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Methotrexate Diarrhoea Side Effects

Methotrexate Diarrhoea Side Effect Reports


The following Methotrexate Diarrhoea side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Diarrhoea, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Pancytopenia, Hyperglycaemia, Diarrhoea, Renal Failure

This Diarrhoea side effect was reported by a physician from COUNTRY NOT SPECIFIED. A 75-year-old patient (weight:NA) experienced the following symptoms/conditions: squamous cell carcinoma of head and neck,diabetes mellitus. The patient was prescribed Methotrexate (dosage: Dose- 40mg/mq), which was started on 2005. Concurrently used drugs:
  • Metforal (2000 Mg)
  • Zyloric (150 Mg)
When starting to take Methotrexate the consumer reported the following symptoms:
  • Pancytopenia
  • Hyperglycaemia
  • Diarrhoea
  • Renal Failure
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Hypokalaemia, Pancytopenia, Vomiting, Diarrhoea

This Diarrhoea Methotrexate side effect was reported by a health professional from FR on Feb 20, 2014. A Female , 50 years of age, weighting 156.5 lb, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Hypokalaemia
  • Pancytopenia
  • Vomiting
  • Diarrhoea
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Cortancyl
  • Mabthera
  • Velcade
  • Doxorubicin
  • Endoxan
The patient was hospitalized.
Febrile Neutropenia, Dermatitis, Thrombocytopenia, Stomatitis, Alopecia, Diarrhoea, Maternal Exposure During Pregnancy, Mouth Ulceration, Haematocrit Decreased

This is a Methotrexate side effect report of a 33-year-old female patient (weight:NA) from TR, suffering from the following symptoms/conditions: ectopic pregnancy, who was treated with Methotrexate (dosage:NA, start time: NS), combined with: NA., and developed a serious reaction and a Diarrhoea side effect. The patient presented with:
  • Febrile Neutropenia
  • Dermatitis
  • Thrombocytopenia
  • Stomatitis
  • Alopecia
  • Diarrhoea
  • Maternal Exposure During Pregnancy
  • Mouth Ulceration
  • Haematocrit Decreased
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from ectopic pregnancy, resulting in Diarrhoea.

Toxicity To Various Agents, Accidental Overdose, Stomatitis, Dysphagia, Diarrhoea, Abdominal Pain, Hypophagia, Skin Ulcer

A 71-year-old female patient (weight: NA) from DE with the following symptoms: rheumatoid arthritis started Methotrexate treatment (dosage: NA) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Toxicity To Various Agents
  • Accidental Overdose
  • Stomatitis
  • Dysphagia
  • Diarrhoea
  • Abdominal Pain
  • Hypophagia
  • Skin Ulcer
. Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Diarrhoea.
Bone Marrow Failure, Agranulocytosis, Febrile Neutropenia, Folate Deficiency, Thrombocytopenia, Pyrexia, Alopecia, Dermatitis, Diarrhoea

A female patient from TR was prescribed and started Methotrexate on Jan 30, 2014. Patient felt the following Methotrexate side effects: bone marrow failure, agranulocytosis, febrile neutropenia, folate deficiency, thrombocytopenia, pyrexia, alopecia, dermatitis, diarrhoea Additional patient health information: Female , 33 years of age, The consumer reported the following symptoms: . Methotrexate dosage: 75 Mg According To 50 Mg/m2 Regimen. Concurrently used drugs:
  • Methylprednisolone (40 Mg, Unk)
  • Folinic Acid (7.5 Mg, Unk)
  • Filgrastim (30 Ml, Bid)
  • Diphenoxylate Hydrochloride
  • Calcium Folinate (15 Mg, Qid)
  • Meropenem (500 Mg, Tid)
  • Teicoplanin (400 Mg, Once/single)
  • Nystatin (1 Df, Qid)
Diarrhoea, Vomiting, Platelet Count Decreased

This report suggests a potential Methotrexate Diarrhoea side effect(s) that can have serious consequences. A 76-year-old female patient from GB (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate (dosage: NA) starting Jan 01, 2010. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Diarrhoea
  • Vomiting
  • Platelet Count Decreased
Drugs used concurrently:
  • Acetylsalicylic Acid (75 Mg, Qd)
  • Lisinopril (Morning)
  • Furosemide (40 Mg, Qd Morning)
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Diarrhoea, may still occur.
Nausea, Decreased Appetite, Diarrhoea, Dry Skin, Contusion, Dyspnoea, Oral Fungal Infection, Speech Disorder, Abscess

