Methotrexate Renal Failure Side Effect Reports


The following Methotrexate Renal Failure side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Renal Failure, can occur, and what you can do about them.

A side effect could appear soon after you start Methotrexate or it might take time to develop.


Pancytopenia, Hyperglycaemia, Diarrhoea, Renal Failure

This Renal Failure side effect was reported by a physician from COUNTRY NOT SPECIFIED. A 75-year-old patient (weight:NA) experienced the following symptoms/conditions: squamous cell carcinoma of head and neck,diabetes mellitus. The patient was prescribed Methotrexate (dosage: Dose- 40mg/mq), which was started on 2005. Concurrently used drugs:
  • Metforal (2000 Mg)
  • Zyloric (150 Mg)
When starting to take Methotrexate the consumer reported the following symptoms:
  • Pancytopenia
  • Hyperglycaemia
  • Diarrhoea
  • Renal Failure
The patient was hospitalized. These side effects may potentially be related to Methotrexate.
Bone Tuberculosis, Hypercalcaemia, Pancytopenia, Renal Failure, Skin Necrosis

This Renal Failure Methotrexate side effect was reported by a physician from US on Jan 30, 2014. A Female , 74 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Bone Tuberculosis
  • Hypercalcaemia
  • Pancytopenia
  • Renal Failure
  • Skin Necrosis
. Methotrexate dosage: NA. Additional drugs used at the same time:
  • Telmisartan (telmisartan)
  • Levothyroxine (levothyroxine)
The patient was hospitalized.
Renal Failure, Oedema Peripheral, Off Label Use

This is a Methotrexate side effect report of a 58-year-old patient (weight:NA) from CH, suffering from the following symptoms/conditions: overlap syndrome, who was treated with Methotrexate (dosage:NA, start time: NS), combined with:
  • Mycophenolate Mofetil
  • Hydroxychloroquine
  • Sildenafil Citrate
  • Sildenafil Citrate
  • Pentoxifylline
  • Prednisone
  • Prednisone
  • Azathioprine
, and developed a serious reaction and a Renal Failure side effect. The patient presented with:
  • Renal Failure
  • Oedema Peripheral
  • Off Label Use
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from overlap syndrome, resulting in Renal Failure.
Intervertebral Discitis, Bone Tuberculosis, Hypercalcaemia, Pancytopenia, Aspartate Aminotransferase Increased, Skin Necrosis, Renal Failure, Muscular Weakness

A 74-year-old female patient (weight: NA) from TR with the following symptoms: rheumatoid arthritis started Methotrexate treatment (dosage: 1 Week) on NS. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Intervertebral Discitis
  • Bone Tuberculosis
  • Hypercalcaemia
  • Pancytopenia
  • Aspartate Aminotransferase Increased
  • Skin Necrosis
  • Renal Failure
  • Muscular Weakness
. Concurrently used drugs:
  • (fenyramidol)
  • (telmisartan)
  • (levothyroxine)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Renal Failure.
Pancytopenia, Renal Failure, Skin Necrosis, Hypercalcaemia, Bone Tuberculosis

A female patient from TR was prescribed and started Methotrexate on Jan 23, 2014. Patient felt the following Methotrexate side effects: pancytopenia, renal failure, skin necrosis, hypercalcaemia, bone tuberculosis Additional patient health information: Female , 74 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: 10 Milligram Daily;. Concurrently used drugs:
  • Telmisartan (80 Milligram Daily;)
  • Levothyroxine Sodium (100 Milligram Daily;)
The patient was hospitalized.
Bone Tuberculosis, Hypercalcaemia, Pancytopenia, Renal Failure

This report suggests a potential Methotrexate Renal Failure side effect(s) that can have serious consequences. A 74-year-old female patient from COUNTRY NOT SPECIFIED (weight:NA) was diagnosed with the following health condition(s): rheumatoid arthritis,pain,hypertension,autoimmune thyroiditis and used Methotrexate (dosage: NA) starting NS. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Bone Tuberculosis
  • Hypercalcaemia
  • Pancytopenia
  • Renal Failure
Drugs used concurrently:
  • Phenyramidol Hydrochloride (200 Mg)
  • Telmisartan (80 Mg)
  • Levothyroxine (100 Mg)
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure, may still occur.
Pancytopenia, Renal Failure, Skin Necrosis, Hypercalcaemia, Bone Tuberculosis

