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Methadone Side Effects List

Common Methadone Side Effects


The following Methadone Side Effects were reported by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers) and manufacturers.

It is important to know potential risks posed by drugs and health products. Staying informed can help you make right decisions and stay healthy.

You can read detailed reports by clicking on a side effect.




Abasia 2 reports0.03%
Abdominal Discomfort 5 reports0.09%
Abdominal Distension 6 reports0.10%
Abdominal Pain 12 reports0.21%
Abdominal Pain Upper 12 reports0.21%
Abnormal Behaviour 8 reports0.14%
Abnormal Dreams 5 reports0.09%
Abnormal Weight Gain 2 reports0.03%
Accident 4 reports0.07%
Accident At Work 2 reports0.03%
Accidental Death 8 reports0.14%
Accidental Exposure 16 reports0.28%
Accidental Overdose 59 reports1.02%
Accidental Poisoning 23 reports0.40%
Acidosis 2 reports0.03%
Activities Of Daily Living Impaired 8 reports0.14%
Acute Coronary Syndrome 2 reports0.03%
Acute Hepatic Failure 4 reports0.07%
Acute Myocardial Infarction 5 reports0.09%
Acute Pulmonary Oedema 2 reports0.03%
Acute Respiratory Distress Syndrome 19 reports0.33%
Acute Respiratory Failure 6 reports0.10%
Adverse Event 2 reports0.03%
Affect Lability 5 reports0.09%
Aggression 7 reports0.12%
Agitation 20 reports0.35%
Alanine Aminotransferase Increased 2 reports0.03%
Alcohol Abuse 2 reports0.03%
Alcohol Use 19 reports0.33%
Alcohol Withdrawal Syndrome 3 reports0.05%
Alopecia 4 reports0.07%
Alpha Haemolytic Streptococcal Infection 2 reports0.03%
Altered State Of Consciousness 6 reports0.10%
Amenorrhoea 3 reports0.05%
Amnesia 15 reports0.26%
Anaemia 4 reports0.07%
Anger 4 reports0.07%
Animal Bite 2 reports0.03%
Anorexia 2 reports0.03%
Anoxic Encephalopathy 9 reports0.16%
Anxiety 22 reports0.38%
Aortic Arteriosclerosis 2 reports0.03%
Apathy 2 reports0.03%
Aphasia 2 reports0.03%
Apnoea 10 reports0.17%
Application Site Burn 2 reports0.03%
Areflexia 3 reports0.05%
Arrhythmia 15 reports0.26%
Arteriosclerosis 8 reports0.14%
Arteriosclerosis Coronary Artery 4 reports0.07%
Arthralgia 15 reports0.26%
Arthritis 4 reports0.07%
Ascites 5 reports0.09%
Aspartate Aminotransferase Increased 4 reports0.07%
Asphyxia 5 reports0.09%
Aspiration 16 reports0.28%
Asthenia 22 reports0.38%
Asthenopia 2 reports0.03%
Atelectasis 4 reports0.07%
Atrial Fibrillation 2 reports0.03%
Back Injury 3 reports0.05%
Back Pain 11 reports0.19%
Bacteraemia 8 reports0.14%
Balance Disorder 5 reports0.09%
Basal Ganglia Infarction 3 reports0.05%
Beta Haemolytic Streptococcal Infection 6 reports0.10%
Biliary Dilatation 2 reports0.03%
Bipolar Disorder 3 reports0.05%
Bladder Cancer 2 reports0.03%
Blister 2 reports0.03%
Blood Alkaline Phosphatase Increased 3 reports0.05%
Blood Bilirubin Increased 2 reports0.03%
Blood Cannabinoids 6 reports0.10%
Blood Creatine Phosphokinase Increased 6 reports0.10%
Blood Creatinine Increased 4 reports0.07%
Blood Culture Positive 2 reports0.03%
Blood Glucose Decreased 2 reports0.03%
Blood Glucose Increased 8 reports0.14%
Blood Magnesium Decreased 11 reports0.19%
Blood Magnesium Increased 3 reports0.05%
Blood Ph Decreased 3 reports0.05%
Blood Potassium Decreased 16 reports0.28%
Blood Pressure Decreased 4 reports0.07%
Blood Pressure Increased 9 reports0.16%
Blood Sodium Decreased 4 reports0.07%
Blood Urea Increased 3 reports0.05%
Body Temperature Decreased 4 reports0.07%
