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Feling Tearful/ Not Liking Myself (75)
Very Tired (70)
Memory Loss (64)
Acid Problems (40)
Overdose (34)
Taste (27)
Sleepy (25)
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Zopiclone Side Effects and Adverse Effects reported to US Food and Drug Administration (FDA)

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Showing 1-25 of 182 

Dizziness, Pseudophaeochromocytoma, Hypertensive Crisis, Anxiety, Tachycardia, Weight Decreased (8368926-4)
on Apr 27, 2012 Female from AUSTRALIA , 51 years of age, was treated with Zopiclone (zopiclone). Directly after, patient experienced the unwanted or unexpected Zopiclone side effects: dizziness, pseudophaeochromocytoma, hypertensive crisis, anxiety, tachycardia, weight decreased. Zopiclone (zopiclone) dosage: N/A.
Associated medications used:
  • Enalapril Maleate
  • Lamotrigine
  • Mirtazapine
  • Clozapine (925 Mg, Qd, Oral)


Pneumonia Aspiration, Hypercholesterolaemia, Hypertriglyceridaemia, Hyponatraemia, Pyrexia, Central Obesity, Type 2 Diabetes Mellitus, Hypertension (8361505-4)
Patient was taking Zopiclone. Patient felt the following Zopiclone side effects: pneumonia aspiration, hypercholesterolaemia, hypertriglyceridaemia, hyponatraemia, pyrexia, central obesity, type 2 diabetes mellitus, hypertension on May 03, 2012 from FRANCE Additional patient health information: Female , weighting 163.1 lb, . Zopiclone dosage: 1 Df, Qd.
Multiple prescriptions taken:
  • Zyprexa (15 Mg, Qd)
Patient was hospitalized.

Osteoporosis, Sciatica, Back Pain (8361095-6)
Adverse event was reported on Apr 30, 2012 by a Female taking Zopiclone (Dosage: N/A) was diagnosed with
  • insomnia
and. Location: CANADA , weighting 124.1 lb, After Zopiclone was administered, patient encountered several Zopiclone side effects: osteoporosis, sciatica, back pain.
Multiple concurrent drugs taken:
  • Leucovorin Calcium
  • Venlafaxine
  • Actemra
  • Crestor
  • Metronidazole
  • Celebrex
  • Lamisil
  • Prednisone Tab
Patient was hospitalized.

Dyspnoea, Hypocalcaemia, Anaemia (8356120-2)
on May 09, 2012 Male from SWEDEN , 66 years of age, weighting 143.3 lb, was treated with Zopiclone. Directly after, patient experienced the unwanted or unexpected Zopiclone side effects: dyspnoea, hypocalcaemia, anaemia. Zopiclone dosage: N/A.
Associated medications used:
  • Allopurinol
  • Oxycontin
  • Fragmin
  • Emgesan
  • Tryptizol /00002202/
  • Renvela
  • Postafen /00072801/
  • Etalpha
Patient was hospitalized.


Oesophageal Adenocarcinoma, Bradycardia, Tachycardia, Feeling Hot, Circulatory Collapse, Pulse Absent, Haematemesis, Neck Pain (8336907-2)
on May 02, 2012 Male from UNITED KINGDOM , 57 years of age, weighting 187.4 lb, was diagnosed with
  • insomnia
  • vomiting
  • pain management
and was treated with Zopiclone. Patient felt the following Zopiclone side effects: oesophageal adenocarcinoma, bradycardia, tachycardia, feeling hot, circulatory collapse, pulse absent, haematemesis, neck pain. Zopiclone dosage: 11.25 Mg, Bid.
Multiple prescriptions taken:
  • Domperidone (Unk)
  • Oxycodone Hcl (Unk)
  • Ondansetron (8 Mg, Unk)
  • Cyclizine (50 Mg, Tid)
  • Domperidone
  • Fentanyl Citrate (175 Ug, Unk)


Hyperglycaemia, Hypertriglyceridaemia (8268045-1)
Patient was taking Zopiclone. After Zopiclone was administered, patient encountered several Zopiclone side effects: hyperglycaemia, hypertriglyceridaemia on Mar 26, 2012 from JAPAN Additional patient health information: Male , 48 years of age, . Zopiclone dosage: N/A.
Multiple concurrent drugs taken:
  • Fluvoxamine Maleate
  • Glimepiride
  • Diazepam
  • Mirtazapine (15 Mg;qd;po)
  • Etizolam
  • Carbamazepine
  • Aripiprazole
  • Quazepam


