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Zyprexa Side Effects

Common Zyprexa Side Effects


The most commonly reported Zyprexa side effects (click to view or check a box to report):

Diabetes Mellitus (2314)
Weight Increased (1179)
Hypertension (846)
Pancreatitis (713)
Blood Triglycerides Increased (658)
Hyperglycaemia (595)
Overdose (591)
Metabolic Disorder (573)
Diabetes Mellitus Non-insulin-dependent (543)
Diabetic Ketoacidosis (524)
Blood Cholesterol Increased (517)
Obesity (438)
Prescribed Overdose (399)
Blood Cholesterol Abnormal (398)
Blood Glucose Increased (367)
Diabetic Coma (339)
Off Label Use (337)
Death (336)
Fall (288)
Anxiety (276)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Zyprexa Side Effects Reported to FDA

The following Zyprexa reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Zyprexa on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Schizoaffective Disorder Bipolar Type, Prescribed Overdose
This is a report of a 50-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: schizoaffective disorder,bipolar disorder, who was treated with Zyprexa (dosage: NA, start time: 201108), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Schizoaffective Disorder Bipolar Type
  • Prescribed Overdose
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Zyprexa treatment in male patients, resulting in schizoaffective disorder bipolar type side effect. The patient was hospitalized.

Suicidal Ideation, Depression
This report suggests a potential Zyprexa Suicidal Ideation, Depression side effect(s) that can have serious consequences. A 54-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: bipolar disorder,depression and used Zyprexa (dosage: 2.5 Mg, Each Evening) starting Feb 20, 2013. Soon after starting Zyprexa the patient began experiencing various side effects, including:
  • Suicidal Ideation
  • Depression
Drugs used concurrently: NA. Although Zyprexa demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as suicidal ideation, may still occur.

Portal Vein Cavernous Transformation, Mesenteric Vein Thrombosis
This Portal Vein Cavernous Transformation, Mesenteric Vein Thrombosis problem was reported by a consumer or non-health professional from FR. A 61-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: psychotic disorder. On NS this consumer started treatment with Zyprexa (dosage: 10 Mg, Qd). The following drugs were being taken at the same time: NA. When commencing Zyprexa, the patient experienced the following unwanted symptoms/side effects:
  • Portal Vein Cavernous Transformation
  • Mesenteric Vein Thrombosis
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as portal vein cavernous transformation, may become evident only after a product is in use by the general population.

Haematoma, Anxiety, Anger, Influenza Like Illness, Dyspnoea, Visual Impairment, Lymphadenopathy, Nasopharyngitis, Neck Pain
This is a report of a 33-year-old female patient (weight: NA) from NL. The patient developed the following symptoms/conditions: anger,sleep disorder,anxiety and was treated with Zyprexa (dosage: 10 Mg, Qd) starting May 10, 2003. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Haematoma
  • Anxiety
  • Anger
  • Influenza Like Illness
  • Dyspnoea
  • Visual Impairment
  • Lymphadenopathy
  • Nasopharyngitis
  • Neck Pain
This opens a possibility that Zyprexa treatment could cause the above reactions, including haematoma, and some female subjects may be more susceptible.


Nystagmus, Off Label Use
A 16-year-old female patient (weight: NA) from DE with the following symptoms/conditions: NA started Zyprexa treatment (dosage: 10 Mg, Each Morning) on 201312. Soon after starting Zyprexa treatment, the subject experienced various side effects, including:
  • Nystagmus
  • Off Label Use
Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Zyprexa.

Injury, Congenital Anomaly
A 69-year-old female patient from US (weight: NA) experienced symptoms, such as: depression and was treated with Zyprexa(dosage: NA). The treatment was initiated on Feb 19, 2014. After that a consumer reported the following side effect(s):
  • Injury
  • Congenital Anomaly
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Zyprexa efficacy: NA.

Hypophagia, Oligodipsia, Weight Decreased, Blood Potassium Decreased, Prescribed Overdose
In this report, Zyprexa was administered for the following condition: schizophrenia,asperger^s disorder.A 53-year-old female consumer from NZ (weight: NA) started Zyprexa treatment (dosage: NA) on 2011.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Hypophagia
  • Oligodipsia
  • Weight Decreased
  • Blood Potassium Decreased
  • Prescribed Overdose
A possible interaction with other drugs could have contributed to this reaction: NA.The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Zyprexa treatment could be related to the listed above side effect(s).

