Tobramycin Side Effects
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Tobramycin Safety Reports reported to FDA
Total Tobramycin reports: 17.Tobramycin FDA safety alerts: No.
Reported hospitalizations: 4.
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Reported Tobramycin Side Effects: renal failure acute, blood creatinine increased, eosinophilia, bronchospasm, nausea, arthritis infective, dacryostenosis acquired, haemodialysis, deafness, condition aggravated, visual acuity reduced.
Tobramycin Usage.
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Tobramycin Side Effects Report #5239013-9
Physician from UNITED STATES reported TOBRAMYCIN problem on Jan 29, 2007. Female patient, 82 years of age, was diagnosed with hip arthroplasty, infection and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, arthritis infective, cellulitis, haematocrit decreased, haemoglobin decreased, incision site erythema, influenza like illness, renal failure acute, septic shock. TOBRAMYCIN dosage: unknown. During the same period patient was treated with INTRANASAL CALCITONIN, WEEKLY ALENDRONATE, FAMOTIDINE. Patient recovered.
Tobramycin Side Effects Report #5239052-8
TOBRAMYCIN problem was reported by a Physician from UNITED STATES on Jan 29, 2007. Male patient, 79 years of age, was diagnosed with device related infection, joint arthroplasty and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: arthritis infective, constipation, dehydration, nausea, renal failure acute, surgical procedure repeated, vomiting. TOBRAMYCIN dosage: unknown. During the same period patient was treated with TRAVOPROST EYE DROPS, TAMSULOSIN, WARFARIN, FUROSEMIDE, VERAPAMIL, POTASSIUM CHLORIDE, POLYETHYLENE GLYCOL IN WATER. Patient recovered.
Tobramycin Side Effects Report #5280340-7
Health Professional from UNITED STATES reported TOBRAMYCIN problem on Mar 26, 2007. Male patient, child 2 years of age, was diagnosed with pseudomonas infection, staphylococcal infection and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: bronchospasm, eosinophilia, hypersensitivity, lung infiltration. TOBRAMYCIN dosage: unknown. During the same period patient was treated with CEFTAZIDIME. Patient was hospitalized. Patient recovered.
Tobramycin Side Effects Report #5316946-6
TOBRAMYCIN problem was reported by a Health Professional from UNITED STATES on May 01, 2007. Female patient, 48 years of age, weighting 155.0 lb, was diagnosed with condition aggravated, cystic fibrosis and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: balance disorder, fall, nausea, ototoxicity, renal failure acute, vestibular disorder. TOBRAMYCIN dosage: TOBRAMYCIN 300MG IV. Patient was hospitalized. Patient recovered.
Tobramycin Side Effects Report #5319902-7
Consumer or non-health professional from UNITED STATES reported TOBRAMYCIN problem on Apr 27, 2007. Male patient, child 5 years of age, was diagnosed with pseudomonas infection and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: bronchospasm, eosinophilia. TOBRAMYCIN dosage: unknown. During the same period patient was treated with PANCREATIC ENZYMES, VITAMINS, ALBUTEROL, CROMOLYN, PULMOZYME. Patient recovered.
Tobramycin Side Effects Report #5085084-2
TOBRAMYCIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 31, 2006. Male patient, 55 years of age, was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: intraocular lens dislocation, intraocular pressure increased, medical device complication, post procedural complication, vision blurred, visual acuity reduced. TOBRAMYCIN dosage: unknown. During the same period patient was treated with CIPROFLOXACIN SOLUTION, PREDNISOLONE, KETOROLAC TROMETHAMINE, PREDNISOLONE ACETATE, LOTEPREDNOL ETABONATE, LEVOFLOXACIN, DICLOFENAC. Patient recovered.
Tobramycin Side Effects Report #5141864-6
Consumer or non-health professional from FRANCE reported TOBRAMYCIN problem on Aug 04, 2006. Female patient, 89 years of age, was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: condition aggravated, renal failure. TOBRAMYCIN dosage: unknown. During the same period patient was treated with TROPICAMIDE, INDOMETHACIN, EPOETIN BETA, RAMIPRIL, FUROSEMIDE, FERROUS SULPHATE, ALLOPURINOL. Patient recovered.
Tobramycin Side Effects Report #5415444-9
TOBRAMYCIN problem was reported by a Pharmacist from UNITED STATES on Aug 13, 2007. Male patient, 78 years of age, weighting 224.9 lb, was diagnosed with upper respiratory tract infection and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: deafness. TOBRAMYCIN dosage: 300 MG TWICE A DAY INHAL. Patient recovered.
Tobramycin Side Effects Report #5425829-2
Consumer or non-health professional from UNITED KINGDOM reported TOBRAMYCIN problem on Aug 16, 2007. Female patient, child 12 years of age, was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, renal failure acute. TOBRAMYCIN dosage: 4.08 MG/KG, BID. During the same period patient was treated with IBUPROFEN, POLYMYXIN. Patient recovered.
Tobramycin Side Effects Report #5427124-4
TOBRAMYCIN problem was reported by a Consumer or non-health professional from UNITED KINGDOM on Aug 16, 2007. Female patient, child 12 years of age, was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, renal failure acute. TOBRAMYCIN dosage: 4.08 MG/KG, BID. During the same period patient was treated with IBUPROFEN, POLYMYXIN. Patient recovered.
