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Methotrexate Fatigue Side Effects

Methotrexate Fatigue Side Effect Reports


The following Methotrexate Fatigue side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Fatigue, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Hypercalcaemia, Pancytopenia, Muscular Weakness, Fatigue, Back Pain, Pyrexia, Bone Pain, Psoas Abscess, Bone Tuberculosis

This Fatigue side effect was reported by a health professional from TR. A 74-year-old female patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis,hypertension,autoimmune thyroiditis. The patient was prescribed Methotrexate (dosage: 10 Mg, Per Week), which was started on NS. Concurrently used drugs:
  • Temisartan (80 Mg, Per Day)
  • Levothyroxine (100 Mg, Per Day)
When starting to take Methotrexate the consumer reported the following symptoms:
  • Hypercalcaemia
  • Pancytopenia
  • Muscular Weakness
  • Fatigue
  • Back Pain
  • Pyrexia
  • Bone Pain
  • Psoas Abscess
  • Bone Tuberculosis
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Neurotoxicity, Dysphemia, Fatigue

This Fatigue Methotrexate side effect was reported by a health professional from COUNTRY NOT SPECIFIED on Dec 10, 2013. A Female , 51 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Neurotoxicity
  • Dysphemia
  • Fatigue
. Methotrexate dosage: NA. Additional drugs used at the same time: NA. The patient was hospitalized.
Neurotoxicity, Dysphemia, Fatigue

This is a Methotrexate side effect report of a 51-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Methotrexate (dosage:7.5mg Weekly, Then 25mg Weekly, start time: NS), combined with: NA., and developed a serious reaction and a Fatigue side effect. The patient presented with:
  • Neurotoxicity
  • Dysphemia
  • Fatigue
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from NA, resulting in Fatigue.

Stomatitis, Diarrhoea, Fatigue, Contusion, Yellow Skin, Pallor, Chest Pain, Headache, Chills

A 22-year-old patient (weight: NA) from US with the following symptoms: juvenile idiopathic arthritis started Methotrexate treatment (dosage: 1 Pill Once A Week (saturday) Mouth) on 201305. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Stomatitis
  • Diarrhoea
  • Fatigue
  • Contusion
  • Yellow Skin
  • Pallor
  • Chest Pain
  • Headache
  • Chills
. Concurrently used drugs:
  • Mobic
This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Fatigue.
Tonsillitis, Joint Swelling, Juvenile Idiopathic Arthritis, Immobile, Hyperglycaemia, Cough, Dyspnoea, Fatigue, Arthralgia

A female patient from GB was prescribed and started Methotrexate (methotrexate) (methotrexate) on Oct 16, 2013. Patient felt the following Methotrexate side effects: tonsillitis, joint swelling, juvenile idiopathic arthritis, immobile, hyperglycaemia, cough, dyspnoea, fatigue, arthralgia Additional patient health information: Female , child 12 years of age, The consumer reported the following symptoms: . Methotrexate (methotrexate) (methotrexate) dosage: NA. Concurrently used drugs:
  • Anakinra
  • Cervarix (1 Dosage Forms, 1 In 1 D)
  • Prednisolone
  • Tocilizumab
The patient was hospitalized.
Dizziness, Personality Change, Suicidal Ideation, Depressed Mood, Fatigue

This report suggests a potential Methotrexate Fatigue side effect(s) that can have serious consequences. A 45-year-old patient from GB (weight:NA) was diagnosed with the following health condition(s): psoriasis and used Methotrexate (dosage: 12.5 Mg, Qw) starting Feb 01, 2013. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Dizziness
  • Personality Change
  • Suicidal Ideation
  • Depressed Mood
  • Fatigue
Drugs used concurrently:NA. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Fatigue, may still occur.
Skin Ulcer, Toxicity To Various Agents, Oral Mucosa Erosion, Fatigue, Alopecia, Overdose

An adverse event was reported by a health professional on Sep 30, 2013 by a male taking Methotrexate (dosage: 7.5mg Per Week) was diagnosed with and. Location: TR , 74 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: skin ulcer, toxicity to various agents, oral mucosa erosion, fatigue, alopecia, overdose. Additional medications/treatments: The patient was hospitalized.
Fatigue, Nausea, Vomiting, Alopecia, Crohn^s Disease

