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Tykerb Side Effects

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Common Tykerb Side Effects


The most commonly reported Tykerb side effects (click to view or check a box to report):

Diarrhoea (1620)
Nausea (603)
Fatigue (464)
Rash (382)
Death (372)
Vomiting (356)
Palmar-plantar Erythrodysaesthesia Syndrome (294)
Decreased Appetite (183)
Dry Skin (164)
Dyspnoea (147)
Pruritus (143)
Disease Progression (132)
Stomatitis (127)
Erythema (124)
Dehydration (123)
Asthenia (120)
Pyrexia (118)
Weight Decreased (101)
Dizziness (100)
Malaise (97)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Tykerb Side Effects Reported to FDA



Tykerb Side Effect Report#9996412
This is a report of a 65-year-old female patient (weight: NA) from IN, suffering from the following health symptoms/conditions: breast cancer metastatic, who was treated with Tykerb (dosage: 4tab Per Day, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Tykerb treatment in female patients, resulting in Death side effect.
Tykerb Side Effect Report#9983790
This report suggests a potential Tykerb Death side effect(s) that can have serious consequences. A 42-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Tykerb (dosage: 1250mg Per Day) starting
Dec 18, 2013. After starting Tykerb the patient began experiencing various side effects, including:Additional drugs used concurrently: NA. Although Tykerb demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Tykerb Side Effect Report#9964345
Diarrhoea, Dehydration, Hypercalcaemia, Vomiting, Pyrexia
This Diarrhoea problem was reported by a physician from JP. A 62-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: breast cancer. On
Jan 12, 2012 this consumer started treatment with Tykerb (dosage: NA). The following drugs were being taken at the same time: NA. When using Tykerb, the patient experienced the following unwanted symptoms/side effects: Diarrhoea, Dehydration, Hypercalcaemia, Vomiting, PyrexiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Diarrhoea, may become evident only after a product is in use by the general population.
Tykerb Side Effect Report#9964329
This Death side effect was reported by a consumer or non-health professional from US. A 45-year-old female patient (weight:NA) experienced the following symptoms/conditions: breast cancer.The patient was prescribed Tykerb (drug dosage: 1250mg Per Day), which was initiated on
Jan 19, 2011. Concurrently used drugs: NA..After starting to take Tykerb the consumer reported adverse symptoms, such as: These side effects may potentially be related to Tykerb.
Tykerb Side Effect Report#9964036
Breast Cancer
This is a report of a 44-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: breast cancer, who was treated with Tykerb (dosage: 1250mg See Dosage Text, start time:
Feb 10, 2014), combined with: NA. and developed a serious reaction and side effect(s): Breast Cancer after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Tykerb treatment in female patients, resulting in Breast Cancer side effect.
Tykerb Side Effect Report#9943216
Jugular Vein Thrombosis
This report suggests a potential Tykerb Jugular Vein Thrombosis side effect(s) that can have serious consequences. A 60-year-old female patient (weight: NA) from JP was diagnosed with the following symptoms/conditions: breast cancer and used Tykerb (dosage: NA) starting
Feb 19, 2011. After starting Tykerb the patient began experiencing various side effects, including: Jugular Vein ThrombosisAdditional drugs used concurrently: NA.The patient was hospitalized. Although Tykerb demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Jugular Vein Thrombosis, may still occur.
Tykerb Side Effect Report#9922311
Disease Progression
This Disease Progression problem was reported by a consumer or non-health professional from IN. A 56-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: breast cancer metastatic. On NS this consumer started treatment with Tykerb (dosage: 1000mg Per Day). The following drugs were being taken at the same time: NA. When using Tykerb, the patient experienced the following unwanted symptoms/side effects: Disease ProgressionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Disease Progression, may become evident only after a product is in use by the general population.
Tykerb Side Effect Report#9919738
Metastases To Lymph Nodes, Erythema, Constipation, Diarrhoea, Photosensitivity Reaction, Rash Erythematous, Feeling Hot, Decreased Appetite, Weight Decreased
This Metastases To Lymph Nodes side effect was reported by a health professional from CA. A 54-year-old female patient (weight:NA) experienced the following symptoms/conditions: breast cancer metastatic.The patient was prescribed Tykerb (drug dosage: 1250mg Per Day), which was initiated on 200504. Concurrently used drugs:
  • Xeloda (1500mg Twice Per Day)
  • Herceptin
  • Kadcyla
  • Calcium Carbonate
  • Vitamin D
.After starting to take Tykerb the consumer reported adverse symptoms, such as: Metastases To Lymph Nodes, Erythema, Constipation, Diarrhoea, Photosensitivity Reaction, Rash Erythematous, Feeling Hot, Decreased Appetite, Weight DecreasedThese side effects may potentially be related to Tykerb.
Tykerb Side Effect Report#9901863
Convulsion
This is a report of a 39-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: breast cancer, who was treated with Tykerb (dosage: 1000mg Per Day, start time:
Oct 12, 2012), combined with:
  • Levetiracetam
and developed a serious reaction and side effect(s): Convulsion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Tykerb treatment in female patients, resulting in Convulsion side effect.
Tykerb Side Effect Report#9901859
This report suggests a potential Tykerb Death side effect(s) that can have serious consequences. A 83-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: breast cancer and used Tykerb (dosage: 1250mg Per Day) starting
May 10, 2012. After starting Tykerb the patient began experiencing various side effects, including:Additional drugs used concurrently:
  • Neupogen
  • Coumadin
Although Tykerb demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Tykerb Side Effect Report#9894274
Neoplasm Malignant, Mobility Decreased
This Neoplasm Malignant problem was reported by a consumer or non-health professional from US. A 63-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: neoplasm malignant. On
Jun 02, 2011 this consumer started treatment with Tykerb (dosage: NA). The following drugs were being taken at the same time: NA. When using Tykerb, the patient experienced the following unwanted symptoms/side effects: Neoplasm Malignant, Mobility DecreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Neoplasm Malignant, may become evident only after a product is in use by the general population.
Tykerb Side Effect Report#9892072
Ascites
This Ascites side effect was reported by a consumer or non-health professional from US. A 39-year-old female patient (weight:NA) experienced the following symptoms/conditions: breast cancer.The patient was prescribed Tykerb (drug dosage: 1250mg Per Day), which was initiated on
Sep 19, 2013. Concurrently used drugs: NA..After starting to take Tykerb the consumer reported adverse symptoms, such as: AscitesThese side effects may potentially be related to Tykerb. The patient was hospitalized.
Tykerb Side Effect Report#9882392
Liver Injury, Disease Progression
