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Trimetazidine Side Effects

Common Trimetazidine Side Effects


The most commonly reported Trimetazidine side effects (click to view or check a box to report):

Gastrointestinal Carcinoma (2)
Dysarthria (2)
Blood Pressure Abnormal (2)
Cerebral Infarction (2)
Headache (2)
Chest Pain (2)
Hemiparesis (2)
Respiratory Failure (2)
Rhabdomyolysis (2)
Multi-organ Failure (2)
Overdose (2)
Leukaemia (1)
Prostate Cancer Metastatic (1)
Shock (1)
Laryngeal Oedema (1)
Hallucination, Visual (1)
Gastrooesophageal Reflux Disease (1)
Hypertrophy (1)
Hypothyroidism (1)
Injection Site Haematoma (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Trimetazidine Side Effects Reported to FDA

The following Trimetazidine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Trimetazidine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Hallucination, Visual, Aggression, Hypothyroidism
This is a report of a 78-year-old male patient (weight: NA) from FRANCE, suffering from the following symptoms/conditions: NA, who was treated with Trimetazidine Hydrochloride (dosage: 35 Mg, 2x/day, start time: NS), combined with:
  • Potassium Chloride (600 Mg, 1x/day)
  • Esomeprazole (40 Mg, 1x/day)
  • Nootropyl (800 Mg, 3x/day)
  • Altace (1.25 Mg, 2x/day)
  • Lasix (20 Mg, 2x/day)
  • Cordarone (200 Mg, Unk)
  • Avodart (Unk)
  • Travatan (Unk)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Hallucination, Visual
  • Aggression
  • Hypothyroidism
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Trimetazidine Hydrochloride treatment in male patients, resulting in hallucination, visual side effect. The patient was hospitalized.

Injection Site Haematoma
This report suggests a potential Trimetazidine Injection Site Haematoma side effect(s) that can have serious consequences. A 34-year-old female patient (weight: NA) from UNITED STATES was diagnosed with the following symptoms/conditions: NA and used Trimetazidine (dosage: NA) starting Oct 01, 2010. Soon after starting Trimetazidine the patient began experiencing various side effects, including:
  • Injection Site Haematoma
Drugs used concurrently:
  • Humira
  • Lorazepam
  • Elmiron
  • Ambien
  • Neurontin
  • Vicodin
  • Nexium
  • Risperdal
Although Trimetazidine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as injection site haematoma, may still occur.

Leukaemia
This Leukaemia problem was reported by a consumer or non-health professional from BRAZIL. A 65-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Dec 01, 2011 this consumer started treatment with Trimetazidine (trimetazidine) (trimetazidine) (dosage: NA). The following drugs were being taken at the same time:
  • Acetylsalicylic Acid Srt
  • Levothyroxine Sodium
  • Warfarin Sodium
  • Nilotinib (nilotinib) (nilotinib)
  • Benicar Hct (40/12.5 Mg (1 In 1 D),per Oral ; 20/12.5 Mg (1 In 1 D),per Oral)
  • Benicar Hct (40/12.5 Mg (1 In 1 D),per Oral ; 20/12.5 Mg (1 In 1 D),per Oral)
  • Amiodarone Hcl
  • Atorvastatin (atorvastatin) (atorvastatin)
When commencing Trimetazidine (trimetazidine) (trimetazidine), the patient experienced the following unwanted symptoms/side effects:
  • Leukaemia
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as leukaemia, may become evident only after a product is in use by the general population.

Shock
This is a report of a 75-year-old female patient (weight: NA) from POLAND. The patient developed the following symptoms/conditions: NA and was treated with Trimetazidine (dosage: NA) starting May 29, 2006. Concurrently used drugs:
  • Siofor
  • Sunitinib Malate (37.5 Mg, 1x/day, Daily 4/2)
  • Effox Long
  • Diabrezide
  • Molsidomina
  • Vitamin B Complex Cap
Soon after that, the consumer experienced the following side effects:
  • Shock
The patient was hospitalized. This opens a possibility that Trimetazidine treatment could cause the above reactions, including shock, and some female subjects may be more susceptible.


Blood Pressure Abnormal, Headache, Gastrointestinal Carcinoma, Overdose
A 80-year-old male patient (weight: NA) from BRAZIL with the following symptoms/conditions: NA started Trimetazidine treatment (dosage: NA) on Jul 01, 2011. Soon after starting Trimetazidine treatment, the subject experienced various side effects, including:
  • Blood Pressure Abnormal
  • Headache
  • Gastrointestinal Carcinoma
  • Overdose
Concurrently used drugs:
  • Benicar (120/15 Mg (1 D), Per Oral : 160/20 Mg (1 D), Per Oral : 40/5 Mg (1 In 1 D), Per Oral)
  • Benicar (120/15 Mg (1 D), Per Oral : 160/20 Mg (1 D), Per Oral : 40/5 Mg (1 In 1 D), Per Oral)
  • Benicar (120/15 Mg (1 D), Per Oral : 160/20 Mg (1 D), Per Oral : 40/5 Mg (1 In 1 D), Per Oral)
  • Diltiazem Hcl
This finding indicates that some male patients could be more vulnerable to Trimetazidine.

