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Methotrexate Injection Site Pain Side Effects

Methotrexate Injection Site Pain Side Effect Reports


The following Methotrexate Injection Site Pain side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Injection Site Pain, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Nausea, Injection Site Pain

This Injection Site Pain side effect was reported by a consumer or non-health professional from US. A 44-year-old female patient (weight:NA) experienced the following symptoms/conditions: colitis ulcerative. The patient was prescribed Methotrexate (dosage: 50mg/2ml-25mg/ml?once Per Week ?injection), which was started on 201304. Concurrently used drugs: NA. When starting to take Methotrexate the consumer reported the following symptoms:
  • Nausea
  • Injection Site Pain
These side effects may potentially be related to Methotrexate.
Injection Site Pain

This Injection Site Pain Methotrexate side effect was reported by a pharmacist from US on Sep 20, 2013. A male , 69 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Injection Site Pain
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Cortisone
  • Crestor
  • Pantoloc
Injection Site Pain, Injection Site Inflammation, Injection Site Pruritus

This is a Methotrexate side effect report of a 48-year-old patient (weight:NA) from GB, suffering from the following symptoms/conditions: crohn^s disease, who was treated with Methotrexate (dosage:NA, start time: Feb 07, 2006), combined with: NA., and developed a serious reaction and a Injection Site Pain side effect. The patient presented with:
  • Injection Site Pain
  • Injection Site Inflammation
  • Injection Site Pruritus
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from crohn^s disease, resulting in Injection Site Pain.

Injection Site Pain, Injection Site Pruritus, Injection Site Inflammation

A 48-year-old patient (weight: NA) from GB with the following symptoms: crohn^s disease started Methotrexate treatment (dosage: 15 Mg) on Jul 07, 2011. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Injection Site Pain
  • Injection Site Pruritus
  • Injection Site Inflammation
. Concurrently used drugs:
  • Humira (40 Mg)
  • Piriton
  • Hydrocortisone
  • Folic Acid
  • Asacol
  • Lansoprazole
This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Injection Site Pain.
Rheumatoid Arthritis, Disease Progression, Injection Site Pain

A female patient from US was prescribed and started Methotrexate on Sep 19, 2012. Patient felt the following Methotrexate side effects: rheumatoid arthritis, disease progression, injection site pain Additional patient health information: Female , 36 years of age, weighting 106.0 lb, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: NA. Concurrently used drugs: NA.
Rheumatoid Arthritis, Abdominal Abscess, Abscess Rupture, Female Genital Tract Fistula, Injection Site Pain, Diverticulitis

This report suggests a potential Methotrexate Injection Site Pain side effect(s) that can have serious consequences. A 70-year-old female patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): NA and used Methotrexate (dosage: Unk Unk, Unk) starting Nov 21, 2008. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Rheumatoid Arthritis
  • Abdominal Abscess
  • Abscess Rupture
  • Female Genital Tract Fistula
  • Injection Site Pain
  • Diverticulitis
Drugs used concurrently:
  • Enbrel (50 Mg, Qwk)
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Injection Site Pain, may still occur.
Influenza, Injection Site Pain, Viral Infection, Menopause, Candidiasis, Injection Site Swelling

An adverse event was reported by a health professional on May 31, 2012 by a Female taking Methotrexate (dosage: 1 Tablet Daily) was diagnosed with and. Location: COLOMBIA , 45 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: influenza, injection site pain, viral infection, menopause, candidiasis, injection site swelling. Additional medications/treatments:
Associated medications used:
  • Enbrel (50 Mg, Every 8 Days)
Injection Site Pain, Nausea

This Injection Site Pain problem was reported by a physician from UNITED STATES. A 55-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On May 01, 2009 a consumer started treatment with Methotrexate (dosage: 3 Mg, Unk). The following drugs/medications were being taken at the same time:
  • Enbrel (50 Mg, Qwk)
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Injection Site Pain
  • Nausea
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Injection Site Pain, may become evident only after a product is in use by the general population.
Fatigue, Dyspepsia, Abdominal Discomfort, Injection Site Pain

