Methotrexate Pyrexia Side Effect Reports


The following Methotrexate Pyrexia side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Pyrexia, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.


Hepatocellular Injury, Cholestasis, Renal Failure Acute, Hypotension, Pyrexia, Rash

This Pyrexia side effect was reported by a health professional from FR. A 59-year-old patient (weight:NA) experienced the following symptoms/conditions: b-cell lymphoma. The patient was prescribed Methotrexate Teva (dosage: NA), which was started on Nov 27, 2013. Concurrently used drugs:
  • Ondansetron Accord
When starting to take Methotrexate Teva the consumer reported the following symptoms:
  • Hepatocellular Injury
  • Cholestasis
  • Renal Failure Acute
  • Hypotension
  • Pyrexia
  • Rash
The patient was hospitalized. These side effects may potentially be related to Methotrexate Teva.
Gastrointestinal Mucosal Necrosis, Oesophageal Stenosis, Large Intestinal Stenosis, Mucosal Inflammation, Pyrexia, Staphylococcal Infection, Pancytopenia

This Pyrexia Methotrexate side effect was reported by a health professional from JP on Mar 03, 2014. A Female , 82 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Gastrointestinal Mucosal Necrosis
  • Oesophageal Stenosis
  • Large Intestinal Stenosis
  • Mucosal Inflammation
  • Pyrexia
  • Staphylococcal Infection
  • Pancytopenia
. Methotrexate dosage: 8mg/week. Additional drugs used at the same time:
  • Loxoprofen (180mg/day)
  • Prednisolone (4-6mg/day)
The patient was hospitalized.
Multi-organ Failure, Septic Shock, Condition Aggravated, Leukoencephalopathy, Aphasia, Mental Status Changes, Pyrexia, Pancytopenia, Faecal Incontinence

This is a Methotrexate side effect report of a 16-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: acute lymphocytic leukaemia, who was treated with Methotrexate (dosage:3 G/m2, start time: NS), combined with: NA., and developed a serious reaction and a Pyrexia side effect. The patient presented with:
  • Multi-organ Failure
  • Septic Shock
  • Condition Aggravated
  • Leukoencephalopathy
  • Aphasia
  • Mental Status Changes
  • Pyrexia
  • Pancytopenia
  • Faecal Incontinence
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in female patients suffering from acute lymphocytic leukaemia, resulting in Pyrexia.
Haemorrhagic Stroke, Acute Respiratory Failure, Pneumonitis, Nuchal Rigidity, Kernig^s Sign, Tachypnoea, Cough, Pyrexia, Renal Failure Acute

A 60-year-old female patient (weight: NA) from BG with the following symptoms: rheumatoid arthritis started Methotrexate treatment (dosage: 1 Mg, Each 10 Days) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Haemorrhagic Stroke
  • Acute Respiratory Failure
  • Pneumonitis
  • Nuchal Rigidity
  • Kernig^s Sign
  • Tachypnoea
  • Cough
  • Pyrexia
  • Renal Failure Acute
. Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Pyrexia.
Tachycardia, Hypoalbuminaemia, Concomitant Disease Aggravated, Pneumonitis, Pyrexia, Dyspnoea, Tachypnoea, Renal Failure Acute

A female patient from BG was prescribed and started Methotrexate on Feb 12, 2014. Patient felt the following Methotrexate side effects: tachycardia, hypoalbuminaemia, concomitant disease aggravated, pneumonitis, pyrexia, dyspnoea, tachypnoea, renal failure acute Additional patient health information: Female , 63 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: 10 Mg, Qw. Concurrently used drugs: NA. The patient was hospitalized.
Pyrexia, Pharyngitis

This report suggests a potential Methotrexate Pyrexia side effect(s) that can have serious consequences. A 16-year-old female patient from AR (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis and used Methotrexate (dosage: 1 Df, Weekly) starting Oct 26, 2011. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Pyrexia
  • Pharyngitis
Drugs used concurrently:
  • Enbrel (50 Mg, Weekly)
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pyrexia, may still occur.
Dyspnoea, Cough, Pyrexia, Bronchitis, Anaemia

