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Methotrexate Interstitial Lung Disease Side Effects

Methotrexate Interstitial Lung Disease Side Effect Reports


The following Methotrexate Interstitial Lung Disease side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Interstitial Lung Disease, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Respiratory Failure, Interstitial Lung Disease, Cardiac Failure, Pyrexia, Jugular Vein Distension, C-reactive Protein Increased

This Interstitial Lung Disease side effect was reported by a consumer or non-health professional from COUNTRY NOT SPECIFIED. A 64-year-old patient (weight:NA) experienced the following symptoms/conditions: psoriasis. The patient was prescribed Methotrexate (dosage: NA), which was started on NS. Concurrently used drugs:
  • Infliximab
  • Cyclosporine
When starting to take Methotrexate the consumer reported the following symptoms:
  • Respiratory Failure
  • Interstitial Lung Disease
  • Cardiac Failure
  • Pyrexia
  • Jugular Vein Distension
  • C-reactive Protein Increased
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Interstitial Lung Disease, Anaemia, Shock, Haematoma, Aneurysm Ruptured

This Interstitial Lung Disease Methotrexate side effect was reported by a health professional from JP on Dec 03, 2013. A male , 65 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Interstitial Lung Disease
  • Anaemia
  • Shock
  • Haematoma
  • Aneurysm Ruptured
. Methotrexate dosage: NA. Additional drugs used at the same time: NA. The patient was hospitalized.
Cardiac Failure, Left Atrial Dilatation, Dilatation Ventricular, Interstitial Lung Disease, Dyspnoea Exertional, Malaise, Pyrexia, Cough, Hypoxia

This is a Methotrexate side effect report of a 64-year-old patient (weight:NA) from GR, suffering from the following symptoms/conditions: psoriasis, who was treated with Methotrexate (dosage:10 Mg, Two Weekly Doses, start time: NS), combined with:
  • Infliximab (5 Mg/kg)
, and developed a serious reaction and a Interstitial Lung Disease side effect. The patient presented with:
  • Cardiac Failure
  • Left Atrial Dilatation
  • Dilatation Ventricular
  • Interstitial Lung Disease
  • Dyspnoea Exertional
  • Malaise
  • Pyrexia
  • Cough
  • Hypoxia
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from psoriasis, resulting in Interstitial Lung Disease.

Exercise Tolerance Decreased, Rales, Interstitial Lung Disease

A 59-year-old female patient (weight: NA) from GB with the following symptoms: rheumatoid arthritis started Methotrexate treatment (dosage: NA) on Jul 01, 2013. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Exercise Tolerance Decreased
  • Rales
  • Interstitial Lung Disease
. Concurrently used drugs:
  • Simvastatin
  • Citalopram
  • Etoricoxib
  • Levothyroxine
  • Metformin
  • Tramadol
  • Folic Acid
  • Amitriptyline
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Interstitial Lung Disease.
Exercise Tolerance Decreased, Rales, Interstitial Lung Disease, Dyspnoea

A female patient from GB was prescribed and started Methotrexate on Feb 11, 2014. Patient felt the following Methotrexate side effects: exercise tolerance decreased, rales, interstitial lung disease, dyspnoea Additional patient health information: Female , 59 years of age, weighting 222.2 lb, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: 15 Mg, Unk. Concurrently used drugs:
  • Simvastatin
  • Citalopram
  • Etoricoxib
  • Levothyroxine
  • Metformin
  • Tramadol
  • Amitriptyline
  • Lansoprazole
The patient was hospitalized.
Exercise Tolerance Decreased, Interstitial Lung Disease

This report suggests a potential Methotrexate Interstitial Lung Disease side effect(s) that can have serious consequences. A 59-year-old female patient from GB (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate (dosage: NA) starting Jul 01, 2013. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Exercise Tolerance Decreased
  • Interstitial Lung Disease
Drugs used concurrently:
  • Amitriptyline (amitriptyline)
  • Citalopram (citalopram)
  • Etoricoxib (etoricoxib)
  • Lansoprazole (lansoprazole)
  • Folic Acid (folic Acid)
  • Levothyroxine (levothyroxine)
  • Metformin (metformin)
  • Simvastatin (simvastatin)
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Interstitial Lung Disease, may still occur.
Interstitial Lung Disease, Visual Acuity Reduced, Hypoxia

