Common Wellbutrin Side Effects


The most commonly reported Wellbutrin side effects (click to view or check a box to report):

Insomnia (503)
Anxiety (449)
Convulsion (445)
Dizziness (402)
Nausea (395)
Depression (389)
Headache (364)
Tremor (265)
Agitation (258)
Rash (250)
Fatigue (228)
Feeling Abnormal (218)
Completed Suicide (205)
Tinnitus (203)
Grand Mal Convulsion (198)
Urticaria (191)
Overdose (187)
Pruritus (174)
Suicidal Ideation (165)
Irritability (160)

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If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Wellbutrin Side Effects Reported to FDA



Wellbutrin Side Effect Report#9999084
Fatigue, Lymphadenopathy, Tonsillitis, Migraine, Neuropathy Peripheral, Rhinitis, Upper-airway Cough Syndrome, Myalgia, Arthralgia
This is a report of a 35-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: seasonal affective disorder, who was treated with Wellbutrin (dosage: 1 Pill Three Times Daily Taken By Mouth, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Fatigue, Lymphadenopathy, Tonsillitis, Migraine, Neuropathy Peripheral, Rhinitis, Upper-airway Cough Syndrome, Myalgia, Arthralgia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Wellbutrin treatment in female patients, resulting in Fatigue side effect.
Wellbutrin Side Effect Report#9996414
Ileus Paralytic, Constipation
This report suggests a potential Wellbutrin Ileus Paralytic side effect(s) that can have serious consequences. A 35-year-old male patient (weight: NA) from SG was diagnosed with the following symptoms/conditions: depression and used Wellbutrin (dosage: 150mg Twice Per Day) starting 201311. After starting Wellbutrin the patient began experiencing various side effects, including: Ileus Paralytic, ConstipationAdditional drugs used concurrently: NA. Although Wellbutrin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Ileus Paralytic, may still occur.
Wellbutrin Side Effect Report#9995611
Urticaria, Swollen Tongue
This Urticaria problem was reported by a health professional from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: major depression. On 2010 this consumer started treatment with Wellbutrin Xl (dosage: Late Summer 2010, 150mg, Daily, Oral). The following drugs were being taken at the same time: NA. When using Wellbutrin Xl, the patient experienced the following unwanted symptoms/side effects: Urticaria, Swollen TongueThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Urticaria, may become evident only after a product is in use by the general population.
Wellbutrin Side Effect Report#9994801
Derealisation, Weight Decreased, Arthralgia, Dyspnoea, Insomnia, Back Pain, Sensory Loss, Chills, Amnesia
This Derealisation side effect was reported by a health professional from NO. A 23-year-old female patient (weight:NA) experienced the following symptoms/conditions: depression.The patient was prescribed Wellbutrin Retard (drug dosage: NA), which was initiated on 201212. Concurrently used drugs: NA..After starting to take Wellbutrin Retard the consumer reported adverse symptoms, such as: Derealisation, Weight Decreased, Arthralgia, Dyspnoea, Insomnia, Back Pain, Sensory Loss, Chills, AmnesiaThese side effects may potentially be related to Wellbutrin Retard. The patient was hospitalized.
Wellbutrin Side Effect Report#9990269
Injection Site Pain
This is a report of a 56-year-old female patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: NA, who was treated with Wellbutrin Xr (dosage: NA, start time:
Jul 23, 2013), combined with:
  • Folic Acid (I Think 1mg)
  • Estrogen
  • Losartan / Hydrochlorothiazid Stada (100/25mg)
  • Cymbalta
  • Humira
  • Methotrexate (Shots)
  • Opana Er
  • Salogen (felocarpine) (Up To 4 Times Daily)
and developed a serious reaction and side effect(s): Injection Site Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Wellbutrin Xr treatment in female patients, resulting in Injection Site Pain side effect.
Wellbutrin Side Effect Report#9981255
Priapism, Enlarged Clitoris
This report suggests a potential Wellbutrin (bupropion Hydrochloride) (bupropion Hydrochloride) Priapism side effect(s) that can have serious consequences. A 29-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Wellbutrin (bupropion Hydrochloride) (bupropion Hydrochloride) (dosage: NA) starting NS. After starting Wellbutrin (bupropion Hydrochloride) (bupropion Hydrochloride) the patient began experiencing various side effects, including: Priapism, Enlarged ClitorisAdditional drugs used concurrently:
  • Trazodone (trazodone) (trazodone)
Although Wellbutrin (bupropion Hydrochloride) (bupropion Hydrochloride) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Priapism, may still occur.
Wellbutrin Side Effect Report#9969687
Myocardial Infarction, Arterial Occlusive Disease, Heart Rate Irregular, Device Malfunction, Nasopharyngitis, Pneumonia Staphylococcal, Immunodeficiency
This Myocardial Infarction problem was reported by a consumer or non-health professional from US. A 59-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: bipolar disorder,migraine. On NS this consumer started treatment with Wellbutrin Sr (dosage: NA). The following drugs were being taken at the same time:
  • Imitrex (sumatriptan Succinate) (tablet) (sumatriptan Succinate)
  • Sertraline (sertraline) (sertraline)
  • Seroquel
  • Lovaza
  • Percocet (oxycocet) (paracetamol, Oxycodone Hydrochloride)
  • Xanax (alprazolam) (alprazolam)
  • Lipitor (atorvastatin Calcium) (atoravastatin Calcium)
  • Plavix (clopidogrel Busulate) (clopidogrel Bisulfate)
When using Wellbutrin Sr, the patient experienced the following unwanted symptoms/side effects: Myocardial Infarction, Arterial Occlusive Disease, Heart Rate Irregular, Device Malfunction, Nasopharyngitis, Pneumonia Staphylococcal, ImmunodeficiencyThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Myocardial Infarction, may become evident only after a product is in use by the general population.
Wellbutrin Side Effect Report#9969659
Pulmonary Haemorrhage
This Pulmonary Haemorrhage side effect was reported by a consumer or non-health professional from US. A 62-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Wellbutrin (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Pravastatin
  • Lisinopril
  • Metoprolol
  • Metformin Hydrochloride
  • Neurontin
.After starting to take Wellbutrin the consumer reported adverse symptoms, such as: Pulmonary HaemorrhageThese side effects may potentially be related to Wellbutrin.
Wellbutrin Side Effect Report#9925105
Influenza Like Illness, Myalgia, Migraine, Palpitations, Oedema Peripheral, Feeling Jittery, Hangover
This is a report of a 52-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Wellbutrin Xr (dosage: Take 1 Tablet In Am Daily, start time:
Feb 24, 2014), combined with: NA. and developed a serious reaction and side effect(s): Influenza Like Illness, Myalgia, Migraine, Palpitations, Oedema Peripheral, Feeling Jittery, Hangover after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Wellbutrin Xr treatment in female patients, resulting in Influenza Like Illness side effect.
Wellbutrin Side Effect Report#9925102
Alopecia
This report suggests a potential Wellbutrin Alopecia side effect(s) that can have serious consequences. A 39-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: depression and used Wellbutrin (dosage: NA) starting NS. After starting Wellbutrin the patient began experiencing various side effects, including: AlopeciaAdditional drugs used concurrently: NA. Although Wellbutrin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Alopecia, may still occur.
Wellbutrin Side Effect Report#9922276
Pulmonary Haemorrhage
This Pulmonary Haemorrhage problem was reported by a consumer or non-health professional from US. A 62-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: ex-tobacco user. On NS this consumer started treatment with Wellbutrin (dosage: NA). The following drugs were being taken at the same time: NA. When using Wellbutrin, the patient experienced the following unwanted symptoms/side effects: Pulmonary HaemorrhageAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pulmonary Haemorrhage, may become evident only after a product is in use by the general population.
Wellbutrin Side Effect Report#9915613
Tinnitus
This Tinnitus side effect was reported by a consumer or non-health professional from US. A 22-year-old female patient (weight:NA) experienced the following symptoms/conditions: irritable bowel syndrome.The patient was prescribed Wellbutrin Xl 150mg Biovail (drug dosage: 1 Pill Twice Daily), which was initiated on
Nov 18, 2012. Concurrently used drugs: NA..After starting to take Wellbutrin Xl 150mg Biovail the consumer reported adverse symptoms, such as: TinnitusThese side effects may potentially be related to Wellbutrin Xl 150mg Biovail.
Wellbutrin Side Effect Report#9914019
Completed Suicide, Treatment Noncompliance