Bone Pain 5 reports0.09%
Bradycardia 23 reports0.40%
Bradypnoea 5 reports0.09%
Brain Herniation 5 reports0.09%
Brain Injury 4 reports0.07%
Brain Oedema 25 reports0.43%
Brain Stem Haemorrhage 3 reports0.05%
Breakthrough Pain 4 reports0.07%
Bronchitis 3 reports0.05%
Bronchopneumonia 36 reports0.62%
Burning Sensation 4 reports0.07%
Cachexia 3 reports0.05%
Carcinoembryonic Antigen Increased 3 reports0.05%
Cardiac Arrest 334 reports5.79%
Cardiac Enzymes Increased 3 reports0.05%
Cardiac Failure 4 reports0.07%
Cardiac Failure Congestive 7 reports0.12%
Cardio-respiratory Arrest 73 reports1.27%
Cardiomegaly 11 reports0.19%
Cardiomyopathy 5 reports0.09%
Cardiovascular Disorder 6 reports0.10%
Cellulitis 6 reports0.10%
Cerebral Atrophy 4 reports0.07%
Cerebral Ischaemia 4 reports0.07%
Chest Discomfort 13 reports0.23%
Chest Pain 11 reports0.19%
Chills 7 reports0.12%
Cholecystitis 3 reports0.05%
Chronic Obstructive Pulmonary Disease 7 reports0.12%
Circulatory Collapse 5 reports0.09%
Cognitive Disorder 7 reports0.12%
Coma 29 reports0.50%
Completed Suicide 256 reports4.44%
Computerised Tomogram Abnormal 4 reports0.07%
Concussion 7 reports0.12%
Condition Aggravated 11 reports0.19%
Confusional State 47 reports0.82%
Congestive Cardiomyopathy 3 reports0.05%
Constipation 27 reports0.47%
Contusion 8 reports0.14%
Convulsion 31 reports0.54%
Coordination Abnormal 4 reports0.07%
Coronary Artery Disease 5 reports0.09%
Cough 3 reports0.05%
Cyanosis 9 reports0.16%
Deafness Neurosensory 8 reports0.14%
Death 147 reports2.55%
Decreased Appetite 13 reports0.23%
Deep Vein Thrombosis 6 reports0.10%
Dehydration 7 reports0.12%
Delirium 18 reports0.31%
Depressed Level Of Consciousness 30 reports0.52%
Depressed Mood 4 reports0.07%
Depression 17 reports0.29%
Diabetes Mellitus 4 reports0.07%
Diabetic Hyperosmolar Coma 3 reports0.05%
Diabetic Ketoacidosis 7 reports0.12%
Dialysis 3 reports0.05%
Diarrhoea 16 reports0.28%
Discomfort 3 reports0.05%
Disorientation 8 reports0.14%
Disturbance In Attention 10 reports0.17%
Dizziness 35 reports0.61%
Dry Mouth 8 reports0.14%
Dysarthria 6 reports0.10%
Dysgeusia 4 reports0.07%
Dyskinesia 6 reports0.10%
Dyspepsia 5 reports0.09%
Dysphagia 5 reports0.09%
Dyspnoea 39 reports0.68%
Dysstasia 5 reports0.09%
Dystonia 6 reports0.10%
Dysuria 5 reports0.09%
Ejection Fraction Decreased 3 reports0.05%
Electrocardiogram Qt Corrected Interval Prolonged 6 reports0.10%
Electrocardiogram Qt Prolonged 142 reports2.46%
Electrocardiogram St Segment Abnormal 3 reports0.05%
Electrolyte Imbalance 3 reports0.05%
Electromechanical Dissociation 3 reports0.05%
Encephalitis 5 reports0.09%
Encephalopathy 8 reports0.14%
Epilepsy 3 reports0.05%
Erythema 4 reports0.07%
Escherichia Sepsis 3 reports0.05%
Exposure Via Ingestion 5 reports0.09%
Extrasystoles 10 reports0.17%
Faecal Incontinence 5 reports0.09%
Fall 37 reports0.64%
Fatigue 25 reports0.43%
Febrile Neutropenia 6 reports0.10%
Feeling Abnormal 26 reports0.45%
Feeling Cold 4 reports0.07%
Feeling Hot 5 reports0.09%
Flushing 5 reports0.09%
Gait Disturbance 7 reports0.12%
Galactorrhoea 4 reports0.07%
Gastrointestinal Haemorrhage 3 reports0.05%
Grand Mal Convulsion 10 reports0.17%
Haemodialysis 3 reports0.05%
Haemorrhoids 4 reports0.07%
Hallucination 13 reports0.23%
Head Injury 6 reports0.10%
Headache 25 reports0.43%
Heart Rate Decreased 3 reports0.05%
Heart Rate Increased 7 reports0.12%
Hepatic Cirrhosis 6 reports0.10%