Diarrhoea, Breakthrough Pain, Hyperhidrosis, Chills (8251493-3)
Adverse event was reported on Mar 14, 2012 by a Female taking Zopiclone (Dosage: 10 Mg, Daily) . Location: NORWAY , 51 years of age, Directly after, patient experienced the unwanted or unexpected Zopiclone side effects: diarrhoea, breakthrough pain, hyperhidrosis, chills.
Associated medications used:
  • Morphine Sulfate (10 Mg, Four Times A Day)
  • Simvastatin (40 Mg, Daily)
  • Remeron (45 Mg, Daily)
  • Diazepam (30 Mg, Daily)
  • Carbamazepine (400 Mg, Daily)
  • Targiniq (20/10 Mg, Three Times Daily)
  • Targiniq
  • Trimeprazine Tab (30 Mg, Daily)


Cardiac Arrest, Electrocardiogram Qt Prolonged (8244542-X)
on Mar 22, 2012 Male from FRANCE , weighting 165.3 lb, was treated with Zopiclone. Patient felt the following Zopiclone side effects: cardiac arrest, electrocardiogram qt prolonged. Zopiclone dosage: N/A.
Multiple prescriptions taken:
  • X-prep
  • Haldol
  • Trimeprazine Tartrate
  • Celestamine Tab
  • Paraffin
  • Risperdal Consta
  • Loxapine Hcl
  • Loxapine Hcl


Faeces Hard, Haemorrhoids, Oedema, Rectal Haemorrhage, Abdominal Distension, Constipation, Dyspepsia, Gastrooesophageal Reflux Disease (8240866-0)
on Mar 14, 2012 Female from NETHERLANDS , weighting 162.3 lb, was diagnosed with
  • insomnia
  • pain
and was treated with Zopiclone. After Zopiclone was administered, patient encountered several Zopiclone side effects: faeces hard, haemorrhoids, oedema, rectal haemorrhage, abdominal distension, constipation, dyspepsia, gastrooesophageal reflux disease. Zopiclone dosage: 7.5 Mg, Qd.
Multiple concurrent drugs taken:
  • Tramadol Hcl (100 Mg, Unk)
  • Mianserin
  • Tramadol Hcl (50 Mg, Unk)
  • Ibumetin (Unk)
  • Nortriptyline Hcl (Unk)
  • Ibuprofen (Unk)
  • Pamol (Unk)
  • Paroxetine Hcl (Unk)


Cholestasis (8235401-7)
Patient was taking Zopiclone. Directly after, patient experienced the unwanted or unexpected Zopiclone side effects: cholestasis on Mar 21, 2012 from NORWAY Additional patient health information: Male , 66 years of age, was diagnosed with
  • insomnia
and. Zopiclone dosage: 5-7,5 Mg/day.
Associated medications used:
  • Bupivacaine Hcl (Continous Epidural Bupivacaine Or Ropivacaine In Low/moderate Doses)
  • Codeine (Up To 180 Mg Codeine/day (given As A Combination Preparation With Acethaminophen).)
  • Pantoprazole (40 Mg, 1x/day)
  • Haloperidol (1 Mg, 1x/day In The Evening)
  • Acetaminophen (Up To 5 Gram/day The First Few Days, Then 3-4 Gram/day.)
  • Oxycodone Hcl (Up To 50 Mg/day)
  • Arthrotec (Up To 100-150 Mg Diclofenac/day)
  • Mucomyst (200 Mg, 3x/day)
Patient was hospitalized.

Swelling Face, Anxiety, Weight Increased, Aggression (8234445-9)
Adverse event was reported on Mar 06, 2012 by a Male taking Zopiclone (Dosage: N/A) . Location: UNITED KINGDOM , 23 years of age, Patient felt the following Zopiclone side effects: swelling face, anxiety, weight increased, aggression.
Multiple prescriptions taken:
  • Mirtazapine (60 Mg; Qd; Po 45 Mg; Qd;)


Nervous System Disorder (8230340-X)
on Mar 09, 2012 Female from GERMANY , 62 years of age, was treated with Zopiclone (zopiclone). After Zopiclone was administered, patient encountered several Zopiclone side effects: nervous system disorder. Zopiclone (zopiclone) dosage: N/A.
Multiple concurrent drugs taken:
  • Sertraline Hydrochloride ((25 Mg), Oral)
Patient was hospitalized.