An adverse event was reported by a health professional on Nov 01, 2013 by a Female taking Methotrexate Sandoz (dosage: 2.5 Mg, Qw2) was diagnosed with and. Location: DK , 78 years of age, weighting 110.2 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: interstitial lung disease, visual acuity reduced, hypoxia. Additional medications/treatments: The patient was hospitalized and became disabled.
Cardiac Arrest, Septic Shock, Superinfection, Pneumothorax, Interstitial Lung Disease, Dyspnoea Exertional, Pneumonia

This Interstitial Lung Disease problem was reported by a consumer or non-health professional from DK. A 15-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): juvenile idiopathic arthritis.On Oct 20, 2010 a consumer started treatment with Methotrexate Sandoz (dosage: 10-15 Mg / Square Meter Weekly Dose). The following drugs/medications were being taken at the same time:
  • Enbrel (50 Mg, Qw)
  • Cyclophosphamide
  • Prednisolon
When commencing Methotrexate Sandoz, the patient experienced the following unwanted symptoms /side effects:
  • Cardiac Arrest
  • Septic Shock
  • Superinfection
  • Pneumothorax
  • Interstitial Lung Disease
  • Dyspnoea Exertional
  • Pneumonia
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Interstitial Lung Disease, may become evident only after a product is in use by the general population.
Pneumonia, Respiratory Failure, Interstitial Lung Disease, Pulmonary Toxicity

This is a Methotrexate side effect report of a 64-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: rheumatoid arthritis and was treated with Methotrexate (dosage: (8tabs/1x/wk)) starting 2010. Concurrently used drugs:
  • Prednisone
  • Folic Acid
Soon after that, the consumer experienced the following of symptoms:
  • Pneumonia
  • Respiratory Failure
  • Interstitial Lung Disease
  • Pulmonary Toxicity
The patient was hospitalized. This opens a possibility that Methotrexate could cause Interstitial Lung Disease and that some female patients may be more susceptible.
Interstitial Lung Disease

This Interstitial Lung Disease side effect was reported by a health professional from IT on Jun 20, 2013. A female patient from IT , 56 years of age, was diagnosed with and was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: interstitial lung disease. Methotrexate dosage: NA.
Associated medications used:
  • Methylprednisolone
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Interstitial Lung Disease, Hypersensitivity, Pneumonia

This Interstitial Lung Disease side effect was reported by a consumer or non-health professional from US. A 64-year-old female patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis. The patient was prescribed Methotrexate Tablets, Usp (dosage: NA), which was started on 2010. Concurrently used drugs: NA. When starting to take Methotrexate Tablets, Usp the consumer reported the following symptoms:
  • Interstitial Lung Disease
  • Hypersensitivity
  • Pneumonia
The patient was hospitalized. These side effects may potentially be related to Methotrexate Tablets, Usp.
Interstitial Lung Disease, Hypersensitivity, Pneumonia

This Interstitial Lung Disease Methotrexate Tablets, Usp side effect was reported by a consumer or non-health professional from US on Jun 12, 2013. A Female , 64 years of age, weighting 172.0 lb, was diagnosed with and was treated with Methotrexate Tablets, Usp. The patient presented the following health conditions:
  • Interstitial Lung Disease
  • Hypersensitivity
  • Pneumonia
. Methotrexate Tablets, Usp dosage: NA. Additional drugs used at the same time: NA. The patient was hospitalized.
Interstitial Lung Disease, Hypersensitivity, Pneumonia

This is a Methotrexate side effect report of a 64-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: rheumatoid arthritis, who was treated with Methotrexate (dosage:NA, start time: 2010), combined with: NA., and developed a serious reaction and a Interstitial Lung Disease side effect. The patient presented with:
  • Interstitial Lung Disease
  • Hypersensitivity
  • Pneumonia
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from rheumatoid arthritis, resulting in Interstitial Lung Disease.
Interstitial Lung Disease

A 77-year-old female patient (weight: NA) from NL with the following symptoms: polymyalgia rheumatica started Methotrexate Tablet 2,5mg treatment (dosage: Strength:2.5mg) on 2011. Soon after starting Methotrexate Tablet 2,5mg treatment, the consumer experienced several side effects, including:
  • Interstitial Lung Disease
. Concurrently used drugs:
  • Atorvastatine Tablet 20mg (als Ca-zout-3-water) (20 Milligram Daily;)
  • Furosemide Tablet 40mg (40 Milligram Daily; Strength: 40mg)
  • Prednisolon Tablet 5mg (Strength: 5mg, 3 Tablets Once A Day)
  • Metformine Tablet 500mg (1500 Milligram Daily; 1 Tablet X 3 / Day)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate Tablet 2,5mg side effects, such as Interstitial Lung Disease.
Dermatomyositis, Interstitial Lung Disease