This is a report of a 60-year-old male patient (weight: NA) from EC, suffering from the following health symptoms/conditions: depression, who was treated with Wellbutrin (dosage: 150mg Per Day, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Completed Suicide, Treatment Noncompliance after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Wellbutrin treatment in male patients, resulting in Completed Suicide side effect.
Wellbutrin Side Effect Report#9908238
Chest Discomfort, Feeling Abnormal, Agitation, Nervousness, Anxiety, Crying, Tremor, Throat Tightness
This report suggests a potential Wellbutrin Xl Chest Discomfort side effect(s) that can have serious consequences. A 42-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Wellbutrin Xl (dosage: 300mg 1 In 1d, Oral) starting
Jan 26, 2014. After starting Wellbutrin Xl the patient began experiencing various side effects, including: Chest Discomfort, Feeling Abnormal, Agitation, Nervousness, Anxiety, Crying, Tremor, Throat TightnessAdditional drugs used concurrently:
  • Celexa (citalopram Hydrobromide) (citalopram Hydrobromide)
Although Wellbutrin Xl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Chest Discomfort, may still occur.
Wellbutrin Side Effect Report#9888907
Chest Discomfort, Throat Tightness, Crying, Agitation, Nervousness, Anxiety, Tremor, Feeling Abnormal
This Chest Discomfort problem was reported by a health professional from US. A 42-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: depression. On
Jan 26, 2014 this consumer started treatment with Wellbutrin Xl (dosage: 300mg Per Day). The following drugs were being taken at the same time:
  • Bupropion Hydrochloride
  • Celexa
When using Wellbutrin Xl, the patient experienced the following unwanted symptoms/side effects: Chest Discomfort, Throat Tightness, Crying, Agitation, Nervousness, Anxiety, Tremor, Feeling AbnormalAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Chest Discomfort, may become evident only after a product is in use by the general population.
Wellbutrin Side Effect Report#9888905
Loss Of Consciousness, Dizziness, Malaise, Anxiety, Off Label Use
This Loss Of Consciousness side effect was reported by a health professional from CA. A 31-year-old female patient (weight:NA) experienced the following symptoms/conditions: ex-tobacco user.The patient was prescribed Wellbutrin Sr (drug dosage: 150mg Twice Per Day), which was initiated on
Jan 03, 2014. Concurrently used drugs: NA..After starting to take Wellbutrin Sr the consumer reported adverse symptoms, such as: Loss Of Consciousness, Dizziness, Malaise, Anxiety, Off Label UseThese side effects may potentially be related to Wellbutrin Sr.
Wellbutrin Side Effect Report#9888262
Joint Stiffness, Nightmare, Pain In Jaw
This is a report of a 39-year-old male patient (weight: NA) from CA, suffering from the following health symptoms/conditions: NA, who was treated with Wellbutrin Xl (dosage: NA, start time: NS), combined with:
  • Novo-porfen (ibuprofen) (tablet) (ibuprofen)
  • Pms-quetiapine (quetiapine Fumarate) (tablet) (quetiapine Fumarate)
  • Ratio-emtec-30 (panadeine Co) (tablet) (codeine Phosphate, Paracetamol)
and developed a serious reaction and side effect(s): Joint Stiffness, Nightmare, Pain In Jaw after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Wellbutrin Xl treatment in male patients, resulting in Joint Stiffness side effect.
Wellbutrin Side Effect Report#9880565
Abdominal Pain, Anxiety, Condition Aggravated, Decreased Appetite
This report suggests a potential Wellbutrin Xl Abdominal Pain side effect(s) that can have serious consequences. A 22-year-old female patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: NA and used Wellbutrin Xl (dosage: 1 In 1 D) starting NS. After starting Wellbutrin Xl the patient began experiencing various side effects, including: Abdominal Pain, Anxiety, Condition Aggravated, Decreased AppetiteAdditional drugs used concurrently: NA. Although Wellbutrin Xl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Abdominal Pain, may still occur.
Wellbutrin Side Effect Report#9880543
Balance Disorder, Bursitis, Dizziness, Fall, Head Discomfort, Loss Of Consciousness, Pain, Pain In Extremity
This Balance Disorder problem was reported by a health professional from CA. A 66-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Wellbutrin Xl (dosage: NA). The following drugs were being taken at the same time:
  • Citalopram
  • Atorvastatin Calcium
  • Ezetrol (ezetimibe)
  • Clonazepam