An adverse event was reported by a consumer or non-health professional on Dec 03, 2013 by a Female taking Methotrexate (dosage: 2.5 Mg, Take 7 Pills On Saturday. Po?once Week, On Saturday) was diagnosed with and. Location: US , 61 years of age, weighting 148.0 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: nausea, decreased appetite, diarrhoea, dry skin, contusion, dyspnoea, oral fungal infection, speech disorder, abscess. Additional medications/treatments: The patient was hospitalized.
Stomatitis, Diarrhoea, Fatigue, Contusion, Yellow Skin, Pallor, Chest Pain, Headache, Chills

This Diarrhoea problem was reported by a consumer or non-health professional from US. A 22-year-old patient (weight: NA) was diagnosed with the following medical condition(s): juvenile idiopathic arthritis.On 201305 a consumer started treatment with Methotrexate (dosage: 1 Pill Once A Week (saturday) Mouth). The following drugs/medications were being taken at the same time:
  • Mobic
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Stomatitis
  • Diarrhoea
  • Fatigue
  • Contusion
  • Yellow Skin
  • Pallor
  • Chest Pain
  • Headache
  • Chills
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Diarrhoea, may become evident only after a product is in use by the general population.
Cheilitis, Malaise, Fluid Retention, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Diarrhoea, Paronychia, Nail Infection

This is a Methotrexate side effect report of a 30-year-old female patient (weight: NA) from COUNTRY NOT SPECIFIED. The patient developed the following symptoms/conditions: adult t-cell lymphoma/leukaemia and was treated with Methotrexate (dosage: NA) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Cheilitis
  • Malaise
  • Fluid Retention
  • Aspartate Aminotransferase Increased
  • Alanine Aminotransferase Increased
  • Diarrhoea
  • Paronychia
  • Nail Infection
This opens a possibility that Methotrexate could cause Diarrhoea and that some female patients may be more susceptible.
Pancytopenia, Diarrhoea, Dehydration, Stomatitis, Oral Candidiasis, Urinary Tract Infection, Hypoalbuminaemia, Renal Impairment, Mean Cell Volume Increased

This Diarrhoea side effect was reported by a health professional from COUNTRY NOT SPECIFIED on Jul 31, 2013. A female patient from COUNTRY NOT SPECIFIED , 71 years of age, was diagnosed with and was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: pancytopenia, diarrhoea, dehydration, stomatitis, oral candidiasis, urinary tract infection, hypoalbuminaemia, renal impairment, mean cell volume increased. Methotrexate dosage: 2.5 Mg. The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Pancytopenia, Dysphagia, Asthenia, Diarrhoea, Dehydration, Stomatitis

This Diarrhoea side effect was reported by a physician from TR. A 71-year-old female patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis. The patient was prescribed Methotrexate (dosage: 2.5 Mg/day Three Days A Week), which was started on NS. Concurrently used drugs: NA. When starting to take Methotrexate the consumer reported the following symptoms:
  • Pancytopenia
  • Dysphagia
  • Asthenia
  • Diarrhoea
  • Dehydration
  • Stomatitis
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Diarrhoea, Nausea, Vomiting, Alopecia, Product Quality Issue, Gastrooesophageal Cancer

This Diarrhoea Methotrexate side effect was reported by a consumer or non-health professional from US on Jul 03, 2013. A Female , weighting 53.99 lb, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Diarrhoea
  • Nausea
  • Vomiting
  • Alopecia
  • Product Quality Issue
  • Gastrooesophageal Cancer
. Methotrexate dosage: NA. Additional drugs used at the same time: NA.
Immunosuppression, Anaemia, Neutropenia, Thrombocytopenia, Diarrhoea, Urinary Tract Infection, Arteriovenous Fistula Site Infection, Enterococcal Infection, Endocarditis

This is a Methotrexate Sodium side effect report of a 52-year-old female patient (weight:NA) from AU, suffering from the following symptoms/conditions: central nervous system lymphoma, who was treated with Methotrexate Sodium (dosage:1g/m2; Total Dose 1600mg Over 2 Hours Every 2 Weeks, start time: NS), combined with:
  • Dexamethasone Sodium Phosphate
  • Cytarabine (100mg)
  • Rituximab (375 Mg/m2, Weekly X 8)
  • Leucovorin (60mg Iv 12 Hours After Mtx Infusion)
  • Leucovorin (50mg Iv Q6h X 2)
  • Leucovorin (200mg Iv Q4h X 12 Doses)
  • Leucovorin (50mg Iv Q6h X 15)
  • Leucovorin (200mg Iv Q6h X 10 Doses)
, and developed a serious reaction and a Diarrhoea side effect. The patient presented with:
  • Immunosuppression
  • Anaemia
  • Neutropenia
  • Thrombocytopenia
  • Diarrhoea
  • Urinary Tract Infection
  • Arteriovenous Fistula Site Infection
  • Enterococcal Infection
  • Endocarditis
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate Sodium treatment in female patients suffering from central nervous system lymphoma, resulting in Diarrhoea.
Cardiac Failure Congestive, Pulmonary Embolism, Deep Vein Thrombosis, Performance Status Decreased, Ileus, Urosepsis, Diarrhoea, Pleural Effusion