An adverse event was reported by a health professional on Jan 20, 2014 by a Female taking Methotrexate (dosage: 10 Mg/week) was diagnosed with and. Location: TR , 74 years of age, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: pancytopenia, renal failure, skin necrosis, hypercalcaemia, bone tuberculosis. Additional medications/treatments:
Associated medications used:
  • Telmisartan (80 Mg/day)
  • Levothyroxine Sodium (100 Mg/day)
The patient was hospitalized.
Hepatic Failure, Renal Failure, Renal Failure Acute, Hepatic Encephalopathy

This Renal Failure problem was reported by a health professional from FR. A 57-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Mar 05, 2010 a consumer started treatment with Methotrexate Sandoz (dosage: 15 Mg, Unk). The following drugs/medications were being taken at the same time:
  • Aracytine
  • Vincristine Paulding (2 Mg, Unk)
  • Cerubidine
  • Endoxan Asta
  • Kidrolase
  • Methylprednisolone Merck
When commencing Methotrexate Sandoz, the patient experienced the following unwanted symptoms /side effects:
  • Hepatic Failure
  • Renal Failure
  • Renal Failure Acute
  • Hepatic Encephalopathy
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Renal Failure, may become evident only after a product is in use by the general population.
Renal Failure, Pyoderma Gangrenosum, Condition Aggravated

This is a Methotrexate side effect report of a 45-year-old patient (weight: NA) from US. The patient developed the following symptoms/conditions: pyoderma gangrenosum and was treated with Methotrexate (dosage: NA) starting NS. Concurrently used drugs:
  • Infliximab
  • Adalimumab
  • Anakinra
  • Corticosteroids
  • Cyclosporine
Soon after that, the consumer experienced the following of symptoms:
  • Renal Failure
  • Pyoderma Gangrenosum
  • Condition Aggravated
This opens a possibility that Methotrexate could cause Renal Failure and that some patients may be more susceptible.
Asthenia, Pancytopenia, Accidental Overdose, Renal Failure

This Renal Failure side effect was reported by a pharmacist from US on Dec 04, 2013. A female patient from US , 82 years of age, weighting 187.4 lb, was diagnosed with and was treated with Methotrexate. Directly after treatment started, patient experienced the unwanted or unexpected Methotrexate side effects: asthenia, pancytopenia, accidental overdose, renal failure. Methotrexate dosage: 1 Pill, Qd, Oral. These side effects may potentially be related to Methotrexate.
Toxicity To Various Agents, Septic Shock, Renal Failure, Hepatocellular Injury

This Renal Failure side effect was reported by a health professional from COUNTRY NOT SPECIFIED. A 32-year-old female patient (weight:NA) experienced the following symptoms/conditions: ectopic pregnancy termination. The patient was prescribed Methotrexate (dosage: 75 Mg), which was started on NS. Concurrently used drugs: NA. When starting to take Methotrexate the consumer reported the following symptoms:
  • Toxicity To Various Agents
  • Septic Shock
  • Renal Failure
  • Hepatocellular Injury
These side effects may potentially be related to Methotrexate.
Renal Failure, Pancytopenia, Hepatocellular Injury, Cholestasis, Bone Marrow Failure, Septic Shock, Toxicity To Various Agents, Diarrhoea Haemorrhagic, Dysphagia

This Renal Failure Methotrexate side effect was reported by a health professional from TN on Oct 25, 2013. A Female , 32 years of age, was diagnosed with and was treated with Methotrexate. The patient presented the following health conditions:
  • Renal Failure
  • Pancytopenia
  • Hepatocellular Injury
  • Cholestasis
  • Bone Marrow Failure
  • Septic Shock
  • Toxicity To Various Agents
  • Diarrhoea Haemorrhagic
  • Dysphagia
. Methotrexate dosage: 75 Mg, Unk. Additional drugs used at the same time: NA.
Pneumocystis Jirovecii Pneumonia, Acute Respiratory Failure, Renal Failure

