Common Trazodone Side Effects


The most commonly reported Trazodone side effects (click to view or check a box to report):

Completed Suicide (152)
Priapism (88)
Dizziness (76)
Insomnia (69)
Nausea (68)
Cardiac Arrest (65)
Respiratory Arrest (63)
Depression (60)
Anxiety (57)
Pain (55)
Headache (52)
Vomiting (49)
Confusional State (46)
Fatigue (46)
Dyspnoea (43)
Asthenia (43)
Overdose (41)
Serotonin Syndrome (41)
Diarrhoea (38)
Suicide Attempt (34)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Trazodone Side Effects Reported to FDA



Trazodone Side Effect Report#9997921
Abdominal Pain Upper
This is a report of a female patient (weight: NA) from US, suffering from the following health symptoms/conditions: insomnia, who was treated with Trazodone Hydrochloride Tablets (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Abdominal Pain Upper after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Trazodone Hydrochloride Tablets treatment in female patients, resulting in Abdominal Pain Upper side effect.
Trazodone Side Effect Report#9997908
Feeling Hot, Aggression, Disturbance In Attention
This report suggests a potential Trazodone Hydrochloride Tablets 50mg Feeling Hot side effect(s) that can have serious consequences. A 48-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Trazodone Hydrochloride Tablets 50mg (dosage: NA) starting 201309. After starting Trazodone Hydrochloride Tablets 50mg the patient began experiencing various side effects, including: Feeling Hot, Aggression, Disturbance In AttentionAdditional drugs used concurrently: NA. Although Trazodone Hydrochloride Tablets 50mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Feeling Hot, may still occur.
Trazodone Side Effect Report#9997903
Pollakiuria
This Pollakiuria problem was reported by a consumer or non-health professional from US. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: insomnia. On NS this consumer started treatment with Trazodone Hydrochloride Tablets 50mg (dosage: NA). The following drugs were being taken at the same time:
  • Plavix (Unk)
When using Trazodone Hydrochloride Tablets 50mg, the patient experienced the following unwanted symptoms/side effects: PollakiuriaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pollakiuria, may become evident only after a product is in use by the general population.
Trazodone Side Effect Report#9997899
Muscular Weakness, Fatigue
This Muscular Weakness side effect was reported by a consumer or non-health professional from US. A 41-year-old female patient (weight:NA) experienced the following symptoms/conditions: insomnia.The patient was prescribed Trazodone Hydrochloride Tablets (drug dosage: NA), which was initiated on 201303. Concurrently used drugs:
  • Trazodone Hydrochloride Tablets 50mg
  • Cymbalta
  • Elmiron
  • Omeprazole
  • Topiramate
  • D3
  • Vitamin B Complex
.After starting to take Trazodone Hydrochloride Tablets the consumer reported adverse symptoms, such as: Muscular Weakness, FatigueThese side effects may potentially be related to Trazodone Hydrochloride Tablets.
Trazodone Side Effect Report#9997893
Aggression, Incorrect Dose Administered
This is a report of a 11-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: insomnia, who was treated with Trazodone Hydrochloride Tablets 50mg (dosage: NA, start time: 201309), combined with: NA. and developed a serious reaction and side effect(s): Aggression, Incorrect Dose Administered after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Trazodone Hydrochloride Tablets 50mg treatment in male patients, resulting in Aggression side effect.
Trazodone Side Effect Report#9997885
Ocular Hyperaemia
This report suggests a potential Trazodone Hydrochloride Tablets 50mg Ocular Hyperaemia side effect(s) that can have serious consequences. A 62-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: insomnia and used Trazodone Hydrochloride Tablets 50mg (dosage: NA) starting 2013. After starting Trazodone Hydrochloride Tablets 50mg the patient began experiencing various side effects, including: Ocular HyperaemiaAdditional drugs used concurrently: NA. Although Trazodone Hydrochloride Tablets 50mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Ocular Hyperaemia, may still occur.
Trazodone Side Effect Report#9981603
Pruritus
This Pruritus problem was reported by a pharmacist from US. A 15-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Feb 18, 2014 this consumer started treatment with Trazodone (dosage: Bedtime). The following drugs were being taken at the same time:
  • Seroquel
  • Prilosec
  • Zoloft
When using Trazodone, the patient experienced the following unwanted symptoms/side effects: PruritusAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pruritus, may become evident only after a product is in use by the general population.
Trazodone Side Effect Report#9975828
Suicidal Ideation, Paranoia, Myalgia, Myalgia, Agitation
This Suicidal Ideation side effect was reported by a consumer or non-health professional from GB. A 65-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Trazodone (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Trazodone the consumer reported adverse symptoms, such as: Suicidal Ideation, Paranoia, Myalgia, Myalgia, AgitationThese side effects may potentially be related to Trazodone.