This is a Methotrexate side effect report of a 47-year-old female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: NA and was treated with Methotrexate (dosage: Unk) starting May 24, 2012. Concurrently used drugs:
  • Enbrel (50 Mg, Qwk)
Soon after that, the consumer experienced the following of symptoms:
  • Fatigue
  • Dyspepsia
  • Abdominal Discomfort
  • Injection Site Pain
This opens a possibility that Methotrexate could cause Injection Site Pain and that some female patients may be more susceptible.
Injection Site Pain, Injection Site Erythema

This Injection Site Pain side effect was reported by a physician from UNITED STATES on May 17, 2012. A female patient from UNITED STATES , 47 years of age, was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: injection site pain, injection site erythema. Methotrexate dosage: Unk.
Associated medications used:
  • Enbrel (50 Mg, Qwk)
These side effects may potentially be related to Methotrexate.
Injection Site Pain

This Injection Site Pain side effect was reported by a consumer or non-health professional from UNITED STATES. A 55-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Methotrexate (dosage: Unk), which was started on Apr 30, 2012. Concurrently used drugs:
  • Enbrel (50 Mg, Qwk)
When starting to take Methotrexate the consumer reported the following symptoms:
  • Injection Site Pain
These side effects may potentially be related to Methotrexate.
Menopause, Injection Site Pain, Injection Site Swelling, Candidiasis, Viral Infection, Influenza

This Injection Site Pain Methotrexate side effect was reported by a consumer or non-health professional from COLOMBIA on Apr 28, 2012. A Female , 45 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Menopause
  • Injection Site Pain
  • Injection Site Swelling
  • Candidiasis
  • Viral Infection
  • Influenza
. Methotrexate dosage: 1 Tablet Daily. Additional drugs used at the same time:
  • Enbrel (50 Mg, Every 8 Days)
Injection Site Pruritus, Injection Site Induration, Injection Site Pain, Therapeutic Response Decreased

This is a Methotrexate side effect report of a 46-year-old female patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: NA, who was treated with Methotrexate (dosage:1 Mg, Unk, start time: Apr 01, 2003), combined with:
  • Enbrel (25 Mg, 2 Times/wk)
, and developed a serious reaction and a Injection Site Pain side effect. The patient presented with:
  • Injection Site Pruritus
  • Injection Site Induration
  • Injection Site Pain
  • Therapeutic Response Decreased
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from NA, resulting in Injection Site Pain.
Gait Disturbance, Injection Site Pain

A 57-year-old female patient (weight: NA) from UNITED STATES with the following symptoms: NA started Methotrexate treatment (dosage: Unk) on Feb 10, 2012. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Gait Disturbance
  • Injection Site Pain
. Concurrently used drugs:
  • Enbrel (50 Mg, Qwk)
This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Injection Site Pain.
Injection Site Haematoma, Urine Output Decreased, Injection Site Pain

A female patient from UNITED STATES was prescribed and started Methotrexate on Apr 04, 2012. After Methotrexate was administered, patient encountered several Methotrexate side effects: injection site haematoma, urine output decreased, injection site pain Additional patient health information: Female , 57 years of age, The consumer reported the following symptoms: . Methotrexate dosage: Unk. Concurrently used drugs:
  • Enbrel (50 Mg, Qwk)
Oedema Peripheral, Injection Site Rash, Ulcer Haemorrhage, Injection Site Pain, Joint Swelling

This report suggests a potential Methotrexate Injection Site Pain side effect(s) that can have serious consequences. A 48-year-old patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): NA and used Methotrexate (dosage: Unk) starting Nov 08, 2005. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Oedema Peripheral
  • Injection Site Rash
  • Ulcer Haemorrhage
  • Injection Site Pain
  • Joint Swelling
Drugs used concurrently:
  • Humira (Unk)
  • Enbrel (Unk)
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Injection Site Pain, may still occur.
Moyamoya Disease, Injection Site Pain, Haemorrhage Intracranial