This is a Methotrexate side effect report of a 66-year-old patient (weight:NA) from NO, suffering from the following symptoms/conditions: rheumatoid arthritis, who was treated with Methotrexate (dosage:NA, start time: Feb 07, 2012), combined with:
  • Enbrel
  • Imigran
  • Fosamax
  • Zestril
  • Folsyre Naf
  • Calcigran Forte
, and developed a serious reaction and a Renal Failure side effect. The patient presented with:
  • Pneumocystis Jirovecii Pneumonia
  • Acute Respiratory Failure
  • Renal Failure
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Methotrexate treatment in patients suffering from rheumatoid arthritis, resulting in Renal Failure.
Renal Failure, Acute Respiratory Failure, Pneumocystis Jirovecii Pneumonia, Dyspnoea

A 66-year-old patient (weight: NA) from NO with the following symptoms: rheumatoid arthritis started Methotrexate treatment (dosage: 25 Mg, Weekly) on Mar 09, 2012. Soon after starting Methotrexate treatment, the consumer experienced several side effects, including:
  • Renal Failure
  • Acute Respiratory Failure
  • Pneumocystis Jirovecii Pneumonia
  • Dyspnoea
. Concurrently used drugs:
  • Enbrel (50 Mg, Weekly)
  • Calcigran Forte (500 Mg, Unk)
  • Zestril
  • Folsyre Naf (1 Mg, Unk)
  • Imigran
  • Fosamax (70 Mg, Unk)
This finding indicates that some patients can be more vulnerable to developing Methotrexate side effects, such as Renal Failure.
Pancytopenia, Stomatitis, Renal Failure, Staphylococcal Infection, Secondary Amyloidosis

A female patient from COUNTRY NOT SPECIFIED was prescribed and started Methotrexate on Aug 16, 2013. After Methotrexate was administered, patient encountered several Methotrexate side effects: pancytopenia, stomatitis, renal failure, staphylococcal infection, secondary amyloidosis Additional patient health information: Female , 58 years of age, The consumer reported the following symptoms: was diagnosed with and. Methotrexate dosage: NA. Concurrently used drugs:
  • Calcium Carbonate
  • Folic Acid
  • Enalapril
  • Calcitriol
  • Metilprednizolon
The patient was hospitalized.
Renal Failure Acute, Tubulointerstitial Nephritis, White Blood Cell Count Increased, Abdominal Pain, Blood Creatine Increased

This report suggests a potential Methotrexate Renal Failure side effect(s) that can have serious consequences. A 15-year-old patient from GB (weight:NA) was diagnosed with the following health condition(s): anaplastic large-cell lymphoma,dyspepsia and used Methotrexate (dosage: 3900 Milligram Daily;) starting May 25, 2013. Soon after starting Methotrexate the patient began experiencing various side effects, including:
  • Renal Failure Acute
  • Tubulointerstitial Nephritis
  • White Blood Cell Count Increased
  • Abdominal Pain
  • Blood Creatine Increased
Drugs used concurrently:
  • Lansoprazole (30 Milligram Daily;)
  • Ondansetron
  • Levomepromazine
  • Paracetamol
  • Piperacillin And Tazobactam
  • Gentamicin
  • Codeine
  • Mesna
The patient was hospitalized. Although Methotrexate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure, may still occur.
Tubulointerstitial Nephritis, White Blood Cell Count Increased, Renal Failure Acute, Blood Creatine Increased, Abdominal Pain

An adverse event was reported by a health professional on Jul 18, 2013 by a male taking Methotrexate (dosage: 3900 Mg, Qd) was diagnosed with and. Location: GB , 15 years of age, weighting 92.59 lb, patient began experiencing various side effects, including: Patient felt the following Methotrexate side effects: tubulointerstitial nephritis, white blood cell count increased, renal failure acute, blood creatine increased, abdominal pain. Additional medications/treatments:
Multiple prescriptions taken:
  • Lansoprazole (30 Mg, Qd)
  • Ondansetron
  • Levomepromazine
  • Paracetamol
  • Piperacillin And Tazobactam
  • Gentamicin
  • Codeine
  • Mesna
The patient was hospitalized.
Convulsion, Renal Failure, Hypertension

