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Methotrexate Malaise Side Effects

Methotrexate Malaise Side Effect Reports


The following Methotrexate Malaise side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Malaise, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Nausea, Dizziness, Malaise, Bronchitis, Cough, Dyspnoea, Pneumonia, Lung Disorder

This Malaise side effect was reported by a consumer or non-health professional from US. A 67-year-old female patient (weight:NA) experienced the following symptoms/conditions: palindromic rheumatism. The patient was prescribed Methotrexate (dosage: 5 Pills 2x/day Once A Week One Day Weekly), which was started on Dec 03, 2012. Concurrently used drugs: NA. When starting to take Methotrexate the consumer reported the following symptoms:
  • Nausea
  • Dizziness
  • Malaise
  • Bronchitis
  • Cough
  • Dyspnoea
  • Pneumonia
  • Lung Disorder
These side effects may potentially be related to Methotrexate.
Myopathy, Muscular Weakness, Blood Creatine Phosphokinase Increased, Gait Disturbance, Skin Lesion, Malaise, Erythema, Arthralgia, Movement Disorder

This Malaise Methotrexate side effect was reported by a health professional from PE on Feb 19, 2014. A Female , 38 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Myopathy
  • Muscular Weakness
  • Blood Creatine Phosphokinase Increased
  • Gait Disturbance
  • Skin Lesion
  • Malaise
  • Erythema
  • Arthralgia
  • Movement Disorder
. Methotrexate dosage: 15 Mg, Per Week. Additional drugs used at the same time: NA.
Nausea, Asthenia, Malaise

This is a Methotrexate side effect report of a female patient (weight:NA) from PL, suffering from the following symptoms/conditions: rheumatoid arthritis, who was treated with Methotrexate (dosage:15 Mg, Qw, start time: Apr 15, 2011), combined with:
  • Metypred (4 Mg, Qd)
  • Olfen (150 Mg, Qd)
  • Nolpaza (20 Mg, Qd)
, and developed a serious reaction and a Malaise side effect. The patient presented with:
  • Nausea
  • Asthenia
  • Malaise
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from rheumatoid arthritis, resulting in Malaise.

Pneumonia, Rash, Immune System Disorder, Malaise

A 77-year-old female patient (weight: NA) from US with the following symptoms: NA started Methotrexate Sodium treatment (dosage: Unk) on NS. Soon after starting Methotrexate Sodium treatment, the consumer experienced several side effects, including:
  • Pneumonia
  • Rash
  • Immune System Disorder
  • Malaise
. Concurrently used drugs:
  • Prednisone (Unk)
  • Prednisone
  • Leflunomide (Unk)
  • Leflunomide
  • Travatan Z (Unk)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate Sodium side effects, such as Malaise.
Cardiac Failure, Left Atrial Dilatation, Dilatation Ventricular, Interstitial Lung Disease, Dyspnoea Exertional, Malaise, Pyrexia, Cough, Hypoxia

A patient from GR was prescribed and started Methotrexate on Nov 27, 2013. Patient felt the following Methotrexate side effects: cardiac failure, left atrial dilatation, dilatation ventricular, interstitial lung disease, dyspnoea exertional, malaise, pyrexia, cough, hypoxia Additional patient health information: male , 64 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: 10 Mg, Two Weekly Doses. Concurrently used drugs:
  • Infliximab (5 Mg/kg)
The patient was hospitalized.
Uveitis, Malaise

This report suggests a potential Methotrexate Malaise side effect(s) that can have serious consequences. A 12-year-old female patient from GB (weight:NA) was diagnosed with the following health condition(s): juvenile idiopathic arthritis,prophylaxis,immunisation,inflammation and used Methotrexate (dosage: Injection To The Arm, Weekly) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Uveitis
  • Malaise
Drugs used concurrently:
  • Folic Acid
  • Folic Acid
  • Infliximab (Once Every 8 Weeks)
Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Malaise, may still occur.
Juvenile Idiopathic Arthritis, Tonsillitis, Joint Swelling, Weight Decreased, Immobile, Hyperglycaemia, Local Swelling, Pain, Malaise

An adverse event was reported by a consumer or non-health professional on Oct 17, 2013 by a Female taking Methotrexate (dosage: NA) . Location: GB , child 12 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: juvenile idiopathic arthritis, tonsillitis, joint swelling, weight decreased, immobile, hyperglycaemia, local swelling, pain, malaise. Additional medications/treatments:
Associated medications used:
  • Human Papilloma Vaccine Cervarix
  • Prednisolone
  • Anakinra
  • Tocilizumab
The patient was hospitalized.
Malaise

This Malaise problem was reported by a consumer or non-health professional from US. A 71-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis.On NS a consumer started treatment with Methotrexate Sodium (dosage: 7 Mg, Weekly). The following drugs/medications were being taken at the same time:
  • Meloxicam (7.5 Mg, 2x/day)
When commencing Methotrexate Sodium, the patient experienced the following unwanted symptoms /side effects:
  • Malaise
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Malaise, may become evident only after a product is in use by the general population.
Uveitis, Malaise

