sponsored
PatientsVille.com Logo

PatientsVille

Methotrexate Side Effects List

Common Methotrexate Side Effects


The following Methotrexate Side Effects were reported by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers) and manufacturers.

It is important to know potential risks posed by drugs and health products. Staying informed can help you make right decisions and stay healthy.

You can read detailed reports by clicking on a side effect.




Abasia 29 reports0.14%
Abdominal Discomfort 33 reports0.16%
Abdominal Distension 28 reports0.13%
Abdominal Pain 152 reports0.72%
Abdominal Pain Lower 20 reports0.10%
Abdominal Pain Upper 57 reports0.27%
Abnormal Behaviour 17 reports0.08%
Abortion Spontaneous 23 reports0.11%
Abscess 30 reports0.14%
Accidental Overdose 42 reports0.20%
Acute Graft Versus Host Disease 50 reports0.24%
Acute Graft Versus Host Disease In Skin 27 reports0.13%
Acute Myeloid Leukaemia 64 reports0.30%
Acute Respiratory Distress Syndrome 58 reports0.28%
Acute Respiratory Failure 22 reports0.10%
Agitation 19 reports0.09%
Agranulocytosis 18 reports0.09%
Alanine Aminotransferase Increased 121 reports0.58%
Alopecia 76 reports0.36%
Altered State Of Consciousness 17 reports0.08%
Alveolitis 18 reports0.09%
Amnesia 18 reports0.09%
Anaemia 195 reports0.93%
Anaphylactic Reaction 29 reports0.14%
Angina Pectoris 22 reports0.10%
Angiocentric Lymphoma 17 reports0.08%
Anorexia 35 reports0.17%
Anxiety 45 reports0.21%
Aphasia 64 reports0.30%
Arachnoiditis 22 reports0.10%
Areflexia 28 reports0.13%
Arrhythmia 16 reports0.08%
Arthralgia 271 reports1.29%
Arthritis 83 reports0.40%
Arthritis Bacterial 28 reports0.13%
Arthropathy 30 reports0.14%
Ascites 48 reports0.23%
Aspartate Aminotransferase Increased 99 reports0.47%
Asthenia 198 reports0.94%
Atelectasis 20 reports0.10%
Atrial Fibrillation 33 reports0.16%
B-cell Lymphoma 34 reports0.16%
Back Pain 87 reports0.41%
Bacteraemia 19 reports0.09%
Bacterial Infection 27 reports0.13%
Balance Disorder 29 reports0.14%
Basal Cell Carcinoma 33 reports0.16%
Blister 49 reports0.23%
Blood Albumin Decreased 27 reports0.13%
Blood Alkaline Phosphatase Increased 42 reports0.20%
Blood Bilirubin Increased 48 reports0.23%
Blood Cholesterol Increased 20 reports0.10%
Blood Creatinine Increased 90 reports0.43%
Blood Culture Positive 20 reports0.10%
Blood Glucose Increased 16 reports0.08%
Blood Lactate Dehydrogenase Increased 39 reports0.19%
Blood Pressure Decreased 35 reports0.17%
Blood Pressure Increased 53 reports0.25%
Blood Urea Increased 25 reports0.12%
Body Temperature Increased 20 reports0.10%
Bone Marrow Depression 24 reports0.11%
Bone Marrow Failure 108 reports0.51%
Bone Pain 27 reports0.13%
Brain Oedema 29 reports0.14%
Breast Cancer 59 reports0.28%
Breast Cancer Female 20 reports0.10%
Bronchitis 51 reports0.24%
Bronchopneumonia 26 reports0.12%
Burning Sensation 23 reports0.11%
C-reactive Protein Increased 61 reports0.29%
Candidiasis 28 reports0.13%
Cardiac Arrest 41 reports0.20%
Cardiac Failure 62 reports0.30%
Cardiac Failure Congestive 40 reports0.19%
Cardio-respiratory Arrest 21 reports0.10%
Cataract 18 reports0.09%
Cellulitis 68 reports0.32%
Central Nervous System Lymphoma 17 reports0.08%
Cerebral Haemorrhage 31 reports0.15%
Cerebral Infarction 36 reports0.17%
Cerebrovascular Accident 61 reports0.29%
Cheilitis 16 reports0.08%
Chest Discomfort 33 reports0.16%
Chest Pain 89 reports0.42%
Chills 89 reports0.42%
Cholelithiasis 23 reports0.11%
Cholestasis 23 reports0.11%
Chronic Graft Versus Host Disease 27 reports0.13%
Chronic Obstructive Pulmonary Disease 24 reports0.11%
