sponsored
PatientsVille.com Logo

PatientsVille

Methotrexate Pain In Extremity Side Effects

Methotrexate Pain In Extremity Side Effect Reports


The following Methotrexate Pain In Extremity side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Pain In Extremity, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Hypersensitivity Vasculitis, Erythema, Rash, Muscle Swelling, Abdominal Tenderness, Pain In Extremity, Local Swelling, Myalgia, Anaemia

This Pain In Extremity side effect was reported by a health professional from US. A 28-year-old patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Methotrexate (dosage: NA), which was started on NS. Concurrently used drugs:
  • Ustekinumab
  • Prednisone
When starting to take Methotrexate the consumer reported the following symptoms:
  • Hypersensitivity Vasculitis
  • Erythema
  • Rash
  • Muscle Swelling
  • Abdominal Tenderness
  • Pain In Extremity
  • Local Swelling
  • Myalgia
  • Anaemia
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Encephalopathy, Pain In Extremity, Restlessness

This Pain In Extremity Methotrexate Sodium side effect was reported by a pharmacist from JP on Nov 21, 2013. A Female , 19 years of age, weighting 93.70 lb, was diagnosed with and was treated with Methotrexate Sodium. The patient presented the following health conditions:
  • Encephalopathy
  • Pain In Extremity
  • Restlessness
. Methotrexate Sodium dosage: 4000 Mg, Unk. Additional drugs used at the same time: NA. The patient was hospitalized.
Necrotising Fasciitis, Fall, Pain In Extremity, Erythema, Cellulitis, Skin Graft, Limb Injury

This is a Methotrexate side effect report of a 64-year-old patient (weight:NA) from IE, suffering from the following symptoms/conditions: psoriasis, who was treated with Methotrexate (dosage:NA, start time: NS), combined with: NA., and developed a serious reaction and a Pain In Extremity side effect. The patient presented with:
  • Necrotising Fasciitis
  • Fall
  • Pain In Extremity
  • Erythema
  • Cellulitis
  • Skin Graft
  • Limb Injury
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from psoriasis, resulting in Pain In Extremity.

Rheumatoid Arthritis, Hepatic Enzyme Increased, Injection Site Bruising, Blood Pressure Increased, Hot Flush, Headache, Arthralgia, Back Pain, Pain In Extremity

A 69-year-old female patient (weight: NA) from US with the following symptoms: rheumatoid arthritis started Methotrexate Sodium treatment (dosage: 2.5 Mg, 6 Tablets Weekly) on Jan 04, 2013. Soon after starting Methotrexate Sodium treatment, the consumer experienced several side effects, including:
  • Rheumatoid Arthritis
  • Hepatic Enzyme Increased
  • Injection Site Bruising
  • Blood Pressure Increased
  • Hot Flush
  • Headache
  • Arthralgia
  • Back Pain
  • Pain In Extremity
. Concurrently used drugs:
  • Ibuprofen (Unk)
  • Lipitor (40 Mg, Once Daily)
  • Humira (40 Mg, 1 In 2 Wk)
  • Furosemide (Unk)
  • Prednisone (5 Mg, Unk)
  • Prednisone (2.5 Mg, 1 In 1 D)
  • Folic Acid (1 Mg, 1 In 1 D)
  • Folic Acid
This finding indicates that some patients can be more vulnerable to developing Methotrexate Sodium side effects, such as Pain In Extremity.
Immobile, Pain In Extremity

A patient from GB was prescribed and started Methotrexate on Aug 01, 2013. Patient felt the following Methotrexate side effects: immobile, pain in extremity Additional patient health information: male , 59 years of age, weighting 319.7 lb, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: 5 Mg, Unk. Concurrently used drugs:
  • Celecoxib (200 Mg, Unk)
  • Dovonex
Deep Vein Thrombosis, Pain In Extremity, Local Swelling, Arthralgia, Decreased Activity

This report suggests a potential Methotrexate (methotrexate) Open Label Pain In Extremity side effect(s) that can have serious consequences. A 65-year-old female patient from US (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate (methotrexate) Open Label (dosage: NA) starting Apr 12, 2011. Soon after starting Methotrexate (methotrexate) Open Label the patient began experiencing various side effects, including:
  • Deep Vein Thrombosis
  • Pain In Extremity
  • Local Swelling
  • Arthralgia
  • Decreased Activity
Drugs used concurrently:
  • Humira (adalimumab) Open Label (40 Mg, 1 In 2 Wk)
  • Zolpidem (zolpidem)
  • Mirtazapine (mirtazapine)
  • Simvastatin (simvastatin)
  • Acetylsalicylic Acid (acetylsalicylic Acid)
  • Olmesartan (olmesartan)
  • Hydrochlorothiazide (hydrochlorothiazide)
  • Carvedilol (carvedilol)
The patient was hospitalized. Although Methotrexate (methotrexate) Open Label demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pain In Extremity, may still occur.
Speech Disorder, Blood Potassium Decreased, Vitamin B12 Increased, Ataxia, Dysphagia, Disturbance In Attention, Muscular Weakness, Pain In Extremity, Hypersomnia