Nervous System Disorder (8228866-8)
on Mar 07, 2012 Female from GERMANY , 62 years of age, was treated with Zopiclone. Directly after, patient experienced the unwanted or unexpected Zopiclone side effects: nervous system disorder. Zopiclone dosage: N/A.
Associated medications used:
  • Sertraline Hydrochloride (25 Mg, Daily)
Patient was hospitalized.

Condition Aggravated, Torticollis, Nervous System Disorder (8221848-1)
Patient was taking Zopiclone (zopiclone). Patient felt the following Zopiclone side effects: condition aggravated, torticollis, nervous system disorder on Mar 07, 2012 from GERMANY Additional patient health information: Female , 62 years of age, . Zopiclone (zopiclone) dosage: N/A.
Multiple prescriptions taken:
  • Sertraline Hydrochloride (25 Mg, Oral)
Patient was hospitalized.

Intraocular Pressure Increased (8208893-7)
Adverse event was reported on Mar 12, 2012 by a Female taking Zopiclone (Dosage: N/A) . Location: CANADA , weighting 110.1 lb, After Zopiclone was administered, patient encountered several Zopiclone side effects: intraocular pressure increased.
Multiple concurrent drugs taken:
  • Arava
  • Prednisone Tab
  • Naprosyn
  • Actemra
  • Synthroid
  • Nexium


Vitreous Floaters (8198318-2)
on Feb 28, 2012 Female from CANADA , weighting 136.7 lb, was diagnosed with
  • insomnia
  • gastrooesophageal reflux disease
  • iron overload
and was treated with Zopiclone. Directly after, patient experienced the unwanted or unexpected Zopiclone side effects: vitreous floaters. Zopiclone dosage: 75 Mg, Qd.
Associated medications used:
  • Omeprazole (20 Mg, Qd)
  • Exjade (Unk)
  • Exjade
  • Tylenol (1-2 Tab)


Blood Testosterone Abnormal, Anxiety, Suicidal Ideation, Depression, Erection Increased, Feeling Abnormal, Psychiatric Symptom, Organic Erectile Dysfunction, Loss Of Libido (8194044-4)
on Mar 05, 2012 Male from UNITED KINGDOM , 35 years of age, was treated with Zopiclone. Patient felt the following Zopiclone side effects: blood testosterone abnormal, anxiety, suicidal ideation, depression, erection increased, feeling abnormal, psychiatric symptom, organic erectile dysfunction, loss of libido. Zopiclone dosage: N/A.

Nail Disorder, Onychomadesis, Onychomycosis, Cough (8174175-5)
Patient was taking Zopiclone (zopiclone). After Zopiclone was administered, patient encountered several Zopiclone side effects: nail disorder, onychomadesis, onychomycosis, cough on Feb 14, 2012 from Additional patient health information: Female , 67 years of age, weighting 110.2 lb, . Zopiclone (zopiclone) dosage: N/A.
Multiple concurrent drugs taken:
  • Indapamide
  • Ramipril (10 Mg (5 Mg, 2 In 1 D),oral)
  • Adcal-d3 (lekovit Ca)


Headache, Influenza, Type 2 Diabetes Mellitus (8173115-2)
Adverse event was reported on Feb 20, 2012 by a Male taking Zopiclone (Dosage: N/A) . Location: CANADA , weighting 319.7 lb, Directly after, patient experienced the unwanted or unexpected Zopiclone side effects: headache, influenza, type 2 diabetes mellitus.
Associated medications used:
  • Crestor
  • Remicade
  • Pantoprazole Sodium
  • Risperidone
  • Imuran
Patient was hospitalized.