Tobramycin Side Effects Report #5440797-5
Physician from UNITED KINGDOM reported TOBRAMYCIN problem on Aug 21, 2007. Female patient, child 11 years of age, was diagnosed with cystic fibrosis and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: renal failure acute. TOBRAMYCIN dosage: unknown. During the same period patient was treated with COLISTIN SULPHATE, IBUPROFEN. Patient recovered.
Tobramycin Side Effects Report #5440804-X
TOBRAMYCIN problem was reported by a Physician from UNITED KINGDOM on Aug 21, 2007. Female patient, 17 years of age, was diagnosed with cystic fibrosis and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: haemodialysis, renal failure acute. TOBRAMYCIN dosage: unknown. During the same period patient was treated with COLISTIN SULPHATE. Patient recovered.
Tobramycin Side Effects Report #5440805-1
Physician from UNITED KINGDOM reported TOBRAMYCIN problem on Aug 21, 2007. Male patient, child 9 years of age, was diagnosed with cystic fibrosis and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: renal failure acute. TOBRAMYCIN dosage: unknown. During the same period patient was treated with GENTAMICIN, INDOMETHACIN. Patient recovered.
Tobramycin Side Effects Report #5440806-3
TOBRAMYCIN problem was reported by a Physician from UNITED KINGDOM on Aug 21, 2007. Female patient, 15 years of age, was diagnosed with cystic fibrosis and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: renal failure acute. TOBRAMYCIN dosage: unknown. During the same period patient was treated with COLISTIN SULPHATE. Patient recovered.
Tobramycin Side Effects Report #5440859-2
Physician from UNITED KINGDOM reported TOBRAMYCIN problem on Aug 21, 2007. Male patient, 15 years of age, was diagnosed with cystic fibrosis and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: renal failure acute. TOBRAMYCIN dosage: unknown. Patient recovered.
Tobramycin Side Effects Report #5444309-1
TOBRAMYCIN problem was reported by a Pharmacist from UNITED STATES on Sept 04, 2007. Female patient, 25 years of age, was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased. TOBRAMYCIN dosage: 120 TO 320 MG -SEE TEXT- Q12 TO Q24 HOURS IV. During the same period patient was treated with ZOSYN. Patient was hospitalized. Patient recovered.
Tobramycin Side Effects Report #5465195-X
Consumer or non-health professional from UNITED STATES reported TOBRAMYCIN problem on July 09, 2007. Male patient was diagnosed with conjunctivitis and was treated with TOBRAMYCIN. After drug was administered, patient experienced the following problems/side effects: dacryostenosis acquired. TOBRAMYCIN dosage: unknown. Patient was hospitalized. Patient recovered.
Drug Information: Tobramycin Sulfate Injection
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a681003.html
(toe bra mye' sin)IMPORTANT WARNING:
| Tobramycin can cause severe hearing and kidney problems. Before administering tobramycin, tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially diuretics ('water pills'), cisplatin (Platinol), amphotericin (Amphotec, Fungizone), other antibiotics, and vitamins.If you experience any of the following symptoms, call your health care provider immediately: dizziness, vertigo, ringing in the ears, hearing loss, numbness, muscle twitching or weakness, difficulty breathing, decreased urination, rash, itching, or sore throat. |
About your treatment
Your doctor has ordered tobramycin, an antibiotic, to help treat your infection. The drug will be either injected into a large muscle (such as your buttock or hip) or added to an intravenous fluid that will drip through a needle or catheter placed in your vein for at least 30 minutes, one to three times a day.
Tobramycin eliminates bacteria that cause many kinds of infections, including lung, skin, bone, joint, stomach, blood, and urinary tract infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how your infection and symptoms respond to the medication.
Precautions
Before administering tobramycin,
- tell your doctor and pharmacist if you are allergic to amikacin, gentamicin (Garamycin), kanamycin (Kantrex), neomycin, netilmicin (Netromycin), streptomycin, tobramycin, or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially diuretics ('water pills'), cisplatin (Platinol), amphotericin (Amphotec, Fungizone), other antibiotics, and vitamins.
- tell your doctor if you have or have ever had kidney disease, vertigo, hearing loss, ringing in the ears, myasthenia gravis, or Parkinson's disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking tobramycin, call your doctor immediately. Tobramycin can harm the fetus.
Administering your medication
Before you administer tobramycin, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.
It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason because your infection could worsen and result in hospitalization. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.
Side effects
Tobramycin occasionally causes side effects. To reduce this risk, your health care provider may adjust your dose based on your blood test results. Follow the directions in the IMPORTANT WARNING section for the symptoms listed there and tell your health care provider if any of the following symptoms are severe or do not go away:
- upset stomach
- vomiting
- fatigue
- pale skin
If you experience any of the following symptoms, call your doctor immediately:
- severe rash
- difficulty breathing
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
Storing your medication
- Your health care provider probably will give you a several-day supply of tobramycin at a time. If you are receiving tobramycin intravenously (in your vein), you probably will be told to store it in the refrigerator or freezer.
- Take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature.
- If you are told to store additional tobramycin in the freezer, always move a 24-hour supply to the refrigerator for the next day's use.
- Do not refreeze medications.
If you are receiving tobramycin intramuscularly (in your muscle), your health care provider will tell you how to store it properly.
Store your medication only as directed. Make sure you understand what you need to store your medication properly.
Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Signs of infection
If you are receiving tobramycin in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these effects near your intravenous catheter, tell your health care provider as soon as possible:
- tenderness
- warmth
- irritation
- drainage
- redness
- swelling
- pain
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