Weight Increased, Hyperhidrosis
This is a report of the following Zyprexa Velotab side effect(s):
  • Weight Increased
  • Hyperhidrosis
A 45-year-old female patient from NL (weight: NA) presented with the following condition: bipolar disorder and received a treatment with Zyprexa Velotab (dosage: 15 Mg, Qd) starting: Jul 01, 2005.The following concurrently used drugs could have generated interactions:
  • Temazepam (10 Mg, Qd)
  • Seresta (10 Mg, Prn)
This report suggests that a Zyprexa Velotab treatment could be associated with the listed above side effect(s).

Dysarthria, Disorientation, Amnesia, Coma, Confusional State, Extrapyramidal Disorder, Sedation, Toxicity To Various Agents
This Zyprexa Relprevv report was submitted by a 72-year-old female consumer from NZ (weight: NA). The patient was diagnosed with: schizoaffective disorder and Zyprexa Relprevv was administered (dosage: 405 Mg, 4 Weekly) starting: Nov 12, 2013. The consumer developed a set of symptoms:
  • Dysarthria
  • Disorientation
  • Amnesia
  • Coma
  • Confusional State
  • Extrapyramidal Disorder
  • Sedation
  • Toxicity To Various Agents
Other drugs used simultaneously:
  • Carbamazepine (200 Mg, Bid)
  • Levothyroxine (100 Mg, Qd)
  • Thiamine (100 Mg, Qd)
The patient was hospitalized.Those unexpected symptoms could be linked to a Zyprexa Relprevv treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Mania, Neuroleptic Malignant Syndrome
This is a report of a possible correlation between Zyprexa use and the following symptoms/side effect(s):
  • Mania
  • Neuroleptic Malignant Syndrome
which could contribute to an assessment of Zyprexa risk profile.A 55-year-old male consumer from JP (weight: NA) was suffering from bipolar disorder and was treated with Zyprexa (dosage: 5 Mg, Unk) starting NS.Other concurrent medications: NA.The patient was hospitalized.

Renal Failure, Extrapyramidal Disorder, Somnolence, Toxicity To Various Agents, Haemodynamic Instability
A 62-year-old female patient from FR (weight: NA) presented with the following symptoms: NA and after a treatment with Zyprexa (dosage: 10 Mg, Qd) experienced the following side effect(s):
  • Renal Failure
  • Extrapyramidal Disorder
  • Somnolence
  • Toxicity To Various Agents
  • Haemodynamic Instability
The treatment was started on NS. Zyprexa was used in combination with the following drugs:
  • Teralhite
  • Lexomil (1.5 Mg, Qd)
  • Venlafaxine (37.5 Mg, Bid)
  • Lamaline /01708901/ (1 Df, Bid)
  • Perindopril
  • Crestor
  • Bisoprolol Fumarate
  • Kardegic
The patient was hospitalized.This report could alert potential Zyprexa consumers.


In this report, a 48-year-old female patient from JP (weight: NA) was affected by a possible Zyprexa side effect.The patient was diagnosed with schizophrenia. After a treatment with Zyprexa (dosage: 10 Mg, Unk, start date: Jan 21, 2014), the patient experienced the following side effect(s):
    The following simultaneously used drugs could have led to this reaction:
    • Rohypnol (Unk Mg, Unk)
    • Lendormin (Unk Mg, Unk)
    • Serenace (Unk)
    • Akineton /00079501/ (Unk)
    The findings here stress that side effects should be taken into consideration when evaluating a Zyprexa treatment.

    Pituitary Tumour
    This is a report of a 73-year-old female patient from DE (weight: NA), who used Zyprexa (dosage: NA) for a treatment of NA. After starting a treatment on NS, the patient experienced the following side effect(s):
    • Pituitary Tumour
    The following drugs could possibly have interacted with the Zyprexa treatment
    • Seroquel
    The patient was hospitalized.Taken together, these observations suggest that a Zyprexa treatment could be related to side effect(s), such as Pituitary Tumour.

    Dizziness, Amnesia, Tinnitus, Depression, Asthenia, Fatigue, Bruxism, Unevaluable Event
    This dizziness side effect was reported by a consumer or non-health professional from US. A 53-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Zyprexa (dosage: NA), which was started on Dec 30, 2013. Concurrently used drugs:
    • Ultram
    When starting to take Zyprexa the consumer reported the following symptoms:
    • Dizziness
    • Amnesia
    • Tinnitus
    • Depression
    • Asthenia
    • Fatigue
    • Bruxism
    • Unevaluable Event
    The patient was hospitalized and became disabled. These side effects may potentially be related to Zyprexa.