A female patient from US was prescribed and started Methotrexate on May 06, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: dermatomyositis, interstitial lung disease Additional patient health information: Female , 56 years of age, The consumer reported the following symptoms: . Methotrexate dosage: NA. Concurrently used drugs: NA. The patient was hospitalized.
Pericardial Effusion, Cardiac Tamponade, Graft Versus Host Disease, Interstitial Lung Disease

This report suggests a potential Methotrexate Interstitial Lung Disease side effect(s) that can have serious consequences. A 47-year-old female patient from COUNTRY NOT SPECIFIED (weight:NA) was diagnosed with the following health condition(s): prophylaxis against graft versus host disease,bone marrow conditioning regimen and used Methotrexate (dosage: NA) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Pericardial Effusion
  • Cardiac Tamponade
  • Graft Versus Host Disease
  • Interstitial Lung Disease
Drugs used concurrently:
  • Cyclophosphamide Tablets Usp
  • Busulfan
  • Cyclosporine
  • Trimethoprim-sulfamethoxazole
Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Interstitial Lung Disease, may still occur.
Pulmonary Tuberculosis, Interstitial Lung Disease, Hepatic Function Abnormal, Rash, Pyrexia, Human Herpes Virus 6 Serology, Alopecia

An adverse event was reported by a consumer or non-health professional on Sep 04, 2012 by a Female taking Methotrexate Sodium (dosage: Unk) was diagnosed with and. Location: COUNTRY NOT SPECIFIED , 56 years of age, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: pulmonary tuberculosis, interstitial lung disease, hepatic function abnormal, rash, pyrexia, human herpes virus 6 serology, alopecia. Additional medications/treatments:
Multiple prescriptions taken:
  • Sulfasalazine (Unk)
  • Sulfasalazine (Unk)
  • Rifampicin (Unk)
  • Rifampicin (Unk)
  • Levofloxacin (Unk)
  • Levofloxacin (Unk)
  • Levofloxacin (Unk)
  • Ethambutol (Unk)
Interstitial Lung Disease

This Interstitial Lung Disease problem was reported by a physician from JAPAN. A 79-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Methotrexate Sodium (dosage: Unk). The following drugs/medications were being taken at the same time:
  • Enbrel (Unk)
  • Prograf (Unk)
When commencing Methotrexate Sodium, the patient experienced the following unwanted symptoms /side effects:
  • Interstitial Lung Disease
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Interstitial Lung Disease, may become evident only after a product is in use by the general population.
Condition Aggravated, Pneumomediastinum, Rheumatoid Arthritis, Interstitial Lung Disease

This is a Methotrexate side effect report of a 63-year-old patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: NA and was treated with Methotrexate (dosage: NA) starting Feb 24, 2011. Concurrently used drugs:
  • Prednisolone
  • Sulpiride
Soon after that, the consumer experienced the following of symptoms:
  • Condition Aggravated
  • Pneumomediastinum
  • Rheumatoid Arthritis
  • Interstitial Lung Disease
The patient was hospitalized. This opens a possibility that Methotrexate could cause Interstitial Lung Disease and that some patients may be more susceptible.
Pulmonary Fibrosis, Myalgia, Interstitial Lung Disease, Pyrexia, Dyspnoea, Pneumonia, Fatigue, Malaise, Cough

This Interstitial Lung Disease side effect was reported by a health professional from DENMARK on Apr 17, 2012. A patient from DENMARK , 61 years of age, was diagnosed with and was treated with Methotrexate Sodium. Patient felt the following Methotrexate side effects: pulmonary fibrosis, myalgia, interstitial lung disease, pyrexia, dyspnoea, pneumonia, fatigue, malaise, cough. Methotrexate Sodium dosage: Unk.
Multiple prescriptions taken:
  • Sulfasalazine (Unk)
  • Prednisolone (Unk)
These side effects may potentially be related to Methotrexate Sodium.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Interstitial Lung Disease Causes and Reviews


Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. The inflammation and scarring make it hard to get enough oxygen. The scarring is called pulmonary fibrosis.

Breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. Specific types include

  • Black lung disease among coal miners, from inhaling coal dust
  • Farmer's lung, from inhaling farm dust
  • Asbestosis, from inhaling asbestos fibers
  • Siderosis, from inhaling iron from mines or welding fumes
  • Silicosis, from inhaling silica dust

Other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. Some types of interstitial lung disease have no known cause.

Treatment depends on the type of exposure and the stage of the disease. It may involve medicines, oxygen therapy, or a lung transplant in severe cases.


Methotrexate Interstitial Lung Disease Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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