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side effects patient, 75 years of age, was diagnosed with breast cancer and took Xgeva 60 Mg, Q6mo Patient was hospitalized.. View more Serious Adverse Events reported to FDA.

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Neuropathy (3)
Joint Swelling In Hand (2)
Toothache (2)
Bloody Discharge (1)
Vomiting (1)
>>View All User Submitted Xgeva Side Effects

List of Xgeva Adverse Effects reported to US Food and Drug Administration (FDA)

  Showing 101-125 of 277 

Osteoarthritis, Hip Arthroplasty (8225620-8)
on Mar 08, 2012 Female patient from AUSTRIA , 75 years of age, was diagnosed with
  • breast cancer
and was treated with Xgeva. Patient experienced the following unwanted or unexpected effects: osteoarthritis, hip arthroplasty. Xgeva dosage: 60 Mg, Q6mo. Patient was hospitalized.

Cardiomegaly, Pain In Extremity, Skin Chapped, Pruritus, Chronic Obstructive Pulmonary Disease, Deep Vein Thrombosis, Rash, Oedema Peripheral (8225162-X)
Patient was taking Xgeva. Patient had the following side effects: cardiomegaly, pain in extremity, skin chapped, pruritus, chronic obstructive pulmonary disease, deep vein thrombosis, rash, oedema peripheral on Mar 16, 2012 from UNITED STATES Additional patient health information: Male patient , 66 years of age, weighting 161.0 lb, was diagnosed with
  • small cell lung cancer metastatic
and. Xgeva dosage: N/A.
Patient also using the following medications:
  • Zometa (Unk)
  • Lipitor
  • Amlodipine
  • Coumadin
  • Decadron (Unk)
Patient was hospitalized.

Hypophosphataemia, Hypocalcaemia, Neoplasm Malignant (8224587-6)
Adverse event was reported on Mar 14, 2012 by a Male patient taking Xgeva (Dosage: 120 Mg, Q4wk) was diagnosed with
  • metastases to bone
and. Location: UNITED STATES , 69 years of age, After Xgeva was administered, patient had the following side effects: hypophosphataemia, hypocalcaemia, neoplasm malignant. Patient was hospitalized.

Osteomyelitis, Bone Pain, Pain In Jaw, Osteonecrosis Of Jaw, Toothache (8223025-7)
on Mar 13, 2012 Female patient from UNITED STATES , 63 years of age, weighting 185.3 lb, was diagnosed with
  • metastases to bone
and was treated with Xgeva. Patient experienced the following unwanted or unexpected effects: osteomyelitis, bone pain, pain in jaw, osteonecrosis of jaw, toothache. Xgeva dosage: 120 Mg, One Time Dose.
Patient also using the following medications:
  • Pravachol (20 Mg, Qd)
  • Wellbutrin (150 Mg, Qd)
  • Calcium Carbonate (1000 Mg, Qd)
  • Vitamin B-12 (Unk Unk, Qd)
  • Faslodex (500 Mg, Qmo)
  • Norco (10 Mg, Qd)
  • Prilosec (20 Mg, Qd)
  • M.v.i. (Unk Unk, Qd)



Disease Progression, Hypocalcaemia (8220786-8)
on Mar 14, 2012 Male patient from UNITED STATES , weighting 200.0 lb, was diagnosed with
  • metastases to bone
and was treated with Xgeva. Patient had the following side effects: disease progression, hypocalcaemia. Xgeva dosage: 120 Mg, Q4wk. Patient was hospitalized.

Hyperkalaemia, Blood Creatinine Abnormal, Hypocalcaemia, Blood Urea Abnormal (8218181-0)
Patient was taking Xgeva. After Xgeva was administered, patient had the following side effects: hyperkalaemia, blood creatinine abnormal, hypocalcaemia, blood urea abnormal on Mar 12, 2012 from UNITED STATES Additional patient health information: Male patient , weighting 145.0 lb, . Xgeva dosage: Unk Unk, One Time Dose.
Patient also using the following medications:
  • Prilosec
  • Terazosin Hcl
Patient was hospitalized.

Bundle Branch Block, Hypoaesthesia, Hypocalcaemia (8216696-2)
Adverse event was reported on Mar 13, 2012 by a Male patient taking Xgeva (Dosage: N/A) was diagnosed with
  • prophylaxis
and. Location: UNITED STATES , 70 years of age, Patient experienced the following unwanted or unexpected effects: bundle branch block, hypoaesthesia, hypocalcaemia.
Patient also using the following medications:
  • Calcium Carbonate (1500 Mg, Qd)
  • Lupron
Patient was hospitalized.

Renal Failure Acute, Pneumonia Aspiration (8215134-3)
on Mar 05, 2012 Male patient from CANADA , 87 years of age, was diagnosed with
  • prostate cancer
and was treated with Xgeva. Patient had the following side effects: renal failure acute, pneumonia aspiration. Xgeva dosage: 1 Ml, Q4wk. Patient was hospitalized.