    Status Epilepticus, Grand Mal Convulsion, Dyspnoea, Dystonia, Memory Impairment, Muscle Rigidity, Speech Disorder, Drooling
    This is a Zyprexa side effect report of a 21-year-old male patient (weight:NA) from SE, suffering from the following symptoms/conditions: NA, who was treated with Zyprexa (dosage:NA, start time: NS), combined with:
    • Cisordinol Acutard
    , and developed a serious reaction and a status epilepticus side effect. The patient presented with:
    • Status Epilepticus
    • Grand Mal Convulsion
    • Dyspnoea
    • Dystonia
    • Memory Impairment
    • Muscle Rigidity
    • Speech Disorder
    • Drooling
    which developed after the beginning of treatment. The patient was hospitalized and became disabled. This side effect report can indicate a possible existence of increased vulnerability to Zyprexa treatment in male patients suffering from NA, resulting in status epilepticus.

    Neurological Decompensation, Underweight, Dyskinesia, Grimacing, Migraine, Peripheral Coldness, Gastrooesophageal Reflux Disease, Platelet Count Decreased, Mastication Disorder
    This report suggests a potential Zyprexa Zydis neurological decompensation side effect(s) that can have serious consequences. A 23-year-old male patient from US (weight:NA) was diagnosed with the following health condition(s): psychotic disorder and used Zyprexa Zydis (dosage: NA) starting 2006. Soon after starting Zyprexa Zydis the patient began experiencing various side effects, including:
    • Neurological Decompensation
    • Underweight
    • Dyskinesia
    • Grimacing
    • Migraine
    • Peripheral Coldness
    • Gastrooesophageal Reflux Disease
    • Platelet Count Decreased
    • Mastication Disorder
    Drugs used concurrently:NA. Although Zyprexa Zydis demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as neurological decompensation, may still occur.

    Depression Suicidal, Neutropenia, Phlebitis
    This depression suicidal problem was reported by a consumer or non-health professional from FR. A 64-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Nov 01, 2013 a consumer started treatment with Zyprexa (dosage: NA). The following drugs/medications were being taken at the same time: NA. When commencing Zyprexa, the patient experienced the following unwanted symptoms /side effects:
    • Depression Suicidal
    • Neutropenia
    • Phlebitis
    The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as depression suicidal, may become evident only after a product is in use by the general population.

    Thrombosis, Muscle Injury, Prescribed Overdose
    This is a Zyprexa side effect report of a 39-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: schizoaffective disorder and was treated with Zyprexa (dosage: 12.5 Mg, Qd) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
    • Thrombosis
    • Muscle Injury
    • Prescribed Overdose
    The patient was hospitalized. This opens a possibility that Zyprexa could cause thrombosis and that some male patients may be more susceptible.

    Condition Aggravated, Transaminases Increased
    A 69-year-old male patient (weight: NA) from FR with the following symptoms: NA started Zyprexa treatment (dosage: NA) on Jun 19, 2012. Soon after starting Zyprexa treatment, the consumer experienced several side effects, including:
    • Condition Aggravated
    • Transaminases Increased
    . Concurrently used drugs:
    • Ciflox /00697201/
    • Efient
    • Tenormine
    • Kardegic
    • Inexium /01479302/
    • Tahor
    • Atacand
    • Tienam
    This finding indicates that some patients can be more vulnerable to developing Zyprexa side effects, such as condition aggravated.

    Coma, Disturbance In Attention, Circulatory Collapse, Oxygen Saturation Decreased, Hypothermia, Pneumonia Aspiration
    This coma side effect was reported by a consumer or non-health professional from FR. A 36-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Zyprexa (dosage: NA), which was started on NS. Concurrently used drugs:
    • Valium /00017001/
    • Stilnox
    • Depakine /00228502/
    • Tercian /00759301/
    • Levomepromazine
    • Seroplex
    • Relpax
    • Ketum (1 Df, Prn)
    .When starting to take Zyprexa the consumer reported symptoms, such as:
    • Coma
    • Disturbance In Attention
    • Circulatory Collapse
    • Oxygen Saturation Decreased
    • Hypothermia
    • Pneumonia Aspiration
    These side effects may potentially be related to Zyprexa. The patient was hospitalized.

