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Methotrexate Pain Side Effects

Methotrexate Pain Side Effect Reports


The following Methotrexate Pain side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Pain, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.



Abasia, Pain

This Pain side effect was reported by a consumer or non-health professional from US. A 30-year-old female patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis. The patient was prescribed Methotrexate (dosage: NA), which was started on Jun 04, 2010. Concurrently used drugs:
  • Etanercept
When starting to take Methotrexate the consumer reported the following symptoms:
  • Abasia
  • Pain
These side effects may potentially be related to Methotrexate.
Off Label Use, Uveitis, Back Pain, Ocular Hyperaemia

This Pain Methotrexate side effect was reported by a consumer or non-health professional from US on Mar 10, 2014. A Female , 36 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Off Label Use
  • Uveitis
  • Back Pain
  • Ocular Hyperaemia
. Methotrexate dosage: NA. Additional drugs used at the same time: NA.
Corneal Disorder, Visual Acuity Reduced, Pain

This is a Methotrexate side effect report of a 61-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: lymphoma, who was treated with Methotrexate (dosage:0.1 Ml, Wekly, start time: NS), combined with: NA., and developed a serious reaction and a Pain side effect. The patient presented with:
  • Corneal Disorder
  • Visual Acuity Reduced
  • Pain
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from lymphoma, resulting in Pain.

Guillain-barre Syndrome, Grand Mal Convulsion, Blast Cell Crisis, Necrosis, Dysaesthesia, Pain, Cytotoxic Oedema, Spinal Cord Disorder

A 11-year-old patient (weight: NA) from COUNTRY NOT SPECIFIED with the following symptoms: acute lymphocytic leukaemia started Methotrexate treatment (dosage: Single Dose, Intrathecal) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Guillain-barre Syndrome
  • Grand Mal Convulsion
  • Blast Cell Crisis
  • Necrosis
  • Dysaesthesia
  • Pain
  • Cytotoxic Oedema
  • Spinal Cord Disorder
. Concurrently used drugs:
  • Cyclophosphamide
  • Etoposide
  • Nelarabine
  • Cytarabine
  • Prednisolone
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Pain.
Pyrexia, Urinary Tract Infection, Arthritis Bacterial, Nasopharyngitis, Gait Disturbance, Weight Bearing Difficulty, Pain, Local Swelling, Chills

A female patient from US was prescribed and started Methotrexate Sodium on Dec 02, 2013. Patient felt the following Methotrexate side effects: pyrexia, urinary tract infection, arthritis bacterial, nasopharyngitis, gait disturbance, weight bearing difficulty, pain, local swelling, chills Additional patient health information: Female , 70 years of age, weighting 260.1 lb, The consumer reported the following symptoms: was diagnosed with and. Methotrexate Sodium dosage: Unk. Concurrently used drugs:
  • Xeljanz (5 Mg, 2x/day)
  • Humira (Unk)
  • Plaquenil (Unk)
  • Zocor (10 Mg, 1x/day)
  • Efexor Xr (Unk, 1x/day)
The patient was hospitalized.
Cough, Sinus Headache, Pain

This report suggests a potential Methotrexate Pain side effect(s) that can have serious consequences. A 54-year-old female patient from US (weight:NA) was diagnosed with the following health condition(s): NA and used Methotrexate (dosage: 1 Pill Once Daily Taken By Mouth) starting Sep 21, 2010. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Cough
  • Sinus Headache
  • Pain
Drugs used concurrently:NA. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pain, may still occur.
Chills, Pain

An adverse event was reported by a health professional on Oct 22, 2013 by a Female taking Methotrexate (dosage: 5 Df) was diagnosed with and. Location: GB , 50 years of age, weighting 176.4 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: chills, pain. Additional medications/treatments:
Associated medications used:
  • Nytol
  • Amitriptyline
  • Venaxx
  • Domperidon//domperidone
  • Omeprazole
  • Orlistat
Juvenile Idiopathic Arthritis, Tonsillitis, Joint Swelling, Weight Decreased, Immobile, Hyperglycaemia, Local Swelling, Pain, Malaise

This Pain problem was reported by a consumer or non-health professional from GB. A 12-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Methotrexate (dosage: NA). The following drugs/medications were being taken at the same time:
  • Human Papilloma Vaccine Cervarix
  • Prednisolone
  • Anakinra
  • Tocilizumab
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Juvenile Idiopathic Arthritis
  • Tonsillitis
  • Joint Swelling
  • Weight Decreased
  • Immobile
  • Hyperglycaemia
  • Local Swelling
  • Pain
  • Malaise
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Pain, may become evident only after a product is in use by the general population.
Juvenile Idiopathic Arthritis, Tonsillitis, Weight Decreased, Immobile, Somnolence, Pain, Local Swelling, Hyperglycaemia, Joint Swelling