Bronchitis (8157317-7)
on Feb 07, 2012 Female from FRANCE , weighting 194.0 lb, was treated with Zopiclone. Patient felt the following Zopiclone side effects: bronchitis. Zopiclone dosage: N/A.
Multiple prescriptions taken:
  • Treanda (8.4667 Milligram;)
  • Olmesartan Medoxomil
  • Rituximab (22.6667 Milligram;)
  • Oxazepam
  • Bactrim
  • Aspirin
  • Omeprazole
  • Valaciclovir


Fatigue, Paraesthesia, Pallor (8152672-6)
on Feb 10, 2012 Female from UNITED KINGDOM , 39 years of age, was treated with Zopiclone. After Zopiclone was administered, patient encountered several Zopiclone side effects: fatigue, paraesthesia, pallor. Zopiclone dosage: 37.5 Mg, Qd.
Multiple concurrent drugs taken:
  • Propranolol (80 Mg, Bid)


Osteonecrosis (8136953-8)
Patient was taking Zopiclone. Directly after, patient experienced the unwanted or unexpected Zopiclone side effects: osteonecrosis on Feb 09, 2012 from SWEDEN Additional patient health information: Female , 80 years of age, . Zopiclone dosage: N/A.
Associated medications used:
  • Omeprazole
  • Citalopram
  • Prednisolone
  • Fosamax


Brain Mass, Depression, Demyelination (8135286-3)
Adverse event was reported on Jan 20, 2012 by a Male taking Zopiclone (Dosage: N/A) . Location: CANADA , weighting 145.9 lb, Patient felt the following Zopiclone side effects: brain mass, depression, demyelination.
Multiple prescriptions taken:
  • Methotrexate
  • Seroquel
  • Remicade
  • Folic Acid
  • Percocet
  • Asacol
Patient was hospitalized.

Hypoglycaemia, Malaise, Hydrocephalus (8119655-3)
on Dec 26, 2011 Male from FRANCE , 84 years of age, weighting 163.1 lb, was treated with Zopiclone. After Zopiclone was administered, patient encountered several Zopiclone side effects: hypoglycaemia, malaise, hydrocephalus. Zopiclone dosage: N/A.
Multiple concurrent drugs taken:
  • Clopidogrel Bisulfate
  • Fosamax Plus D
  • Trusopt
  • Glyburide
  • Fluvastatin Sodium
  • Acetaminophen
  • Januvia
  • Tamsulosin Hydrochloride
Patient was hospitalized.

Tremor, Memory Impairment, Transient Ischaemic Attack, Vomiting, Muscular Weakness (8105756-2)
on Jan 23, 2012 Female from CANADA , 68 years of age, weighting 160.1 lb, was treated with Zopiclone. Directly after, patient experienced the unwanted or unexpected Zopiclone side effects: tremor, memory impairment, transient ischaemic attack, vomiting, muscular weakness. Zopiclone dosage: At Night.
Associated medications used:
  • Metformin Hcl
  • Elavil
  • Nicotine (As Required)
  • Plavix
  • Simvastatin
  • Crestor
  • Aspirin
  • Glyburide
Patient was hospitalized.

Showing 1-25 of 182 

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jeez looking at all the bad experiences I am wondering if its the same ...Keep Reading

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It is very important to keep track of all side effects and discuss them with your doctor. If you think you may have a medical emergency, call your doctor or 911 immediately.

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Most drugs have a large list of nonsevere or mild adverse effects which do not rule out continued usage. These effects depend on individual sensitivity, and can include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. Check commonly reported side effects . These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Zopiclone Information

More About Zopiclone

Side Effects reported to FDA: 182. View Zopiclone Adverse Reports

Zopiclone safety alerts: 2007

Reported deaths: 25

Reported hospitalizations: 55

Lunesta (eszopiclone)

Audience: Healthcare professionals, consumers

[Posted 03/14/2007] FDA notified healthcare professionals of its request that all manufacturers of sedative-hypnotic drug products, a class of drugs used to induce and/or maintain sleep, strengthen their product labeling to include stronger language concerning potential risks. These risks include severe allergic reactions and complex sleep-related behaviors, which may include sleep-driving. Sleep driving is defined as driving while not fully awake after ingestion of a sedative-hypnotic product, with no memory of the event. FDA also requested that each product manufacturer send letters to health care providers to notify them about the new warnings, and that manufacturers develop Patient Medication Guides for the products to inform consumers about risks and advise them of potential precautions that can be taken.

[March 14, 2007 - News Release - FDA]

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