Tretinoin Safety Questions, Tretinoin Answers
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Tretinoin Safety Reports
Total Tretinoin reports: 12.Tretinoin FDA safety alerts: 2001 2002 2005 2006 2007 .
Reported deaths: 2 Reported hospitalizations: 7.
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Reported Tretinoin Side Effects: renal failure, embolism, aplasia, myelodysplastic syndrome, metastases to liver, septic shock, pleurisy, colitis, adenocarcinoma, synovitis, pyrexia.
Tretinoin Usage.
Tretinoin Side Effects Report #5288952-1
Physician from UNITED STATES reported TRETINOIN problem on Nov 29, 2005. Male patient, 34 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: scrotal ulcer. TRETINOIN dosage: 50 MG/M2 2 PER DAY. During the same period patient was treated with IDARUBICIN. Patient recovered.
Tretinoin Side Effects Report #5238205-2
TRETINOIN problem was reported by a Health Professional from UNITED KINGDOM on Feb 13, 2007. Female patient, 34 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: embolism, renal failure, respiratory failure. TRETINOIN dosage: unknown. During the same period patient was treated with APROTININ, CYTOSINE ARABINOSIDE, DAUNORUBICIN. Patient died.
Tretinoin Side Effects Report #5294571-3
Consumer or non-health professional from UNITED STATES reported TRETINOIN problem on Apr 09, 2007. Female patient, weighting 125.0 lb, was diagnosed with acne and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: blister, erythema, pruritus, swelling. TRETINOIN dosage: unknown. Patient was hospitalized. Patient recovered.
Tretinoin Side Effects Report #5327262-0
TRETINOIN problem was reported by a Health Professional from AUSTRALIA on May 08, 2007. Male patient, child 3 years of age, was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: blood amylase increased, pancreatitis, sepsis. TRETINOIN dosage: unknown. During the same period patient was treated with SULFAMETHOXAZOLE AND TRIMETHOPRIM, FRUSEMIDE, ONDANSETRON HYDROCHLORIDE DIHYDRATE, OMEPRAZOLE, MELPHALAN, FLUCONAZOLE, GENTAMICIN, CLAVULANIC ACID. Patient was hospitalized. Patient recovered.
Tretinoin Side Effects Report #5060460-2
Pharmacist from UNITED STATES reported TRETINOIN problem on July 21, 2006. Male patient, 74 years of age, weighting 189.6 lb, was diagnosed with acute promyelocytic leukaemia and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: pleural effusion, retinoic acid syndrome, weight increased. TRETINOIN dosage: 30 MG TID PO. Patient was hospitalized. Patient recovered.
Tretinoin Side Effects Report #5082682-7
TRETINOIN problem was reported by a Physician from UNITED STATES on Aug 16, 2006. Female patient, 24 years of age, weighting 126.7 lb, was diagnosed with acne and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: swelling face, urticaria. TRETINOIN dosage: unknown. During the same period patient was treated with SEASONALE, MELATONIN, VALERIAN ROOT, CLONIDINE. Patient recovered.
Tretinoin Side Effects Report #5097231-7
Consumer or non-health professional from UNITED KINGDOM reported TRETINOIN problem on Aug 25, 2006. Female patient, 34 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: acute promyelocytic leukaemia, cerebral haemorrhage, cerebral infarction, embolism, haemodialysis, hepatic infarction, pulmonary infarction, renal failure, renal necrosis. TRETINOIN dosage: unknown. During the same period patient was treated with APROTININ, THIOGUANINE, CYTOSINE ARABINOSIDE, DAUNORUBICIN. Patient was hospitalized. Patient died.
Tretinoin Side Effects Report #5121814-9
TRETINOIN problem was reported by a Physician from JAPAN on Sept 27, 2006. Female patient, 45 years of age, was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, pyrexia, synovitis. TRETINOIN dosage: unknown. Patient was hospitalized. Patient recovered.
Tretinoin Side Effects Report #5411381-4
Physician from ITALY reported TRETINOIN problem on Aug 08, 2007. Male patient, weighting 154.3 lb, was diagnosed with acute promyelocytic leukaemia and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: adenocarcinoma. TRETINOIN dosage: 80 MG. During the same period patient was treated with METHOTREXATE, MERCAPTOPURINE. Patient recovered.