Hepatic Encephalopathy 4 reports0.07%
Hepatic Failure 3 reports0.05%
Hepatic Steatosis 11 reports0.19%
Hepatitis C 9 reports0.16%
Hepatosplenomegaly 8 reports0.14%
Herpes Simplex 5 reports0.09%
Hyperaesthesia 7 reports0.12%
Hypercalcaemia 3 reports0.05%
Hypercapnia 5 reports0.09%
Hyperglycaemia 3 reports0.05%
Hyperhidrosis 31 reports0.54%
Hyperkalaemia 7 reports0.12%
Hyperreflexia 4 reports0.07%
Hypersomnia 6 reports0.10%
Hypertension 9 reports0.16%
Hypertensive Heart Disease 4 reports0.07%
Hypoaesthesia 15 reports0.26%
Hypoglycaemia 10 reports0.17%
Hypokalaemia 26 reports0.45%
Hypomagnesaemia 9 reports0.16%
Hypophagia 4 reports0.07%
Hypopnoea 5 reports0.09%
Hypotension 31 reports0.54%
Hypothermia 3 reports0.05%
Hypothyroidism 5 reports0.09%
Hypoventilation 5 reports0.09%
Hypoxia 15 reports0.26%
Hypoxic-ischaemic Encephalopathy 21 reports0.36%
Impaired Driving Ability 3 reports0.05%
Inadequate Analgesia 10 reports0.17%
Incoherent 8 reports0.14%
Incorrect Dose Administered 23 reports0.40%
Influenza Like Illness 7 reports0.12%
Injury 3 reports0.05%
Insomnia 22 reports0.38%
Intentional Misuse 3 reports0.05%
Intentional Overdose 27 reports0.47%
Intestinal Obstruction 6 reports0.10%
Irritability 3 reports0.05%
Ischaemic Stroke 3 reports0.05%
Joint Swelling 3 reports0.05%
Laceration 3 reports0.05%
Lacrimation Increased 3 reports0.05%
Lactic Acidosis 3 reports0.05%
Left Ventricular Dysfunction 3 reports0.05%
Lethargy 24 reports0.42%
Leukocytosis 3 reports0.05%
Leukoencephalopathy 17 reports0.29%
Liver Disorder 4 reports0.07%
Liver Function Test Abnormal 3 reports0.05%
Lobar Pneumonia 3 reports0.05%
Long Qt Syndrome 4 reports0.07%
Loss Of Consciousness 54 reports0.94%
Lung Neoplasm Malignant 8 reports0.14%
Malaise 30 reports0.52%
Memory Impairment 11 reports0.19%
Mental Disorder 7 reports0.12%
Mental Impairment 3 reports0.05%
Mental Status Changes 38 reports0.66%
Metabolic Acidosis 8 reports0.14%
Metabolic Alkalosis 3 reports0.05%
Metastases To Bone 3 reports0.05%
Metastases To Liver 7 reports0.12%
Metastatic Pain 3 reports0.05%
Middle Insomnia 3 reports0.05%
Migraine 7 reports0.12%
Miosis 22 reports0.38%
Multi-organ Disorder 15 reports0.26%
Multi-organ Failure 8 reports0.14%
Multiple Injuries 4 reports0.07%
Muscle Rigidity 3 reports0.05%
Muscle Spasms 9 reports0.16%
Muscular Weakness 3 reports0.05%
Musculoskeletal Stiffness 6 reports0.10%
Myalgia 3 reports0.05%
Myocardial Infarction 9 reports0.16%
Myocardial Ischaemia 5 reports0.09%
Myoclonus 12 reports0.21%
Narcotic Intoxication 3 reports0.05%
Nasopharyngitis 4 reports0.07%
Nausea 57 reports0.99%
Neck Injury 3 reports0.05%
Neck Pain 4 reports0.07%
Needle Track Marks 4 reports0.07%
Neoplasm Malignant 9 reports0.16%
Nephropathy 3 reports0.05%
Nervous System Disorder 7 reports0.12%
Nightmare 7 reports0.12%
No Adverse Event 3 reports0.05%
Non-cardiogenic Pulmonary Oedema 4 reports0.07%
Oedema 6 reports0.10%
Oedema Peripheral 11 reports0.19%
Off Label Use 3 reports0.05%
Oropharyngeal Pain 4 reports0.07%
Osteoporosis 4 reports0.07%
Overdose 197 reports3.42%
Oxygen Saturation Decreased 12 reports0.21%
Pain 37 reports0.64%
Pain In Extremity 10 reports0.17%
Pallor 3 reports0.05%
Palpitations 5 reports0.09%
Pancreatic Carcinoma 3 reports0.05%
Panic Attack 4 reports0.07%
Paraesthesia 6 reports0.10%
Paranoia 4 reports0.07%
Peripheral Ischaemia 3 reports0.05%
Pleural Effusion 4 reports0.07%
Pneumonia 40 reports0.69%
Pneumonia Aspiration 15 reports0.26%