Trazodone Side Effect Report#9961328
Uterine Perforation, Ectopic Pregnancy With Contraceptive Device, Ectopic Pregnancy With Contraceptive Device, Ruptured Ectopic Pregnancy, Depression, Anxiety, Fear Of Pregnancy, Injury
This is a report of a 21-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Trazodone (dosage: Unk, start time:
Apr 04, 2006), combined with:
  • Lorazepam (Unk)
  • Mirena (20 Mcg/24hr, Cont)
  • Percocet
  • Ibuprofen
and developed a serious reaction and side effect(s): Uterine Perforation, Ectopic Pregnancy With Contraceptive Device, Ectopic Pregnancy With Contraceptive Device, Ruptured Ectopic Pregnancy, Depression, Anxiety, Fear Of Pregnancy, Injury after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Trazodone treatment in female patients, resulting in Uterine Perforation side effect. The patient was hospitalized.
Trazodone Side Effect Report#9931964
Arthralgia, Joint Crepitation, Post Procedural Complication
This report suggests a potential Trazodone Arthralgia side effect(s) that can have serious consequences. A 72-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: sleep disorder and used Trazodone (dosage: 1-2 Tabs At Bedtime W/food?) starting
Feb 13, 2014. After starting Trazodone the patient began experiencing various side effects, including: Arthralgia, Joint Crepitation, Post Procedural ComplicationAdditional drugs used concurrently:
  • Heart Meds
  • Warfarin
The patient was hospitalized. Although Trazodone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Arthralgia, may still occur.
Trazodone Side Effect Report#9928401
Myalgia, Disorientation, Hallucination, Fall, Muscle Spasms, Hand Fracture, Contusion, Cerebrovascular Accident, Laceration
This Myalgia problem was reported by a health professional from US. A 68-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: insomnia,anxiety. On NS this consumer started treatment with Trazodone (dosage: More Than 1 Year 2 Pills As Needed Prn As Needed Oral). The following drugs were being taken at the same time: NA. When using Trazodone, the patient experienced the following unwanted symptoms/side effects: Myalgia, Disorientation, Hallucination, Fall, Muscle Spasms, Hand Fracture, Contusion, Cerebrovascular Accident, LacerationThe patient was hospitalized and became disabled.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Myalgia, may become evident only after a product is in use by the general population.
Trazodone Side Effect Report#9909192
Priapism
This Priapism side effect was reported by a pharmacist from US. A 30-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Trazodone (drug dosage: 200 Po), which was initiated on NS. Concurrently used drugs:
  • Zolpidem
  • Quetiapine
.After starting to take Trazodone the consumer reported adverse symptoms, such as: PriapismThese side effects may potentially be related to Trazodone.
Trazodone Side Effect Report#9887787
Hypotension, Neuroleptic Malignant Syndrome, Arrhythmia
This is a report of a 39-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: sleep disorder, who was treated with Trazodone (dosage: NA, start time:
Mar 18, 2010), combined with:
  • Zolpidem
and developed a serious reaction and side effect(s): Hypotension, Neuroleptic Malignant Syndrome, Arrhythmia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Trazodone treatment in female patients, resulting in Hypotension side effect. The patient was hospitalized.
Trazodone Side Effect Report#9884174
Palpitations, Anxiety, Nasal Congestion, Chest Pain
This report suggests a potential Trazodone 50 Mg Palpitations side effect(s) that can have serious consequences. A 44-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: insomnia and used Trazodone 50 Mg (dosage: NA) starting
Feb 05, 2014. After starting Trazodone 50 Mg the patient began experiencing various side effects, including: Palpitations, Anxiety, Nasal Congestion, Chest PainAdditional drugs used concurrently: NA. Although Trazodone 50 Mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Palpitations, may still occur.
Trazodone Side Effect Report#9870251
Completed Suicide
This Completed Suicide problem was reported by a physician from US. A 91-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Trazodone Hydrochloride (dosage: NA). The following drugs were being taken at the same time:
  • Hydromorphone
  • Acetaminophen
When using Trazodone Hydrochloride, the patient experienced the following unwanted symptoms/side effects: Completed SuicideAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Completed Suicide, may become evident only after a product is in use by the general population.
Trazodone Side Effect Report#9867211
This Death side effect was reported by a physician from US. A 32-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Trazodone Hydrochloride (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Citalopram
  • Heroin