Lower Limb Fracture, Hypercalcaemia, Hypophosphataemia, Vomiting, Fall (8206916-2)
on Mar 02, 2012 Male patient from UNITED STATES , child 9 years of age, was diagnosed with
  • fibrous dysplasia of bone
and was treated with Xgeva. After Xgeva was administered, patient had the following side effects: lower limb fracture, hypercalcaemia, hypophosphataemia, vomiting, fall. Xgeva dosage: 1.0 Mg, One Time Dose. Patient was hospitalized.

(8205101-8)
Patient was taking Xgeva. on Mar 09, 2012 from CANADA Additional patient health information: Female patient , 73 years of age, . Xgeva dosage: N/A.

Osteonecrosis Of Jaw, Eating Disorder, Oral Discomfort, Temporomandibular Joint Syndrome, Stomatitis (8204648-8)
Adverse event was reported on Mar 08, 2012 by a Male patient taking Xgeva (Dosage: 120 Mg, Unk) . Location: CANADA , 78 years of age, Patient had the following side effects: osteonecrosis of jaw, eating disorder, oral discomfort, temporomandibular joint syndrome, stomatitis.

(8203389-0)
on Mar 08, 2012 Female patient from UNITED STATES , 56 years of age, was diagnosed with
  • prophylaxis
and was treated with Xgeva. . Xgeva dosage: N/A.

Cough, Chest Discomfort, Respiratory Distress, Dyspnoea (8202291-8)
on Mar 05, 2012 Female patient from UNITED STATES , 37 years of age, weighting 105.8 lb, was diagnosed with
  • breast cancer
and was treated with Xgeva. Patient experienced the following unwanted or unexpected effects: cough, chest discomfort, respiratory distress, dyspnoea. Xgeva dosage: 120 Mug, Q4wk.
Patient also using the following medications:
  • Decadron (Unk)
  • Ativan (Unk)
  • Senna
  • Oxycontin (Unk)
  • Marinol (Unk)
  • Ambien
  • Senna Lax (Unk)
  • Diflucan Duo (Unk)
Patient was hospitalized.

Pain In Extremity, Chronic Obstructive Pulmonary Disease, Oedema Peripheral, Cardiomegaly, Skin Chapped, Pruritus, Deep Vein Thrombosis (8199670-4)
Patient was taking Xgeva. Patient had the following side effects: pain in extremity, chronic obstructive pulmonary disease, oedema peripheral, cardiomegaly, skin chapped, pruritus, deep vein thrombosis on Mar 07, 2012 from UNITED STATES Additional patient health information: Male patient , 66 years of age, weighting 161.0 lb, was diagnosed with
  • metastases to bone
and. Xgeva dosage: 120 Mg, Q4wk.
Patient also using the following medications:
  • Lipitor
  • Symbicort
  • Aloxi (Unk)
  • Metoprolol Succinate
  • Ventolin
  • Decadron (Unk)
  • Amlodipine
  • Coumadin
Patient was hospitalized.

(8199424-9)
Adverse event was reported on Mar 08, 2012 by a Female patient taking Xgeva (Dosage: 120 Mg, Qmo) . Location: UNITED STATES , 53 years of age, weighting 98.98 lb, .
Patient also using the following medications:
  • Navelbine (40 Mg, Qwk)
  • Carboplatin (465 Mg, Unk)
  • Xeloda (1000 Mg, Bid)
  • Adriamycin Pfs (20 Mg, Qwk)
  • Gemzar (1266 Mg, Unk)


Pain In Extremity, Meningitis, Metastatic Neoplasm (8198944-0)
on Mar 06, 2012 Female patient from UNITED STATES , 60 years of age, was diagnosed with
  • breast cancer
and was treated with Xgeva. Patient experienced the following unwanted or unexpected effects: pain in extremity, meningitis, metastatic neoplasm. Xgeva dosage: Unk.

Croup Infectious, Seborrhoeic Dermatitis, Otitis Media, Upper Respiratory Tract Infection, Viral Upper Respiratory Tract Infection (8198539-9)
on Jan 03, 2012 Male patient from UNITED STATES , weighting 23.80 lb, was treated with Xgeva. Patient had the following side effects: croup infectious, seborrhoeic dermatitis, otitis media, upper respiratory tract infection, viral upper respiratory tract infection. Xgeva dosage: Unk.