Blood Pressure Abnormal, Headache, Gastrointestinal Carcinoma, Overdose
A 80-year-old male patient from BRAZIL (weight: NA) experienced symptoms, such as: NA and was treated with Trimetazidine(dosage: NA). The treatment was initiated on Jul 01, 2011. After that a consumer reported the following side effect(s):
  • Blood Pressure Abnormal
  • Headache
  • Gastrointestinal Carcinoma
  • Overdose
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Trimetazidine efficacy:
  • Amlodipine Besylate And Olmesartan Medoxomil (120/15 Mg (1 D), Per Oral : 160/20 Mg (1 D), Per Oral : 40/5 Mg (1 In 1 D), Per Oral)
  • Amlodipine Besylate And Olmesartan Medoxomil (120/15 Mg (1 D), Per Oral : 160/20 Mg (1 D), Per Oral : 40/5 Mg (1 In 1 D), Per Oral)
  • Amlodipine Besylate And Olmesartan Medoxomil (120/15 Mg (1 D), Per Oral : 160/20 Mg (1 D), Per Oral : 40/5 Mg (1 In 1 D), Per Oral)
  • Diltiazem Hcl


Rhabdomyolysis, Chest Pain, Hemiparesis, Multi-organ Failure, Cerebral Infarction, Respiratory Failure, Dysarthria
In this report, Trimetazidine was administered for the following condition: NA.A 60-year-old male consumer from CHINA (weight: NA) started Trimetazidine treatment (dosage: NA) on Jun 03, 2011.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Rhabdomyolysis
  • Chest Pain
  • Hemiparesis
  • Multi-organ Failure
  • Cerebral Infarction
  • Respiratory Failure
  • Dysarthria
A possible interaction with other drugs could have contributed to this reaction:
  • Tcms
  • Crestor
  • Amlodipine
  • Aspirin
  • Clopidogrel
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Trimetazidine treatment could be related to the listed above side effect(s).

Gastrointestinal Haemorrhage
This is a report of the following Trimetazidine side effect(s):
  • Gastrointestinal Haemorrhage
A 73-year-old female patient from PHILIPPINES (weight: NA) presented with the following condition: NA and received a treatment with Trimetazidine (dosage: NA) starting: Aug 01, 2011.The following concurrently used drugs could have generated interactions:
  • Beta-blocker
  • Pradaxa (220 Mg)
  • Lanoxin
This report suggests that a Trimetazidine treatment could be associated with the listed above side effect(s).

Hemiparesis, Multi-organ Failure, Chest Pain, Dysarthria, Rhabdomyolysis, Respiratory Failure, Cerebral Infarction
This Trimetazidine report was submitted by a 60-year-old male consumer from CHINA (weight: NA). The patient was diagnosed with: NA and Trimetazidine was administered (dosage: NA) starting: Jun 03, 2011. The consumer developed a set of symptoms:
  • Hemiparesis
  • Multi-organ Failure
  • Chest Pain
  • Dysarthria
  • Rhabdomyolysis
  • Respiratory Failure
  • Cerebral Infarction
Other drugs used simultaneously:
  • Tcms
  • Clopidogrel
  • Amlodipine
  • Crestor
  • Aspirin
The patient was hospitalized.Those unexpected symptoms could be linked to a Trimetazidine treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Acute Myocardial Infarction
This is a report of a possible correlation between Trimetazidine Hydrochloride use and the following symptoms/side effect(s):
  • Acute Myocardial Infarction
which could contribute to an assessment of Trimetazidine Hydrochloride risk profile.A 72-year-old female consumer from JAPAN (weight: NA) was suffering from NA and was treated with Trimetazidine Hydrochloride (dosage: Unk) starting Jun 09, 2011.Other concurrent medications:
  • Ferrous Sulfate Tab (Unk)
  • Rebamipide (Unk)
  • Omega 3 /00931501/ (Unk)
  • Cinacalcet Hydrochloride (Unk)
  • Simvastatin (Unk)
  • Vitamin B/c Complex (Unk Unk, Unk)
  • Vitamin B/c Complex (Uncertainty)
  • Vitamin B/c Complex (Uncertainty)
The patient was hospitalized.