This Renal Failure problem was reported by a physician from US. A 15-year-old patient (weight: NA) was diagnosed with the following medical condition(s): acute lymphocytic leukaemia.On NS a consumer started treatment with Methotrexate (dosage: NA). The following drugs/medications were being taken at the same time:
  • Levetiracetam
When commencing Methotrexate, the patient experienced the following unwanted symptoms /side effects:
  • Convulsion
  • Renal Failure
  • Hypertension
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Renal Failure, may become evident only after a product is in use by the general population.
Convulsion, Vomiting, Renal Failure, Hypertension, Toxicity To Various Agents

This is a Methotrexate side effect report of a 15-year-old patient (weight: NA) from FR. The patient developed the following symptoms/conditions: acute lymphocytic leukaemia,epilepsy and was treated with Methotrexate (dosage: 5, G/m2/24 Hr) starting NS. Concurrently used drugs:
  • Levetiracetam (15 Mg/kg, Mg/kg Day)
  • Ondansetron (ondansetron)
  • Metopimazine (metopimazine)
Soon after that, the consumer experienced the following of symptoms:
  • Convulsion
  • Vomiting
  • Renal Failure
  • Hypertension
  • Toxicity To Various Agents
The patient was hospitalized. This opens a possibility that Methotrexate could cause Renal Failure and that some patients may be more susceptible.
Toxicity To Various Agents, Blood Pressure Increased, Renal Failure, Vomiting

This Renal Failure side effect was reported by a health professional from FR on Dec 04, 2013. A patient from FR , 15 years of age, was treated with Methotrexate. Patient felt the following Methotrexate side effects: toxicity to various agents, blood pressure increased, renal failure, vomiting. Methotrexate dosage: NA.
Multiple prescriptions taken:
  • Levetiracetam (15 Mg/kg, Per Day In Two Divided Doses)
These side effects may potentially be related to Methotrexate.
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DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Methotrexate Renal Failure Causes and Reviews


Healthy kidneys clean your blood by removing excess fluid, minerals, and wastes. They also make hormones that keep your bones strong and your blood healthy. But if the kidneys are damaged, they don't work properly. Harmful wastes can build up in your body. Your blood pressure may rise. Your body may retain excess fluid and not make enough red blood cells. This is called kidney failure.

If your kidneys fail, you need treatment to replace the work they normally do. The treatment options are dialysis or a kidney transplant. Each treatment has benefits and drawbacks. No matter which treatment you choose, you'll need to make some changes in your life, including how you eat and plan your activities. But with the help of health care providers, family, and friends, most people with kidney failure can lead full and active lives.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


Methotrexate Renal Failure Reviews

Mon, 21 Feb 2011

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it ultimately RA could be fatal. I am only in my 50's not ready to die yet!

Sat, 26 Oct 2013

has anybody had any positive affects from taking " Methoblastin " (Methotrexate) for psoaratic arthritis ? these reviews sound terrible and i have been told to go on it... im a little scared now :(

Sun, 15 May 2011

I have been on Methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is there anything I can do other than drink a lot of water. Thank you

Sat, 20 Dec 2008
Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine again. I would want to know if I should reduce the dose.
Sun, 24 Jan 2010
I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause disseminated herpes which can be potentially fatal. My Rheum told me to take Benadryl. I believe this is going to be my one and only shot this drug scares the death out of me.
Tue, 27 Apr 2010
painful cough after 2 days of 1st dose lasting-- to date-- 6 days
Thu, 27 May 2010
I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spots, Stomach pains, reflux, Unable to properly swollow food, confussion, memmory loss, anxiety attacks, nightmares, hard on sleeping, high fevers, diahria, halusanations, itching, dry skin, mouth and eyes, coughin, sore tendons etc.. After i had stoped taking it, specialist said the side effects would go away. The side effects have never gone.. I try to controll it by taking Folic Acid 1mg a day, Glusamine (Joint food). 3 days a week i will take a small amount of Milk Thistle. Too much of Milk thistle would cause Mood swings and Constipation. Doctors are no help.
Sat, 18 Sep 2010
im a 44yrs old female who took Methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
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Diarrhoea (238)
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Renal Failure Acute (177)
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Abdominal Pain (152)
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Pain In Extremity (141)
Convulsion (139)
Rash (139)
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Condition Aggravated (129)
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Toxicity To Various Agents (125)
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Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
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Respiratory Failure (108)
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Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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