This is a Methotrexate side effect report of a 12-year-old female patient (weight: NA) from GB. The patient developed the following symptoms/conditions: NA and was treated with Methotrexate (dosage: Unk Ukn, Unk) starting 201010. Concurrently used drugs:
  • Cervarix (1 Df (1inj Single Dose))
  • Prednisolone (Unk Ukn, Unk)
  • Prednisolone (5 Mg, Unk)
  • Prednisolone (100 Mg, (drip))
  • Prednisolone (20 Mg)
  • Anakinra (100 Mg, Daily)
  • Tocilizumab (Unk Ukn, Unk)
Soon after that, the consumer experienced the following of symptoms:
  • Juvenile Idiopathic Arthritis
  • Tonsillitis
  • Weight Decreased
  • Immobile
  • Somnolence
  • Pain
  • Local Swelling
  • Hyperglycaemia
  • Joint Swelling
The patient was hospitalized. This opens a possibility that Methotrexate could cause Pain and that some female patients may be more susceptible.
Toxicity To Various Agents, Psoriasis, Skin Ulcer, Pain, Skin Hyperpigmentation, Oral Mucosa Erosion, Incorrect Dose Administered, Overdose, Alopecia

This Pain side effect was reported by a health professional from TR on Sep 19, 2013. A patient from TR , 74 years of age, was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: toxicity to various agents, psoriasis, skin ulcer, pain, skin hyperpigmentation, oral mucosa erosion, incorrect dose administered, overdose, alopecia. Methotrexate dosage: 7.5 Mg Per Week. These side effects may potentially be related to Methotrexate.
Neutropenia, Stomatitis, Mucosal Inflammation, Agitation, Pain, Pancytopenia, Dystonia, Respiratory Distress, Otitis Media Acute

This Pain side effect was reported by a consumer or non-health professional from US. A patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Methotrexate (dosage: NA), which was started on Aug 16, 2013. Concurrently used drugs:
  • Lestaurtinib
When starting to take Methotrexate the consumer reported the following symptoms:
  • Neutropenia
  • Stomatitis
  • Mucosal Inflammation
  • Agitation
  • Pain
  • Pancytopenia
  • Dystonia
  • Respiratory Distress
  • Otitis Media Acute
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Pancytopenia, Stomatitis, Staphylococcal Infection, Pain, Perianal Erythema, Anal Ulcer

This Pain Methotrexate side effect was reported by a health professional from SI on Jul 15, 2013. A Female , 58 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Pancytopenia
  • Stomatitis
  • Staphylococcal Infection
  • Pain
  • Perianal Erythema
  • Anal Ulcer
. Methotrexate dosage: 10-12.5mg Once Per Week. Additional drugs used at the same time:
  • Folic Acid
  • Enalapril
  • Calcitriol
  • Methylprednisolone
  • Calcium
The patient was hospitalized.
Dermatitis, Parakeratosis, Skin Erosion, Pain, Blister, Thrombocytopenia, Pancytopenia, Eosinophil Count Increased, Toxicity To Various Agents

This is a Methotrexate side effect report of a 79-year-old patient (weight:NA) from US, suffering from the following symptoms/conditions: psoriasis, who was treated with Methotrexate (dosage:12.5 Mg, Qw, start time: NS), combined with: NA., and developed a serious reaction and a Pain side effect. The patient presented with:
  • Dermatitis
  • Parakeratosis
  • Skin Erosion
  • Pain
  • Blister
  • Thrombocytopenia
  • Pancytopenia
  • Eosinophil Count Increased
  • Toxicity To Various Agents
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from psoriasis, resulting in Pain.
Therapeutic Response Decreased, Musculoskeletal Stiffness, Pain, Abdominal Discomfort

A 52-year-old female patient (weight: NA) from US with the following symptoms: NA started Methotrexate Sodium treatment (dosage: Unk) on NS. Soon after starting Methotrexate Sodium treatment, the consumer experienced several side effects, including:
  • Therapeutic Response Decreased
  • Musculoskeletal Stiffness
  • Pain
  • Abdominal Discomfort
. Concurrently used drugs:
  • Meloxicam (7.5 Mg, Unk)
This finding indicates that some patients can be more vulnerable to developing Methotrexate Sodium side effects, such as Pain.
Pancytopenia, Gingival Bleeding, Pain, Fatigue, Petechiae, Haematoma, Toxicity To Various Agents

