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International Normalised Ratio Increased (7893482-4)
on Oct 04, 2011 Male from JAPAN , weighting 132.3 lb, was diagnosed with
  • hypertension
  • atrial fibrillation
and was treated with Wytens. Directly after, patient experienced the unwanted or unexpected Wytens side effects: international normalised ratio increased. Wytens dosage: 2 Mg.
Associated medications used:
  • Pradaxa (220 Mg)
  • Amlodipine (5 Mg)
  • Diovan (80 Mg)
  • Doxazon (2 Mg)
  • Kallikrein (30 Mg)


Oedema Genital, Nephrotic Syndrome, Oedema Peripheral (7604918-8)
Patient was taking Wytens. Patient felt the following Wytens side effects: oedema genital, nephrotic syndrome, oedema peripheral on Jun 29, 2011 from JAPAN Additional patient health information: Male , 68 years of age, . Wytens dosage: N/A.
Multiple prescriptions taken:
  • Corinael
  • Pamilcon
  • Lipitor
  • Lantus
  • Cilostazol
  • Diovan


Anaemia Haemolytic Autoimmune, Antiphospholipid Syndrome, Coombs Positive Haemolytic Anaemia, Cytolytic Hepatitis, Double Stranded Dna Antibody, Hyperproteinaemia, Systemic Lupus Erythematosus (5414920-2)
Adverse event was reported on Jul 26, 2007 by a Female taking Wytens (tablet) (hydrochlorothiazide, Bisoprolol Fumarate) (Dosage: Oral) was diagnosed with
  • hypertension
and. Location: FRANCE , 71 years of age, After Wytens was administered, patient encountered several Wytens side effects: anaemia haemolytic autoimmune, antiphospholipid syndrome, coombs positive haemolytic anaemia, cytolytic hepatitis, double stranded dna antibody, hyperproteinaemia, systemic lupus erythematosus.
Multiple concurrent drugs taken:
  • Rabeprazole Sodium (Oral)
  • Xanax (0,125 Mg (0,1125 Mg, 1 In 1 D) Oral)
Patient was hospitalized.

Condition Aggravated, Diabetes Mellitus, Fatigue, Systemic Lupus Erythematosus (5343410-0)
on May 21, 2007 Female from FRANCE , 65 years of age, was diagnosed with
  • hypertension
and was treated with Wytens (tablet) (hydrochlorothiazide, Bisoprolol Fumarate). Directly after, patient experienced the unwanted or unexpected Wytens side effects: condition aggravated, diabetes mellitus, fatigue, systemic lupus erythematosus. Wytens (tablet) (hydrochlorothiazide, Bisoprolol Fumarate) dosage: Oral.


Amnesia, Delirium, Memory Impairment, Road Traffic Accident (5275636-9)
on Mar 14, 2007 Male from JAPAN , 56 years of age, was treated with Wytens. Patient felt the following Wytens side effects: amnesia, delirium, memory impairment, road traffic accident. Wytens dosage: 2 Mg.
Multiple prescriptions taken:
  • Diovan (80 Mg)
  • Myslee (10 Mg)


Eczema (4906311-5)
Patient was taking Wytens /spa/. After Wytens was administered, patient encountered several Wytens side effects: eczema on Feb 02, 2006 from FRANCE Additional patient health information: Male , 75 years of age, . Wytens /spa/ dosage: N/A.
Multiple concurrent drugs taken:
  • Befizal
  • Allopurinol
  • Xanax
  • Tareg (160 Mg, Qd)


Blood Lactate Dehydrogenase Increased, Blood Triglycerides Increased, Carotid Artery Atheroma, Cerebrovascular Accident, Loss Of Consciousness, Renal Failure Acute (4699649-0)
Adverse event was reported on Jun 16, 2005 by a Male taking Wytens (bisoprolol/hydrochlorothiazide, Tablet, 0) (Dosage: See Image) . Location: , 58 years of age, Directly after, patient experienced the unwanted or unexpected Wytens side effects: blood lactate dehydrogenase increased, blood triglycerides increased, carotid artery atheroma, cerebrovascular accident, loss of consciousness, renal failure acute.
Associated medications used:
  • Valsartan (160 Mg 1x Per 1 Day Oral)
  • Daonin (glibenclamide)
  • Di-actane (naftidrofuryl Oxalate)
  • Allopurinol
  • Plavix
Patient was hospitalized.

Blood Creatinine Increased, Blood Lactate Dehydrogenase Increased, Blood Triglycerides Increased, Blood Urea Increased, Cerebrovascular Accident, Glycosylated Haemoglobin Increased, Loss Of Consciousness, Malaise, Proteinuria (4695982-7)
on Jun 14, 2005 Male from , 58 years of age, weighting 185.2 lb, was treated with Wytens. Patient felt the following Wytens side effects: blood creatinine increased, blood lactate dehydrogenase increased, blood triglycerides increased, blood urea increased, cerebrovascular accident, glycosylated haemoglobin increased, loss of consciousness, malaise, proteinuria. Wytens dosage: 10 Mg, Qd.
Multiple prescriptions taken:
  • Daonil
  • Di-actane (200 Mg, Bid)
  • Allopurinol (200 Mg, Qd)
  • Tareg (160 Mg, Qd)
  • Plavix (75 Mg, Qd)
Patient was hospitalized.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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