An adverse event was reported by a consumer or non-health professional on Apr 26, 2013 by a Female taking Methotrexate (dosage: NA) was diagnosed with and. Location: COUNTRY NOT SPECIFIED , 59 years of age, weighting 118.1 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: speech disorder, blood potassium decreased, vitamin b12 increased, ataxia, dysphagia, disturbance in attention, muscular weakness, pain in extremity, hypersomnia. Additional medications/treatments: The patient was hospitalized.
Joint Swelling, Rheumatoid Arthritis, Erythema, Pain, Pain In Extremity, Gait Disturbance, Contusion, Headache, Sinus Headache

This Pain In Extremity problem was reported by a consumer or non-health professional from COUNTRY NOT SPECIFIED. A 46-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis,hypertension,tachycardia.On 201203 a consumer started treatment with Methotrexate (dosage: NA). The following drugs/medications were being taken at the same time:
  • Cardizem
  • Cardizem
  • Humira 40 Mg/0.8 Ml Pen
  • Humira 40 Mg/0.8 Ml Pen
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Joint Swelling
  • Rheumatoid Arthritis
  • Erythema
  • Pain
  • Pain In Extremity
  • Gait Disturbance
  • Contusion
  • Headache
  • Sinus Headache
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Pain In Extremity, may become evident only after a product is in use by the general population.
Chest Pain, Pain In Extremity, Oedema Peripheral, Nodule, Mental Status Changes, Intraocular Pressure Increased, Nerve Injury, Hallucination, Swelling Face

This is a Methotrexate side effect report of a 69-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: rheumatoid arthritis and was treated with Methotrexate (dosage: NA) starting Nov 10, 2006. Concurrently used drugs:
  • Folic Acid
Soon after that, the consumer experienced the following of symptoms:
  • Chest Pain
  • Pain In Extremity
  • Oedema Peripheral
  • Nodule
  • Mental Status Changes
  • Intraocular Pressure Increased
  • Nerve Injury
  • Hallucination
  • Swelling Face
This opens a possibility that Methotrexate could cause Pain In Extremity and that some female patients may be more susceptible.
Fall, Pain In Extremity, Stress Fracture, Femur Fracture, Anaemia Postoperative, Urinary Tract Infection, Bone Callus Excessive, Fracture Displacement, Fracture Delayed Union

This Pain In Extremity side effect was reported by a health professional from UNITED STATES on Jun 08, 2012. A female patient from UNITED STATES , 57 years of age, weighting 149.9 lb, was treated with Methotrexate Sodium. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: fall, pain in extremity, stress fracture, femur fracture, anaemia postoperative, urinary tract infection, bone callus excessive, fracture displacement, fracture delayed union. Methotrexate Sodium dosage: NA.
Associated medications used:
  • Humira
  • Lisinopril
  • Aspirin
  • Ferrous Sulfate Tab
  • Prednisone Tab
  • Valtrex
  • Levothyroxine Sodium
  • Pantoprazole Sodium (pantoprazole Sodium Sesquihydrate)
The patient was hospitalized. These side effects may potentially be related to Methotrexate Sodium.
Myocardial Infarction, Precancerous Cells Present, Wrist Fracture, Pruritus, Pain In Extremity, Pain In Jaw, Laceration, Rash Maculo-papular, Skin Exfoliation

This Pain In Extremity side effect was reported by a consumer or non-health professional from UNITED STATES. A 65-year-old female patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis. The patient was prescribed Methotrexate (dosage: NA), which was started on Jan 01, 2006. Concurrently used drugs:
  • Humira
  • Norco (7.5/325 1 Tab Every 4 Hours)
  • Folic Acid (2 Tabs 6 Days A Week (except Not On Day Of Methotrexate))
When starting to take Methotrexate the consumer reported the following symptoms:
  • Myocardial Infarction
  • Precancerous Cells Present
  • Wrist Fracture
  • Pruritus
  • Pain In Extremity
  • Pain In Jaw
  • Laceration
  • Rash Maculo-papular
  • Skin Exfoliation
These side effects may potentially be related to Methotrexate.
Post Transplant Distal Limb Syndrome, Pain In Extremity

This Pain In Extremity Methotrexate side effect was reported by a health professional from JAPAN on Jun 19, 2012. A male , 51 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Post Transplant Distal Limb Syndrome
  • Pain In Extremity
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Tacrolimus
Pruritus, Pain In Extremity, Post Transplant Distal Limb Syndrome

This is a Methotrexate side effect report of a 43-year-old patient (weight:NA) from JAPAN, suffering from the following symptoms/conditions: prophylaxis against graft versus host disease, who was treated with Methotrexate (dosage:NA, start time: NS), combined with:
  • Tacrolimus
, and developed a serious reaction and a Pain In Extremity side effect. The patient presented with:
  • Pruritus
  • Pain In Extremity
  • Post Transplant Distal Limb Syndrome
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from prophylaxis against graft versus host disease, resulting in Pain In Extremity.
Acute Graft Versus Host Disease, Post Transplant Distal Limb Syndrome, Pain In Extremity