This Fatigue problem was reported by a consumer or non-health professional from US. A 35-year-old patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Methotrexate Injection (methotrexate) (dosage: 1 Week). The following drugs/medications were being taken at the same time:
  • (humira)
When commencing Methotrexate Injection (methotrexate), the patient experienced the following unwanted symptoms /side effects:
  • Fatigue
  • Nausea
  • Vomiting
  • Alopecia
  • Crohn^s Disease
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Fatigue, may become evident only after a product is in use by the general population.
Cough, Fatigue, Decreased Appetite, Pneumonia, Pneumonia Fungal

This is a Methotrexate side effect report of a 73-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: sjogren^s syndrome and was treated with Methotrexate (dosage: NA) starting Apr 11, 2012. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Cough
  • Fatigue
  • Decreased Appetite
  • Pneumonia
  • Pneumonia Fungal
The patient was hospitalized. This opens a possibility that Methotrexate could cause Fatigue and that some female patients may be more susceptible.
Dysphagia, Fatigue, Asthenia, Lip Erosion, Emotional Distress, Dehydration, Mouth Ulceration, Renal Failure Acute

This Fatigue side effect was reported by a health professional from US on Jun 11, 2013. A female patient from US , 68 years of age, was diagnosed with and was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: dysphagia, fatigue, asthenia, lip erosion, emotional distress, dehydration, mouth ulceration, renal failure acute. Methotrexate dosage: 7.5 Mg, Qd. The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Abscess, Nausea, Fatigue, Myalgia, Mood Altered, Liquid Product Physical Issue

This Fatigue side effect was reported by a consumer or non-health professional from US. A 32-year-old female patient (weight:NA) experienced the following symptoms/conditions: morphoea,systemic lupus erythematosus. The patient was prescribed Methotrexate (dosage: 0.4 Cc, Once Weekly), which was started on NS. Concurrently used drugs: NA. When starting to take Methotrexate the consumer reported the following symptoms:
  • Abscess
  • Nausea
  • Fatigue
  • Myalgia
  • Mood Altered
  • Liquid Product Physical Issue
These side effects may potentially be related to Methotrexate.
Nausea, Vomiting, Dizziness, Fatigue, Asthenia, Anaemia

This Fatigue Methotrexate side effect was reported by a health professional from US on Apr 08, 2013. A Female , 77 years of age, weighting 116.6 lb, was treated with Methotrexate. The patient presented the following health conditions:
  • Nausea
  • Vomiting
  • Dizziness
  • Fatigue
  • Asthenia
  • Anaemia
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Procarbazine
  • Rituximab (moab C2b8 Anti Cd20, Chimeric)
  • Vincristine Sulfate
The patient was hospitalized.
Influenza Like Illness, Asthenia, Contusion, Fatigue, Myalgia, Headache, Vision Blurred, Malaise

This is a Methotrexate side effect report of a 51-year-old female patient (weight:NA) from GB, suffering from the following symptoms/conditions: NA, who was treated with Methotrexate (dosage:NA, start time: Nov 28, 2012), combined with:
  • Trimethoprim
  • Aspirin
  • (limecycline)
  • Folic Acid
  • Beclometasone Dipropionate
  • Salbutamol
, and developed a serious reaction and a Fatigue side effect. The patient presented with:
  • Influenza Like Illness
  • Asthenia
  • Contusion
  • Fatigue
  • Myalgia
  • Headache
  • Vision Blurred
  • Malaise
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from NA, resulting in Fatigue.
Pancytopenia, Gingival Bleeding, Pain, Fatigue, Petechiae, Haematoma, Toxicity To Various Agents

A 79-year-old female patient (weight: NA) from SI with the following symptoms: rheumatoid arthritis,cystitis started Methotrexate Sodium treatment (dosage: 7.5 To 10 Mg Once A Week, Low Dose) on 1998. Soon after starting Methotrexate Sodium treatment, the consumer experienced several side effects, including:
  • Pancytopenia
  • Gingival Bleeding
  • Pain
  • Fatigue
  • Petechiae
  • Haematoma
  • Toxicity To Various Agents
. Concurrently used drugs:
  • Trimethoprim, Sulfamethoxazole (For One Week)
  • Folic Acid (5 Mg)
  • Asasantin (Unk)
  • Nifedipine (Unk)
  • Escitalopram (Unk)
  • Repaglinide (Unk)
  • Bisoprolol (Unk)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate Sodium side effects, such as Fatigue.
Vision Blurred, Contusion, Malaise, Asthenia, Influenza Like Illness, Headache, Fatigue, Myalgia