Clostridium Difficile Colitis 19 reports0.09%
Coagulopathy 25 reports0.12%
Cognitive Disorder 25 reports0.12%
Colitis 24 reports0.11%
Colon Cancer 23 reports0.11%
Coma 38 reports0.18%
Condition Aggravated 129 reports0.61%
Confusional State 64 reports0.30%
Constipation 26 reports0.12%
Contusion 55 reports0.26%
Convulsion 139 reports0.66%
Coordination Abnormal 16 reports0.08%
Cough 196 reports0.93%
Crohn's Disease 32 reports0.15%
Cystitis 16 reports0.08%
Cytolytic Hepatitis 16 reports0.08%
Cytomegalovirus Infection 43 reports0.20%
Death 66 reports0.31%
Decreased Appetite 75 reports0.36%
Deep Vein Thrombosis 40 reports0.19%
Dehydration 80 reports0.38%
Delirium 18 reports0.09%
Demyelination 27 reports0.13%
Depressed Level Of Consciousness 41 reports0.20%
Depression 62 reports0.30%
Dermatitis 17 reports0.08%
Device Malfunction 48 reports0.23%
Diabetes Mellitus 33 reports0.16%
Dialysis 19 reports0.09%
Diarrhoea 238 reports1.13%
Diarrhoea Haemorrhagic 20 reports0.10%
Diffuse Large B-cell Lymphoma 39 reports0.19%
Diplopia 16 reports0.08%
Disease Progression 50 reports0.24%
Disease Recurrence 35 reports0.17%
Disorientation 20 reports0.10%
Disseminated Intravascular Coagulation 42 reports0.20%
Disseminated Tuberculosis 21 reports0.10%
Disturbance In Attention 22 reports0.10%
Diverticulitis 23 reports0.11%
Dizziness 131 reports0.62%
Dysarthria 49 reports0.23%
Dyskinesia 17 reports0.08%
Dyspepsia 27 reports0.13%
Dysphagia 71 reports0.34%
Dysphonia 26 reports0.12%
Dyspnoea 248 reports1.18%
Dyspnoea Exertional 17 reports0.08%
Emotional Distress 17 reports0.08%
Encephalitis 24 reports0.11%
Encephalopathy 69 reports0.33%
Epilepsy 19 reports0.09%
Epistaxis 50 reports0.24%
Epstein-barr Virus Associated Lymphoproliferative Disorder 30 reports0.14%
Epstein-barr Virus Infection 75 reports0.36%
Epstein-barr Virus Test Positive 17 reports0.08%
Erythema 113 reports0.54%
Eye Pain 16 reports0.08%
Facial Palsy 18 reports0.09%
Facial Paresis 24 reports0.11%
Faecal Incontinence 16 reports0.08%
Fall 103 reports0.49%
Fatigue 223 reports1.06%
Febrile Neutropenia 152 reports0.72%
Feeling Abnormal 28 reports0.13%
Feeling Hot 19 reports0.09%
Femur Fracture 16 reports0.08%
Flushing 23 reports0.11%
Fungal Infection 24 reports0.11%
Gait Disturbance 82 reports0.39%
Gamma-glutamyltransferase Increased 22 reports0.10%
Gastritis 20 reports0.10%
Gastroenteritis 19 reports0.09%
Gastrointestinal Disorder 23 reports0.11%
Gastrointestinal Haemorrhage 39 reports0.19%
Glioma 45 reports0.21%
Graft Versus Host Disease 60 reports0.29%
Grand Mal Convulsion 43 reports0.20%
Guillain-barre Syndrome 21 reports0.10%
Haematemesis 20 reports0.10%
Haematocrit Decreased 23 reports0.11%
Haematuria 24 reports0.11%
Haemodialysis 31 reports0.15%
Haemoglobin Decreased 88 reports0.42%
Haemorrhage 40 reports0.19%
Headache 269 reports1.28%
Heart Rate Increased 29 reports0.14%
Hemiparesis 78 reports0.37%
Hepatic Cirrhosis 32 reports0.15%
Hepatic Enzyme Increased 78 reports0.37%
Hepatic Failure 37 reports0.18%
Hepatic Function Abnormal 46 reports0.22%
Hepatic Steatosis 33 reports0.16%
Hepatitis 40 reports0.19%
Hepatitis B 29 reports0.14%
Hepatomegaly 30 reports0.14%
Hepatotoxicity 37 reports0.18%
Herpes Simplex 18 reports0.09%
Herpes Zoster 76 reports0.36%
Hip Arthroplasty 19 reports0.09%
Histiocytosis Haematophagic 30 reports0.14%
Histoplasmosis 18 reports0.09%
Hodgkin's Disease 26 reports0.12%
Hydrocephalus 18 reports0.09%
Hypercalcaemia 17 reports0.08%
Hyperglycaemia 31 reports0.15%
Hyperhidrosis 35 reports0.17%
Hyperkalaemia 18 reports0.09%