.After starting to take Trazodone Hydrochloride the consumer reported adverse symptoms, such as: These side effects may potentially be related to Trazodone Hydrochloride.
Trazodone Side Effect Report#9861733
Completed Suicide
This is a report of a 85-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Trazodone Hydrochloride Tablets (dosage: NA, start time: NS), combined with:
  • Acetaminophen W/hydrocodone
and developed a serious reaction and side effect(s): Completed Suicide after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Trazodone Hydrochloride Tablets treatment in female patients, resulting in Completed Suicide side effect.
Trazodone Side Effect Report#9857409
This report suggests a potential Trazodone Death side effect(s) that can have serious consequences. A 45-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Trazodone (dosage: NA) starting NS. After starting Trazodone the patient began experiencing various side effects, including:Additional drugs used concurrently:
  • Morphine Sulfate
  • Oxycodone
Although Trazodone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Trazodone Side Effect Report#9856470
Completed Suicide
This Completed Suicide problem was reported by a physician from US. A 44-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Trazodone Hydrochloride Tablets (dosage: NA). The following drugs were being taken at the same time:
  • Propranolol
When using Trazodone Hydrochloride Tablets, the patient experienced the following unwanted symptoms/side effects: Completed SuicideAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Completed Suicide, may become evident only after a product is in use by the general population.
Trazodone Side Effect Report#9854900
Completed Suicide
This Completed Suicide side effect was reported by a physician from US. A 54-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Trazodone Hydrochloride Tablets (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Lamotrigine Tablets
  • Citalopram
  • Fluoxetine Hydrochloride Oral Solution
  • Ethanol
.After starting to take Trazodone Hydrochloride Tablets the consumer reported adverse symptoms, such as: Completed SuicideThese side effects may potentially be related to Trazodone Hydrochloride Tablets.
Trazodone Side Effect Report#9852532
Completed Suicide
This is a report of a 39-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Trazodone Hydrochloride Tablets (dosage: ; Po, start time: NS), combined with:
  • Amitriptyline (; Po)
and developed a serious reaction and side effect(s): Completed Suicide after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Trazodone Hydrochloride Tablets treatment in female patients, resulting in Completed Suicide side effect.
Trazodone Side Effect Report#9852502
Accidental Exposure To Product
This report suggests a potential Trazodone Hydrochloride Tablets Accidental Exposure To Product side effect(s) that can have serious consequences. A 48-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Trazodone Hydrochloride Tablets (dosage: NA) starting NS. After starting Trazodone Hydrochloride Tablets the patient began experiencing various side effects, including: Accidental Exposure To ProductAdditional drugs used concurrently:
  • Amitriptyline
Although Trazodone Hydrochloride Tablets demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Accidental Exposure To Product, may still occur.
Trazodone Side Effect Report#9851793
Cardio-respiratory Arrest
This Cardio-respiratory Arrest problem was reported by a consumer or non-health professional from US. A 56-year-old patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Trazodone Hydrochloride Tablets (dosage: NA). The following drugs were being taken at the same time:
  • Citalopram
  • Ethanol
When using Trazodone Hydrochloride Tablets, the patient experienced the following unwanted symptoms/side effects: Cardio-respiratory ArrestAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cardio-respiratory Arrest, may become evident only after a product is in use by the general population.
Trazodone Side Effect Report#9849300
Narcolepsy, Arthralgia, Myalgia
This Narcolepsy side effect was reported by a consumer or non-health professional from US. A 67-year-old male patient (weight:NA) experienced the following symptoms/conditions: insomnia.The patient was prescribed Trazodone (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Trazodone the consumer reported adverse symptoms, such as: Narcolepsy, Arthralgia, MyalgiaThese side effects may potentially be related to Trazodone.
Trazodone Side Effect Report#9832620
Stevens-johnson Syndrome, Laboratory Test Abnormal
This is a report of a 43-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Trazodone (dosage: NA, start time: NS), combined with:
  • Allopurinol Tablets
  • Revatio
  • Coreg
  • Omeprazole
  • Ativan (Prn)
  • Lasix
  • Kcl
  • Oxycodone
and developed a serious reaction and side effect(s): Stevens-johnson Syndrome, Laboratory Test Abnormal after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Trazodone treatment in male patients, resulting in Stevens-johnson Syndrome side effect. The patient was hospitalized.