A 19-year-old female patient (weight: NA) from JAPAN with the following symptoms: NA started Methotrexate treatment (dosage: NA) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Acute Graft Versus Host Disease
  • Post Transplant Distal Limb Syndrome
  • Pain In Extremity
. Concurrently used drugs:
  • Tacrolimus
This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Pain In Extremity.
Pain In Extremity, Acute Graft Versus Host Disease, Pruritus, Post Transplant Distal Limb Syndrome

A patient from JAPAN was prescribed and started Methotrexate on Jun 19, 2012. After Methotrexate was administered, patient encountered several Methotrexate side effects: pain in extremity, acute graft versus host disease, pruritus, post transplant distal limb syndrome Additional patient health information: male , 29 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: Unk. Concurrently used drugs:
  • Cyclosporine (Unk)
  • Tacrolimus
Pain In Extremity, Post Transplant Distal Limb Syndrome

This report suggests a potential Methotrexate Pain In Extremity side effect(s) that can have serious consequences. A 32-year-old patient from JAPAN (weight:NA) was diagnosed with the following health condition(s): prophylaxis against graft versus host disease and used Methotrexate (dosage: NA) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Pain In Extremity
  • Post Transplant Distal Limb Syndrome
Drugs used concurrently:
  • Cyclosporine
Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pain In Extremity, may still occur.
Pain In Extremity

An adverse event was reported by a health professional on May 25, 2012 by a male taking Methotrexate (dosage: Unk Mg, Unk) . Location: UNITED STATES , 59 years of age, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: pain in extremity. Additional medications/treatments:
Multiple prescriptions taken:
  • Folic Acid (Unk Mg, Unk)
  • Enbrel (50 Mg, Qwk)
Fall, Spinal Disorder, Muscular Weakness, Muscle Spasms, Hypoaesthesia, Pain In Extremity

This Pain In Extremity problem was reported by a physician from UNITED STATES. A 39-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): psoriatic arthropathy,psoriasis,muscular weakness.On Oct 11, 2011 a consumer started treatment with Methotrexate (dosage: 25 Mg, Qwk 6 Tabs). The following drugs/medications were being taken at the same time:
  • Enbrel (50 Mg, Qwk)
  • Cymbalta (40 Mg, Qhs)
  • Celebrex (200 Mg, Qd)
  • Enbrel
  • Savella (50 Mg, Bid)
  • Folic Acid (1 Mg, Qd)
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Fall
  • Spinal Disorder
  • Muscular Weakness
  • Muscle Spasms
  • Hypoaesthesia
  • Pain In Extremity
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Pain In Extremity, may become evident only after a product is in use by the general population.
Sinusitis, Musculoskeletal Pain, Pain In Extremity, Bundle Branch Block Right, Chest Pain

This is a Methotrexate side effect report of a female patient (weight: NA) from CANADA. The patient developed the following symptoms/conditions: NA and was treated with Methotrexate (dosage: NA) starting Feb 15, 2011. Concurrently used drugs:
  • Prinivil
  • Calcium/vitamin D
  • Actemra
  • Folic Acid
  • Actemra
  • Tylenol (caplet)
Soon after that, the consumer experienced the following of symptoms:
  • Sinusitis
  • Musculoskeletal Pain
  • Pain In Extremity
  • Bundle Branch Block Right
  • Chest Pain
This opens a possibility that Methotrexate could cause Pain In Extremity and that some female patients may be more susceptible.
Cardiomegaly, Pain In Extremity, Joint Swelling, Malaise, Oedema Peripheral, Joint Range Of Motion Decreased, Arthralgia, Joint Lock

This Pain In Extremity side effect was reported by a consumer or non-health professional from BRAZIL on Mar 27, 2012. A female patient from BRAZIL , weighting 119.0 lb, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: cardiomegaly, pain in extremity, joint swelling, malaise, oedema peripheral, joint range of motion decreased, arthralgia, joint lock. Methotrexate dosage: Once Daily In The Morning.
Multiple prescriptions taken:
  • Omeprazole (Once Daily, Fasting)
  • Ulufrolamida (Once Daily In The Morning)
  • Atenolol (One Tablet In The Moring And One At Night)
  • Spironolactone
  • Humira
  • Diuretide (Once Daily In The Morning)
  • Methyldopa
  • Omeprazole
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
1 of 7 

DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Pain In Extremity Causes and Reviews


Of the 206 bones in your body, three of them are in your arm: the humerus, radius, and ulna. Your arms are also made up of muscles, joints, tendons, and other connective tissue. Injuries to any of these parts of the arm can occur during sports, a fall, or an accident.

Types of arm injuries include

  • Tendinitis and bursitis
  • Sprains
  • Dislocations
  • Broken bones
  • Nerve problems
  • Osteoarthritis

You may also have problems or injure specific parts of your arm, such as your hand, wrist, elbow, or shoulder.


Methotrexate Pain In Extremity Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Common Drugs

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Top Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
Anaemia (195)
Pain (188)
Renal Failure Acute (177)
Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
Neutropenia (129)
Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
Interstitial Lung Disease (113)
Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

➢ More

Discuss Methotrexate Side Effects