This is a Methotrexate side effect report of a 12-year-old female patient (weight: NA) from GB. The patient developed the following symptoms/conditions: juvenile idiopathic arthritis and was treated with Methotrexate (dosage: Unk Ukn, Unk) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Uveitis
  • Malaise
This opens a possibility that Methotrexate could cause Malaise and that some female patients may be more susceptible.
Uveitis, Malaise

This Malaise side effect was reported by a health professional from GB on Oct 16, 2013. A female patient from GB , child 12 years of age, was diagnosed with and was treated with Methotrexate Sodium. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: uveitis, malaise. Methotrexate Sodium dosage: Unk. These side effects may potentially be related to Methotrexate Sodium.
Cholestasis, Histoplasmosis Disseminated, Hepatic Infection Fungal, Malaise, Pyrexia, Weight Decreased, Night Sweats, Abdominal Pain

This Malaise side effect was reported by a health professional from NL. A 74-year-old female patient (weight:NA) experienced the following symptoms/conditions: necrotising scleritis. The patient was prescribed Methotrexate (dosage: 20 Mg, Per Week), which was started on 201104. Concurrently used drugs:
  • Prednisolone (1 Mg/kg, Per Day)
  • Prednisolone (15 Mg, Per Day)
  • Adalimumab (40 Mg, Per Week)
When starting to take Methotrexate the consumer reported the following symptoms:
  • Cholestasis
  • Histoplasmosis Disseminated
  • Hepatic Infection Fungal
  • Malaise
  • Pyrexia
  • Weight Decreased
  • Night Sweats
  • Abdominal Pain
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Coma, Malaise

This Malaise Methotrexate side effect was reported by a health professional from US on Sep 12, 2013. A Female , 59 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Coma
  • Malaise
. Methotrexate dosage: Unk Unk Oral. Additional drugs used at the same time:
  • Enbrel (50mg Weekly Sc)
  • Levothyroxine
  • Prednisone
The patient was hospitalized.
Cheilitis, Malaise, Fluid Retention, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Diarrhoea, Paronychia, Nail Infection

This is a Methotrexate side effect report of a 30-year-old female patient (weight:NA) from COUNTRY NOT SPECIFIED, suffering from the following symptoms/conditions: adult t-cell lymphoma/leukaemia, who was treated with Methotrexate (dosage:NA, start time: NS), combined with: NA., and developed a serious reaction and a Malaise side effect. The patient presented with:
  • Cheilitis
  • Malaise
  • Fluid Retention
  • Aspartate Aminotransferase Increased
  • Alanine Aminotransferase Increased
  • Diarrhoea
  • Paronychia
  • Nail Infection
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from adult t-cell lymphoma/leukaemia, resulting in Malaise.
Urinary Tract Infection, Renal Cyst Haemorrhage, Pyelonephritis, Abscess, Infected Cyst, Diverticulitis, Malaise, Abdominal Pain, Decreased Appetite

A 71-year-old patient (weight: NA) from US with the following symptoms: transitional cell carcinoma,urinary tract carcinoma in situ started Methotrexate treatment (dosage: Chemo Every 2 Weeks) on May 10, 2013. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Urinary Tract Infection
  • Renal Cyst Haemorrhage
  • Pyelonephritis
  • Abscess
  • Infected Cyst
  • Diverticulitis
  • Malaise
  • Abdominal Pain
  • Decreased Appetite
. Concurrently used drugs:
  • Vinblastine
  • Doxorubicin
  • Cisplatin
  • Neulasta
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Malaise.
Malaise, Off Label Use

A female patient from US was prescribed and started Methotrexate Sodium on Jun 06, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: malaise, off label use Additional patient health information: Female , 64 years of age, The consumer reported the following symptoms: . Methotrexate Sodium dosage: 25 Mg Once A Week. Concurrently used drugs: NA.
Encephalomyelitis, Haemorrhage, Malaise, Balance Disorder, Unresponsive To Stimuli, Coma Scale Abnormal, Musculoskeletal Stiffness, Posturing, Lymphopenia

This report suggests a potential Methotrexate Malaise side effect(s) that can have serious consequences. A 53-year-old female patient from GB (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate (dosage: 20 Mg, Unk) starting Jan 07, 2013. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Encephalomyelitis
  • Haemorrhage
  • Malaise
  • Balance Disorder
  • Unresponsive To Stimuli
  • Coma Scale Abnormal
  • Musculoskeletal Stiffness
  • Posturing
  • Lymphopenia
Drugs used concurrently:
  • Enbrel (50 Mg, Qw)
  • Mobic (50 Mg, Qd Taken For Years)
  • Frusemide (20 Mg, Qd)
  • Bendrofluazide (2.5 Mg, Qd)
  • Candesartan
  • Folic Acid (5 Mg, Taken For Years)
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Malaise, may still occur.
Influenza Like Illness, Asthenia, Contusion, Fatigue, Myalgia, Headache, Vision Blurred, Malaise