A female patient from SI was prescribed and started Methotrexate Sodium on Mar 19, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: pancytopenia, gingival bleeding, pain, fatigue, petechiae, haematoma, toxicity to various agents Additional patient health information: Female , 79 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate Sodium dosage: 7.5 To 10 Mg Once A Week, Low Dose. Concurrently used drugs:
  • Trimethoprim, Sulfamethoxazole (For One Week)
  • Folic Acid (5 Mg)
  • Asasantin (Unk)
  • Nifedipine (Unk)
  • Escitalopram (Unk)
  • Repaglinide (Unk)
  • Bisoprolol (Unk)
The patient was hospitalized.
Joint Swelling, Rheumatoid Arthritis, Erythema, Pain, Pain In Extremity, Gait Disturbance, Contusion, Headache, Sinus Headache

This report suggests a potential Methotrexate Pain side effect(s) that can have serious consequences. A 46-year-old female patient from COUNTRY NOT SPECIFIED (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis,hypertension,tachycardia and used Methotrexate (dosage: NA) starting 201203. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Joint Swelling
  • Rheumatoid Arthritis
  • Erythema
  • Pain
  • Pain In Extremity
  • Gait Disturbance
  • Contusion
  • Headache
  • Sinus Headache
Drugs used concurrently:
  • Cardizem
  • Cardizem
  • Humira 40 Mg/0.8 Ml Pen
  • Humira 40 Mg/0.8 Ml Pen
Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pain, may still occur.
Skin Lesion, Pain, Mouth Ulceration

An adverse event was reported by a health professional on Dec 10, 2012 by a Female taking Methotrexate (dosage: 25 Mg, Qw) . Location: GB , 61 years of age, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: skin lesion, pain, mouth ulceration. Additional medications/treatments:
Multiple prescriptions taken:
  • Simponi (50 Mg, Unk)
Pustular Psoriasis, Malaise, Rash Erythematous, Pain, Gastrointestinal Disorder

This Pain problem was reported by a health professional from ES. A 32-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis.On 2008 a consumer started treatment with Methotrexate (dosage: NA). The following drugs/medications were being taken at the same time:
  • Leflunomide
  • Adalimumab
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Pustular Psoriasis
  • Malaise
  • Rash Erythematous
  • Pain
  • Gastrointestinal Disorder
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Pain, may become evident only after a product is in use by the general population.
Enterocolitis Infectious, Vomiting, Constipation, Melaena, Stomatitis, Pain, Rash

This is a Methotrexate side effect report of a 65-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: rheumatoid arthritis and was treated with Methotrexate (dosage: (1 In 2 Wk), Po Cntd) starting May 23, 2012. Concurrently used drugs:
  • Humira (40mg (1 In 2 Wk), Sc, Cnt)
  • Savella (milnacipran Hydrochloride)
  • Aspirin Low Dose (acetylsalicylic Acid)
  • Levothyroxine (levothyroxine Sodium)
  • Neurontin (gabapentin)
  • Zocor (simvastatin)
  • Oracea (doxycycline)
  • Folic Acid (folic Acid)
Soon after that, the consumer experienced the following of symptoms:
  • Enterocolitis Infectious
  • Vomiting
  • Constipation
  • Melaena
  • Stomatitis
  • Pain
  • Rash
The patient was hospitalized. This opens a possibility that Methotrexate could cause Pain and that some female patients may be more susceptible.
Pain, Alopecia, Urinary Tract Infection, Dengue Fever, Herpes Zoster

This Pain side effect was reported by a physician from BRAZIL on Jun 13, 2012. A female patient from BRAZIL , 60 years of age, weighting 178.6 lb, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: pain, alopecia, urinary tract infection, dengue fever, herpes zoster. Methotrexate dosage: 5 Mg, Weekly.
Multiple prescriptions taken:
  • Remicade (Unk)
  • Amlodipine (Unk)
  • Losartan Potassium (Unk)
  • Enbrel (50 Mg, Qwk)
  • Enbrel (50 Mg, Qwk)
  • Levothyroxine Sodium (Unk)
  • Prednisone Tab (Unk)
  • Alprazolam (Unk)
These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Pain Causes and Reviews


Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel Pain in one area of your body, such as your back, abdomen, chest, pelvis, or you may feel Pain all over

Pain can be helpful in diagnosing a problem. If you never felt Pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment.

There are two types of Pain: acute and chronic. Acute Pain usually comes on suddenly, because of a disease, injury, or inflammation. It can often be diagnosed and treated. It usually goes away, though sometimes it can turn into chronic Pain. Chronic Pain lasts for a long time, and can cause severe problems.

Pain is not always curable, but there are many ways to treat it. Treatment depends on the cause and type of Pain. Pain relievers and other medicines, acupuncture, physical therapy, and sometimes surgery may be helpful.

NIH: National Institute of Neurological Disorders and Stroke


Methotrexate Pain Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the Pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe Pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Tue, 27 Apr 2010
Painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach Pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
Anaemia (195)
Pain (188)
Renal Failure Acute (177)
Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
Neutropenia (129)
Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
Interstitial Lung Disease (113)
Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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