An adverse event was reported by a physician on Jan 17, 2014 by a male taking Methotrexate (dosage: NA) . Location: US , 63 years of age, weighting 147.9 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: dyspnoea, cough, pyrexia, bronchitis, anaemia. Additional medications/treatments:
Associated medications used:
  • Procarbazine
  • Rituximab
  • Vincristine Sulfate
The patient was hospitalized.
Hypercalcaemia, Pancytopenia, Muscular Weakness, Fatigue, Back Pain, Pyrexia, Bone Pain, Psoas Abscess, Bone Tuberculosis

This Pyrexia problem was reported by a health professional from TR. A 74-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): rheumatoid arthritis,hypertension,autoimmune thyroiditis.On NS a consumer started treatment with Methotrexate (dosage: 10 Mg, Per Week). The following drugs/medications were being taken at the same time:
  • Temisartan (80 Mg, Per Day)
  • Levothyroxine (100 Mg, Per Day)
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Hypercalcaemia
  • Pancytopenia
  • Muscular Weakness
  • Fatigue
  • Back Pain
  • Pyrexia
  • Bone Pain
  • Psoas Abscess
  • Bone Tuberculosis
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Pyrexia, may become evident only after a product is in use by the general population.
Respiratory Failure, Interstitial Lung Disease, Cardiac Failure, Pyrexia, Jugular Vein Distension, C-reactive Protein Increased

This is a Methotrexate side effect report of a 64-year-old patient (weight: NA) from COUNTRY NOT SPECIFIED. The patient developed the following symptoms/conditions: psoriasis and was treated with Methotrexate (dosage: NA) starting NS. Concurrently used drugs:
  • Infliximab
  • Cyclosporine
Soon after that, the consumer experienced the following of symptoms:
  • Respiratory Failure
  • Interstitial Lung Disease
  • Cardiac Failure
  • Pyrexia
  • Jugular Vein Distension
  • C-reactive Protein Increased
The patient was hospitalized. This opens a possibility that Methotrexate could cause Pyrexia and that some patients may be more susceptible.
Bone Marrow Failure, Agranulocytosis, Febrile Neutropenia, Folate Deficiency, Thrombocytopenia, Pyrexia, Alopecia, Dermatitis, Diarrhoea

This Pyrexia side effect was reported by a health professional from TR on Jan 30, 2014. A female patient from TR , 33 years of age, was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: bone marrow failure, agranulocytosis, febrile neutropenia, folate deficiency, thrombocytopenia, pyrexia, alopecia, dermatitis, diarrhoea. Methotrexate dosage: 75 Mg According To 50 Mg/m2 Regimen.
Associated medications used:
  • Methylprednisolone (40 Mg, Unk)
  • Folinic Acid (7.5 Mg, Unk)
  • Filgrastim (30 Ml, Bid)
  • Diphenoxylate Hydrochloride
  • Calcium Folinate (15 Mg, Qid)
  • Meropenem (500 Mg, Tid)
  • Teicoplanin (400 Mg, Once/single)
  • Nystatin (1 Df, Qid)
These side effects may potentially be related to Methotrexate.
Stomatitis, Oral Pain, Pyrexia, Lethargy, Pallor, Oral Mucosal Erythema, Stomatitis Necrotising, Oral Disorder, Mouth Haemorrhage

This Pyrexia side effect was reported by a health professional from LB. A 5-year-old female patient (weight:NA) experienced the following symptoms/conditions: acute lymphocytic leukaemia. The patient was prescribed Methotrexate (dosage: 12 Mg, Unk), which was started on NS. Concurrently used drugs:
  • Prednisone (60 Mg/m2, Per Day)
  • Vincristine (1.5 Mg/m2, Unk)
  • Hydrocortisone (12 Mg, Unk)
  • Daunorubicin (30 Mg/m2, Unk)
  • L-asparaginase (1000 U Per Sq.m)
  • Cytosine Arabinoside (30 Mg, Unk)
When starting to take Methotrexate the consumer reported the following symptoms:
  • Stomatitis
  • Oral Pain
  • Pyrexia
  • Lethargy
  • Pallor
  • Oral Mucosal Erythema
  • Stomatitis Necrotising
  • Oral Disorder
  • Mouth Haemorrhage
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Stomatitis, Tongue Exfoliation, Pyrexia, Candida Infection, Staphylococcal Infection