  • Quetiapine ( Quetiapine)
  • Pantoprazole
  • Trazodone
When using Wellbutrin Xl, the patient experienced the following unwanted symptoms/side effects: Balance Disorder, Bursitis, Dizziness, Fall, Head Discomfort, Loss Of Consciousness, Pain, Pain In ExtremityAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Balance Disorder, may become evident only after a product is in use by the general population.
Wellbutrin Side Effect Report#9880541
Abnormal Behaviour, Aggression, Agitation, Depression, Feeling Cold, Feeling Hot, Memory Impairment, Pyrexia, Self Injurious Behaviour
This Abnormal Behaviour side effect was reported by a pharmacist from CA. A 37-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Wellbutrin Xl (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Vyvanse (lisdexamfetamine Dimesylate) Capsule
  • Cannabis
  • Cialis
  • Lyrica (pregabalin) (pregabalin)
  • Ramipril (ramipril) (ramipril)
.After starting to take Wellbutrin Xl the consumer reported adverse symptoms, such as: Abnormal Behaviour, Aggression, Agitation, Depression, Feeling Cold, Feeling Hot, Memory Impairment, Pyrexia, Self Injurious BehaviourThese side effects may potentially be related to Wellbutrin Xl. The patient was hospitalized.
Wellbutrin Side Effect Report#9878801
Convulsion
This is a report of a 28-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Wellbutrin (dosage: NA, start time: NS), combined with:
  • Clozapine
and developed a serious reaction and side effect(s): Convulsion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Wellbutrin treatment in female patients, resulting in Convulsion side effect.
Wellbutrin Side Effect Report#9870288
Product Quality Issue, Malaise, Product Physical Issue, Product Substitution Issue
This report suggests a potential Wellbutrin Xl 300 Mg Product Quality Issue side effect(s) that can have serious consequences. A 63-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: fibromyalgia,depression and used Wellbutrin Xl 300 Mg (dosage: 300 Mj 1 Pill A Day Once Daily Taken By Mouth) starting
Jan 01, 2014. After starting Wellbutrin Xl 300 Mg the patient began experiencing various side effects, including: Product Quality Issue, Malaise, Product Physical Issue, Product Substitution IssueAdditional drugs used concurrently: NA. Although Wellbutrin Xl 300 Mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Product Quality Issue, may still occur.
Wellbutrin Side Effect Report#9869534
Abdominal Pain Upper, Nausea, Balance Disorder, Vertigo
This Abdominal Pain Upper problem was reported by a consumer or non-health professional from IT. A 45-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Nov 15, 2013 this consumer started treatment with Wellbutrin (bupropion Hydrochloride) (tablet) (bupropion Hydrochloride) (dosage: NA). The following drugs were being taken at the same time:
  • Lorazepam (lorazepam) (lorazepam)
  • Gabapentin (gabapentin) (gabapentin)
When using Wellbutrin (bupropion Hydrochloride) (tablet) (bupropion Hydrochloride), the patient experienced the following unwanted symptoms/side effects: Abdominal Pain Upper, Nausea, Balance Disorder, VertigoAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Abdominal Pain Upper, may become evident only after a product is in use by the general population.
Wellbutrin Side Effect Report#9866901
Mania, Feeling Abnormal, Malaise, Aggression, Product Substitution Issue
This Mania side effect was reported by a consumer or non-health professional from US. A 20-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Wellbutrin Sr (drug dosage: NA), which was initiated on 201305. Concurrently used drugs:
  • Lamotrigine (200 Mg, 2 In 1 D, Oral)
  • Klonopin (clonazepam) (clonazepam)
.After starting to take Wellbutrin Sr the consumer reported adverse symptoms, such as: Mania, Feeling Abnormal, Malaise, Aggression, Product Substitution IssueThese side effects may potentially be related to Wellbutrin Sr. The patient was hospitalized.
Wellbutrin Side Effect Report#9863842
Adverse Event
This is a report of a 62-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: depression, who was treated with Wellbutrin (dosage: 100mg Per Day, start time: 201011), combined with:
  • Effexor Xr
  • Venlafaxine Hydrochloride
and developed a serious reaction and side effect(s): Adverse Event after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Wellbutrin treatment in female patients, resulting in Adverse Event side effect. The patient was hospitalized.