Hypersensitivity 73 reports0.35%
Hypertension 115 reports0.55%
Hypoaesthesia 84 reports0.40%
Hypokalaemia 31 reports0.15%
Hyponatraemia 26 reports0.12%
Hypophagia 20 reports0.10%
Hypotension 95 reports0.45%
Hypoxia 39 reports0.19%
Ill-defined Disorder 17 reports0.08%
Immunosuppression 29 reports0.14%
Impaired Healing 25 reports0.12%
Incorrect Dose Administered 55 reports0.26%
Infection 103 reports0.49%
Inflammation 40 reports0.19%
Influenza 37 reports0.18%
Influenza Like Illness 29 reports0.14%
Infusion Related Reaction 51 reports0.24%
Injection Site Erythema 145 reports0.69%
Injection Site Haematoma 81 reports0.39%
Injection Site Haemorrhage 56 reports0.27%
Injection Site Nodule 23 reports0.11%
Injection Site Pain 265 reports1.26%
Injection Site Pruritus 86 reports0.41%
Injection Site Rash 21 reports0.10%
Injection Site Reaction 69 reports0.33%
Injection Site Swelling 80 reports0.38%
Injection Site Urticaria 21 reports0.10%
Injection Site Warmth 38 reports0.18%
Insomnia 29 reports0.14%
Interstitial Lung Disease 113 reports0.54%
Intestinal Obstruction 17 reports0.08%
Jaundice 28 reports0.13%
Joint Effusion 17 reports0.08%
Joint Stiffness 24 reports0.11%
Joint Swelling 88 reports0.42%
Juvenile Arthritis 19 reports0.09%
Lethargy 35 reports0.17%
Leukaemia Recurrent 23 reports0.11%
Leukoencephalopathy 85 reports0.40%
Leukopenia 104 reports0.49%
Liver Disorder 44 reports0.21%
Liver Function Test Abnormal 68 reports0.32%
Local Swelling 29 reports0.14%
Loss Of Consciousness 41 reports0.20%
Lower Respiratory Tract Infection 34 reports0.16%
Lung Disorder 38 reports0.18%
Lung Infection 24 reports0.11%
Lung Infiltration 32 reports0.15%
Lung Neoplasm 34 reports0.16%
Lung Neoplasm Malignant 32 reports0.15%
Lymphadenopathy 65 reports0.31%
Lymphoma 39 reports0.19%
Lymphopenia 35 reports0.17%
Lymphoproliferative Disorder 67 reports0.32%
Malaise 156 reports0.74%
Malignant Melanoma 28 reports0.13%
Malignant Neoplasm Progression 25 reports0.12%
Maternal Exposure During Pregnancy 19 reports0.09%
Memory Impairment 37 reports0.18%
Mental Disorder 17 reports0.08%
Mental Status Changes 35 reports0.17%
Metastases To Liver 21 reports0.10%
Metastasis 17 reports0.08%
Migraine 22 reports0.10%
Mobility Decreased 18 reports0.09%
Mouth Ulceration 79 reports0.38%
Mucosal Inflammation 241 reports1.15%
Multi-organ Failure 91 reports0.43%
Muscle Spasms 34 reports0.16%
Muscular Weakness 76 reports0.36%
Musculoskeletal Pain 30 reports0.14%
Musculoskeletal Stiffness 57 reports0.27%
Myalgia 45 reports0.21%
Myelodysplastic Syndrome 44 reports0.21%
Myelopathy 61 reports0.29%
Myocardial Infarction 71 reports0.34%
Nasal Congestion 39 reports0.19%
Nasopharyngitis 93 reports0.44%
Nausea 321 reports1.53%
Neck Pain 20 reports0.10%
Necrotising Fasciitis 17 reports0.08%
Nephrolithiasis 21 reports0.10%
Nephropathy Toxic 23 reports0.11%
Nervous System Disorder 22 reports0.10%
Neuropathy Peripheral 23 reports0.11%
Neurotoxicity 138 reports0.66%
Neutropenia 129 reports0.61%
Neutropenic Sepsis 25 reports0.12%
Night Sweats 18 reports0.09%
No Therapeutic Response 26 reports0.12%
Nodule 22 reports0.10%
Non-hodgkin's Lymphoma 31 reports0.15%
Normochromic Normocytic Anaemia 17 reports0.08%
Oedema 27 reports0.13%
Oedema Peripheral 121 reports0.58%
Off Label Use 40 reports0.19%
Oral Candidiasis 20 reports0.10%
Oral Herpes 20 reports0.10%
Oropharyngeal Pain 81 reports0.39%
Osteoarthritis 34 reports0.16%
Osteomyelitis 22 reports0.10%
Osteonecrosis 25 reports0.12%
Overdose 44 reports0.21%
Oxygen Saturation Decreased 24 reports0.11%