A 64-year-old patient (weight: NA) from US with the following symptoms: NA started Methotrexate treatment (dosage: NA) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Cardiac Failure Congestive
  • Pulmonary Embolism
  • Deep Vein Thrombosis
  • Performance Status Decreased
  • Ileus
  • Urosepsis
  • Diarrhoea
  • Pleural Effusion
. Concurrently used drugs:
  • Procarbazine
  • Dexamethasone
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Diarrhoea.
Toxicity To Various Agents, Pyrexia, Chills, Diarrhoea, Mucosal Inflammation, Skin Necrosis, Stem Cell Transplant

A female patient from FR was prescribed and started Methotrexate on May 06, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: toxicity to various agents, pyrexia, chills, diarrhoea, mucosal inflammation, skin necrosis, stem cell transplant Additional patient health information: Female , 28 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: NA. Concurrently used drugs:
  • Sodium Bicarbonate
  • Cefotaxime (cefotaxime)
The patient was hospitalized.
Febrile Neutropenia, Stomatitis, Nausea, Diarrhoea, Haemoglobin Decreased, White Blood Cell Count Decreased

This report suggests a potential Methotrexate Diarrhoea side effect(s) that can have serious consequences. A 47-year-old female patient from IT (weight:NA) was diagnosed with the following health condition(s): breast cancer and used Methotrexate (dosage: 65 Mg Milligram(s) (cyclical) Intravenous (not Otherwise Specified)) starting Oct 22, 2012. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Febrile Neutropenia
  • Stomatitis
  • Nausea
  • Diarrhoea
  • Haemoglobin Decreased
  • White Blood Cell Count Decreased
Drugs used concurrently:
  • Endoxan (970 Mg Milligram(s), Cyclical, Intravenous)
  • Fluorouracil (970 Mg Milligram(s) (yclical) Intravenous )not Otherwise Specified))
  • Kytril
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Diarrhoea, may still occur.
Abdominal Pain, Diarrhoea, Vomiting

An adverse event was reported by a physician on Mar 06, 2013 by a male taking Methotrexate (dosage: NA) . Location: COUNTRY NOT SPECIFIED , weighting 31.39 lb, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: abdominal pain, diarrhoea, vomiting. Additional medications/treatments:
Multiple prescriptions taken:
  • Dexamethasone
  • Cytarabine
  • Oncaspar
  • Vincristine Sulfate
The patient was hospitalized.
Leukopenia, Diarrhoea, Liver Function Test Abnormal, Abdominal Pain

This Diarrhoea problem was reported by a health professional from US. A 48-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): cutaneous sarcoidosis.On NS a consumer started treatment with Methotrexate (dosage: 15 Mg/week). The following drugs/medications were being taken at the same time: NA. When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Leukopenia
  • Diarrhoea
  • Liver Function Test Abnormal
  • Abdominal Pain
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Diarrhoea, may become evident only after a product is in use by the general population.
Leukopenia, Diarrhoea, Liver Function Test Abnormal, Abdominal Pain

This is a Methotrexate side effect report of a 48-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: cutaneous sarcoidosis and was treated with Methotrexate (dosage: 15 Mg/week) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Leukopenia
  • Diarrhoea
  • Liver Function Test Abnormal
  • Abdominal Pain
This opens a possibility that Methotrexate could cause Diarrhoea and that some female patients may be more susceptible.
Hypophagia, Rectal Haemorrhage, Abdominal Pain, Chills, Diarrhoea, Dyspnoea Exertional, Febrile Neutropenia, Mouth Ulceration, Pancytopenia

This Diarrhoea side effect was reported by a pharmacist from CA on Feb 15, 2013. A patient from CA , 66 years of age, weighting 178.6 lb, was treated with Methotrexate. Patient felt the following Methotrexate side effects: hypophagia, rectal haemorrhage, abdominal pain, chills, diarrhoea, dyspnoea exertional, febrile neutropenia, mouth ulceration, pancytopenia. Methotrexate dosage: 20 Milligram Daily;.
Multiple prescriptions taken:
  • Advair (Powder)
  • Amlodipine
  • Atorvastatin
  • Citalopram
  • Cozaar
  • Folic Acid
  • Furosemide
  • Rabeprazole
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Diarrhoea Causes and Reviews


What is diarrhea?