This Pyrexia Methotrexate side effect was reported by a health professional from LB on Dec 23, 2013. A Female , child 5 years of age, weighting 26.90 lb, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Stomatitis
  • Tongue Exfoliation
  • Pyrexia
  • Candida Infection
  • Staphylococcal Infection
. Methotrexate dosage: 12mg On Days 1, 8 And 22. Additional drugs used at the same time:
  • Prednisone (60 Mg/m2/day On Days 1-28)
  • Vincristine (1.5 Mg/m2 On Days 8, 15, 22 And 29)
  • Daunorubicin (30 Mg/m2 On Days 8, 15, 22 And 29)
  • Asparaginase (10 000 U/m2 On Days 12, 15, 18, 22, 25, 29, 32 And 35)
  • Hydrocortisone (15mg On Days 8, 22)
  • Cytarabine (30mg On Days 8, 22)
The patient was hospitalized.
Odynophagia, Oral Herpes, Pyrexia, Decreased Appetite, Asthenia, Stomatitis, Herpes Simplex Meningoencephalitis, Mental Status Changes, Mucosal Inflammation

This is a Methotrexate side effect report of a 67-year-old patient (weight:NA) from US, suffering from the following symptoms/conditions: stomatitis,pancytopenia,renal impairment,infection, who was treated with Methotrexate (dosage:7.5 Mg, Qweek, Po, start time: Sep 03, 2010), combined with: NA., and developed a serious reaction and a Pyrexia side effect. The patient presented with:
  • Odynophagia
  • Oral Herpes
  • Pyrexia
  • Decreased Appetite
  • Asthenia
  • Stomatitis
  • Herpes Simplex Meningoencephalitis
  • Mental Status Changes
  • Mucosal Inflammation
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from stomatitis,pancytopenia,renal impairment,infection, resulting in Pyrexia.
Pyrexia, Urinary Tract Infection, Arthritis Bacterial, Nasopharyngitis, Gait Disturbance, Weight Bearing Difficulty, Pain, Local Swelling, Chills

A 70-year-old female patient (weight: NA) from US with the following symptoms: rheumatoid arthritis started Methotrexate Sodium treatment (dosage: Unk) on Nov 01, 2013. Soon after starting Methotrexate Sodium treatment, the consumer experienced several side effects, including:
  • Pyrexia
  • Urinary Tract Infection
  • Arthritis Bacterial
  • Nasopharyngitis
  • Gait Disturbance
  • Weight Bearing Difficulty
  • Pain
  • Local Swelling
  • Chills
. Concurrently used drugs:
  • Xeljanz (5 Mg, 2x/day)
  • Humira (Unk)
  • Plaquenil (Unk)
  • Zocor (10 Mg, 1x/day)
  • Efexor Xr (Unk, 1x/day)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate Sodium side effects, such as Pyrexia.
Cardiac Failure, Left Atrial Dilatation, Dilatation Ventricular, Interstitial Lung Disease, Dyspnoea Exertional, Malaise, Pyrexia, Cough, Hypoxia

A patient from GR was prescribed and started Methotrexate on Nov 27, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: cardiac failure, left atrial dilatation, dilatation ventricular, interstitial lung disease, dyspnoea exertional, malaise, pyrexia, cough, hypoxia Additional patient health information: male , 64 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: 10 Mg, Two Weekly Doses. Concurrently used drugs:
  • Infliximab (5 Mg/kg)
The patient was hospitalized.
Multi-organ Disorder, Toxicity To Various Agents, Mucosal Inflammation, Dysphagia, Odynophagia, Pyrexia, Erythema, Skin Hyperpigmentation, Skin Lesion

This report suggests a potential Methotrexate Pyrexia side effect(s) that can have serious consequences. A 32-year-old female patient from TN (weight:NA) was diagnosed with the following health condition(s): ectopic pregnancy and used Methotrexate (dosage: NA) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Multi-organ Disorder
  • Toxicity To Various Agents
  • Mucosal Inflammation
  • Dysphagia
  • Odynophagia
  • Pyrexia
  • Erythema
  • Skin Hyperpigmentation
  • Skin Lesion
Drugs used concurrently:NA. The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pyrexia, may still occur.
Febrile Neutropenia, Pyrexia, Chills, Haematotoxicity