    Altered State Of Consciousness, Suicidal Ideation, Weight Increased, Facial Paresis, Balance Disorder, Disorientation, Delirium, Occult Blood, Visual Impairment
    This is a report of a 28-year-old male patient (weight: NA) from DE, suffering from the following symptoms/conditions: psychotic disorder,schizophrenia, paranoid type, who was treated with Zyprexa (dosage: NA, start time: 1998), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
    • Altered State Of Consciousness
    • Suicidal Ideation
    • Weight Increased
    • Facial Paresis
    • Balance Disorder
    • Disorientation
    • Delirium
    • Occult Blood
    • Visual Impairment
    which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Zyprexa treatment in male patients, resulting in altered state of consciousness side effect.

    Weight Decreased, Fall, Head Injury, Laceration, Crying, Fatigue
    This report suggests a potential Zyprexa Weight Decreased, Fall, Head Injury, Laceration, Crying, Fatigue side effect(s) that can have serious consequences. A 26-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: huntington^s disease and used Zyprexa (dosage: NA) starting NS. Soon after starting Zyprexa the patient began experiencing various side effects, including:
    • Weight Decreased
    • Fall
    • Head Injury
    • Laceration
    • Crying
    • Fatigue
    Drugs used concurrently:
    • Remeron
    • Depakote
    • Neurontin
    • Ativan
    • Trazadone
    Although Zyprexa demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as weight decreased, may still occur.

    Water Intoxication
    This Water Intoxication problem was reported by a physician from JP. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: schizophrenia. On NS this consumer started treatment with Zyprexa (dosage: 10 Mg, Qd). The following drugs were being taken at the same time: NA. When commencing Zyprexa, the patient experienced the following unwanted symptoms/side effects:
    • Water Intoxication
    Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as water intoxication, may become evident only after a product is in use by the general population.

    Vaginal Haemorrhage
    This is a report of a 56-year-old female patient (weight: NA) from PT. The patient developed the following symptoms/conditions: NA and was treated with Zyprexa Velotab (dosage: NA) starting 1998. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
    • Vaginal Haemorrhage
    This opens a possibility that Zyprexa Velotab treatment could cause the above reactions, including vaginal haemorrhage, and some female subjects may be more susceptible.

    Fall
    A 57-year-old female patient (weight: NA) from US with the following symptoms/conditions: panic disorder started Zyprexa treatment (dosage: By Mouth) on Oct 25, 2013. Soon after starting Zyprexa treatment, the subject experienced various side effects, including:
    • Fall
    Concurrently used drugs:
    • Citalopram
    • Hbr
    • Clonazepam
    This finding indicates that some female patients could be more vulnerable to Zyprexa.

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    Keep Track of Side Effects

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    Why Your Notes are Important

    Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Zyprexa Side Effects

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    How Effective is Zyprexa for You?

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    Zyprexa Safety Alerts, Active Ingredients, Usage Information

    NDC0002-4112
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameZyprexa
    NameOlanzapine
    Dosage FormTABLET
    RouteORAL
    On market since19970623
    LabelerEli Lilly and Company
    Active Ingredient(s)OLANZAPINE
    Strength(s)2.5
    Unit(s)mg/1
    Pharma ClassAtypical Antipsychotic [EPC]

    Zyprexa Dosage, Warnings, Usage.

    Side Effects reported to FDA: 11086

    Zyprexa safety alerts: 2014 2010 2005 2004 2002

    Reported deaths: 2077

    Reported hospitalizations: 5835

    Zyprexa (olanzapine): Use in Adolescents

    Audience: Neuropsychiatric healthcare professionals

    [Posted 01/29/2010] Lilly and FDA notified healthcare professionals of changes to the Prescribing Information for Zyprexa related to its indication for use in adolescents (ages 13-17) for treatment of schizophrenia and bipolar I disorder [manic or mixed episodes]. The revised labeling states that:

    Section 1, Indications and Usage: When deciding among the alternative treatments available for adolescents, clinicians should consider the increased potential (in adolescents as compared with adults) for weight gain and hyperlipidemia. Clinicians should consider the potential long-term risks when prescribing to adolescents, and in many cases this may lead them to consider prescribing other drugs first in adolescents.

    Section 17.14, Need for comprehensive Treatment Program in Pediatric Patients: Zyprexa is indicated as an integral part of a total treatment program for pediatric patients with schizophrenia and bipolar disorder that may include other measures (psychological, educational, social) for patients with the disorder. Effectiveness and safety of ZYPREXA have not been established in pediatric patients less than 13 years of age.

    [01/04/2010 - Dear Healthcare Professional Letter - Lilly]
    [12/2009 - Prescribing Information - Lilly]

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