Oral Mucosal Erythema, Gingival Pain (8198083-9)
Patient was taking Xgeva. After Xgeva was administered, patient had the following side effects: oral mucosal erythema, gingival pain on Jan 17, 2012 from UNITED STATES Additional patient health information: Female patient , 64 years of age, was diagnosed with
  • breast cancer
and. Xgeva dosage: Unk Unk, Q6wk.
Patient also using the following medications:
  • Synthroid (1 Unk, Unk)


Tooth Extraction (8198073-6)
Adverse event was reported on Feb 09, 2012 by a Male patient taking Xgeva (Dosage: 120 Mg, Q4wk) was diagnosed with
  • neoplasm
and. Location: UNITED STATES , 85 years of age, Patient experienced the following unwanted or unexpected effects: tooth extraction.

Rash (8198072-4)
on Feb 22, 2012 Female patient from UNITED STATES , 68 years of age, weighting 145.5 lb, was diagnosed with
  • breast cancer metastatic
and was treated with Xgeva. Patient had the following side effects: rash. Xgeva dosage: 120 Mg, Qmo.
Patient also using the following medications:
  • Faslodex (Unk)


Blood Calcium Decreased (8198068-2)
on Feb 23, 2012 Male patient from UNITED STATES , 87 years of age, weighting 150.1 lb, was diagnosed with
  • prophylaxis
  • prostate cancer
and was treated with Xgeva. After Xgeva was administered, patient had the following side effects: blood calcium decreased. Xgeva dosage: 120 Mg, Q4wk.
Patient also using the following medications:
  • Taxotere (71.6 Mg, Q3wk)
  • Prednisone (5 Mg, Bid)


Insomnia, Back Pain, Initial Insomnia, Hot Flush (8198065-7)
Patient was taking Xgeva. Patient experienced the following unwanted or unexpected effects: insomnia, back pain, initial insomnia, hot flush on Feb 17, 2012 from UNITED STATES Additional patient health information: Male patient , 67 years of age, was diagnosed with
  • metastases to bone
and. Xgeva dosage: N/A.
Patient also using the following medications:
  • Calcium
  • Trelstar
  • Fish Oil
  • Trelstar (Unk)
  • Lisinopril Combino (Unk)
  • Vitamin D
  • Omeprazole (Unk)
  • Zolpidem


Pain In Jaw (8198062-1)
Adverse event was reported on Feb 16, 2012 by a Female patient taking Xgeva (Dosage: 120 Mg, Qmo) was diagnosed with
  • lung neoplasm malignant
and. Location: UNITED STATES , 72 years of age, weighting 134.5 lb, Patient had the following side effects: pain in jaw.
Patient also using the following medications:
  • Tarceva (100 Mg, Qd)
  • Aredia (90 Mg, Unk)
  • Aredia (60 Mg, Unk)


Vision Blurred (8198060-8)
on Feb 13, 2012 Male patient from UNITED STATES , 84 years of age, was diagnosed with
  • prostate cancer metastatic
and was treated with Xgeva. After Xgeva was administered, patient had the following side effects: vision blurred. Xgeva dosage: Unk.
Patient also using the following medications:
  • Hormones (Unk)
  • Toviaz (Unk)


Hypocalcaemia, Hypophosphataemia (8198056-6)
on Feb 17, 2012 Male patient from UNITED STATES , 74 years of age, was treated with Xgeva. Patient experienced the following unwanted or unexpected effects: hypocalcaemia, hypophosphataemia. Xgeva dosage: N/A.

  Showing 101-125 of 277 

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Xgeva Information

Alternative XGEVA Names:DENOSUMAB

Substance:DENOSUMAB

More About Xgeva

Side Effects reported to FDA: 277. View FDA Adverse Reports

Xgeva safety alerts: No

Reported deaths: 34

Reported hospitalizations: 102

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Xgeva Adverse Reactions

Hypocalcaemia ( 45 Reports)

Osteonecrosis Of Jaw ( 30 Reports)

Death ( 21 Reports)

Bone Pain ( 18 Reports)

Dyspnoea ( 17 Reports)

Headache ( 13 Reports)

Pain In Jaw ( 13 Reports)

Back Pain ( 10 Reports)

Pain In Extremity ( 10 Reports)

Nausea ( 9 Reports)

Asthenia ( 8 Reports)

Dizziness ( 8 Reports)

Feeling Abnormal ( 8 Reports)

Pyrexia ( 8 Reports)

Toothache ( 8 Reports)

Vomiting ( 8 Reports)

Arthralgia ( 6 Reports)

Hypophosphataemia ( 6 Reports)

Muscle Spasms ( 6 Reports)

Neoplasm Malignant ( 6 Reports)

Oedema Peripheral ( 6 Reports)

Pneumonia ( 6 Reports)

Rash ( 6 Reports)

Renal Failure Acute ( 6 Reports)

Blood Calcium Decreased ( 5 Reports)

Deep Vein Thrombosis ( 5 Reports)

Dysgeusia ( 5 Reports)

Fatigue ( 5 Reports)

Pain ( 5 Reports)

Upper Respiratory Tract Infection ( 5 Reports)

side effects
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