An adverse event was reported by a health professional on Feb 26, 2013 by a Female taking Methotrexate (dosage: NA) . Location: GB , 51 years of age, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: influenza like illness, asthenia, contusion, fatigue, myalgia, headache, vision blurred, malaise. Additional medications/treatments:
Multiple prescriptions taken:
  • Trimethoprim
  • Aspirin
  • (limecycline)
  • Folic Acid
  • Beclometasone Dipropionate
  • Salbutamol
Vision Blurred, Contusion, Malaise, Asthenia, Influenza Like Illness, Headache, Fatigue, Myalgia

This Malaise problem was reported by a health professional from GB. A 51-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Nov 28, 2012 a consumer started treatment with Methotrexate (dosage: 30 Mg, Qw). The following drugs/medications were being taken at the same time:
  • Trimethoprim
  • Aspirin
  • Lymecycline
  • Folic Acid
  • Clenil Modulite
  • Salbutamol
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Vision Blurred
  • Contusion
  • Malaise
  • Asthenia
  • Influenza Like Illness
  • Headache
  • Fatigue
  • Myalgia
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Malaise, may become evident only after a product is in use by the general population.
Asthenia, Malaise, Dysstasia, Fall, Dyspnoea, Lung Disorder, Pneumocystis Jirovecii Pneumonia, Tachycardia

This is a Methotrexate side effect report of a female patient (weight: NA) from US. The patient developed the following symptoms/conditions: corneal lesion and was treated with Methotrexate (dosage: 10 Tablets 1 X Week Orally) starting Sep 20, 2012. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Asthenia
  • Malaise
  • Dysstasia
  • Fall
  • Dyspnoea
  • Lung Disorder
  • Pneumocystis Jirovecii Pneumonia
  • Tachycardia
This opens a possibility that Methotrexate could cause Malaise and that some female patients may be more susceptible.
Ascites, Gastrointestinal Disorder, Spermatic Cord Disorder, Local Swelling, Abdominal Pain Lower, Malaise

This Malaise side effect was reported by a physician from DE on Dec 18, 2012. A patient from DE , 57 years of age, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: ascites, gastrointestinal disorder, spermatic cord disorder, local swelling, abdominal pain lower, malaise. Methotrexate dosage: 15 Mg, Unk.
Multiple prescriptions taken:
  • Humira (Unk)
  • Cortisone
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Malaise Causes and Reviews


What is chronic fatigue syndrome?

Chronic fatigue syndrome (CFS) is a serious, long-term illness that affects many body systems. Another name for it is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). CFS can often make you unable to do your usual activities. Sometimes you may not even be able to get out of bed.

What are the symptoms of chronic fatigue syndrome?

CFS symptoms can include

  • Severe fatigue that is not improved by rest
  • Sleep problems
  • Post-exertional Malaise (PEM), where your symptoms get worse after any physical or mental activity
  • Problems with thinking and concentrating
  • Pain
  • Dizziness

CFS can be unpredictable. Your symptoms may come and go. They may change over time - sometimes they might get better, and other times they may get worse.

Who gets chronic fatigue syndrome?

Anyone can get CFS, but it is most common in people between 40 and 60 years old. Adult women have it more often that adult men. Whites are more likely than other races to get a diagnosis of CFS, but many people with CFS have not been diagnosed with it.

What causes chronic fatigue syndrome?

Scientists don't know what causes CFS. There may be more than one thing that causes it. It is possible that two or more triggers might work together to cause the illness.

How is chronic fatigue syndrome diagnosed?

CFS can be difficult to diagnose. There are no tests for it, and other illnesses can cause similar symptoms. Your health care provider has to rule out other diseases before making a diagnosis of CFS. He or she will do a thorough medical exam, including

  • Asking about your health history and your family's medical history
  • Asking about your current illness, including your symptoms. Your doctor will want to know how often you have symptoms, how bad they are, how long they have lasted, and how they affect your life.
  • A thorough physical and mental status exam
  • Blood, urine or other tests
What are the treatments for chronic fatigue syndrome?

There is no cure or approved treatment for CFS, but you may be able to treat or manage some of your symptoms. You, your family, and your health care provider should work together to decide on a plan. You should figure out which symptom causes the most problems, and try to treat that first. For example, if sleep problems affect you the most, you might first try using good sleep habits. If those do not help, you may need to take medicines or see a sleep specialist.

Strategies such as learning new ways to manage activity can also be helpful. You need to make sure that you do not "push and crash." This can happen when you feel better, do too much, and then get worse again.

Since the process of developing a treatment plan and attending to self-care can be hard if you have CFS, it is important to have support from family members and friends.

Don't try any new treatments without talking to your health care provider. Some treatments that are promoted as cures for CFS are unproven, often costly, and could be dangerous.

Centers for Disease Control and Prevention


Methotrexate Malaise Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
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Rheumatoid Arthritis (260)
Dyspnoea (248)
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Diarrhoea (238)
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Malaise (156)
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Pain In Extremity (141)
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Hypertension (115)
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Infection (103)
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Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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