Tretinoin Side Effects Report #5413248-4
TRETINOIN problem was reported by a Physician from ITALY on Aug 08, 2007. Male patient, weighting 167.6 lb, was diagnosed with acute promyelocytic leukaemia, prophylaxis and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: colitis, pleurisy, septic shock. TRETINOIN dosage: unknown. During the same period patient was treated with ALLOPURINOL, VANCOMYCIN, CEFTAZIDIME, AMIKACIN, IDARUBICIN, ITRACONAZOLE. Patient was hospitalized. Patient recovered.
Tretinoin Side Effects Report #5413338-6
Physician from ITALY reported TRETINOIN problem on Aug 08, 2007. Male patient, weighting 154.3 lb, was diagnosed with acute promyelocytic leukaemia and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: metastases to liver, myelodysplastic syndrome. TRETINOIN dosage: 80 MG. During the same period patient was treated with MERCAPTOPURINE, METHOTREXATE. Patient was hospitalized and became disabled. Patient recovered.
Tretinoin Side Effects Report #5415627-8
TRETINOIN problem was reported by a Physician from ITALY on Aug 08, 2007. Male patient, weighting 158.7 lb, was diagnosed with acute promyelocytic leukaemia and was treated with TRETINOIN. After drug was administered, patient experienced the following problems/side effects: aplasia. TRETINOIN dosage: unknown. During the same period patient was treated with MERCAPTOPURINE, METHOTREXATE, FOLIC ACID. Patient recovered.
Drug Information: Tretinoin
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682437.html
(tret' i noyn)Why is this medication prescribed?
Tretinoin is used to treat acne. It promotes peeling of affected skin areas and unclogs pores. Tretinoin controls acne but does not cure it.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Tretinoin comes in topical liquid, cream, and gel. Tretinoin usually is used daily at bedtime or once every 2 or 3 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use tretinoin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Your acne probably will get worse (red, scaling skin and an increase in acne sores) during the first 7-10 days that you use this medication. Nevertheless, continue to use it; the acne sores should disappear. Usually 2-3 weeks (and sometimes more than 6 weeks) of regular use of tretinoin is required before improvement is seen.
Use only nonmedicated cosmetics on cleansed skin. Do not use topical preparations with a lot of alcohol, menthol, spices, or lime (e.g., shaving lotions, astringents, and perfumes); they can sting your skin, especially when you first use tretinoin.
Do not use any other topical medications, especially benzoyl peroxide, salicylic acid (wart remover), and dandruff shampoos containing sulfur or resorcinol unless your doctor directs you to do so. If you have used any of these topical medications recently, ask your doctor if you should wait before using tretinoin.
If you are to apply any form of tretinoin, follow these steps:
- Wash your hands and affected skin area thoroughly with mild, bland soap (not medicated or abrasive soap or soap that dries the skin) and water. To be sure that your skin is thoroughly dry, wait 20-30 minutes before applying tretinoin.
- Use clean fingertips, a gauze pad, or a cotton swab to apply the medication.
- Use enough medication to cover the affected area lightly. Do not oversaturate the gauze pad or cotton swab.
Apply the medication to the affected skin area only (e.g., skin with acne sores).
What special precautions should I follow?
Before using tretinoin,
- tell your doctor and pharmacist if you are allergic to tretinoin or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using tretinoin, call your doctor.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Tretinoin may make your skin sensitive to sunlight.
What should I do if I forget a dose?
If you use tretinoin once a day, skip the missed dose completely. Do not use this medication more often than once a day. If you use tretinoin every 2 or 3 days and remember a missed dose within 12 hours of the time when you should have applied it, apply the missed dose immediately. Otherwise, skip the missed dose; do not apply a double dose.
What side effects can this medication cause?
Tretinoin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- warmth or slight stinging of the skin
- lightening or darkening of the skin
- red, scaling skin
- increase in acne sores
- swelling, blistering, or crusting of the skin
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
What other information should I know?
Keep all appointments with your doctor. Tretinoin is for external use only. Do not let tretinoin get into your eyes, the corner of your nose, or mouth, or any broken skin, and do not swallow it. Do not apply dressings, bandages, cosmetics, lotions, or other skin medications to the area being treated unless your doctor tells you.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
Tell your doctor if your skin condition gets worse or does not go away.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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