An adverse event was reported by a consumer or non-health professional on Apr 23, 2012 by a Female taking Methotrexate (dosage: Unk) . Location: UNITED STATES , 47 years of age, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: moyamoya disease, injection site pain, haemorrhage intracranial. Additional medications/treatments:
Multiple prescriptions taken:
  • Enbrel (50 Mg, Qwk)
  • Enbrel (50 Mg, Qwk)
The patient was hospitalized.
Nausea, Injection Site Pain, Temperature Intolerance

This Injection Site Pain problem was reported by a consumer or non-health professional from UNITED STATES. A 50-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Methotrexate Sodium (dosage: Unk). The following drugs/medications were being taken at the same time:
  • Enbrel (Unk)
  • Folic Acid (Unk)
When commencing Methotrexate Sodium, the patient experienced the following unwanted symptoms /side effects:
  • Nausea
  • Injection Site Pain
  • Temperature Intolerance
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Injection Site Pain, may become evident only after a product is in use by the general population.
Seasonal Allergy, Injection Site Pain, Injection Site Haemorrhage, Abdominal Discomfort, Blood Cholesterol Increased, Foot Fracture, Impaired Healing

This is a Methotrexate side effect report of a female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: NA and was treated with Methotrexate (dosage: NA) starting Jan 01, 2011. Concurrently used drugs:
  • Klonopin
Soon after that, the consumer experienced the following of symptoms:
  • Seasonal Allergy
  • Injection Site Pain
  • Injection Site Haemorrhage
  • Abdominal Discomfort
  • Blood Cholesterol Increased
  • Foot Fracture
  • Impaired Healing
This opens a possibility that Methotrexate could cause Injection Site Pain and that some female patients may be more susceptible.
Injection Site Pain, Peripheral Vascular Disorder, Pruritus, Pain In Extremity, Oedema Peripheral, Depression, Foot Fracture, Joint Range Of Motion Decreased, Injection Site Haemorrhage

This Injection Site Pain side effect was reported by a physician from UNITED STATES on Feb 07, 2012. A female patient from UNITED STATES , weighting 150.1 lb, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: injection site pain, peripheral vascular disorder, pruritus, pain in extremity, oedema peripheral, depression, foot fracture, joint range of motion decreased, injection site haemorrhage. Methotrexate dosage: 6 Pills Weekly.
Multiple prescriptions taken:
  • Simvastatin
  • Simvastatin
  • Plavix
  • Zyrtec
  • Alprazolam (0.25mg Nightly)
  • Humira
  • Aspirin (At Bedtime)
  • Folic Acid
These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Injection Site Pain Causes and Reviews


Botox is a drug made from a toxin produced by the bacterium Clostridium botulinum. It's the same toxin that causes a life-threatening type of food poisoning called botulism. Doctors use it in small doses to treat health problems, including

  • Temporary smoothing of facial wrinkles and improving your appearance
  • Severe underarm sweating
  • Cervical dystonia - a neurological disorder that causes severe neck and shoulder muscle contractions
  • Blepharospasm - uncontrollable blinking
  • Strabismus - misaligned eyes
  • Chronic migraine
  • Overactive bladder

Botox injections work by weakening or paralyzing certain muscles or by blocking certain nerves. The effects last about three to twelve months, depending on what you are treating. The most common side effects are pain, swelling, or bruising at the injection site. You could also have flu-like symptoms, headache, and upset stomach. Injections in the face may also cause temporary drooping eyelids. You should not use Botox if you are pregnant or breastfeeding.


Methotrexate Injection Site Pain Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
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Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
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Pain (188)
Renal Failure Acute (177)
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Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
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Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
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Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
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Fall (103)
Infection (103)
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Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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