effects Report #5457593-5
Consumer or non-health professional from UNITED STATES reported TIPRANAVIR problem on Sept 11, 2007. Male patient, weighting 194.0 lb, was diagnosed with hiv infection and was treated with TIPRANAVIR. After drug was administered, patient experienced the following problems/side effects: condition aggravated, neuropathy peripheral, oedema peripheral, pulmonary embolism. TIPRANAVIR dosage: unknown. During the same period patient was treated with ABACAVIR, VIRAMUNE, OXYCODONE, COZAAR, ZETIA, TRAZODONE, LYRICA, AMBIEN. Patient was hospitalized. Patient recovered.
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Drug Information: Tipranavir
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a606009.html
(tip ra' na veer)IMPORTANT WARNING:
| Tipranavir taken with ritonavir (Norvir) may cause bleeding in the brain. This condition may be life-threatening. Tell your doctor if you have recently had surgery or if you have recently been injured in any way. Also tell your doctor if you have a bleeding disorder such as hemophilia (condition in which the blood does not clot normally). Tell your doctor and pharmacist if you are taking any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin), aspirin, cilostazol (Pletal), clopidogrel (Plavix), or ticlopidine (Ticlid). If you need to get emergency medical treatment for any reason, be sure to tell all of the doctors who treat you that you are taking tipranavir. Call your doctor immediately if you experience unusual bruising or bleeding during your treatment with tipranavir.Tipranavir taken with ritonavir (Norvir) may cause liver damage that may be life-threatening. Tell your doctor if you have or have ever had hepatitis (swelling of the liver caused by a virus) or any other liver disease. Tell your doctor and pharmacist if you are taking acetaminophen (Tylenol, others); cholesterol lowering medications (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor) and simvastatin (Zocor); iron products; isoniazid (INH, Nydrazid);methotrexate (Rheumatrex); niacin (nicotinic acid);rifampin (Rifadin, Rimactane); and salicylate pain relievers (aspirin, others). If you experience any of the following symptoms, stop taking tipranavir and call your doctor immediately: tiredness; flu-like symptoms; loss of appetite; upset stomach; pain, ache, swelling, or sensitivity on your right side below your ribs; yellowing of the skin or eyes; dark (tea-colored) urine; or pale bowel movements.Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to tipranavir. Talk to your doctor about the risks of taking tipranavir. |
Why is this medication prescribed?
Tipranavir is used with ritonavir (Norvir) and at least two other medications to treat human immunodeficiency virus (HIV). Tipranavir is in a class of medications called protease inhibitors. It works by slowing the spread of HIV in the body. Tipranavir does not cure HIV infection and may not prevent you from developing HIV-related illnesses. Tipranavir does not prevent you from spreading HIV to other people.
How should this medicine be used?
Tipranavir comes as a capsule to take by mouth. It is usually taken with food and with ritonavir twice a day. Take tipranavir and ritonavir at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tipranavir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Do not take tipranavir without ritonavir.
Swallow the capsules whole; do not chew them.
Tipranavir controls HIV but does not cure it. Continue to take tipranavir even if you feel well. Do not stop taking tipranavir without talking to your doctor. If you stop taking tipranavir or skip doses, your condition may become more difficult to treat. When your supply of tipranavir starts to run low, get more from your doctor or pharmacist.
Ask your doctor or pharmacist for a copy of the manufacturer's information for the patient. Read this information carefully and ask your doctor or pharmacist if you have any questions.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking tipranavir,
- tell your doctor and pharmacist if you are allergic to tipranavir, ritonavir (Norvir), sulfa medications, any other medications, or any of the ingredients in tipranavir. Ask your pharmacist if you are unsure if a medication you are allergic to is a sulfa medication.
- do not take tipranavir if you are taking astemizole (Hismanal) (no longer available in the United States); cisapride (Propulsid) (no longer available in the United States); ergot medications for migraines such as dihydroergotamine (D.H.E. 45, Migranal), ergoloid mesylate (Hydergine), ergotamine (Bellamine, Cafergot, Ergomar, others), or methylergonovine (Methergine); certain medications for irregular heartbeat including amiodarone (Pacerone), bepridil (Vascor) (no longer available in the United States), flecainide (Tambocor), propafenone (Rythmol), or quinidine (Quinaglute); midazolam (Versed); pimozide (Orap); terfenadine (Seldane) (no longer available in the United States); and triazolam (Halcion).
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend); calcium-channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Lexxel, Plendil), nicardipine (Cardene), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan, others); clarithromycin (Biaxin, in Prevpac); desipramine (Norpramin); disulfiram (Antabuse); immunosuppressants such as cyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf); medications for diabetes such as glimepiride (Amaryl), glipizide (Glucotrol, in Metaglip), glyburide (Diabeta, Glycron, Glynase, Micronase, others), pioglitazone (Actos, in Actoplus), repaglinide (Prandin), or tolbutamide; certain medications for erectile dysfunction including sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra); other medications for HIV including amprenavir (Agenerase), lopinavir (in Kaletra), and saquinavir (Invirase); meperidine (Demerol, in Mepergan); methadone (Dolophine, Methadose); metronidazole (Flagyl); rifabutin (Mycobutin); and selective-serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem, in Symbyax), paroxetine (Paxil), or sertraline (Zoloft). Many other medications may also interact with tipranavir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Be sure to talk to your doctor or pharmacist before you begin taking any new medications during your treatment with tipranavir. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- If you are taking didanosine, take it 2 hours before or 2 hours after you take tipranavir.
- If you are taking antacids, take them 2 hours before or 4 hours after you take tipranavir.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had diabetes or high blood sugar; high blood cholesterol or triglycerides (blood fats); or an infection that comes and goes such as tuberculosis (TB), cytomegalovirus (CMV), herpes, shingles, or pneumonia.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking tipranavir, call your doctor. Do not breastfeed if you are infected with HIV or are taking tipranavir.
- you should know that tipranavir may decrease the effectiveness of hormonal contraceptives (birth control pills, rings, patches, and injections). Talk to your doctor about other ways to prevent pregnancy while you are taking this medication.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tipranavir.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Tipranavir may make your skin sensitive to sunlight.
- you should know that your body fat may increase or move to different areas of your body such as your breasts and upper back.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Tipranavir may cause hyperglycemia (high blood sugar). Call your doctor if you have any of the following symptoms of hyperglycemia:
- extreme thirst
- frequent urination
- extreme hunger
- weakness
- blurred vision
If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of the these symptoms:
- dry mouth
- upset stomach and vomiting
- shortness of breath
- breath that smells fruity
- decreased consciousness
Tipranavir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea
- vomiting
- headache
- difficulty falling asleep or staying asleep
- depression
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
- fever, chills, cough, or other signs of infection
- rash
- itching
- throat tightness
- difficulty breathing or swallowing
- joint pain or stiffness
Tipranavir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store unopened bottles of tipranavir capsules in the refrigerator. Store opened bottles of tipranavir at room temperature, and away from excess heat and moisture (not in the bathroom). Throw away any unused tipranavir capsules 60 days after you open the bottle Mark the date you open the bottle of tipranavir on the label so you will know when it is time to throw the remaining medication away. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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