Pneumonia Staphylococcal 3 reports0.05%
Pneumothorax 3 reports0.05%
Poisoning 18 reports0.31%
Poisoning Deliberate 3 reports0.05%
Polysubstance Abuse 13 reports0.23%
Posterior Reversible Encephalopathy Syndrome 3 reports0.05%
Premature Delivery 3 reports0.05%
Premature Rupture Of Membranes 3 reports0.05%
Presyncope 4 reports0.07%
Product Quality Issue 10 reports0.17%
Product Substitution Issue 4 reports0.07%
Product Tampering 3 reports0.05%
Product Taste Abnormal 6 reports0.10%
Productive Cough 3 reports0.05%
Pruritus 18 reports0.31%
Psychotic Disorder 6 reports0.10%
Pulmonary Congestion 26 reports0.45%
Pulmonary Embolism 9 reports0.16%
Pulmonary Oedema 57 reports0.99%
Pulse Absent 4 reports0.07%
Pupillary Reflex Impaired 3 reports0.05%
Pyrexia 19 reports0.33%
Rash 7 reports0.12%
Renal Failure 13 reports0.23%
Renal Failure Acute 26 reports0.45%
Renal Impairment 5 reports0.09%
Respiratory Acidosis 9 reports0.16%
Respiratory Arrest 316 reports5.48%
Respiratory Depression 82 reports1.42%
Respiratory Disorder 4 reports0.07%
Respiratory Distress 9 reports0.16%
Respiratory Failure 24 reports0.42%
Respiratory Rate Decreased 7 reports0.12%
Restlessness 4 reports0.07%
Rhabdomyolysis 24 reports0.42%
Rhinorrhoea 3 reports0.05%
Road Traffic Accident 7 reports0.12%
Scar 4 reports0.07%
Secondary Hypogonadism 3 reports0.05%
Sedation 36 reports0.62%
Sepsis 4 reports0.07%
Septic Shock 4 reports0.07%
Serotonin Syndrome 17 reports0.29%
Sexual Dysfunction 3 reports0.05%
Shock 3 reports0.05%
Sinus Bradycardia 7 reports0.12%
Sinus Tachycardia 6 reports0.10%
Skin Discolouration 5 reports0.09%
Sleep Apnoea Syndrome 9 reports0.16%
Sleep Attacks 3 reports0.05%
Sleep Disorder 7 reports0.12%
Snoring 12 reports0.21%
Somnolence 65 reports1.13%
Speech Disorder 5 reports0.09%
Spinal Operation 3 reports0.05%
Splenomegaly 3 reports0.05%
Staphylococcal Bacteraemia 4 reports0.07%
Staphylococcal Infection 4 reports0.07%
Stress 3 reports0.05%
Stress Cardiomyopathy 5 reports0.09%
Substance Abuse 6 reports0.10%
Substance-induced Psychotic Disorder 7 reports0.12%
Sudden Cardiac Death 3 reports0.05%
Sudden Death 11 reports0.19%
Suicidal Ideation 7 reports0.12%
Suicide Attempt 6 reports0.10%
Syncope 39 reports0.68%
Tachycardia 10 reports0.17%
Therapeutic Agent Toxicity 17 reports0.29%
Therapeutic Response Decreased 3 reports0.05%
Thermal Burn 3 reports0.05%
Tinnitus 4 reports0.07%
Tonic Clonic Movements 4 reports0.07%
Tooth Disorder 6 reports0.10%
Tooth Extraction 5 reports0.09%
Torsade De Pointes 97 reports1.68%
Toxic Encephalopathy 4 reports0.07%
Toxicity To Various Agents 601 reports10.4%
Toxicologic Test Abnormal 3 reports0.05%
Transient Ischaemic Attack 4 reports0.07%
Treatment Noncompliance 14 reports0.24%
Tremor 15 reports0.26%
Troponin I Increased 3 reports0.05%
Unevaluable Event 3 reports0.05%
Unresponsive To Stimuli 27 reports0.47%
Urinary Retention 6 reports0.10%
Urinary Tract Infection 4 reports0.07%
Urine Analysis Abnormal 3 reports0.05%
Ventricular Arrhythmia 8 reports0.14%
Ventricular Extrasystoles 7 reports0.12%
Ventricular Fibrillation 10 reports0.17%
Ventricular Tachycardia 25 reports0.43%
Victim Of Homicide 4 reports0.07%
Vision Blurred 6 reports0.10%
Vomiting 51 reports0.88%
Weight Decreased 4 reports0.07%
Weight Increased 6 reports0.10%
Withdrawal Syndrome 18 reports0.31%

Displaying 400 Methadone side effects


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