Fall, Vertigo
A 89-year-old female patient from FRANCE (weight: NA) presented with the following symptoms: NA and after a treatment with Trimetazidine Hydrochloride (dosage: NA) experienced the following side effect(s):
  • Fall
  • Vertigo
The treatment was started on Jun 15, 2011. Trimetazidine Hydrochloride was used in combination with the following drugs:
  • Tramadol Hcl
  • Seretide Diskus
  • Trimebutine
  • Isosorbide Dinitrate
  • Nitroderm
  • Acetaminophen
  • Lasix
  • Escitalopram Oxalate
The patient was hospitalized.This report could alert potential Trimetazidine Hydrochloride consumers.


In this report, a 80-year-old female patient from MOROCCO (weight: NA) was affected by a possible Trimetazidine side effect.The patient was diagnosed with NA. After a treatment with Trimetazidine (dosage: Unk, start date: Jan 01, 2008), the patient experienced the following side effect(s):
    The following simultaneously used drugs could have led to this reaction:
    • Valsartan And Hydrochlorothiazide (160/12.5 Mg, Unk)
    • Simvastatin (Unk)
    • Aspirin (Unk)
    • Insuline (Unk)
    • Digoxin (Unk)
    The findings here stress that side effects should be taken into consideration when evaluating a Trimetazidine treatment.

    Prostate Cancer Metastatic
    This is a report of a 83-year-old male patient from TUNISIA (weight: NA), who used Trimetazidine Hydrochloride (dosage: NA) for a treatment of NA. After starting a treatment on Feb 02, 2010, the patient experienced the following side effect(s):
    • Prostate Cancer Metastatic
    The following drugs could possibly have interacted with the Trimetazidine Hydrochloride treatment
    • Lasix
    • Atorvastatin
    • Aspirin
    • Nitroglycerin
    • Plavix
    • Aspirin
    • Corvasal
    • Omeprazole
    Taken together, these observations suggest that a Trimetazidine Hydrochloride treatment could be related to side effect(s), such as Prostate Cancer Metastatic.

    Gastrooesophageal Reflux Disease, Cough, Dyspepsia
    This gastrooesophageal reflux disease side effect was reported by a health professional from GREECE. A 70-year-old patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Trimetazidine Hydrochloride (dosage: NA), which was started on Jan 01, 2006. Concurrently used drugs:
    • Amlodipine Besylate
    • Amlodipine Besylate
    • Gliclazide
    • Janumet
    • Ticlopidine Hydrochloride
    • Simvastatin
    When starting to take Trimetazidine Hydrochloride the consumer reported the following symptoms:
    • Gastrooesophageal Reflux Disease
    • Cough
    • Dyspepsia
    These side effects may potentially be related to Trimetazidine Hydrochloride.

    Acute Respiratory Failure, Bronchopneumopathy
    This is a Trimetazidine Biogaran side effect report of a 72-year-old female patient (weight:NA) from FRANCE, suffering from the following symptoms/conditions: NA, who was treated with Trimetazidine Biogaran (dosage:NA, start time: NS), combined with:
    • Actonel
    • Chondrosulf
    • Bisoprolol Fumarate And Hydrochlorothiazide
    • Arava
    • Ketoprofen
    • Nexium
    • Fenofibrate
    • Buspirone Hcl
    , and developed a serious reaction and a acute respiratory failure side effect. The patient presented with:
    • Acute Respiratory Failure
    • Bronchopneumopathy
    which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Trimetazidine Biogaran treatment in female patients suffering from NA, resulting in acute respiratory failure.

    Dysphonia, Enlarged Uvula, Hypertrophy, Laryngeal Oedema
    This report suggests a potential Trimetazidine (ngx) (trimetazidine) dysphonia side effect(s) that can have serious consequences. A 85-year-old male patient from FRANCE (weight:NA) was diagnosed with the following health condition(s): NA and used Trimetazidine (ngx) (trimetazidine) (dosage: Oral) starting NS. Soon after starting Trimetazidine (ngx) (trimetazidine) the patient began experiencing various side effects, including:
    • Dysphonia
    • Enlarged Uvula
    • Hypertrophy
    • Laryngeal Oedema
    Drugs used concurrently:
    • Bisoprolol Gnr (ngx) (bisoprolol) (Oral)
    The patient was hospitalized. Although Trimetazidine (ngx) (trimetazidine) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as dysphonia, may still occur.



    Keep Track of Side Effects

    Note Your Observations

    It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

    Why Your Notes are Important

    Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    Trimetazidine Safety Alerts, Active Ingredients, Usage Information

    More About Trimetazidine

    Side Effects reported to FDA: 16

    Trimetazidine safety alerts: No

    Reported deaths: 3

    Reported hospitalizations: 4

    Latest Trimetazidine clinical trials