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The appearance of Wellbutrin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Wellbutrin Side Effects for Women?

Women Side Effects Reports
Insomnia 348
Nausea 324
Convulsion 303
Anxiety 299
Dizziness 298
Headache 267
Depression 260
Tremor 193
Rash 188
Fatigue 175

What are common Wellbutrin Side Effects for Men?

Men Side Effects Reports
Insomnia 150
Anxiety 146
Convulsion 138
Depression 127
Dizziness 99
Headache 95
Agitation 87
Completed Suicide 86
Tremor 71
Nausea 68

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Wellbutrin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Wellbutrin Side Effects

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    How Effective is Wellbutrin for You?

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    Wellbutrin Safety Alerts, Active Ingredients, Usage Information

    NDC 0173-0135
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name WELLBUTRIN SR
    Name bupropion hydrochloride
    Dosage Form TABLET, FILM COATED
    Route ORAL
    On market since 19961115
    Labeler GlaxoSmithKline LLC
    Active Ingredient(s) BUPROPION HYDROCHLORIDE
    Strength(s) 150
    Unit(s) mg/1
    Pharma Class Aminoketone [EPC],Dopamine Uptake Inhibitors [MoA],Increased Dopamine Activity [PE],Increased Norepi

    Wellbutrin Dosage, Warnings, Usage.

    Side Effects reported to FDA: 6324

    Wellbutrin safety alerts: 2009 2005 2004

    Reported deaths: 253

    Reported hospitalizations: 595

    Varenicline (marketed as Chantix) and Bupropion (marketed as Zyban, Wellbutrin, and generics)

    Audience: Neuropsychiatric healthcare professionals, patients

    FDA notified healthcare professionals and patients that it has required the manufacturers of the smoking cessation aids varenicline (Chantix) and bupropion (Zyban and generics) to add new Boxed Warnings and develop patient Medication Guides highlighting the risk of serious neuropsychiatric symptoms in patients using these products. These symptoms include changes in behavior, hostility, agitation, depressed mood, suicidal thoughts and behavior, and attempted suicide. The added warnings are based on the continued review of postmarketing adverse event reports for varenicline and bupropion received by the FDA. These reports included those with a temporal relationship between the use of varenicline or bupropion and suicidal events and the occurrence of suicidal ideation and suicidal behavior in patients with no history of psychiatric disease.

    Healthcare professionals should advise patients to stop taking varenicline or bupropion and contact a healthcare provider immediately if they experience agitation, depressed mood, and any changes in behavior that are not typical of nicotine withdrawal, or if they experience suicidal thoughts or behavior.

    [07/01/2009 - Public Health Advisory - FDA]

    [07/01/2009 - Information for Healthcare Professionals - FDA]

    [07/01/2009 - News Release - FDA]

    Previous MedWatch Alert:

    [02/01/2008]

    Latest Wellbutrin clinical trials



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