This is a report of a 57-year-old female patient (weight: NA) from IN, suffering from the following health symptoms/conditions: breast cancer metastatic, who was treated with Tykerb (dosage: 1250mg Per Day, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Liver Injury, Disease Progression after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Tykerb treatment in female patients, resulting in Liver Injury side effect.
Tykerb Side Effect Report#9878828
This report suggests a potential Tykerb Death side effect(s) that can have serious consequences. A 59-year-old female patient (weight: NA) from IN was diagnosed with the following symptoms/conditions: breast cancer metastatic and used Tykerb (dosage: 250mg Per Day) starting NS. After starting Tykerb the patient began experiencing various side effects, including:Additional drugs used concurrently: NA. Although Tykerb demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Tykerb Side Effect Report#9878771
Cough, Pain, Asthma, Upper Respiratory Tract Infection
This Cough problem was reported by a consumer or non-health professional from US. A 69-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: breast cancer. On
Apr 02, 2012 this consumer started treatment with Tykerb (dosage: 1250mg Per Day). The following drugs were being taken at the same time:
  • Venlafaxine
When using Tykerb, the patient experienced the following unwanted symptoms/side effects: Cough, Pain, Asthma, Upper Respiratory Tract InfectionThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cough, may become evident only after a product is in use by the general population.
Tykerb Side Effect Report#9871222
Device Related Infection, Dysphonia, Diarrhoea, Epistaxis, Breast Prosthesis User, Rhinorrhoea, Dehydration, Nasal Congestion, Frequent Bowel Movements
This Device Related Infection side effect was reported by a consumer or non-health professional from US. A 58-year-old female patient (weight:NA) experienced the following symptoms/conditions: breast cancer.The patient was prescribed Tykerb (drug dosage: 1250mg Cyclic), which was initiated on NS. Concurrently used drugs: NA..After starting to take Tykerb the consumer reported adverse symptoms, such as: Device Related Infection, Dysphonia, Diarrhoea, Epistaxis, Breast Prosthesis User, Rhinorrhoea, Dehydration, Nasal Congestion, Frequent Bowel MovementsThese side effects may potentially be related to Tykerb.
Tykerb Side Effect Report#9856695
Cholecystectomy
This is a report of a 65-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: breast cancer, who was treated with Tykerb (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Cholecystectomy after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Tykerb treatment in female patients, resulting in Cholecystectomy side effect.
Tykerb Side Effect Report#9856671
Respiratory Disorder
This report suggests a potential Tykerb Respiratory Disorder side effect(s) that can have serious consequences. A 70-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: breast cancer and used Tykerb (dosage: 250mg Cyclic) starting 2011. After starting Tykerb the patient began experiencing various side effects, including: Respiratory DisorderAdditional drugs used concurrently:
  • Lovaza (2g Twice Per Day)
  • Omeprazole (20mg Per Day)
  • Atorvastatin
  • Vitamin D
  • Diovan (80mg Per Day)
  • Venlafaxine
  • Carvedilol (1.5tab Twice Per Day)
  • Xeloda
The patient was hospitalized. Although Tykerb demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Respiratory Disorder, may still occur.
Tykerb Side Effect Report#9850301
Metastases To Central Nervous System
This Metastases To Central Nervous System problem was reported by a consumer or non-health professional from IN. A 47-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: breast cancer metastatic. On NS this consumer started treatment with Tykerb (dosage: 250mg Per Day). The following drugs were being taken at the same time: NA. When using Tykerb, the patient experienced the following unwanted symptoms/side effects: Metastases To Central Nervous SystemAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Metastases To Central Nervous System, may become evident only after a product is in use by the general population.
Tykerb Side Effect Report#9846618
Chest Pain, Chest Discomfort, Dyspnoea, Fatigue, Rash, Diarrhoea, Sensation Of Foreign Body, Speech Disorder
This Chest Pain side effect was reported by a physician from ZA. A 41-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Tykerb (drug dosage: 1250mg Per Day), which was initiated on
Jul 23, 2013. Concurrently used drugs:
  • Xeloda (1000mg Twice Per Day)
.After starting to take Tykerb the consumer reported adverse symptoms, such as: Chest Pain, Chest Discomfort, Dyspnoea, Fatigue, Rash, Diarrhoea, Sensation Of Foreign Body, Speech DisorderThese side effects may potentially be related to Tykerb.
Tykerb Side Effect Report#9842242
Cardiac Arrest, Arrhythmia
This is a report of a 49-year-old female patient (weight: NA) from JP, suffering from the following health symptoms/conditions: NA, who was treated with Tykerb (dosage: NA, start time: NS), combined with:
  • Xeloda
and developed a serious reaction and side effect(s): Cardiac Arrest, Arrhythmia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Tykerb treatment in female patients, resulting in Cardiac Arrest side effect.
Tykerb Side Effect Report#9842212
Disease Progression
This report suggests a potential Tykerb Death side effect(s) that can have serious consequences. A 94-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: breast cancer stage iv and used Tykerb (dosage: NA) starting
Jul 03, 2013. After starting Tykerb the patient began experiencing various side effects, including: Disease ProgressionAdditional drugs used concurrently: NA. Although Tykerb demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Tykerb Side Effect Report#9838369
Disease Progression, Metastases To Lung
This Disease Progression problem was reported by a physician from IN. A 45-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: breast cancer metastatic. On NS this consumer started treatment with Tykerb (dosage: 250mg Per Day). The following drugs were being taken at the same time: NA. When using Tykerb, the patient experienced the following unwanted symptoms/side effects: Disease Progression, Metastases To LungThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Disease Progression, may become evident only after a product is in use by the general population.
Tykerb Side Effect Report#9834939
This Death side effect was reported by a consumer or non-health professional from IN. A 76-year-old female patient (weight:NA) experienced the following symptoms/conditions: breast cancer metastatic.The patient was prescribed Tykerb (drug dosage: 1000mg Per Day), which was initiated on NS. Concurrently used drugs: NA..After starting to take Tykerb the consumer reported adverse symptoms, such as: These side effects may potentially be related to Tykerb. The patient was hospitalized.
Tykerb Side Effect Report#9828375
Metastases To Central Nervous System
This is a report of a 62-year-old female patient (weight: NA) from IN, suffering from the following health symptoms/conditions: breast cancer metastatic, who was treated with Tykerb (dosage: 1250mg Per Day, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Metastases To Central Nervous System after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Tykerb treatment in female patients, resulting in Metastases To Central Nervous System side effect. The patient was hospitalized.