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The appearance of Trazodone on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Trazodone Side Effects for Women?

Women Side Effects Reports
Completed Suicide 83
Nausea 56
Dizziness 49
Depression 42
Anxiety 38
Headache 38
Pain 38
Cardiac Arrest 37
Fatigue 37
Insomnia 37

What are common Trazodone Side Effects for Men?

Men Side Effects Reports
Priapism 87
Completed Suicide 46
Insomnia 32
Dizziness 25
Respiratory Arrest 21
Suicide Attempt 21
Cardiac Arrest 20
Confusional State 20
Anxiety 19
Erectile Dysfunction 19

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Trazodone reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    How Effective is Trazodone for You?

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    Trazodone Safety Alerts, Active Ingredients, Usage Information

    NDC 0179-1118
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name Trazodone Hydrochloride
    Name Trazodone Hydrochloride
    Dosage Form TABLET
    Route ORAL
    On market since 19871222
    Labeler KAISER FOUNDATION HOSPITALS
    Active Ingredient(s) TRAZODONE HYDROCHLORIDE
    Strength(s) 50
    Unit(s) mg/1
    Pharma Class Serotonin Reuptake Inhibitor [EPC]

    More About Trazodone

    Side Effects reported to FDA: 1458

    Trazodone safety alerts: 2004

    Reported deaths: 160

    Reported hospitalizations: 350

    Desyrel (trazodone hydrochloride)

    Audience: Neuropsychiatric healthcare professionals

    FDA and Bristol-Myers Squibb notified healthcare professionals of revisions to the CLINICAL PHARMACOLOGY and PRECAUTIONS sections of the Desyrel labeling. Desyrel is indicated for the treatment of depression. In vitro drug metabolism studies suggest that there is a potential for drug interactions when trazodone is given with the CYP3A4 inhibitors ketoconazole, ritonavir, and indinavir. It is likely that CYP3A4 inhibitors may lead to substantial increases in trazodone plasma concentrations with the potential for adverse effects. If trazodone is used with a potent CYP3A4 inhibitor, a lower dose of trazodone should be considered. Conversely, carbamazepine reduced plasma concentrations of trazodone when coadministered. Patients should be closely monitored to see if there is a need for an increased dose of trazodone when taken with carbamazepine.

    [May, 2004 - Letter - Bristol-Myers Squibb]

    Latest Trazodone clinical trials