A female patient from GB was prescribed and started Methotrexate on Feb 11, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: vision blurred, contusion, malaise, asthenia, influenza like illness, headache, fatigue, myalgia Additional patient health information: Female , 51 years of age, The consumer reported the following symptoms: . Methotrexate dosage: 30 Mg, Qw. Concurrently used drugs:
  • Trimethoprim
  • Aspirin
  • Lymecycline
  • Folic Acid
  • Clenil Modulite
  • Salbutamol
Gingival Bleeding, Haematoma, Erythropoiesis Abnormal, Megakaryocytes Decreased, Pancytopenia, Pyrexia, Fatigue, Petechiae, Neutropenia

This report suggests a potential Methotrexate Fatigue side effect(s) that can have serious consequences. A 79-year-old female patient from SI (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate (dosage: 7.5 - 10 Mg Once A Week) starting 1998. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Gingival Bleeding
  • Haematoma
  • Erythropoiesis Abnormal
  • Megakaryocytes Decreased
  • Pancytopenia
  • Pyrexia
  • Fatigue
  • Petechiae
  • Neutropenia
Drugs used concurrently:
  • Folic Acid (5 Mg)
  • Asasantin
  • Nifedipine
  • Escitalopram
  • Repaglinide
  • Bisoprolol
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Fatigue, may still occur.
Pneumonia, Septic Shock, Fatigue, Dyspnoea, Pyrexia, Respiratory Failure

An adverse event was reported by a physician on Dec 14, 2012 by a Female taking Methotrexate (dosage: 1.0714 Milligram Daily;) was diagnosed with and. Location: TH , 68 years of age, weighting 103.8 lb, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: pneumonia, septic shock, fatigue, dyspnoea, pyrexia, respiratory failure. Additional medications/treatments: The patient was hospitalized.
Dyspnoea, Fatigue, Cardiogenic Shock, Cardiomyopathy

This Fatigue problem was reported by a consumer or non-health professional from US. A 80-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis.On NS a consumer started treatment with Methotrexate (dosage: NA). The following drugs/medications were being taken at the same time: NA. When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Dyspnoea
  • Fatigue
  • Cardiogenic Shock
  • Cardiomyopathy
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Fatigue, may become evident only after a product is in use by the general population.
Colonic Pseudo-obstruction, Fatigue, Abdominal Pain, Diarrhoea, Malaise, Abdominal Distension, Abdominal Tenderness, Proctocolitis, Back Pain

This is a Methotrexate side effect report of a 70-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: central nervous system lymphoma and was treated with Methotrexate (dosage: NA) starting NS. Concurrently used drugs:
  • Rituximab
Soon after that, the consumer experienced the following of symptoms:
  • Colonic Pseudo-obstruction
  • Fatigue
  • Abdominal Pain
  • Diarrhoea
  • Malaise
  • Abdominal Distension
  • Abdominal Tenderness
  • Proctocolitis
  • Back Pain
The patient was hospitalized. This opens a possibility that Methotrexate could cause Fatigue and that some female patients may be more susceptible.
Asthenia, Impaired Healing, Oropharyngeal Pain, Fatigue, Blood Disorder

This Fatigue side effect was reported by a consumer or non-health professional from UNITED STATES on Jun 27, 2012. A patient from UNITED STATES , weighting 150.0 lb, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: asthenia, impaired healing, oropharyngeal pain, fatigue, blood disorder. Methotrexate dosage: 6 Weekly Mouth. The patient was hospitalized. These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Fatigue Causes and Reviews


Everyone feels tired now and then. Sometimes you may just want to stay in bed. But, after a good night's sleep, most people feel refreshed and ready to face a new day. If you continue to feel tired for weeks, it's time to see your doctor. He or she may be able to help you find out what's causing your Fatigue and recommend ways to relieve it.

Fatigue itself is not a disease. Medical problems, treatments, and personal habits can add to Fatigue. These include

  • Taking certain medicines, such as antidepressants, antihistamines, and medicines for nausea and pain
  • Having medical treatments, like chemotherapy and radiation
  • Recovering from major surgery
  • Anxiety, stress, or depression
  • Staying up too late
  • Drinking too much alcohol or too many caffeinated drinks
  • Pregnancy

One disorder that causes extreme Fatigue is chronic Fatigue syndrome (CFS). This Fatigue is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities.

NIH: National Institute on Aging


Methotrexate Fatigue Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
Anaemia (195)
Pain (188)
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Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
Neutropenia (129)
Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
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Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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