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The appearance of Tykerb on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Tykerb Side Effects for Women?

Women Side EffectsReports
Diarrhoea 1590
Nausea 596
Fatigue 451
Rash 370
Death 352
Vomiting 352
Palmar-plantar Erythrodysaesthesia Syndrome 293
Decreased Appetite 178
Dry Skin 162
Pruritus 139

What are common Tykerb Side Effects for Men?

Men Side EffectsReports
Diarrhoea 22
Death 17
Rash 12
Dyspnoea 10
Fatigue 10
Off Label Use 9
Pyrexia 6
Anaphylactic Reaction 5
Decreased Appetite 5
Mobility Decreased 5

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Tykerb reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Tykerb Safety Alerts, Active Ingredients, Usage Information

    NDC0173-0752
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameTYKERB
    Namelapatinib
    Dosage FormTABLET
    RouteORAL
    On market since20070316
    LabelerGlaxoSmithKline LLC
    Active Ingredient(s)LAPATINIB DITOSYLATE
    Strength(s)250
    Unit(s)mg/1
    Pharma ClassKinase Inhibitor [EPC],Protein Kinase Inhibitors [MoA]

    Tykerb Dosage, Warnings, Usage.

    Side Effects reported to FDA: 3792

    Tykerb safety alerts: No

    Reported deaths: 657

    Reported hospitalizations: 849

    Latest Tykerb clinical trials

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