Diarrhea is loose, watery stools (bowel movements). You have diarrhea if you have loose stools three or more times in one day. Acute diarrhea is diarrhea that lasts a short time. It is a common problem. It usually lasts about one or two days, but it may last longer. Then it goes away on its own.

Diarrhea lasting more than a few days may be a sign of a more serious problem. Chronic diarrhea -- diarrhea that lasts at least four weeks -- can be a symptom of a chronic disease. Chronic diarrhea symptoms may be continual, or they may come and go.

Who gets diarrhea?

People of all ages can get diarrhea. On average, adults In the United States have acute diarrhea once a year. Young children have it an average of twice a year.

People who visit developing countries are at risk for traveler's diarrhea. It is caused by consuming contaminated food or water.

What causes diarrhea?

The most common causes of diarrhea include

  • Bacteria from contaminated food or water
  • Viruses such as the flu, norovirus, or rotavirus . Rotavirus is the most common cause of acute diarrhea in children.
  • Parasites, which are tiny organisms found in contaminated food or water
  • Medicines such as antibiotics, cancer drugs, and antacids that contain magnesium
  • Food intolerances and sensitivities, which are problems digesting certain ingredients or foods. An example is lactose intolerance.
  • Diseases that affect the stomach, small intestine, or colon, such as Crohn's disease
  • Problems with how the colon functions, such as irritable bowel syndrome

Some people also get diarrhea after stomach surgery, because sometimes the surgeries can cause food to move through your digestive system more quickly.

Sometimes no cause can be found. If your diarrhea goes away within a few days, finding the cause is usually not necessary.

What other symptoms might I have with diarrhea?

Other possible symptoms of diarrhea include

  • Cramps or pain in the abdomen
  • An urgent need to use the bathroom
  • Loss of bowel control

If a virus or bacteria is the cause of your diarrhea, you may also have a fever, chills, and bloody stools.

Diarrhea can cause dehydration, which means that your body does not have enough fluid to work properly. Dehydration can be serious, especially for children, older adults, and people with weakened immune systems.

When should I see a doctor for diarrhea?

Although it is usually not harmful, diarrhea can become dangerous or signal a more serious problem. Contact your health care provider if you have

  • Signs of dehydration
  • Diarrhea for more than 2 days, if you are an adult. For children, contact the provider if it lasts more than 24 hours.
  • Severe pain in your abdomen or rectum (for adults)
  • A fever of 102 degrees or higher
  • Stools containing blood or pus
  • Stools that are black and tarry

If children have diarrhea, parents or caregivers should not hesitate to call a health care provider. Diarrhea can be especially dangerous in newborns and infants.

How is the cause of diarrhea diagnosed?

To find the cause of diarrhea, your health care provider may

  • Do a physical exam
  • Ask about any medicines you are taking
  • Test your stool or blood to look for bacteria, parasites, or other signs of disease or infection
  • Ask you to stop eating certain foods to see whether your diarrhea goes away

If you have chronic diarrhea, your health care provider may perform other tests to look for signs of disease.

What are the treatments for diarrhea?

Diarrhea is treated by replacing lost fluids and electrolytes to prevent dehydration. Depending on the cause of the problem, you may need medicines to stop the diarrhea or treat an infection.

Adults with diarrhea should drink water, fruit juices, sports drinks, sodas without caffeine, and salty broths. As your symptoms improve, you can eat soft, bland food.

Children with diarrhea should be given oral rehydration solutions to replace lost fluids and electrolytes.

Can diarrhea be prevented?

Two types of diarrhea can be prevented - rotavirus diarrhea and traveler's diarrhea. There are vaccines for rotavirus. They are given to babies in two or three doses.

You can help prevent traveler's diarrhea by being careful about what you eat and drink when you are in developing countries:

  • Use only bottled or purified water for drinking, making ice cubes, and brushing your teeth
  • If you do use tap water, boil it or use iodine tablets
  • Make sure that the cooked food you eat is fully cooked and served hot
  • Avoid unwashed or unpeeled raw fruits and vegetables

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


Methotrexate Diarrhoea Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
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Pain (188)
Renal Failure Acute (177)
Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
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Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
Interstitial Lung Disease (113)
Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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