Pain 188 reports0.89%
Pain In Extremity 141 reports0.67%
Palpitations 18 reports0.09%
Pancreatitis 22 reports0.10%
Pancytopenia 356 reports1.69%
Paraesthesia 93 reports0.44%
Paraplegia 18 reports0.09%
Pericardial Effusion 26 reports0.12%
Petechiae 17 reports0.08%
Pharyngitis 17 reports0.08%
Pharyngolaryngeal Pain 18 reports0.09%
Photosensitivity Reaction 19 reports0.09%
Platelet Count Decreased 54 reports0.26%
Pleural Effusion 89 reports0.42%
Pleurisy 25 reports0.12%
Pneumocystis Jiroveci Pneumonia 72 reports0.34%
Pneumonia 304 reports1.45%
Pneumonia Bacterial 18 reports0.09%
Pneumonitis 72 reports0.34%
Posterior Reversible Encephalopathy Syndrome 27 reports0.13%
Product Quality Issue 30 reports0.14%
Productive Cough 27 reports0.13%
Progressive Multifocal Leukoencephalopathy 28 reports0.13%
Prostate Cancer 24 reports0.11%
Pruritus 83 reports0.40%
Psoriasis 88 reports0.42%
Psoriatic Arthropathy 37 reports0.18%
Pulmonary Embolism 62 reports0.30%
Pulmonary Fibrosis 44 reports0.21%
Pulmonary Hypertension 17 reports0.08%
Pulmonary Oedema 22 reports0.10%
Pulmonary Toxicity 18 reports0.09%
Pulmonary Tuberculosis 39 reports0.19%
Pustular Psoriasis 17 reports0.08%
Pyrexia 411 reports1.96%
Rash 139 reports0.66%
Rash Erythematous 22 reports0.10%
Rash Macular 18 reports0.09%
Rash Pruritic 27 reports0.13%
Red Blood Cell Sedimentation Rate Increased 24 reports0.11%
Renal Disorder 22 reports0.10%
Renal Failure 118 reports0.56%
Renal Failure Acute 177 reports0.84%
Renal Impairment 66 reports0.31%
Respiratory Disorder 20 reports0.10%
Respiratory Distress 39 reports0.19%
Respiratory Failure 108 reports0.51%
Respiratory Tract Congestion 22 reports0.10%
Respiratory Tract Infection 36 reports0.17%
Reversible Posterior Leukoencephalopathy Syndrome 38 reports0.18%
Rheumatoid Arthritis 260 reports1.24%
Rheumatoid Nodule 17 reports0.08%
Rhinorrhoea 30 reports0.14%
Sarcoidosis 21 reports0.10%
Sepsis 195 reports0.93%
Septic Shock 91 reports0.43%
Shock 28 reports0.13%
Sinusitis 89 reports0.42%
Skin Cancer 17 reports0.08%
Skin Exfoliation 26 reports0.12%
Skin Lesion 30 reports0.14%
Skin Ulcer 50 reports0.24%
Somnolence 43 reports0.20%
Speech Disorder 29 reports0.14%
Splenomegaly 23 reports0.11%
Squamous Cell Carcinoma 24 reports0.11%
Staphylococcal Infection 46 reports0.22%
Stomatitis 108 reports0.51%
Swelling 28 reports0.13%
Swelling Face 21 reports0.10%
Syncope 35 reports0.17%
Systemic Lupus Erythematosus 22 reports0.10%
Tachycardia 58 reports0.28%
Therapeutic Response Decreased 40 reports0.19%
Thrombocytopenia 127 reports0.60%
Thrombosis 18 reports0.09%
Toxicity To Various Agents 125 reports0.59%
Transaminases Increased 29 reports0.14%
Treatment Related Secondary Malignancy 20 reports0.10%
Tremor 38 reports0.18%
Tuberculosis 44 reports0.21%
Tumour Lysis Syndrome 26 reports0.12%
Ulcer 24 reports0.11%
Upper Respiratory Tract Infection 29 reports0.14%
Urinary Incontinence 33 reports0.16%
Urinary Retention 29 reports0.14%
Urinary Tract Infection 82 reports0.39%
Urticaria 51 reports0.24%
Uveitis 20 reports0.10%
Vasculitis 18 reports0.09%
Viral Infection 29 reports0.14%
Visceral Leishmaniasis 27 reports0.13%
Vision Blurred 38 reports0.18%
Visual Impairment 34 reports0.16%
Vomiting 231 reports1.10%
Weight Decreased 114 reports0.54%
Weight Increased 49 reports0.23%
White Blood Cell Count Decreased 68 reports0.32%
White Blood Cell Count Increased 22 reports0.10%

Displaying 400 Methotrexate side effects


Common Drugs


Common Drugs

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)


Discuss Methotrexate Side Effects