An adverse event was reported by a health professional on Oct 10, 2013 by a male taking Methotrexate Injection (methotrexate) (dosage: NA) was diagnosed with and. Location: US , child 4 years of age, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: febrile neutropenia, pyrexia, chills, haematotoxicity. Additional medications/treatments:
Multiple prescriptions taken:
  • Dasatinib
  • Cyclophosphamide (1000 Mg/m2 On Day 1 And 28 (1 Hour))
  • Cytarabine (75 Mg/m2 Day, Intravenous)
  • Mercaptopurine
  • Chlorhexidine
  • Lactulose
  • Macrogol
  • Sulfatrim
The patient was hospitalized.
Febrile Neutropenia, Pyrexia, Chills, Haematotoxicity

This Pyrexia problem was reported by a physician from US. A 4-year-old patient (weight: NA) was diagnosed with the following medical condition(s): acute lymphocytic leukaemia.On Dec 26, 2012 a consumer started treatment with Methotrexate Injection (methotrexate) (dosage: NA). The following drugs/medications were being taken at the same time:
  • Dasatinib
  • Cyclophosphamide (1000 Mg/m2 On Day 1 And 28 (1 Hour))
  • Cytarabine (75 Mg/m2 Day, Intravenous)
  • Mercaptopurine
  • Mesna (55 Mg Milligram(s), 1 Hour)
  • Dexamethasone (5.25 Mg Milligram(s), 3 Day)
  • Folinic Acid
  • Vincristine
When commencing Methotrexate Injection (methotrexate), the patient experienced the following unwanted symptoms /side effects:
  • Febrile Neutropenia
  • Pyrexia
  • Chills
  • Haematotoxicity
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Pyrexia, may become evident only after a product is in use by the general population.
Cholestasis, Histoplasmosis Disseminated, Hepatic Infection Fungal, Malaise, Pyrexia, Weight Decreased, Night Sweats, Abdominal Pain

This is a Methotrexate side effect report of a 74-year-old female patient (weight: NA) from NL. The patient developed the following symptoms/conditions: necrotising scleritis and was treated with Methotrexate (dosage: 20 Mg, Per Week) starting 201104. Concurrently used drugs:
  • Prednisolone (1 Mg/kg, Per Day)
  • Prednisolone (15 Mg, Per Day)
  • Adalimumab (40 Mg, Per Week)
Soon after that, the consumer experienced the following of symptoms:
  • Cholestasis
  • Histoplasmosis Disseminated
  • Hepatic Infection Fungal
  • Malaise
  • Pyrexia
  • Weight Decreased
  • Night Sweats
  • Abdominal Pain
The patient was hospitalized. This opens a possibility that Methotrexate could cause Pyrexia and that some female patients may be more susceptible.
Sepsis, Lymphoproliferative Disorder, Papule, Scab, Pyrexia, Erythema, Skin Lesion, Pseudomonas Infection, Skin Necrosis

This Pyrexia side effect was reported by a health professional from JP on Aug 30, 2013. A female patient from JP , 64 years of age, was diagnosed with and was treated with Methotrexate. Patient felt the following Methotrexate side effects: sepsis, lymphoproliferative disorder, papule, scab, pyrexia, erythema, skin lesion, pseudomonas infection, skin necrosis. Methotrexate dosage: 5 Mg, Qw2.
Multiple prescriptions taken:
  • Piperacillin+tazobactam
  • Sulfadiazine
  • Prednisolone
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Pyrexia Causes and Reviews


A fever is a body temperature that is higher than normal. A normal temperature can vary from person to person, but it is usually around 98.6 F. A fever is not a disease. It is usually a sign that your body is trying to fight an illness or infection.

Infections cause most fevers. You get a fever because your body is trying to kill the virus or bacteria that caused the infection. Most of those bacteria and viruses do well when your body is at your normal temperature. But if you have a fever, it is harder for them to survive. Fever also activates your body's immune system.

Other causes of fevers include

  • Medicines, including some antibiotics, blood pressure medicines, and anti-seizure medicines
  • Heat illness
  • Cancers
  • Autoimmune diseases
  • Some childhood immunizations

Treatment depends on the cause of your fever. If the fever is very high, your health care provider may recommend taking an over-the-counter medicine such as acetaminophen or ibuprofen. Adults can also take aspirin, but children with fevers should not take aspirin. It is also important to drink enough liquids, to prevent dehydration.


Methotrexate Pyrexia Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
Anaemia (195)
Pain (188)
Renal Failure Acute (177)
Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
Neutropenia (129)
Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
Interstitial Lung Disease (113)
Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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